Article
Neurosciences
Linn Streubel-Gallasch, Veronica Giusti, Michele Sandre, Isabella Tessari, Nicoletta Plotegher, Elena Giusto, Anna Masato, Ludovica Iovino, Ilaria Battisti, Giorgio Arrigoni, Derya Shimshek, Elisa Greggio, Marie-Eve Tremblay, Luigi Bubacco, Anna Erlandsson, Laura Civiero
Summary: This study compared the ability of astrocytes carrying PD-linked gene mutations with normal astrocytes in handling α-synuclein, finding a decreased clearance capacity in mutant cells linked to a loss of function in AnxA2.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Cell Biology
Xin He, Yue Xie, Qiongping Zheng, Zeyu Zhang, Shanshan Ma, Junyu Li, Mingtao Li, Qiaoying Huang
Summary: The transcription factor TFE3 has been found to play a crucial role in maintaining autophagy and the survival of dopaminergic neurons in Parkinson's disease. Activation of TFE3 may serve as a promising strategy for PD therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anna S. Vetchinova, Marina R. Kapkaeva, Mikhail V. Ivanov, Kristina A. Kutukova, Natalia M. Mudzhiri, Lydia E. Frumkina, Anatoly V. Brydun, Vladimir S. Sukhorukov, Sergey N. Illarioshkin
Summary: Parkinson's disease is a common neurodegenerative disease that can be caused by genetic factors. Induced pluripotent stem cell technology provides new opportunities for studying biomarkers of Parkinson's disease. Gene expression analysis and electron microscopy revealed differences in mitochondrial structure and activity between diseased and normal cells.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Review
Genetics & Heredity
Gunjan Thakur, Vikas Kumar, Keun Woo Lee, Chungkil Won
Summary: Parkinson's disease is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the midbrain. Mutations in the gene encoding LRRK2 have been identified as potential therapeutic targets for PD. Therefore, the search for LRRK2 inhibitors has become the focus of drug discovery, and various investigations have been conducted to study its mechanism and develop inhibitors.
Article
Cell Biology
Jonas Walter, Silvia Bolognin, Suresh K. Poovathingal, Stefano Magni, Deborah Gerard, Paul M. A. Antony, Sarah L. Nickels, Luis Salamanca, Emanuel Berger, Lisa M. Smits, Kamil Grzyb, Rita Perfeito, Fredrik Hoel, Xiaobing Qing, Jochen Ohnmacht, Michele Bertacchi, Javier Jarazo, Tomasz Ignac, Anna S. Monzel, Laura Gonzalez-Cano, Rejko Krueger, Thomas Sauter, Michele Studer, Luis Pereira de Almeida, Karl J. Tronstad, Lasse Sinkkonen, Alexander Skupin, Jens C. Schwamborn
Summary: Research has shown that the LRRK2-G2019S mutation associated with Parkinson's disease accelerates the differentiation of dopaminergic neurons, leading to an increase in cell death. The key transcription factor NR2F1 plays a role in this pathogenic mechanism by regulating the dynamics of dopaminergic differentiation.
Article
Immunology
Itzia Jimenez-Ferrer, Filip Backstrom, Alfredo Duenas-Rey, Michael Jewett, Antonio Boza-Serrano, Kelvin C. Luk, Tomas Deierborg, Maria Swanberg
Summary: The study demonstrates that Mhc2ta gene modulates aggregation, propagation, and dopaminergic pathology of alpha-synuclein in a PD model, affecting neurodegeneration and motor impairment.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Pharmacology & Pharmacy
Sonia Azeggagh, Daniel C. Berwick
Summary: Current therapeutic approaches for Parkinson's disease focus on symptom relief rather than disease progression. Inhibition of LRRK2 function is a promising strategy due to its role in familial and idiopathic Parkinson's disease. Progress has been made in finding effective LRRK2 inhibitors, but the complexity of LRRK2 presents challenges and opportunities for unintended consequences. Multiple molecules are in clinical trials, providing cause for optimism in the search for alternative treatment options.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Ramona D'Amico, Daniela Impellizzeri, Tiziana Genovese, Roberta Fusco, Alessio Filippo Peritore, Rosalia Crupi, Livia Interdonato, Gianluca Franco, Ylenia Marino, Alessia Arangia, Enrico Gugliandolo, Salvatore Cuzzocrea, Rosanna Di Paola, Rosalba Siracusa, Marika Cordaro
Summary: This study explores a new neuroprotective strategy for Parkinson's disease by supplementing with Acai berry. The results show that daily supplementation with Acai berry significantly reduces motor and non-motor symptoms and protects dopaminergic neurons from damage. This beneficial effect may be attributed to the activation of nuclear factor erythroid 2-related factor 2 (Nrf2) to counteract oxidative stress and neuroinflammation.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Cell Biology
Leonie M. Heger, Rachel M. Wise, J. Tabitha Hees, Angelika B. Harbauer, Lena F. Burbulla
Summary: This review assesses mitochondrial phenotypes in iPSC-derived neurons from PD patients, focusing on the role of mitochondrial respiration, morphology, trafficking, mitophagy, and calcium handling in health and disease. It also summarizes the unique advantages and challenges of iPSC disease modeling for future mechanistic and therapeutic applications, highlighting the importance of studying mitochondrial dynamics in PD pathophysiology.
Article
Biochemistry & Molecular Biology
Lujain Bader Eddin, Sheikh Azimullah, Niraj Kumar Jha, Mohamed Fizur Nagoor Meeran, Rami Beiram, Shreesh Ojha
Summary: The study aims to investigate the potential neuroprotective effects of limonene in a rodent model of Parkinson's disease induced by rotenone. The findings demonstrate that limonene can correct the changes in pathological and molecular parameters caused by rotenone, effectively protecting against neurodegenerative effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Integrative & Complementary Medicine
Wen Jing, Zhang Yuan-Qiang, Liu Dong-Qing, Yao Xu-Tao, Jiang Hua, Zhang Yu-Bin
Summary: This study aimed to explore the neuroprotective effects and pharmacological mechanism of Demethylenetetrahydroberberine (DMTHB) on Parkinson's disease. The results showed that DMTHB could alleviate behavioral disorders, protect dopaminergic neurons, and exhibit multiple-target effects including anti-apoptotic, anti-inflammatory, and antioxidant properties.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
Editorial Material
Multidisciplinary Sciences
Zak Doric, Ken Nakamura
Summary: By disrupting mitochondria in vulnerable neuronal cells, mice provide a new model of Parkinson's disease that challenges long-held ideas about the disease's motor symptoms.
Review
Biochemistry & Molecular Biology
Maria Dolores Perez-Carrion, Inmaculada Posadas, Javier Solera, Valentin Cena
Summary: This review summarizes the main pathological mutations in LRRK2 that contribute to Parkinson's disease and discusses the different cellular and therapeutic strategies to correct LRRK2 homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Ruben Fernandez-Santiago, Anna Esteve-Codina, Manel Fernandez, Francesc Valldeoriola, Almudena Sanchez-Gomez, Esteban Munoz, Yaroslau Compta, Eduardo Tolosa, Mario Ezquerra, Maria J. Marti
Summary: Differential gene expression related to biological processes in PD patients was identified through RNA-seq analysis of dermal fibroblasts, regardless of glucose concentration.
NPJ PARKINSONS DISEASE
(2021)
Article
Clinical Neurology
Laura Munoz-Delgado, Miguel Angel Labrador-Espinosa, Daniel Macias-Garcia, Silvia Jesus, Belen Benitez Zamora, Paula Fernandez-Rodriguez, Astrid D. Adarmes-Gomez, Maria Isabel Reina Castillo, Sandra Castro-Labrador, Jesus Silva-Rodriguez, Fatima Carrillo, David Garcia Solis, Michel J. Grothe, Pablo Mir
Summary: Two independent studies found that peripheral immune responses are associated with dopaminergic degeneration in Parkinson's disease (PD), with a main correlation found with lymphocyte count.
MOVEMENT DISORDERS
(2023)
Article
Biology
Michael E. Hughes, Katherine C. Abruzzi, Ravi Allada, Ron Anafi, Alaaddin Bulak Arpat, Gad Asher, Pierre Baldi, Charissa de Bekker, Deborah Bell-Pedersen, Justin Blau, Steve Brown, M. Fernanda Ceriani, Zheng Chen, Joanna C. Chiu, Juergen Cox, Alexander M. Crowell, Jason P. DeBruyne, Derk-Jan Dijk, Luciano DiTacchio, Francis J. Doyle, Giles E. Duffield, Jay C. Dunlap, Kristin Eckel-Mahan, Karyn A. Esser, Garret A. FitzGerald, Daniel B. Forger, Lauren J. Francey, Ying-Hui Fu, Frederic Gachon, David Gatfield, Paul de Goede, Susan S. Golden, Carla Green, John Harer, Stacey Harmer, Jeff Haspel, Michael H. Hastings, Hanspeter Herzel, Erik D. Herzog, Christy Hoffmann, Christian Hong, Jacob J. Hughey, Jennifer M. Hurley, Horacio O. de la Iglesia, Carl Johnson, Steve A. Kay, Nobuya Koike, Karl Kornacker, Achim Kramer, Katja Lamia, Tanya Leise, Scott A. Lewis, Jiajia Li, Xiaodong Li, Andrew C. Liu, Jennifer J. Loros, Tami A. Martino, Jerome S. Menet, Martha Merrow, Andrew J. Millar, Todd Mockler, Felix Naef, Emi Nagoshi, Michael N. Nitabach, Maria Olmedo, Dmitri A. Nusinow, Louis J. Ptacek, David Rand, Akhilesh B. Reddy, Maria S. Robles, Till Roenneberg, Michael Rosbash, Marc D. Ruben, Samuel S. C. Rund, Aziz Sancar, Paolo Sassone-Corsi, Amita Sehgal, Scott Sherrill-Mix, Debra J. Skene, Kai-Florian Storch, Joseph S. Takahashi, Hiroki R. Ueda, Han Wang, Charles Weitz, Pal O. Westermark, Herman Wijnen, Ying Xu, Gang Wu, Seung-Hee Yoo, Michael Young, Eric Erquan Zhang, Tomasz Zielinski, John B. Hogenesch
JOURNAL OF BIOLOGICAL RHYTHMS
(2017)
Article
Neurosciences
Anatoly Kozlov, Edouard Jaumouille, Pedro Machado Almeida, Rafael Koch, Joseph Rodriguez, Katharine C. Abruzzi, Emi Nagoshi
JOURNAL OF NEUROSCIENCE
(2017)
Article
Multidisciplinary Sciences
Wen-bin Alfred Chng, Rafael Koch, Xiaoxue Li, Shu Kondo, Emi Nagoshi, Bruno Lemaitre
Article
Neurosciences
Virginie Sabado, Ludovic Vienne, Emi Nagoshi
FRONTIERS IN CELLULAR NEUROSCIENCE
(2017)
Article
Genetics & Heredity
Damla Tas, Luca Stickley, Federico Miozzo, Rafael Koch, Nicolas Loncle, Virginie Sabado, Bettina Gnagi, Emi Nagoshil
Article
Multidisciplinary Sciences
Virginie Sabado, Emi Nagoshi
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2018)
Article
Multidisciplinary Sciences
Virginie Sabado, Ludovic Vienne, Jose Manuel Nunes, Michael Rosbash, Emi Nagoshi
Scientific Reports
(2017)
Review
Biochemistry & Molecular Biology
Emi Nagoshi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Review
Biology
Anatoly Kozlov, Emi Nagoshi
CURRENT OPINION IN INSECT SCIENCE
(2019)
Article
Genetics & Heredity
Anatoly Kozlov, Rafael Koch, Emi Nagoshi
Article
Multidisciplinary Sciences
Clement Immarigeon, Yohan Frei, Sofie Y. N. Delbare, Dragan Gligorov, Pedro Machado Almeida, Jasmine Grey, Lea Fabbro, Emi Nagoshi, Jean-Christophe Billeter, Mariana F. Wolfner, Francois Karch, Robert K. Maeda
Summary: Many transcripts previously considered noncoding RNAs are now found to produce peptides with important biological functions, such as the micropeptide encoded by male-specific abdominal RNA. This micropeptide is expressed exclusively in the secondary cells of the male accessory gland of Drosophila, and its loss of function results in defects in sperm competition, highlighting the importance of small peptides in biological processes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Physiology
Edouard Jaumouille, Rafael Koch, Emi Nagoshi
Summary: Studies on Drosophila melanogaster's circadian rhythms have shown that approximately 150 pacemaker neurons, each equipped with a molecular oscillator, form a circuit that acts as the central pacemaker. New evidence challenges the traditional dual-oscillator model and proposes coordination of multiple oscillators through network interactions. The disruption of molecular clocks or neural output of the main pacemaker acts additively to sustain rhythmic locomotor output.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Pedro Machado Almeida, Blanca Lago Solis, Alexis Feidler, Emi Nagoshi, Luca Stickley
Summary: Research shows that in the mushroom body neurons of Drosophila, circadian clocks drive rhythmic expression of hundreds of genes, including the tumor suppressor gene Neurofibromin 1 (Nf1) and Pka-C1. This rhythm also drives calcium rhythms via NF1-cAMP/PKA-C1 signaling, promoting daytime wakefulness and revealing the important role of circadian rhythms in the brain.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Federico Miozzo, Luca Stickley, Eva P. Valencia-Alarcon, Michaela Dorcikova, Francesco Petrelli, Damla Tas, Nicolas Loncle, Irina Nikonenko, Peter Bou Dib, Emi Nagoshi
Summary: This study identifies a conserved mechanism by which a transcription factor regulates mitochondrial health in dopaminergic neurons. By studying fruit fly and mouse models, the researchers demonstrate that this transcription factor maintains mitochondrial structure and function during aging, playing a crucial role in neuroprotection.
NATURE COMMUNICATIONS
(2022)