期刊
JOURNAL OF THE ROYAL SOCIETY INTERFACE
卷 13, 期 117, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rsif.2016.0112
关键词
agent-based modelling; coalescent theory; lineage tracing; developmental biology; tissue growth models
资金
- Biotechnological and Biological Research Council [BB/K003909/1]
- BBSRC [BB/K003909/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/K003909/1] Funding Source: researchfish
Development is a process that needs to be tightly coordinated in both space and time. Cell tracking and lineage tracing have become important experimental techniques in developmental biology and allow us to map the fate of cells and their progeny. A generic feature of developing and homeostatic tissues that these analyses have revealed is that relatively few cells give rise to the bulk of the cells in a tissue; the lineages of most cells come to an end quickly. Computational and theoretical biologists/physicists have, in response, developed a range of modelling approaches, most notably agent-based modelling. These models seem to capture features observed in experiments, but can also become computationally expensive. Here, we develop complementary genealogical models of tissue development that trace the ancestry of cells in a tissue back to their most recent common ancestors. We show that with both bounded and unbounded growth simple, but universal scaling relationships allow us to connect coalescent theory with the fractal growth models extensively used in developmental biology. Using our genealogical perspective, it is possible to study bulk statistical properties of the processes that give rise to tissues of cells, without the need for large-scale simulations.
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