Review
Materials Science, Multidisciplinary
Shaohua Wu, Ting Dong, Yiran Li, Mingchao Sun, Ye Qi, Jiao Liu, Mitchell A. Kuss, Shaojuan Chen, Bin Duan
Summary: The COVID-19 pandemic has increased the use of biotextiles in our daily lives. Nanofibrous materials, with their superior properties compared to microfibers, are being used to create nanofibrous biotextiles through innovative electrospinning techniques. This review covers the strategies for nanofiber fabrication and the applications of nanofibrous biotextiles in various biomedical fields.
APPLIED MATERIALS TODAY
(2022)
Article
Nanoscience & Nanotechnology
Dalila Miele, Marco Ruggeri, Barbara Vigani, Cesar Viseras, Francesca Natali, Elena Del Favero, Silvia Rossi, Giuseppina Sandri
Summary: This study investigated the application of hectorite (HEC) and montmorillonite (MMT) doped polymeric scaffolds for the treatment of deep and chronic skin lesions. The presence of nanoclays altered the surface arrangement of the scaffold and increased its potential for interacting with biological proteins. MMT performed better than HEC due to its higher hydrophilicity and protein adhesion.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Polymer Science
Muhammad Zikri Aiman Zulkifli, Darman Nordin, Norazuwana Shaari, Siti Kartom Kamarudin
Summary: Tissue engineering integrates biology, medicine, and engineering to design biological substitutes for tissue functions, aiming to avoid organ transplantation. Electrospinning, a widely used technique, can fabricate nanofibrous scaffolds with high surface-to-volume ratio and the ability to mimic extracellular matrices, which are desirable for tissue engineering. However, electrospun scaffolds have limitations such as poor cell penetration and load-bearing capabilities. Various research groups have proposed solutions to overcome these limitations.
Article
Polymer Science
Xiu-Ping Li, Meng-Meng Wu, Hao-Kai Peng, Xue-Fei Zhang, Yan Ting Wang, Ting-Ting Li, Ching-Wen Lou, Jia-Horng Lin
Summary: This study successfully fabricated a wearable electronic skin composite yarn with high sensitivity and self-power, and a fabric based on this yarn showed good signal output and sensitivity. This fiber-based sensor provides an idea for monitoring subtle physiological signals of the human body and has broad potential in medical care and clinical diagnosis.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Article
Engineering, Environmental
Lubin Zhou, Ping Xu, Peixin Dong, Xiaolan Ou, Xuan Du, Ying Chen, Xi Zhang, Wenlai Guo, Guanghui Gao
Summary: Improper management of wound exudate delays diabetic wound healing. A novel diabetic wound dressing with double-layer structure and hydrophobic nanofibers on a hydrophilic non-woven fabric is reported. It diverts excessive exudate away from the wound bed and prevents rewetting, resulting in low inflammatory response and excellent wound healing. The self-pumping dressing has clinical significance for designing next-generation dressing for diabetic wound healing.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Abigail Herrera-Ruiz, Benjamin Betancourt Tovar, Ruben Gutierrez Garcia, Maria Fernanda Leal Tamez, Narsimha Mamidi
Summary: GelMA-based composites have wide-ranging applications in biomedical field due to their exceptional properties, but their potential in bone tissue engineering is still limited. Further research and development are needed to design more efficient composites for bone regeneration, although challenges remain.
Review
Biotechnology & Applied Microbiology
Britani N. Blackstone, Summer C. Gallentine, Heather M. Powell
Summary: This systematic review examines the use of electrospun collagen in tissue engineering applications, finding that different crosslinking methods can affect degradation resistance and strength of the scaffolds, which are capable of forming engineered tissues with high similarity to native structures.
BIOENGINEERING-BASEL
(2021)
Article
Materials Science, Multidisciplinary
David Sonnleitner, Natascha Schaefer, Annalena Wieland, Lena Fischer, Patrick Pasberg, Ingo Thievessen, Gregor Lang
Summary: This study presents a completely novel morphology of dumbbell-shaped PCL micro-particles, which combines structural features of fibers and spheres and has great potential in medical applications. The complex structures can be achieved by balancing parameters and spinning dope compositions, allowing for precise control over the aspect ratio of the particles and significantly enhanced cell adhesion.
APPLIED MATERIALS TODAY
(2021)
Review
Biotechnology & Applied Microbiology
Fei Xu, Chloe Dawson, Makenzie Lamb, Eva Mueller, Evan Stefanek, Mohsen Akbari, Todd Hoare
Summary: This review addresses the key design criteria and emerging fabrication techniques for translationally-relevant tissue engineering hydrogels. It suggests combining integrated fabrication approaches with successful translational experiences to accelerate the implementation of hydrogels in tissue engineering.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Chong Li, Haoyu Wang, Xiao Yan, Hanxige Chen, Yudong Fu, Qinhua Meng
Summary: By doping and modifying PVDF fibers, the piezoelectric and mechanical properties were enhanced, with discussions on the effects of dopants on the properties.
Review
Nanoscience & Nanotechnology
Mingyu Lee, Min Chul Kim, Jae Young Lee
Summary: Cardiovascular disease is a leading cause of death, and biomaterial-based tissue engineering approaches have shown promise in cardiac repair. This review focuses on the use of nanomaterial-incorporated conductive hydrogels for improving cardiac function post-myocardial infarction.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Materials Science, Multidisciplinary
Ahmad Saudi, Seyed Mojtaba Zebarjad, Hossein Salehi, Elham Katoueizadeh, Aliakbar Alizadeh
Summary: The study examined the morphology, surface contact angle, mechanical properties, in vitro degradation behavior, and water uptake of PCL/PGS/HAp fibers, showing that HAp particles have a positive effect on PC12 viability and adhesion.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Review
Pharmacology & Pharmacy
Vijay Bhooshan Kumar, Om Shanker Tiwari, Gal Finkelstein-Zuta, Sigal Rencus-Lazar, Ehud Gazit
Summary: Tissue engineering is focused on restoring or replacing damaged tissues, and peptide self-assembly, particularly RGD peptides, is an effective method for developing tissue structures and functionalities. This review summarizes the progress of RGD application in tissue and organ development, examines its impact on TE efficacy in clinical and preclinical studies, and outlines recent advancements in the use of RGD functionalized biomaterials for tissue regeneration.
Review
Materials Science, Multidisciplinary
Miaomiao Zhang, Shixin Xu, Ruoying Wang, Yongan Che, Cuicui Han, Wei Feng, Chengwei Wang, Wen Zhao
Summary: Electrospun nanofiber/hydrogel composites have gained significant attention due to their combination of excellent biochemical properties of hydrogel with the biomimetic nature of electrospun fibers. These composites, with tunable mechanical properties, can mimic the microstructure of extracellular matrix (ECM) and microenvironment of cells, making them advantageous for tissue repair. However, a comprehensive review on their application as tissue engineering scaffolds is lacking. This article systematically reviews the preparation and application of electrospun fiber/hydrogel composites in tissue engineering, providing insights for future research directions.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Muheeb Rafiq, Sami-ullah Rather, Taha Umair Wani, Anjum Hamid Rather, Rumysa Saleem Khan, Anees Ellahi Khan, Ibtisam Hamid, Haseeb A. Khan, Abdullah S. Alhomida, Faheem A. Sheikh
Summary: After the discovery of MXene, a new class of 2D material, researchers have found a new scope for their research. MXenes have remarkable physical, chemical, and biological properties, making them useful in various research disciplines. They have been applied in biosensors, bioimaging, tissue engineering, drug delivery systems, and more. MXenes can be functionalized with different atoms/molecules, making them diverse materials. Their potential in nanofibers is even greater than expected.
CHINESE CHEMICAL LETTERS
(2023)
Article
Engineering, Biomedical
Shaohua Wu, Ye Qi, Wen Shi, Mitchell Kuss, Shaojuan Chen, Bin Duan
Summary: This study developed conductive PPDO/CNT composite nanofiber yarns, demonstrating their potential for nerve regeneration applications. The PPDO/CNT NYs showed excellent mechanical properties and biocompatibility, and were able to promote cell differentiation and maturation through electrical stimulation.
ACTA BIOMATERIALIA
(2022)
Article
Materials Science, Textiles
Ye Qi, Huiyuan Zhai, Yaning Sun, Hongxing Xu, Shaohua Wu, Shaojuan Chen
Summary: Electrospun nanofibrous scaffolds made of biodegradable PCL/PPDO blends were fabricated in this study, with varying ratios of PCL and PPDO components. The study found that the properties of the nanofibrous meshes could be adjusted by changing the composition, and different ratios of PCL/PPDO meshes showed varying effects on promoting the adhesion and proliferation of human adipose derived mesenchymal stem cells.
TEXTILE RESEARCH JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Mingchao Sun, Shaojuan Chen, Peixue Ling, Jianwei Ma, Shaohua Wu
Summary: This study successfully fabricated methacrylated gelatin/poly(L-lactic acid) hybrid nanofiber mats and demonstrated their excellent hydrophilic properties and high water absorption capacity. The UV crosslinking process significantly improved the structural stability and mechanical properties of the nanofiber mats. Crosslinked nanofiber mats with higher MeGel content showed enhanced attachment, growth, and proliferation of human dermal fibroblasts.
Article
Chemistry, Applied
Fang Zhou, Congjing Cui, Shibin Sun, Shaohua Wu, Shaojuan Chen, Jianwei Ma, Chang Ming Li
Summary: A multifunctional bilayer membrane with antibacterial, anti-inflammatory, and effective cell contact guide functions was designed and fabricated using electrospinning. The outer layer exhibited great antibacterial activity, while the inner layer provided anti-inflammatory and cell contact guide functions. The membrane showed obvious inhibitory effects against E. coli and S. aureus and was non-cytotoxic to fibroblasts.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Congjing Cui, Shibin Sun, Xueyan Li, Shaojuan Chen, Shaohua Wu, Fang Zhou, Jianwei Ma
Summary: This study successfully optimized the structure and drug release characteristics of a nanofibrous membrane, resulting in controlled release of ciprofloxacin and exhibiting good antibacterial properties and biocompatibility. The findings of this research are of great significance for promoting wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Biomedical
Shaohua Wu, Yiran Li, Caidan Zhang, Litao Tao, Mitchell Kuss, Jung Yul Lim, Jonathan Butcher, Bin Duan
Summary: In this study, tri-layered gel-like nanofibrous PLGA-PASP scaffolds were successfully fabricated, which featured anisotropic mechanical properties similar to native heart valve tissues and promoted the proliferation and secretion of human aortic valvular interstitial cells. Furthermore, these scaffolds effectively inhibited the osteogenic differentiation of cells. RNA sequencing analysis revealed the significant influence of age on cell behavior.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Tao Li, Mingchao Sun, Shaohua Wu
Summary: Electrospun nanofiber materials, particularly those based on gelatin, have shown promise as advanced dressings for wound healing and skin regeneration. They possess high porosity, excellent barrier performance against pathogens, and a mimicry of extracellular matrix fibrils. Various crosslinking approaches and innovative electrospinning strategies have been used to enhance their mechanical properties. Additionally, bioactive components and therapeutic agents can be incorporated to impart multiple functions to these nanofiber dressings. This review provides a comprehensive overview of gelatin-based nanofiber dressings and their applications in wound healing and skin regeneration.
Review
Materials Science, Multidisciplinary
Shaohua Wu, Ting Dong, Yiran Li, Mingchao Sun, Ye Qi, Jiao Liu, Mitchell A. Kuss, Shaojuan Chen, Bin Duan
Summary: The COVID-19 pandemic has increased the use of biotextiles in our daily lives. Nanofibrous materials, with their superior properties compared to microfibers, are being used to create nanofibrous biotextiles through innovative electrospinning techniques. This review covers the strategies for nanofiber fabrication and the applications of nanofibrous biotextiles in various biomedical fields.
APPLIED MATERIALS TODAY
(2022)
Review
Chemistry, Multidisciplinary
Yiran Li, Ting Dong, Zhiwei Li, Shilei Ni, Fang Zhou, Olawale A. Alimi, Shaojuan Chen, Bin Duan, Mitchell Kuss, Shaohua Wu
Summary: Spinal cord injury is a devastating neurological condition, and neural tissue engineering combined with electrospinning technique shows great potential for its treatment.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Engineering, Biomedical
Jiangyu Cai, Jiao Liu, Junjie Xu, Yufeng Li, Ting Zheng, Tianlun Zhang, Kang Han, Shaojuan Chen, Jia Jiang, Shaohua Wu, Jinzhong Zhao
Summary: In this study, innovative nano-micro fibrous woven scaffolds with tendon-like structure and high-strength mechanical properties were fabricated for the treatment of large-size tendon injury. These scaffolds showed improved cell adhesion, elongation, proliferation, and maintained tenocyte phenotype. In vivo experiments demonstrated that the scaffold facilitated Achilles tendon regeneration with improved structure and biomechanical properties.
Article
Materials Science, Biomaterials
Shibin Sun, Qifan Yuan, Xueyan Li, Xueqin Wang, Shaohua Wu, Shaojuan Chen, Jianwei Ma, Fang Zhou
Summary: This study developed curcumin functionalized composite fibers with pH real-time monitoring, antibacterial, and anti-inflammatory properties, which showed great potential for the treatment of wound infection.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Engineering, Biomedical
Yiran Li, Qi Meng, Shaojuan Chen, Peixue Ling, Mitchell A. Kuss, Bin Duan, Shaohua Wu
Summary: Surgical sutures play a vital role in the closure and healing of damaged tissues and organs. Recent advancements in multiple disciplines have led to the development of innovative surgical sutures with humanization and multi-functionalization. This review summarizes the materials, fabrication strategies, structures, functionalizations, and commercial products of surgical sutures, and discusses the challenges and future prospects in the field.
ACTA BIOMATERIALIA
(2023)
Article
Agricultural Engineering
Yiran Li, Hui Zhao, Tao Li, Dawei Shang, Limin Wu, Ning Guan, Shaohua Wu
Summary: A novel two-step modification strategy was used to functionalize commonly used cotton fibers into highly effective antibacterial fibers. These fibers demonstrated high antibacterial sustainability and durability, while maintaining low cost. By blending only 10% of these functionalized fibers into nonwoven fabrics, strong antibacterial efficiency was achieved without compromising cytocompatibility. This study presents a simple and cost-effective technique for fabricating advanced functional textiles that can be widely applied in daily lives.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Engineering, Biomedical
Shaohua Wu, Yiran Li, Shaojuan Chen, Huiyuan Zhai, Peixue Ling
Summary: This study developed a simple and cost-effective technique roadmap for generating high performance PLLA nanofiber-constructed yarns or threads with controllable structures. By combining a modified electrospinning method with traditional textile processes such as hot stretching, twisting, and plying, PLLA ENYs with adjustable morphology, structure, and tensile properties were successfully fabricated. The study investigated the effects of different treatments on the alignment and crystallinity of the fibers, as well as the enhancements in tensile properties.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Polymer Science
Mustafa Kalay, Abidin Esidir, Mahmut Ruzi, N. Burak Kiremitler, Mustafa Serdar Onses
Summary: This study proposes stable and addressable polymer PUFs, utilizing a cross-linkable polymer system, which demonstrates high stochastic characteristics and low-cost production. The performance of the polymer features is evaluated through various analyses, and direct image authentication is achieved using feature matching algorithms.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Jingyu Jin, Guoqiang Lu, Jun Nie, Xiaoqun Zhu
Summary: Photopolymerization technology is limited in the fields of food packaging and biomedicine due to the high migration of small molecules from photoinitiators. In this study, a polymerizable 2-vinyl thioxanthone (ETX) was synthesized to improve the migration stability of photoinitiators. Macromolecular photoinitiators (PPI1, PPI2) were also prepared to further reduce migration. The results showed that the ETX/TEOA system had higher initiation performance and PPI2 displayed favorable initiation ability. Additionally, the migration of ETX, PPI1, and PPI2 in photocured film was significantly reduced. These low-migration photoinitiators have potential applications in the fields of food packaging and biological materials.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Weijie Li, Jun Nie, Yingying Zhao, Xiaoqun Zhu
Summary: This study focuses on the development of high-performance, low-migration photoinitiators. A polymerizable photoinitiator (VBP) was synthesized by introducing an ethylene group into benzophenone, and three different molecular weight single-component photoinitiators (PVBN1-3) were synthesized based on VBP. The results show that these new photoinitiators have stronger absorption ability compared to benzophenone and significantly reduce the migration of initiators and co-initiators, addressing the safety concerns caused by migration.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Seira Morimune-Moriya, Yuki Iwahashi, Mitsuru Nakamura, Daisuke Ogawa, Keiji Nakamura
Summary: This study investigates the effect of plasma treatment on carbon nanotubes (CNTs) and the structure/properties of polyimide (PI) nanocomposites with ultra-low content of CNTs. The results show that plasma treatment introduces isocyanate groups on the surface of CNTs and enhances the interfacial interaction between PI and treated CNTs. This leads to a significant improvement in the mechanical properties of the nanocomposites, with even a small addition of treated CNTs showing a substantial increase in Young's modulus, tensile strength and toughness.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Yuanlong Li, Chaojie Chen, Guoqing Cui, Li Liu, Chao Zhou, Guangfeng Wu
Summary: In this study, a novel ion-conducting hydrogel was fabricated using a straightforward approach. The hydrogel showed excellent tensile properties and high toughness due to physical interactions and covalent binding. Additionally, the introduction of hydroxyethyl cellulose and lithium chloride improved the biocompatibility, mechanical properties, electrical conductivity, and frost resistance of the hydrogel, demonstrating its potential for cold climate applications.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Dengwei Yan, Jinxian Yang, Xuejun Pan, Xiaozheng Duan, Lianwei Li, Mo Zhu
Summary: The influence of backbone length on grafting efficiency during the graft-onto reaction process was investigated. It was found that the polydispersity effect of backbone length does not affect the final grafting efficiency, indicating that the local dynamics of chain segments dominate the graft-onto process.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Zhaoyi Luo, Xianjie Pan, Fanqi Liu, Quanxi Yi, Yanning Zeng, Yunhua Chen, Chaoyang Wang
Summary: This study provides a method to prepare high-performance epoxy materials with good malleability and thermal stability. The materials have self-healing and welding capabilities, thanks to the addition of specific chemical bonds and network structures. They exhibit mechanical properties comparable to commercial epoxy resins and show great potential for sustainable industrial development.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Chaoji Xiong, Hao Wang, Lihua Deng, Kun Liang, Chunhua Wu, Wei Wu, Qian Chen
Summary: In this study, four polyamides were synthesized and their adsorption performances for Hg2+ in aqueous systems were investigated. The polyamides exhibited high adsorption capacities and excellent reusability, with the involvement of sulfur, nitrogen, and oxygen in the chemical adsorption process of Hg2+.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Siim Laanesoo, Olivier Bonjour, Rauno Sedrik, Iris Tamsalu, Patric Jannasch, Lauri Vares
Summary: The insertion of rigid aliphatic or aromatic building blocks in polymer structures is an effective way to synthesize high -Tg polymer materials. In this study, a series of isosorbide-2-aryl carboxylate-5-methacrylate monomers (ArIMAs) were synthesized by functionalizing isosorbide 5-methacrylate with various aromatic lignin-inspired esters. These monomers were polymerized to obtain high molecular-weight poly(aryl carboxylate isosorbide methacrylates) (PArIMAs). The resulting polymers showed high glass transition temperatures and thermal stability, making them suitable for use as high-performance plastics and coatings.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Yuqian Wu, Weijie Xu, Jianliang Li, Zhangfeng Zhong, Liqing Huang, Shengke Li, Huaping Tan
Summary: This study investigates the improvement of degradation and drug release characteristics of dynamic Schiff base-mediated natural polysaccharide hydrogels using tannic acid (TA), leading to enhanced stability and functionality.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Xi Zhang, Xiangli Kong, Xin Zhou, Yiyan Gao, Yibo Sun, Guanghui Gao, Wei Liu, Kai Shi
Summary: Conductive hydrogels have great development prospects in flexible strain sensors, but long-term direct contact with human skin can cause bacterial infection. A hydrogel with antibacterial, biocompatibility, and toughness was designed and manufactured using a freeze-thaw method. The hydrogel maintains tensile properties and fatigue resistance at low temperatures and is resistant to bacteria. Therefore, hydrogel sensors can be used to monitor human movements.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Wei Zhang, Jiangang Yu, Mingyang Wu, Rui Li, Anqiang Zhang, Yaling Lin
Summary: In this study, polyacrylamide containing quaternary ammonium salts (PAM-X) were synthesized and found to effectively inhibit soil-borne pathogenic fungi while maintaining the balance of microbial population in soil. PAM-X also showed low toxicity to earthworms and fish, providing a new method for the prevention and control of soil-borne fungal diseases.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Jiawen He, Haojie Yu, Li Wang, Jian Yang, Yanhui Zhang, Wenbing Huang, Chenguang Ouyang
Summary: This review discusses the use of polymeric hydrogels for atmospheric water harvesting (AWH), including the mechanism of water sorption, fabrication methods, and strategies for optimizing the structure of hydrogels. The extended applications of hygroscopic photothermal hydrogels, such as agricultural irrigation and dehumidification, are also explored. The challenges and prospects of using polymeric hydrogels for AWH are summarized.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Ying Du, Shuaishuai Lu, Yuanna Sun, Qingshan Li, Xinhai He
Summary: This study introduces a method to improve the performance of hydrogels by incorporating proline, resulting in hydrogels with excellent stretchability, high conductivity, and long-term stability. The hydrogel remains flexible and conductive even at ultra-low temperatures.
EUROPEAN POLYMER JOURNAL
(2024)