标题
Investigating the cell permeability of proteolysis-targeting chimeras (PROTACs)
作者
关键词
-
出版物
Expert Opinion on Drug Discovery
Volume 18, Issue 4, Pages 357-361
出版商
Informa UK Limited
发表日期
2023-03-13
DOI
10.1080/17460441.2023.2187047
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation
- (2022) Charles E. Hendrick et al. ACS Medicinal Chemistry Letters
- Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties
- (2021) Peter S. Dragovich et al. JOURNAL OF MEDICINAL CHEMISTRY
- Cancer Selective Target Degradation by Folate-Caged PROTACs
- (2021) Jing Liu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Semiconducting polymer nano-PROTACs for activatable photo-immunometabolic cancer therapy
- (2021) Chi Zhang et al. Nature Communications
- Aptamer‐PROTAC Conjugates (APCs) for Tumor‐Specific Targeting in Breast Cancer
- (2021) Shipeng He et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Peptide Stapling Improves the Sustainability of a Peptide-Based Chimeric Molecule That Induces Targeted Protein Degradation
- (2021) Hidetomo Yokoo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase via In Silico Design
- (2021) Hidetomo Yokoo et al. JOURNAL OF MEDICINAL CHEMISTRY
- Amide-to-Ester Substitution as a Strategy for Optimizing PROTAC Permeability and Cellular Activity
- (2021) Victoria G. Klein et al. JOURNAL OF MEDICINAL CHEMISTRY
- Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity,
- (2021) Dongwen Lv et al. Nature Communications
- Optimising proteolysis-targeting chimeras (PROTACs) for oral drug delivery: a drug metabolism and pharmacokinetics perspective
- (2020) Andy Pike et al. DRUG DISCOVERY TODAY
- Systematic Investigation of the Permeability of Androgen Receptor PROTACs
- (2020) Duncan E. Scott et al. ACS Medicinal Chemistry Letters
- First orally bioavailable prodrug of proteolysis targeting chimera (PROTAC) degrades cyclin-dependent kinases 2/4/6 in vivo
- (2020) Mingming Wei et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras
- (2016) Honorine Lebraud et al. ACS Central Science
- Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities
- (2014) Carles Galdeano et al. JOURNAL OF MEDICINAL CHEMISTRY
- In Vitro Solubility Assays in Drug Discovery
- (2008) Edward Kerns et al. CURRENT DRUG METABOLISM
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