Activation of Gq-Coupled Receptors in Astrocytes Restores Cognitive Function in Alzheimer’s Disease Mice Model

Blood GFAP as an emerging biomarker in brain and spinal cord disorders

(2022) Ahmed Abdelhak et al.   Nature Reviews Neurology

CaMKIIβ knockdown decreases store-operated calcium entry in hippocampal dendritic spines

(2022) Nikita Zernov et al.   IBRO Neuroscience Reports

Impaired astrocytic Ca2+ signaling in awake-behaving Alzheimer’s disease transgenic mice

(2022) Knut Sindre Åbjørsbråten et al.   eLife

EAAT2 as a therapeutic research target in Alzheimer's disease: A systematic review

(2022) Oliver W. G. Wood et al.   Frontiers in Neuroscience

Prolonged Febrile Seizures Impair Synaptic Plasticity and Alter Developmental Pattern of Glial Fibrillary Acidic Protein (GFAP)-Immunoreactive Astrocytes in the Hippocampus of Young Rats

(2022) Alexandra V. Griflyuk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of Microglia and Astrocytes in Alzheimer’s Disease: From Neuroinflammation to Ca2+ Homeostasis Dysregulation

(2022) Giulia Di Benedetto et al.   Cells

Alzheimer's disease – Where do we go from here?

(2022) Ilya Bezprozvanny   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bidirectional regulation by “star forces”: Ionotropic astrocyte's optical stimulation suppresses synaptic plasticity, metabotropic one strikes back

(2022) Alexander Maltsev et al.   HIPPOCAMPUS

New Positive TRPC6 Modulator Penetrates Blood–Brain Barrier, Eliminates Synaptic Deficiency and Restores Memory Deficit in 5xFAD Mice

(2022) Nikita Zernov et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Spatial memory deficiency early in 6xTg Alzheimer’s disease mouse model

(2021) Shinwoo Kang et al.   Scientific Reports

Reactive astrocyte nomenclature, definitions, and future directions

(2021) Carole Escartin et al.   NATURE NEUROSCIENCE

Optogenetic and chemogenetic modulation of astroglial secretory phenotype

(2021) Alla B. Salmina et al.   REVIEWS IN THE NEUROSCIENCES

Sensing and Regulating Synaptic Activity by Astrocytes at Tripartite Synapse

(2021) José Antonio Noriega-Prieto et al.   NEUROCHEMICAL RESEARCH

Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus

(2021) Fumikazu Sano et al.   JCI Insight

Optogenetic Activation of Astrocytes—Effects on Neuronal Network Function

(2021) Evgenii Gerasimov et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study

(2021) Adrian L. Oblak et al.   Frontiers in Aging Neuroscience

The Many Faces of Astrocytes in Alzheimer's Disease

(2021) Michael D. Monterey et al.   Frontiers in Neurology

Optogenetic stimulation of CA3 pyramidal neurons restores synaptic deficits to improve spatial short-term memory in APP/PS1 mice

(2021) Qinghu Yang et al.   PROGRESS IN NEUROBIOLOGY

Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease

(2021) Stefania Forner et al.   Scientific Data

Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer’s Disease

(2020) Juliette Le Douce et al.   Cell Metabolism

Reversal of calcium dysregulation as potential approach for treating Alzheimer's Disease

(2020) Elena Popugaeva et al.   Current Alzheimer Research

Disease-associated astrocytes in Alzheimer’s disease and aging

(2020) Naomi Habib et al.   NATURE NEUROSCIENCE

Attenuation of Spatial Memory in 5xFAD Mice by Halting Cholinesterases, Oxidative Stress and Neuroinflammation Using a Cyclopentanone Derivative

(2020) Rahim Ullah et al.   Pharmaceuticals

Melanopsin for precise optogenetic activation of astrocyte-neuron networks

(2019) Sara Mederos et al.   GLIA

Astrocytes Maintain Glutamate Homeostasis in the CNS by Controlling the Balance between Glutamate Uptake and Release

