Inhibition of Canonical Transient Receptor Potential Channels 4/5 with Highly Selective and Potent Small-Molecule HC-070 Alleviates Mechanical Hypersensitivity in Rat Models of Visceral and Neuropathic Pain

Nonselective TRPC channel inhibition and suppression of aminoglycoside-induced premature termination codon readthrough by the small molecule AC1903

(2022) Alireza Baradaran-Heravi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors

(2022) Diana Tavares-Ferreira et al.   Science Translational Medicine

Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection

(2022) Daping Yang et al.   CELL

Subunit composition, molecular environment, and activation of native TRPC channels encoded by their interactomes

(2022) Astrid Kollewe et al.   NEURON

Reduced mechanical hypersensitivity by inhibition of the amygdala in experimental neuropathy: Sexually dimorphic contribution of spinal neurotransmitter receptors

(2022) Hong Wei et al.   BRAIN RESEARCH

Odontoblast TRPC5 channels signal cold pain in teeth

(2021) Laura Bernal et al.   Science Advances

Advances in TRP channel drug discovery: from target validation to clinical studies

(2021) Ari-Pekka Koivisto et al.   NATURE REVIEWS DRUG DISCOVERY

Transient receptor potential canonical 5 mediates inflammatory mechanical and spontaneous pain in mice

(2021) Katelyn E. Sadler et al.   Science Translational Medicine

Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders

(2021) Chris Eijsbouts et al.   NATURE GENETICS

Treasure Troves of Pharmacological Tools to Study TRPC1/4/5 Channels

(2019) Hussein N. Rubaiy   BRITISH JOURNAL OF PHARMACOLOGY

An amygdalar neural ensemble that encodes the unpleasantness of pain

(2019) Gregory Corder et al.   SCIENCE

Leaky gut: mechanisms, measurement and clinical implications in humans

(2019) Michael Camilleri   GUT

Structure–Function Relationship and Physiological Roles of Transient Receptor Potential Canonical (TRPC) 4 and 5 Channels

(2019) Jinsung Kim et al.   Cells

Single-cell RNAseq reveals seven classes of colonic sensory neuron

(2018) James R F Hockley et al.   GUT

Comparative transcriptome profiling of the human and mouse dorsal root ganglia

(2018) Pradipta Ray et al.   PAIN

Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice

(2018) Stefan Just et al.   PLoS One

Muscarinic receptor-induced contractions of the detrusor are impaired in TRPC4 deficient mice

(2018) Caoimhin S. Griffin et al.   Scientific Reports

Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies

(2017) Siew C Ng et al.   LANCET

Rapid changes in epidemiology of inflammatory bowel disease

(2017) Michael A Kamm   LANCET

A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models

(2017) Yiming Zhou et al.   SCIENCE

Neural Correlates of Fear of Movement in Patients with Chronic Low Back Pain vs. Pain-Free Individuals

(2016) Michael L. Meier et al.   Frontiers in Human Neuroscience

Pain in IBD Patients: Very Frequent and Frequently Insufficiently Taken into Account

(2016) Jonas Zeitz et al.   PLoS One

Stress and the Microbiota-Gut-Brain Axis in Visceral Pain: Relevance to Irritable Bowel Syndrome

(2015) Rachel D. Moloney et al.   CNS Neuroscience & Therapeutics

Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2015) Theo Vos et al.   LANCET

Regulation of neuropathic pain behavior by amygdaloid TRPC4/C5 channels

(2015) Hong Wei et al.   NEUROSCIENCE LETTERS

Plasma Membrane Mechanical Stress Activates TRPC5 Channels

(2015) Bing Shen et al.   PLoS One

Decreased Anxiety-Like Behavior and G q/11-Dependent Responses in the Amygdala of Mice Lacking TRPC4 Channels

(2014) A. Riccio et al.   JOURNAL OF NEUROSCIENCE

Neuroplasticity and dysfunction after gastrointestinal inflammation

(2014) Stuart M. Brierley et al.   Nature Reviews Gastroenterology & Hepatology

A rat knockout model implicates TRPC4 in visceral pain sensation

(2014) K.N. Westlund et al.   NEUROSCIENCE

Central Amygdala Metabotropic Glutamate Receptor 5 in the Modulation of Visceral Pain

(2012) L. W. Crock et al.   JOURNAL OF NEUROSCIENCE

The Epidemiology of low back pain

(2011) D. Hoy et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Identification of ML204, a Novel Potent Antagonist That Selectively Modulates Native TRPC4/C5 Ion Channels

(2011) Melissa Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system

(2011) K. Zimmermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRP channels in neurogastroenterology: opportunities for therapeutic intervention

(2010) Werend Boesmans et al.   BRITISH JOURNAL OF PHARMACOLOGY

Essential Role for TRPC5 in Amygdala Function and Fear-Related Behavior

(2009) Antonio Riccio et al.   CELL

Pain and inflammatory bowel disease

(2009) Klaus Bielefeldt et al.   INFLAMMATORY BOWEL DISEASES

Neuropathic pain is associated with depressive behaviour and induces neuroplasticity in the amygdala of the rat

(2008) Leonor Gonçalves et al.   EXPERIMENTAL NEUROLOGY

Hypoosmotic- and pressure-induced membrane stretch activate TRPC5 channels

(2008) Ana Gomis et al.   JOURNAL OF PHYSIOLOGY-LONDON