Virtual screening identifies tipranavir as a SIRT1 inhibitor with anti-hepatocarcinoma effect

Synthesis of Sugar and Nucleoside Analogs and Evaluation of Their Anticancer and Analgesic Potentials

(2022) Fahad Hussain et al.   MOLECULES

Identify promising IKK-β inhibitors: A docking-based 3D-QSAR study combining molecular design and molecular dynamics simulation

(2022) Liang Li et al.   Arabian Journal of Chemistry

In silico approaches using pharmacophore model combined with molecular docking for discovery of novel ULK1 inhibitors

(2021) Siyu He et al.   Future Medicinal Chemistry

The Chemical Constituents from Fruits of Catalpa bignonioides Walt. and Their α-Glucosidase Inhibitory Activity and Insulin Secretion Effect

(2021) Youngse Oh et al.   MOLECULES

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Trending topics of SIRT1 in tumorigenicity

(2021) Liz M. Garcia-Peterson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Synthesis and biological evaluation of novel pyrimidine-5-carbonitriles featuring morpholine moiety as antitumor agents

(2020) Amira A Helwa et al.   Future Medicinal Chemistry

A Deep Learning Approach to Antibiotic Discovery

(2020) Jonathan M. Stokes et al.   CELL

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

(2020) Zhenming Jin et al.   NATURE

Sirtuin 1 and 2 inhibitors enhance the inhibitory effect of sorafenib in hepatocellular carcinoma cells

(2020) María Paula Ceballos et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A Structure-Based Drug Discovery Paradigm

(2019) Maria Batool et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer

(2019) Débora Kristina Alves-Fernandes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Assessment of Antioxidant and Cytotoxic Activities of Extracts of Dendrobium crepidatum

(2019) Mukti Ram Paudel et al.   Biomolecules

Dihydrodiosgenin protects against experimental acute pancreatitis and associated lung injury through mitochondrial protection and PI3Kγ/Akt inhibition

(2018) Yan Shen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Small Molecules as SIRT Modulators

(2018) Xinfa Bai et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Inhibition of sirtuins 1 and 2 impairs cell survival and migration and modulates the expression of P-glycoprotein and MRP3 in hepatocellular carcinoma cell lines

(2018) María Paula Ceballos et al.   TOXICOLOGY LETTERS

Potentiation of the anticancer effects of everolimus using a dual mTORC1/2 inhibitor in hepatocellular carcinoma cells

(2016) Jong-Ok Kim et al.   Oncotarget

Prognostic and clinicopathologic significance of SIRT1 expression in hepatocellular carcinoma

(2016) Hongyuan Jiang et al.   Oncotarget

SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1α-mediated mitochondrial biogenesis

(2016) Yuming Li et al.   Oncotarget

Safety, pharmacokinetics, pharmacogenomics and QT concentration−effect modelling of the SirT1 inhibitor selisistat in healthy volunteers

(2015) Goran Westerberg et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

An exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington's disease

(2015) Sigurd D. Süssmuth et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Sirtuin 1 promotes the growth and cisplatin resistance of endometrial carcinoma cells: a novel therapeutic target

(2015) Ryoichi Asaka et al.   LABORATORY INVESTIGATION

Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma

(2015) Chong Hao et al.   BMC CANCER

Design and synthesis of 2-phenylnaphthalenoids as inhibitors of DNA topoisomeraseIIα and antitumor agents

(2014) Wang Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Multifunctional Sorting Protein PACS-2 Regulates SIRT1-Mediated Deacetylation of p53 to Modulate p21-Dependent Cell-Cycle Arrest

(2014) Katelyn M. Atkins et al.   Cell Reports

The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD+) and an Indole (EX527 Analogue) Reveals a Novel Mechanism of Histone Deacetylase Inhibition

(2013) Xun Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antitumor Effect of SIRT1 Inhibition in Human HCC Tumor Models In Vitro and In Vivo

(2013) S. Portmann et al.   MOLECULAR CANCER THERAPEUTICS

Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism

(2013) M. Gertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

SIRT1 and c-Myc Promote Liver Tumor Cell Survival and Predict Poor Survival of Human Hepatocellular Carcinomas

(2012) Kyu Yun Jang et al.   PLoS One

SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2

(2010) Barrie Peck et al.   MOLECULAR CANCER THERAPEUTICS

The Critical Role of the Class III Histone Deacetylase SIRT1 in Cancer

(2009) T. Liu et al.   CANCER RESEARCH

Tipranavir: a new protease inhibitor for the pediatric population

(2008) Joshua D Courter et al.   Expert Review of Anti-Infective Therapy

The ups and downs of SIRT1

(2008) Hye-Sook Kwon et al.   TRENDS IN BIOCHEMICAL SCIENCES