Perspective: How Fast Dynamics Affect Slow Function in Protein Machines

Fast dynamics shape the function of the AAA + machine ClpB :Lessons from single‐molecule FRET spectroscopy

(2022) Inbal Riven et al.   FEBS Journal

Role of Repeated Conformational Transitions in Substrate Binding of Adenylate Kinase

(2022) Jiajun Lu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Using Catalysis to Drive Chemistry Away from Equilibrium: Relating Kinetic Asymmetry, Power Strokes, and the Curtin–Hammett Principle in Brownian Ratchets

(2022) Shuntaro Amano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Entropic Inhibition: How the Activity of a AAA+ Machine Is Modulated by Its Substrate-Binding Domain

(2021) Marija Iljina et al.   ACS Chemical Biology

Out-of-Equilibrium Biophysical Chemistry: The Case for Multidimensional, Integrated Single-Molecule Approaches

(2021) Narendar Kolimi et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Ultrafast pore-loop dynamics in a AAA+ machine point to a Brownian-ratchet mechanism for protein translocation

(2021) Hisham Mazal et al.   Science Advances

Processive extrusion of polypeptide loops by a Hsp100 disaggregase

(2020) Mario J. Avellaneda et al.   NATURE

Resolving dynamics and function of transient states in single enzyme molecules

(2020) Hugo Sanabria et al.   Nature Communications

Tunable microsecond dynamics of an allosteric switch regulate the activity of a AAA+ disaggregation machine

(2019) Hisham Mazal et al.   Nature Communications

Symmetry, Rigidity, and Allosteric Signaling: From Monomeric Proteins to Molecular Machines

(2019) D. Thirumalai et al.   CHEMICAL REVIEWS

Stairway to translocation: AAA+ motor structures reveal the mechanisms of ATP‐dependent substrate translocation

(2019) Stephanie N. Gates et al.   PROTEIN SCIENCE

Slow domain reconfiguration causes power-law kinetics in a two-state enzyme

(2018) Iris Grossman-Haham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct observation of ultrafast large-scale dynamics of an enzyme under turnover conditions

(2018) Haim Yuval Aviram et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Entropy redistribution controls allostery in a metalloregulatory protein

(2017) Daiana A. Capdevila et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Perspective: Defining and quantifying the role of dynamics in enzyme catalysis

(2016) Arieh Warshel et al.   JOURNAL OF CHEMICAL PHYSICS

Large-Scale Conformational Dynamics Control H5N1 Influenza Polymerase PB2 Binding to Importin α

(2015) Elise Delaforge et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dissection of Axial-Pore Loop Function during Unfolding and Translocation by a AAA+ Proteolytic Machine

(2015) Ohad Iosefson et al.   Cell Reports

The ensemble nature of allostery

(2014) Hesam N. Motlagh et al.   NATURE

Protein rescue from aggregates by powerful molecular chaperone machines

(2013) Shannon M. Doyle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Allostery and the Monod-Wyman-Changeux Model After 50 Years

(2012) Jean-Pierre Changeux   Annual Review of Biophysics

AAA+ Proteases: ATP-Fueled Machines of Protein Destruction

(2011) Robert T. Sauer et al.   Annual Review of Biochemistry

Hidden dynamic allostery in a PDZ domain

(2009) C. M. Petit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Artificial Brownian motors: Controlling transport on the nanoscale

(2009) Peter Hänggi et al.   REVIEWS OF MODERN PHYSICS