Article
Integrative & Complementary Medicine
Ming-jun Lei, Fan Bai, Qing-yun Zhang, Qing-qing Yang, Zan Tian
Summary: This study aimed to investigate the therapeutic effects of total glucosides of paeony (TGP) on psoriasis based on the immunomodulatory effect of dermal mesenchymal stem cells (DMSCs). The results showed that TGP alleviated skin pathological injury, reduced epidermis layer thickness, inhibited apoptosis, and regulated the secretion of inflammatory cytokines and the proportion of Treg and Th17. Furthermore, TGP treatment of psoriatic DMSCs increased cell viability, decreased apoptosis, relieved inflammatory response, and inhibited the expression of toll-like receptor 4 and P65.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Review
Integrative & Complementary Medicine
Shu-jun Wei, Qing-man He, Qing Zhang, Kang-hua Fu, Ruo-lan Li, Wei Peng, Yong-xiang Gao
Summary: Primary Sjogren's syndrome is a chronic autoimmune disease involving exocrine glands, and traditional Chinese medicines have been investigated for their treatment effects on this syndrome. These medicines are used in various ways, such as upregulation of aquaporin proteins, suppression of cell apoptosis, and suppression of abnormal activation of T and B lymphocytes. However, more research is needed on the active constituents, quality control, pharmacokinetics, toxicity, and modern preparations of these traditional Chinese medicines.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2021)
Article
Immunology
Suzhi Zhang, Jun Zhang, Xiaojian Zhang, Peng Lv, Sanxing Guo
Summary: This study aimed to investigate the effect and mechanism of total glucosides of white peony capsule (TGP) on the animal model of multiple sclerosis (MS) called experimental autoimmune encephalomyelitis (EAE). The results showed that TGP treatment significantly reduced the severity of the disease model, reduced CNS infiltration of inflammatory cells and demyelination, decreased the expression of adhesion factors and cytokines, and increased the expression of junction proteins in glial and inflammatory cells.
Article
Food Science & Technology
Lin Peng, Zhe Ma, Wenhui Chu, Peisi Jiang, Yongqian Fu, Pan Wang
Summary: The aim of this study was to obtain total glucosides of paeony (TGP) with high content of paeoniflorin and evaluate its hepatoprotective properties. Optimized conditions were determined through response surface methodology, resulting in a yield of TGP of 47.68 mg/g. Macroporous resin purification increased the paeoniflorin content of TGP to 67.6%. The purified TGP effectively reduced biochemical indexes and inflammatory cytokines in liver tissue of acute alcoholic liver injury mice model.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Rui Xu, Jine Peng, Zhe Ma, Kaili Xie, Meijing Li, Qi Wang, Xiaomeng Guo, Nan Nan, Sihui Wang, Jing Li, Jingjing Xu, Muxin Gong
Summary: Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation and joint damage. Dysregulation of intestinal mucosal immunity and epithelial barrier damage have been found to be closely related to the occurrence of RA. Total glucosides of paeony (TGP), a traditional Chinese medicine, has been used for decades to treat RA, but its pharmacological mechanism remains uncertain. This study investigated the regulatory effect and mechanism of TGP on intestinal immunity and epithelial barrier in RA model rats. The results showed that TGP alleviated immune hyperfunction and restored the intestinal epithelial barrier. Additionally, purine metabolism may play an important role in the process of TGP improving RA-induced intestinal immune imbalance and impaired epithelial barrier.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Zhihui Zhang, Yan Jia, Liyuan Tao, Xiaodan Liu, Ying Han, Xiao Wang
Summary: This study investigated the efficacy of combining dexamethasone and gentamicin mouthwash with total glucosides of paeony (TGP) in the treatment of non-erosive and erosive oral lichen planus (OLP) patients. The results showed that TGP significantly improved the cure rate and clinical manifestations in OLP patients. Therefore, the combination of dexamethasone, gentamicin mouthwash, and TGP can be considered a safe and effective treatment for OLP.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Yanfang Liao, Xue Wang, Liting Huang, Hu Qian, Wei Liu
Summary: Neurodegenerative diseases (NDs) are characterized by neuron degeneration and loss of function. Pyroptosis, a type of inflammatory process caused by Gasdermins (GSDMs) proteins, has been found to be enhanced in NDs, along with the aggregation of pathological proteins. This review aims to provide an overview of the molecular mechanisms driving pyroptosis, the links between pyroptosis and NDs, and emerging therapeutic strategies in Traditional Chinese Medicine (TCM) for inhibiting pyroptosis in the treatment of NDs.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Yiwen Li, Yanfei Liu, Jing Cui, Hui Zhao, Yue Liu, Luqi Huang