(2019) Shaimaa Mahmoud et al.   Cells

The Role of NMDA Receptors in Alzheimer’s Disease

(2019) Jinping Liu et al.   Frontiers in Neuroscience

Astrocyte Heterogeneity: Impact to Brain Aging and Disease

(2019) Isadora Matias et al.   Frontiers in Aging Neuroscience

Derivatives of Piperazines as Potential Therapeutic Agents for Alzheimer’s Disease

(2019) Elena Popugaeva et al.   MOLECULAR PHARMACOLOGY

Interval timing is disrupted in female 5xFAD mice: An indication of altered memory processes

(2019) Ezgi Gür et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Astroglial Calcium Signaling in Aging and Alzheimer's Disease

(2019) Alexei Verkhratsky   Cold Spring Harbor Perspectives in Biology

Adiponectin improves long-term potentiation in the 5XFAD mouse brain

(2019) Ming Wang et al.   Scientific Reports

Light Stimulation Parameters Determine Neuron Dynamic Characteristics

(2019) Alexander Erofeev et al.   Applied Sciences-Basel

Role of Astrocytes in Post-traumatic Epilepsy

(2019) Songbai Xu et al.   Frontiers in Neurology

The use of chemogenetics in behavioural neuroscience: receptor variants, targeting approaches and caveats

(2018) Erin J Campbell et al.   BRITISH JOURNAL OF PHARMACOLOGY

Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement

(2018) Adar Adamsky et al.   CELL

Calcium signaling and molecular mechanisms underlying neurodegenerative diseases

(2018) Ekaterina Pchitskaya et al.   CELL CALCIUM

Functional Roles of Astrocyte Calcium Elevations: From Synapses to Behavior

(2018) Sónia Guerra-Gomes et al.   Frontiers in Cellular Neuroscience

Septal and Hippocampal Neurons Contribute to Auditory Relay and Fear Conditioning

(2018) Cuiyu Xiao et al.   Frontiers in Cellular Neuroscience

Deciphering the Astrocyte Reaction in Alzheimer’s Disease

(2018) Beatriz G. Perez-Nievas et al.   Frontiers in Aging Neuroscience

Neuronal activity determines distinct gliotransmitter release from a single astrocyte

(2018) Ana Covelo et al.   eLife

Evidence for Early Cognitive Impairment Related to Frontal Cortex in the 5XFAD Mouse Model of Alzheimer's Disease

(2018) Stéphane D. Girard et al.   JOURNAL OF ALZHEIMERS DISEASE

Role of Glutamate and NMDA Receptors in Alzheimer’s Disease

(2017) Rui Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Alterations in protein phosphorylation in the amygdala of the 5XFamilial Alzheimer's disease animal model

(2017) Eun-Jeong Yang et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Plaque formation and the intraneuronal accumulation of β-amyloid in Alzheimer's disease

(2017) Reisuke H. Takahashi et al.   PATHOLOGY INTERNATIONAL

Restoring synaptic plasticity and memory in mouse models of Alzheimer’s disease by PKR inhibition

(2017) Kyoung-Doo Hwang et al.   Molecular Brain

Alzheimer's Disease and the Amyloid-β Peptide

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

Astrocyte calcium waves propagate proximally by gap junction and distally by extracellular diffusion of ATP released from volume-regulated anion channels

(2017) Yuki Fujii et al.   Scientific Reports

Interaction between dorsal hippocampal NMDA receptors and lithium on spatial learning consolidation in rats

(2016) Leila Parsaei et al.   BRAIN RESEARCH BULLETIN

Gamma frequency entrainment attenuates amyloid load and modifies microglia

(2016) Hannah F. Iaccarino et al.   NATURE

DREADDs for Neuroscientists

(2016) Bryan L. Roth   NEURON

Glutamate Receptors in Alzheimer’s Disease: Mechanisms and Therapies

(2016) Victor Anggono et al.   NEURAL PLASTICITY

The Use of DREADDs to Deconstruct Behavior

(2016) Paul D. Whissell et al.   Frontiers in Genetics

DREADDs (Designer Receptors Exclusively Activated by Designer Drugs): Chemogenetic Tools with Therapeutic Utility

