Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype

Molecular Portraits of Epithelial, Mesenchymal, and Hybrid States in Lung Adenocarcinoma and Their Relevance to Survival

(2015) M. J. Schliekelman et al.   CANCER RESEARCH

The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?

(2015) Vicki Plaks et al.   Cell Stem Cell

Cancer stem cells: small subpopulation or evolving fraction?

(2015) Heiko Enderling   Integrative Biology

Conversion to stem-cell state in response to microenvironmental cues is regulated by balance between epithelial and mesenchymal features in lung cancer cells

(2015) Francesca Andriani et al.   Molecular Oncology

Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway

(2015) Spencer C. Wei et al.   NATURE CELL BIOLOGY

Operating principles of Notch–Delta–Jagged module of cell–cell communication

(2015) Mohit Kumar Jolly et al.   NEW JOURNAL OF PHYSICS

Modeling of Cancer Stem Cell State Transitions Predicts Therapeutic Response

(2015) Mary E. Sehl et al.   PLoS One

Stemness of the hybrid Epithelial/Mesenchymal State in Breast Cancer and Its Association with Poor Survival

(2015) Anne Grosse-Wilde et al.   PLoS One

Jagged–Delta asymmetry in Notch signaling can give rise to a Sender/Receiver hybrid phenotype

(2015) Marcelo Boareto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition

(2015) Aaron Goldman et al.   Nature Communications

OVOL guides the epithelial-hybrid-mesenchymal transition

(2015) Dongya Jia et al.   Oncotarget

Coupling the modules of EMT and stemness: A tunable ‘stemness window’ model

(2015) Mohit Kumar Jolly et al.   Oncotarget

Evolution and Phenotypic Selection of Cancer Stem Cells

(2015) Jan Poleszczuk et al.   PLoS Computational Biology

Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis

(2015) Mohit Kumar Jolly   Frontiers in Oncology

Network Modeling of TGF  Signaling in Hepatocellular Carcinoma Epithelial-to-Mesenchymal Transition Reveals Joint Sonic Hedgehog and Wnt Pathway Activation

(2014) S. N. Steinway et al.   CANCER RESEARCH

Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis

(2014) Nicola Aceto et al.   CELL

Reinforcing targeted therapeutics with phenotypic stability factors

(2014) Paul Yaswen   CELL CYCLE

Ligand-dependent Notch signaling strength orchestrates lateral induction and lateral inhibition in the developing inner ear

(2014) J. Petrovic et al.   DEVELOPMENT

Biology, detection, and clinical implications of circulating tumor cells

(2014) S. A. Joosse et al.   EMBO Molecular Medicine

Niche Inheritance: A Cooperative Pathway to Enhance Cancer Cell Fitness Through Ecosystem Engineering

(2014) Kimberline R Yang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Towards elucidating the connection between epithelial-mesenchymal transitions and stemness

(2014) M. K. Jolly et al.   Journal of the Royal Society Interface

Extracellular matrix density promotes EMT by weakening cell–cell adhesions

(2014) Sandeep Kumar et al.   Molecular BioSystems

Tackling the cancer stem cells — what challenges do they pose?

(2014) Diwakar R. Pattabiraman et al.   NATURE REVIEWS DRUG DISCOVERY

Tumour Control Probability in Cancer Stem Cells Hypothesis

(2014) Andrew Dhawan et al.   PLoS One

NOTCH Decoys That Selectively Block DLL/NOTCH or JAG/NOTCH Disrupt Angiogenesis by Unique Mechanisms to Inhibit Tumor Growth

(2014) Thaned Kangsamaksin et al.   Cancer Discovery

Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts

(2014) Suling Liu et al.   Stem Cell Reports

The Notch ligand Jagged1 as a target for anti-tumor therapy

(2014) Demin Li   Frontiers in Oncology

Coupled Reversible and Irreversible Bistable Switches Underlying TGFβ-induced Epithelial to Mesenchymal Transition

(2013) Xiao-Jun Tian et al.   BIOPHYSICAL JOURNAL

Endothelial Cells Promote the Colorectal Cancer Stem Cell Phenotype through a Soluble Form of Jagged-1

(2013) Jia Lu et al.   CANCER CELL

Deadly crosstalk: Notch signaling at the intersection of EMT and cancer stem cells