Summary: In recent years, there has been a significant increase in cohort studies focusing on the treatment of chronic non-communicable diseases with traditional Chinese medicine, particularly in the areas of tumor, cardiovascular, and cerebrovascular diseases. While the overall quality of cohort studies needs improvement, there has been a noticeable growth in the number of studies in the past 5 years.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Dongyang Qian, Hui Zhou, Pan Fan, Tao Yu, Anish Patel, Morgan O'Brien, Zhe Wang, Shiguang Lu, Guoqiang Tong, Yimin Shan, Lei Wang, Yuan Gao, Yuan Xiong, Lily Zhang, Xin Wang, Yuancai Liu, Shuanhu Zhou
Summary: The study found that traditional Chinese medicine herbal extracts can prevent alcohol-induced osteopenia in male mice, effectively regulate abnormal bone metabolism, improve bone density, and have the potential therapeutic effect.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Integrative & Complementary Medicine
Chenyang Ai, Yi Zou, Hao Liu, Zheqiong Yang, Jinlei Xi
Summary: The prevalence of allergic disorders has increased, leading to a lower quality of life for patients and a higher demand for drugs to treat these diseases. Traditional Chinese medicine offers distinct benefits in treating allergic illnesses, such as long-term treatment maintenance, prevention of disease recurrence, and fewer adverse reactions. Recent developments in Chinese herbal formula, Chinese patent medicine, and active ingredients of traditional Chinese medicine have been analyzed, discussing their components, efficacy, and mechanisms of action. The importance of improving traditional Chinese herbal formulas and developing safe and effective Chinese patent medicines is emphasized in the field of traditional Chinese medicine research.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Xiaoya Li, Changxin Sun, Jingyi Zhang, Lanqing Hu, Zongliang Yu, Xiaonan Zhang, Zeping Wang, Jiye Chen, Min Wu, Longtao Liu
Summary: This review evaluates the pharmacological effects and potential mechanisms of paeoniflorin in the treatment of cardiovascular diseases, aiming to advance its further development and application. Paeoniflorin can protect the cardiovascular system by regulating glucose and lipid metabolism, exerting anti-inflammatory, anti-oxidative stress, and anti-arteriosclerotic activities, improving cardiac function, and inhibiting cardiac remodeling. However, further studies on its bioavailability, toxicology, safety, and clinical efficacy are needed.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Xiaohong Gong, Huan Li, Hongtao Guo, Shangwen Wu, Chaoqun Lu, Yiming Chen, Songwei Li
Summary: For systemic lupus erythematosus (SLE), total glucosides of paeony (TGP) combined with different conventional therapeutic agents are more effective in reducing disease activity and incidence of adverse reactions compared to conventional treatments, although the quality of evidence is poor.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jia Liu, Chi Zhang, Yao Xie, Li Zhou, Li Guo, Bin Li, Zhen Jia, Jingze Zhang, Kazuo Sugimoto, Ying Gao
Summary: DATE-TCM is the first, largest, most geographically extensive, and standard registry-based observational study that systematically document the real-world data regarding the TCM application in the DDC populations. It aims to clarify the comprehensive characteristics and outcomes of TCM in DDC, further shed light on standardizing and optimizing the TCM measures for DDC management, and establishing evidence-based clinical practice guidelines for TCM application in DDC.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Song Li, Zhengzhi Wu, Weidong Le
Summary: In Western medicine, dementia affects cognition, mental health, and physical abilities, while Traditional Chinese Medicine explains it from the perspectives of brain dystrophy, Spleen-Kidney weakness, Blood stasis, and Phlegm stagnation. Ancient Chinese physicians believed that dementia manifests not only as cognitive symptoms but also as psychiatric disorders and sleep disturbance, offering various treatment methods.
ALZHEIMERS & DEMENTIA
(2021)
Review
Immunology
Aiping Zhang, Shilei Chen, Riyang Lin
Summary: This meta-analysis demonstrates that the combination of total glucosides of paeony (TGP) and hydroxychloroquine (HCQ) has significant therapeutic effects for primary Sjo''gren's syndrome (pSS). In clinical practice, TGP + HCQ can be considered as a potentially effective and safe combination treatment for pSS.
IMMUNITY INFLAMMATION AND DISEASE
(2023)