(2015) Daniel J. Urban et al.   Annual Review of Pharmacology and Toxicology

Insulin Attenuates Beta-Amyloid-Associated Insulin/Akt/EAAT Signaling Perturbations in Human Astrocytes

(2015) Xiaojuan Han et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The evolving role of dendritic spines and memory: Interaction(s) with estradiol

(2015) Maya Frankfurt et al.   HORMONES AND BEHAVIOR

Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer’s disease

(2015) Kou Takahashi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's Disease

(2015) H. Zhang et al.   JOURNAL OF NEUROSCIENCE

STIM2 protects hippocampal mushroom spines from amyloid synaptotoxicity

(2015) Elena Popugaeva et al.   Molecular Neurodegeneration

Spatial and Working Memory Is Linked to Spine Density and Mushroom Spines

(2015) Rasha Refaat Mahmmoud et al.   PLoS One

Assessing Spatial Learning and Memory in Rodents

(2014) C. V. Vorhees et al.   ILAR JOURNAL

Reduced Synaptic STIM2 Expression and Impaired Store-Operated Calcium Entry Cause Destabilization of Mature Spines in Mutant Presenilin Mice

(2014) Suya Sun et al.   NEURON

β-amyloid Peptides and Amyloid Plaques in Alzheimer’s Disease

(2014) Gunnar K. Gouras et al.   Neurotherapeutics

Dendritic Spines: The Locus of Structural and Functional Plasticity

(2014) Carlo Sala et al.   PHYSIOLOGICAL REVIEWS

How Do Astrocytes Participate in Neural Plasticity?

(2014) Philip G. Haydon et al.   Cold Spring Harbor Perspectives in Biology

Optogenetic astrocyte activation modulates response selectivity of visual cortex neurons in vivo

(2014) Gertrudis Perea et al.   Nature Communications

Area-Specific Alterations of Synaptic Plasticity in the 5XFAD Mouse Model of Alzheimer’s Disease: Dissociation between Somatosensory Cortex and Hippocampus

(2013) Nadine Crouzin et al.   PLoS One

Emerging role for astroglial networks in information processing: from synapse to behavior

(2013) Ulrike Pannasch et al.   TRENDS IN NEUROSCIENCES

Astrocytes: Implications for Neuroinflammatory Pathogenesis of Alzheimers Disease

(2011) Chuanyu Li et al.   Current Alzheimer Research

Large-Scale Calcium Waves Traveling through Astrocytic Networks In Vivo

(2011) N. Kuga et al.   JOURNAL OF NEUROSCIENCE

High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels

(2011) A. Berndt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of low-dose d-serine on recognition and working memory in mice

(2011) Patricia Bado et al.   PSYCHOPHARMACOLOGY

Integrated Brain Circuits: Astrocytic Networks Modulate Neuronal Activity and Behavior

(2010) Michael M. Halassa et al.   Annual Review of Physiology

Astrocytes in Alzheimer’s disease

(2010) Alexei Verkhratsky et al.   Neurotherapeutics

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Cognitive Decline in Alzheimer's Disease Is Associated with Selective Changes in Calcineurin/NFAT Signaling

(2009) H. M. Abdul et al.   JOURNAL OF NEUROSCIENCE

Spatiotemporal control of cell signalling using a light-switchable protein interaction

(2009) Anselm Levskaya et al.   NATURE

Temporally precise in vivo control of intracellular signalling

(2009) Raag D. Airan et al.   NATURE

Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors

(2009) Georgia M. Alexander et al.   NEURON

Reversal of long-term dendritic spine alterations in Alzheimer disease models

(2009) D. L. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tripartite synapses: astrocytes process and control synaptic information

(2009) Gertrudis Perea et al.   TRENDS IN NEUROSCIENCES

Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model

(2008) Ryoichi Kimura et al.   NEUROBIOLOGY OF DISEASE

Automated Three-Dimensional Detection and Shape Classification of Dendritic Spines from Fluorescence Microscopy Images

(2008) Alfredo Rodriguez et al.   PLoS One