Mechanisms of Si-Wu Decoction in the treatment of ulcerative colitis revealed by network pharmacology and experimental verification

Pulsatilla chinensis saponins improve SCFAs regulating GPR43-NLRP3 signaling pathway in the treatment of ulcerative colitis

(2023) Zexie Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Sustainable extraction of ligustilide and ferulic acid from Angelicae Sinensis Radix, for antioxidant and anti-inflammatory activities

(2023) Xuejiao Song et al.   ULTRASONICS SONOCHEMISTRY

Angelica sinensis aboveground part polysaccharide and its metabolite 5-MT ameliorate colitis via modulating gut microbiota and TLR4/MyD88/NF-κB pathway

(2023) Yuan-Feng Zou et al.   International Journal of Biological Macromolecules

Pulsatilla chinensis saponins ameliorated murine depression by inhibiting intestinal inflammation mediated IDO1 overexpression and rebalancing tryptophan metabolism

(2023) Tingting Wang et al.   PHYTOMEDICINE

Etiology of IBD—Is It Still a Mystery?

(2022) Anna Kofla-Dłubacz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ginsenoside Rh2 alleviates ulcerative colitis by regulating the STAT3/miR-214 signaling pathway

(2021) Xuanqing Chen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Structural characterization and immunomodulatory activities of two polysaccharides from Rehmanniae Radix Praeparata

(2021) Yan Zhou et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Kaempferol Alleviates Murine Experimental Colitis by Restoring Gut Microbiota and Inhibiting the LPS-TLR4-NF-κB Axis

(2021) Yifan Qu et al.   Frontiers in Immunology

Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management

(2021) Gerhard Rogler et al.   GASTROENTEROLOGY

Anti-Inflammatory Effects of Huangqin Decoction on Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice Through Regulation of the Gut Microbiota and Suppression of the Ras-PI3K-Akt-HIF-1α and NF-κB Pathways

(2020) Min-yao Li et al.   Frontiers in Pharmacology

β-Sitosterol Reverses Multidrug Resistance via BCRP Suppression by Inhibiting the p53–MDM2 Interaction in Colorectal Cancer

(2020) Ziyuan Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

β-sitosterol ameliorates influenza A virus-induced proinflammatory response and acute lung injury in mice by disrupting the cross-talk between RIG-I and IFN/STAT signaling

(2020) Bei-xian Zhou et al.   ACTA PHARMACOLOGICA SINICA

The NF-κB Signaling Pathway, the Microbiota, and Gastrointestinal Tumorigenesis: Recent Advances

(2020) Chao Peng et al.   Frontiers in Immunology

The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets

(2020) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Paeoniflorin modulates gut microbial production of indole-3-lactate and epithelial autophagy to alleviate colitis in mice

(2020) Qilin Fan et al.   PHYTOMEDICINE

Protective effects of berberine hydrochloride on DSS-induced ulcerative colitis in rats

(2019) Lei Zhu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Hepatic Complications of Inflammatory Bowel Disease

(2019) Mahmoud Mahfouz et al.   Clinics in Liver Disease

Review article: managing the adverse events caused by anti-TNF therapy in inflammatory bowel disease

(2019) Uday N. Shivaji et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Effect of β-sitosterol self-microemulsion and β-sitosterol ester with linoleic acid on lipid-lowering in hyperlipidemic mice

(2019) Chuanxun Yuan et al.   Lipids in Health and Disease

Comorbidities in inflammatory bowel disease: a call for action

(2019) Marjorie Argollo et al.   Lancet Gastroenterology & Hepatology

The Methodological Trends of Traditional Herbal Medicine Employing Network Pharmacology

(2019) Won-Yung Lee et al.   Biomolecules

Rehmannioside A attenuates cognitive deficits in rats with vascular dementia (VD) through suppressing oxidative stress, inflammation and apoptosis

(2019) Miao Sun et al.   BIOMEDICINE & PHARMACOTHERAPY

Anti-inflammatory and immunoregulatory effects of paeoniflorin and total glucosides of paeony

(2019) Lingling Zhang et al.   PHARMACOLOGY & THERAPEUTICS

Kaempferol-3-o-β- d -glucuronate exhibit potential anti-inflammatory effect in LPS stimulated RAW 264.7 cells and mice model

(2018) Vidushi Khajuria et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ferulic Acid Supplementation Improves Lipid Profiles, Oxidative Stress, and Inflammatory Status in Hyperlipidemic Subjects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

(2018) Akkarach Bumrungpert et al.   Nutrients

Rhubarb Peony Decoction Ameliorates Ulcerative Colitis in Mice by Regulating Gut Microbiota to Restoring Th17/Treg Balance

(2018) Shuang Luo et al.   JOURNAL OF ETHNOPHARMACOLOGY

New insights into the ameliorative effects of ferulic acid in pathophysiological conditions

(2017) Sumit Ghosh et al.   FOOD AND CHEMICAL TOXICOLOGY

DrugBank 5.0: a major update to the DrugBank database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Colorectal Cancer and Dysplasia in Inflammatory Bowel Disease: A Review of Disease Epidemiology, Pathophysiology, and Management

(2016) P. S. Dulai et al.   Cancer Prevention Research

Biologic Therapies and Risk of Infection and Malignancy in Patients With Inflammatory Bowel Disease: A Systematic Review and Network Meta-analysis

(2016) Stefanos Bonovas et al.   Clinical Gastroenterology and Hepatology

SwissTargetPrediction: a web server for target prediction of bioactive small molecules

(2014) David Gfeller et al.   NUCLEIC ACIDS RESEARCH

OMIM.org: Online Mendelian Inheritance in Man (OMIM®), an online catalog of human genes and genetic disorders

(2014) Joanna S. Amberger et al.   NUCLEIC ACIDS RESEARCH

TCMSP: a database of systems pharmacology for drug discovery from herbal medicines

(2014) Jinlong Ru et al.   Journal of Cheminformatics

The burden of inflammatory bowel disease in Europe

(2013) Johan Burisch et al.   Journal of Crohns & Colitis

Extraintestinal manifestations and complications in IBD

(2013) Claudia Ott et al.   Nature Reviews Gastroenterology & Hepatology

NF-κB and STAT3 signaling pathways collaboratively link inflammation to cancer

(2013) Yihui Fan et al.   Protein & Cell

Pharmacogenomics Knowledge for Personalized Medicine

(2012) M Whirl-Carrillo et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

NF-κB and the link between inflammation and cancer

(2012) Joseph A. DiDonato et al.   IMMUNOLOGICAL REVIEWS

Ulcerative colitis

(2012) Ingrid Ordás et al.   LANCET

Analgesic and anti-inflammatory activity of β-sitosterol isolated from Nyctanthes arbortristis leaves

(2011) Sunil A. Nirmal et al.   INFLAMMOPHARMACOLOGY

Assessment and comparison of immunoregulatory activity of four hydrosoluble fractions of Angelica sinensis in vitro on the peritoneal macrophages in ICR mice

(2010) Ying Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Isolation and identification of anti-inflammatory constituents from Ligusticum chuanxiong and their underlying mechanisms of action on microglia

(2010) Terry C.T. Or et al.   NEUROPHARMACOLOGY

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

β-Sitosterol exhibits anti-inflammatory activity in human aortic endothelial cells

(2009) Stella Loizou et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology