Article
Immunology
Milena Petkova, Marle Kraft, Simon Stritt, Ines Martinez-Corral, Henrik Ortsaeter, Michael Vanlandewijck, Bojana Jakic, Eulalia Baselga, Sandra D. Castillo, Mariona Graupera, Christer Betsholtz, Taija Maekinen
Summary: Researchers have identified a new subtype of lymphatic endothelial cells called iLECs, which are positive for Ptx3 and are involved in PI3K-driven lymphatic malformations. These cells recruit pro-lymphangiogenic macrophages and promote pathological lymphatic vessel growth. Understanding the specific disease pathogenesis of different vessel types could lead to the development of more efficient therapies.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Qierra R. Brockman, Amanda Scherer, Gavin R. McGivney, Wade R. Gutierrez, Andrew P. Voigt, Alexandra L. Isaacson, Emily A. Laverty, Grace Roughton, Vickie Knepper-Adrian, Benjamin Darbro, Munir R. Tanas, Christopher S. Stipp, Rebecca D. Dodd
Summary: Loss of PRC2 has a critical role in driving metastasis in malignant peripheral nerve sheath tumors (MPNSTs), leading to increased collagen-dependent invasion, upregulation of matrix-remodeling enzymes, and elevated lung metastasis. Clinical sample analysis confirms that PRC2 loss is associated with metastatic disease, increased fibrosis, and decreased survival in MPNST patients.
Article
Biochemistry & Molecular Biology
Wojciech M. Ciszewski, Malgorzata Chmielewska-Kassassir, Lucyna A. Wozniak, Katarzyna Sobierajska
Summary: This study found a close correlation between TYMS and invasion ability in colon cancer cells, as well as its crucial role in EMT regulation. It suggests that chemotherapeutics targeting TYMS expression may enhance the effectiveness of colon cancer treatment, especially in the metastatic stage.
Article
Multidisciplinary Sciences
Huey-Miin Chen, Justin A. MacDonald
Summary: The study identified a module containing 151 genes that was significantly correlated with lymphatic invasion in colon cancer, with DAPK3 identified as the pseudohub of the module. High expression of DAPK3 was significantly associated with greater lymphatic invasion and poor overall survival. Gene ontology analysis suggested that the module is involved in tumor cell survival, migration, and epithelial-mesenchymal transformation.
Article
Medicine, General & Internal
Shuzo Kohno, Masahiro Ikegami, Toru Ikegami, Hiroaki Aoki, Masaichi Ogawa, Fumiaki Yano, Ken Eto
Summary: This retrospective study investigated the characteristics of gastroenteropancreatic neuroendocrine tumors using a unified classification. Tumor size, depth, lymphatic invasion, venous invasion, and neuroendocrine tumor grade were significantly correlated with metastasis. Venous invasion was found to be more strongly correlated with metastasis than lymphatic invasion. These findings highlight the importance of a unified classification and standardized assessment framework in neuroendocrine tumor research.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Sang Sik Cho, Ji Won Park, Gyeong Hoon Kang, Jung Ho Kim, Jeong Mo Bae, Sae-Won Han, Tae-You Kim, Min Jung Kim, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park
Summary: This study aimed to determine whether the location of lymphatic invasion, vascular invasion, and perineural invasion could affect the survival of patients with stage II colon cancer. The results showed that extramural invasion was associated with a worse prognosis, while intramural invasion was not. Therefore, pathologic reports about the location of invasion may be helpful for predicting prognosis and determining the need for adjuvant chemotherapy in stage II colon cancers.
DISEASES OF THE COLON & RECTUM
(2023)
Article
Gastroenterology & Hepatology
Boonsanay Boonsanay, Mohammed H. Mosa, Mario Looso, Dieter Weichenhan, Fatih Ceteci, Lorenz Pudelko, Andre Lechel, Christian S. Michel, Carsten Kuenne, Henner F. Farin, Christoph Plass, Florian R. Greten
Summary: SUV420H2 is an important regulator of epithelial cell plasticity and its loss contributes to right-sided colorectal tumorigenesis through epigenetic regulation of chromatin compaction. Reduced levels of H4K20me3 and increased chromatin accessibility are observed in patient-derived right-sided colorectal cancer organoids. Inhibition of histone demethylases can lead to re-compaction of chromatin and selective growth inhibition in right-sided colorectal tumors.
Article
Cell Biology
Xin Dong, Xiaoying Li, Yu Gan, Jie Ding, Baojun Wei, Li Zhou, Wei Cui, Wei Li
Summary: The E3 ligase TNF receptor-associated factor 4 (TRAF4) is increased in colorectal cancer (CRC), and its depletion impairs CRC cell phenotype and enhances radiation-induced cell death. Irradiation activates the JNKs/c-Jun signaling, contributing to radioresistance by activating the antiapoptotic protein Bcl-xL. TRAF4 is positively correlated with c-Jun and Bcl-xL, and targeting the TRAF4/Bcl-xL axis sensitizes CRC cells to radiotherapy.
CELL DEATH & DISEASE
(2023)
Review
Cell Biology
Noriki Fujimoto, Lothar C. Dieterich
Summary: This review discusses the role of tumor-associated lymphatic vessels in tumor progression, the mechanisms of tumor cell invasion into lymphatic vessels, and the clinical significance of lymphatic invasion in relation to local recurrence, lymph node, and distant metastasis.
Article
Oncology
Andreia S. Margarido, Rebeca Uceda-Castro, Kerstin Hahn, Roebi de Bruijn, Lennart Kester, Ingrid Hofland, Jeroen Lohuis, Danielle Seinstra, Annegien Broeks, Jos Jonkers, Marike L. D. Broekman, Pieter Wesseling, Claire Vennin, Miguel Vizoso, Jacco van Rheenen
Summary: The study demonstrates that breast cancer brain metastasis cells undergo epithelial-to-mesenchymal transition (EMT) when infiltrating the brain parenchyma, and removing these infiltrated tumor cells can improve surgical efficacy, providing new avenues for patient treatment.
Article
Cell Biology
Feng Gao, Guoliang Zhang, Yiwen Liu, Yiqing He, Yumeng Sheng, Xiaodan Sun, Yan Du, Cuixia Yang
Summary: This study reveals a novel mechanism of collective metastasis in breast cancer, where tumor-associated macrophages (TAMs) induce the conversion of cancer cell clusters to an invasive state with high CD44 expression. The activation of the MDM2/p53 pathway by TAMs-released CCL8 mediates the acquisition of the CD44(high) state, leading to cohesive detachment and spread.
CELL DEATH & DISEASE
(2022)
Article
Peripheral Vascular Disease
Anqi Li, Linyu Zhu, Ningjing Lei, Jiajia Wan, Xixi Duan, Shuangqing Liu, Yanru Cheng, Ming Wang, Zhuoyu Gu, Huilei Zhang, Yueyue Bai, Li Zhang, Fazhan Wang, Chen Ni, Zhihai Qin
Summary: The expression of S100A4 in lymphatic endothelial cells promotes lymphatic vessel sprouting in growing tumors by regulating glycolysis. S100A4 plays a crucial role in the position and motility of tip cells, and its expression is upregulated under hypoxic conditions. These findings suggest that S100A4 is a novel regulator of tumor-induced lymphangiogenesis.
Article
Cell Biology
Panneerselvam Jayabal, Fuchun Zhou, Xiuye Ma, Kathryn M. Bondra, Barron Blackman, Susan T. Weintraub, Yidong Chen, Patricia Chevez-Barrios, Peter J. Houghton, Brenda Gallie, Yuzuru Shiio
Summary: This study identifies an autocrine signaling pathway mediated by SFRP2 that suppresses nitric oxide production and promotes retinoblastoma growth.
Article
Multidisciplinary Sciences
Ru Wang, Ines Godet, Yongkang Yang, Shaima Salman, Haiquan Lu, Yajing Lyu, Qiaozhu Zuo, Yufeng Wang, Yayun Zhu, Chelsey Chen, Jianjun He, Daniele M. Gilkes, Gregg L. Semenza
Summary: This study discovered that HIFs induce the expression of ADAM12, leading to EGFR signaling activation and subsequently promoting breast cancer cell migration, invasion, and metastasis. Inhibition of ADAM12 expression or activity can effectively reduce tumor cell migration, invasion, and lung metastasis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Xin Pang, Tian-Jiao Li, Rong-Jia Shi, Zi-Xin Wan, Yue-Yang Tang, Ya-Ling Tang, Xin-Hua Liang
Summary: IRF2BP2 is associated with lymph node metastasis in oral squamous cell carcinoma (OSCC). It promotes invasion and epithelial-mesenchymal transition (EMT) by regulating fatty acid oxidation (FAO) and mitochondrial fission. Targeting IRF2BP2-FAO may serve as a potential therapeutic strategy for LNM+ OSCC.
MOLECULAR CARCINOGENESIS
(2023)
Article
Reproductive Biology
Wei-Ting Hung, Xioman Hong, Lane K. Christenson, Lynda K. McGinnis
BIOLOGY OF REPRODUCTION
(2015)
Article
Biotechnology & Applied Microbiology
Vivek Agrahari, Jianing Meng, Miezan J. M. Ezoulin, Ibrahima Youm, Daniel C. Dim, Agostino Molteni, Wei-Ting Hung, Lane K. Christenson, Bi-Botti C. Youan
Article
Multidisciplinary Sciences
Raphatphorn Navakanitworakul, Wei-Ting Hung, Sumedha Gunewardena, John S. Davis, Wilaiwan Chotigeat, Lane K. Christenson
SCIENTIFIC REPORTS
(2016)
Review
Cell Biology
Arvind Subramanian, Vijayalaxmi Gupta, Sandipto Sarkar, Gargi Maity, Snigdha Banerjee, Arnab Ghosh, LaCoiya Harris, Lane K. Christenson, WeiTing Hung, Ajay Bansal, Sushanta K. Banerjee
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2016)
Article
Biochemistry & Molecular Biology
Ky G. Pohler, Jonathan A. Green, Laura A. Moley, Sumedha Gunewardena, Wei-Ting Hung, Rebecca R. Payton, Xiaoman Hong, Lane K. Christenson, Tom W. Geary, Michael F. Smith
MOLECULAR REPRODUCTION AND DEVELOPMENT
(2017)
Article
Reproductive Biology
Wei-Ting Hung, Fang-Ju Wu, Chun-Jen Wang, Ching-Wei Luo
BIOLOGY OF REPRODUCTION
(2012)
Article
Biophysics
Chun-Jen Wang, Shih-Han Hsu, Wei-Ting Hung, Ching-Wei Luo
BIOSENSORS & BIOELECTRONICS
(2009)
Article
Genetics & Heredity
Johannes G. Reiter, Wei-Ting Hung, I-Hsiu Lee, Shriya Nagpal, Peter Giunta, Sebastian Degner, Gang Liu, Emma C. E. Wassenaar, William R. Jeck, Martin S. Taylor, Alexander A. Farahani, Hetal D. Marble, Simon Knott, Onno Kranenburg, Jochen K. Lennerz, Kamila Naxerova
Article
Cell Biology
Ann L. Wozniak, Abby Adams, Kayla E. King, Winston Dunn, Lane K. Christenson, Wei-Ting Hung, Steven A. Weinman
JOURNAL OF CELL BIOLOGY
(2020)
Article
Reproductive Biology
Wei-Ting Hung, Raphatphorn Navakanitworakul, Tarique Khan, Pan Zhang, John S. Davis, Lynda K. McGinnis, Lane K. Christenson
BIOLOGY OF REPRODUCTION
(2017)