(2013) Ingrid Espinoza et al.   CANCER LETTERS

A microRNA miR-34a-Regulated Bimodal Switch Targets Notch in Colon Cancer Stem Cells

(2013) Pengcheng Bu et al.   Cell Stem Cell

Epithelial-mesenchymal plasticity in carcinoma metastasis

(2013) J. H. Tsai et al.   GENES & DEVELOPMENT

The epigenetics of epithelial-mesenchymal plasticity in cancer

(2013) Wai Leong Tam et al.   NATURE MEDICINE

Wnt/Rspondin/ -catenin signals control axonal sorting and lineage progression in Schwann cell development

(2013) T. Grigoryan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells

(2013) M. A. Nieto   SCIENCE

Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

(2013) M. Yu et al.   SCIENCE

An EMT spectrum defines an anoikis-resistant and spheroidogenic intermediate mesenchymal state that is sensitive to e-cadherin restoration by a src-kinase inhibitor, saracatinib (AZD0530)

(2013) R Y-J Huang et al.   Cell Death & Disease

miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions

(2012) Helge Siemens et al.   CELL CYCLE

ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression

(2012) Young-Ho Ahn et al.   JOURNAL OF CLINICAL INVESTIGATION

On the role of lateral stabilization during early patterning in the pancreas

(2012) W. de Back et al.   Journal of the Royal Society Interface

Bacterial survival strategies suggest rethinking cancer cooperativity

(2012) Eshel Ben-Jacob et al.   TRENDS IN MICROBIOLOGY

Hybrid Models and Biological Model Reduction with PyDSTool

(2012) Robert Clewley   PLoS Computational Biology

Circulating Tumor Cells as a Window on Metastasis Biology in Lung Cancer

(2011) Jian-Mei Hou et al.   AMERICAN JOURNAL OF PATHOLOGY

Detection of circulating tumour cells with a hybrid (epithelial/mesenchymal) phenotype in patients with metastatic non-small cell lung cancer

(2011) A Lecharpentier et al.   BRITISH JOURNAL OF CANCER

Notch Activation of Jagged1 Contributes to the Assembly of the Arterial Wall

(2011) Lauren J. Manderfield et al.   CIRCULATION

Notch signaling: simplicity in design, versatility in function

(2011) E. R. Andersson et al.   DEVELOPMENT

The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells

(2011) Simone Brabletz et al.   EMBO JOURNAL

Circulating Tumor Cells from Patients with Advanced Prostate and Breast Cancer Display Both Epithelial and Mesenchymal Markers

(2011) A. J. Armstrong et al.   MOLECULAR CANCER RESEARCH

MiR-34a Targeting of Notch Ligand Delta-Like 1 Impairs CD15+/CD133+ Tumor-Propagating Cells and Supports Neural Differentiation in Medulloblastoma

(2011) Pasqualino de Antonellis et al.   PLoS One

Notch signaling specifies prosensory domains via lateral induction in the developing mammalian inner ear

(2010) B. H. Hartman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epithelial–mesenchymal transition in cancer metastasis: Mechanisms, markers and strategies to overcome drug resistance in the clinic

(2009) Angeliki Voulgari et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis

(2009) Rui Benedito et al.   CELL

Notch signaling is required for lateral induction of Jagged1 during FGF-induced lens fiber differentiation

(2009) Senthil S. Saravanamuthu et al.   DEVELOPMENTAL BIOLOGY

TNF induction of jagged-1 in endothelial cells is NFκB-dependent

(2009) Douglas A. Johnston et al.   GENE

A Double-Negative Feedback Loop between ZEB1-SIP1 and the microRNA-200 Family Regulates Epithelial-Mesenchymal Transition

(2008) C. P. Bracken et al.   CANCER RESEARCH

A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

(2008) Ulrike Burk et al.   EMBO REPORTS

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

(2008) S.-M. Park et al.   GENES & DEVELOPMENT

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

(2008) Kyle Niessen et al.   JOURNAL OF CELL BIOLOGY

Rational targeting of Notch signaling in cancer

(2008) P Rizzo et al.   ONCOGENE

Notch signaling mediates hypoxia-induced tumor cell migration and invasion

(2008) C. Sahlgren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA