VGLL4-TEAD1 promotes vascular smooth muscle cell differentiation from human pluripotent stem cells via TET2

YAP induces an oncogenic transcriptional program through TET1-mediated epigenetic remodeling in liver growth and tumorigenesis

(2022) Bo-Kuan Wu et al.   NATURE GENETICS

Generation of Vascular Smooth Muscle Cells From Induced Pluripotent Stem Cells

(2021) Mengcheng Shen et al.   CIRCULATION RESEARCH

TET2 Protects Against Vascular Smooth Muscle Cell Apoptosis and Intimal Thickening in Transplant Vasculopathy

(2021) Allison C. Ostriker et al.   CIRCULATION

YAP1/TEAD1 upregulate platelet-derived growth factor receptor beta to promote vascular smooth muscle cell proliferation and neointima formation

(2021) Islam Osman et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

H3K4 di-methylation governs smooth muscle lineage identity and promotes vascular homeostasis by restraining plasticity

(2021) Mingjun Liu et al.   DEVELOPMENTAL CELL

YAP inhibition promotes endothelial cell differentiation from pluripotent stem cell through EC master transcription factor FLI1

(2021) Yingyi Quan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

TET methylcytosine oxidases: new insights from a decade of research

(2020) Chan-Wang J. Lio et al.   JOURNAL OF BIOSCIENCES

VGLL4 promotes osteoblast differentiation by antagonizing TEADs-inhibited Runx2 transcription

(2020) Jinlong Suo et al.   Science Advances

Circular RNA CircMAP3K5 Acts as a MicroRNA-22-3p Sponge to Promote Resolution of Intimal Hyperplasia Via TET2-Mediated Smooth Muscle Cell Differentiation

(2020) Zhi Zeng et al.   CIRCULATION

VGLL4 plays a critical role in heart valve development and homeostasis

(2019) Wei Yu et al.   PLoS Genetics

Transcription factor TEAD1 is essential for vascular development by promoting vascular smooth muscle differentiation

(2019) Tong Wen et al.   CELL DEATH AND DIFFERENTIATION

Dual function of VGLL 4 in muscle regeneration

(2019) Xue Feng et al.   EMBO JOURNAL

The Hippo Signaling Pathway in Development and Disease

(2019) Yonggang Zheng et al.   DEVELOPMENTAL CELL

Tumor suppressor TET2 promotes cancer immunity and immunotherapy efficacy

(2019) Yan-ping Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

Zebrafish Vestigial Like Family Member 4b Is Required for Valvulogenesis Through Sequestration of Transcription Factor Myocyte Enhancer Factor 2c

(2019) Chang Xue et al.   Frontiers in Cell and Developmental Biology

Recent advances in the applications of iPSC technology

(2019) Connor Wiegand et al.   CURRENT OPINION IN BIOTECHNOLOGY

TET2: A Novel Epigenetic Regulator and Potential Intervention Target for Atherosclerosis

(2018) Yami Liu et al.   DNA AND CELL BIOLOGY

TGFβ-TAZ/SRF signalling regulates vascular smooth muscle cell differentiation

(2017) Christina Pagiatakis et al.   FEBS Journal

Role of TET enzymes in DNA methylation, development, and cancer

(2016) Kasper Dindler Rasmussen et al.   GENES & DEVELOPMENT

Efficient, footprint-free human iPSC genome editing by consolidation of Cas9/CRISPR and piggyBac technologies

(2016) Gang Wang et al.   Nature Protocols

Yes-Associated Protein Inhibits Transcription of Myocardin and Attenuates Differentiation of Vascular Smooth Muscle Cell from Cardiovascular Progenitor Cell Lineage

(2016) Lunchang Wang et al.   STEM CELLS

Induced pluripotent stem cell-derived vascular smooth muscle cells: methods and application

(2015) Biraja C. Dash et al.   BIOCHEMICAL JOURNAL

Epigenetic regulation of smooth muscle cell plasticity

(2015) Renjing Liu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The TET2 interactors and their links to hematological malignancies

(2015) Feng Pan et al.   IUBMB LIFE

Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells

(2015) Christoph Patsch et al.   NATURE CELL BIOLOGY

Acute loss of TET function results in aggressive myeloid cancer in mice

(2015) Jungeun An et al.   Nature Communications

The Hippo Transducer YAP1 Transforms Activated Satellite Cells and Is a Potent Effector of Embryonal Rhabdomyosarcoma Formation

(2014) Annie M. Tremblay et al.   CANCER CELL

A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer

(2014) Shi Jiao et al.   CANCER CELL

VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex

(2014) Wenjing Zhang et al.   CELL RESEARCH

TET2 Deficiency Inhibits Mesoderm and Hematopoietic Differentiation in Human Embryonic Stem Cells

(2014) Thierry Langlois et al.   STEM CELLS

Ten-Eleven Translocation-2 (TET2) Is a Master Regulator of Smooth Muscle Cell Plasticity

(2013) Renjing Liu et al.   CIRCULATION

The Transcription Factor TEAD1 Represses Smooth Muscle-specific Gene Expression by Abolishing Myocardin Function

(2013) Fang Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TET enzymes, TDG and the dynamics of DNA demethylation

(2013) Rahul M. Kohli et al.   NATURE

TETonic shift: biological roles of TET proteins in DNA demethylation and transcription

(2013) William A. Pastor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epigenetic Control of Smooth Muscle Cell Differentiation and Phenotypic Switching in Vascular Development and Disease

(2011) Matthew R. Alexander et al.   Annual Review of Physiology

Signaling Mechanisms That Regulate Smooth Muscle Cell Differentiation

(2011) Christopher P. Mack   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Smooth Muscle Cell Differentiation In Vitro

(2011) Changqing Xie et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY