Article
Biophysics
Miaomiao Zhang, Shixin Xu, Chen Du, Ruoying Wang, Cuicui Han, Yongan Che, Wei Feng, Chengwei Wang, Shan Gao, Wen Zhao
Summary: In this study, a novel bilayer wound dressing made of poly(L-lactate-caprolactone) copolymer (PLCL) nanofibrous and keratin hydrogel loaded with fibroblast growth factor (FGF-2) was prepared using the low-pressure filtration-assisted method. The bilayer dressing was found to mimic the dermis and epidermis. It exhibited good porosity, maximum water absorption, and tight bond at the interface. In vitro and in vivo studies demonstrated the biocompatibility, biodegradability, and ability to promote skin healing of the bilayer dressing, making it a promising biomedical wound dressing for skin tissue engineering applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Polymer Science
Jia Liang, Honglin Chen, Zhengchao Guo, Piet Dijkstra, Dirk Grijpma, Andre Poot
Summary: Hybrid fibrous mats composed of PTMC-tMA and GelMA were prepared by electrospinning and photo-crosslinking, showing good cell adhesive properties and high toughness.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Materials Science, Textiles
Marziyeh Ranjbar-Mohammadi, Mohammad Nouri
Summary: In this study, catechin was successfully loaded into gelatin/poly(lactic acid) fibrous structure using double-nozzle electrospinning technique, leading to enhanced antibacterial activity and improved cell viability.
JOURNAL OF INDUSTRIAL TEXTILES
(2022)
Article
Polymer Science
Youngchae Cho, Heeseok Jeong, Baeyeon Kim, Juwoong Jang, Yo-Seung Song, Deuk Yong Lee
Summary: By adjusting the content of PLLA and gelatin, the mechanical properties, water absorption capacity, degradation rate, and cell compatibility of the polymer membranes can be modified. High PLLA content improves the strength of the membranes and reduces their water absorption, while high gelatin content enhances both strength and water absorption.
Article
Materials Science, Biomaterials
Busra Moran Bozer, Bengi Ozkahraman, Humeyra Mert
Summary: Oleuropein-loaded photocrosslinked hydrogels were developed as a new hydrogel wound dressing, composed of methacrylated pectin and methacrylated hyaluronic acid. The composite hydrogels were prepared by photocrosslinking of the methacrylated polymer precursors. The bioactivity studies demonstrated the potential of oleuropein-loaded photocrosslinked hybrid hydrogels for wound healing applications.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2023)
Article
Engineering, Biomedical
Yan Hu, Bangrui Yu, Yuanbo Jia, Meng Lei, Zhijie Li, Hao Liu, Haishui Huang, Feng Xu, Jing Li, Zhao Wei
Summary: A bioadhesive and injectable ECM-mimicking hydrogel dressing with antibacterial capacity has been developed for burn injury therapy. The HG/Doxy hydrogel dressing exhibits biocompatibility and antibacterial activity against both Gram-positive and Gram-negative bacteria. In a rat model of burn wound, the HG/Doxy hydrogel dressing significantly accelerates wound closure and promotes skin structure regeneration, demonstrating its potential for clinical applications.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Mahla Lashkari, Mahya Rahmani, Yaser Yousefpoor, Meysam Ahmadi-Zeidabadi, Reza Faridi-Majidi, Zahra Ameri, Moein Salary, Shahrzad Azizi, Arman Shahabi, Amid Rahi, Mohamad Javad Mirzaei-Parsa
Summary: In this study, a bilayer scaffold composed of hydrogel and nanofibers was fabricated to improve the regeneration of injured skin. The results showed that re-epithelialization, angiogenesis, and collagen remodeling were enhanced in ADSCs-seeded bilayer scaffolds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Lu Wang, Fengling Liu, Xinrang Zhai, Wei Dong, Wei Wei, Zhenhua Hu
Summary: A composite hydrogel (GelNB@SIS) was designed for the repair of skin injuries. GelNB provides photo-triggering tissue adhesive property, while SIS has a 3D microporous structure and contains high levels of growth factors and collagen. This study demonstrated that GelNB@SIS can improve the healing process by promoting vascular renewal, dermal remodeling, and epidermal regeneration, making it a promising candidate for tissue repair applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Susan Bayati, Parmida Harirchi, Payam Zahedi, Abdolmajid Bayandori Moghaddam
Summary: This study aimed to develop a new bioactive wound dressing based on electrospun nanofibers containing Lawsonia inermis for burn wounds. The results showed that the dressing had a positive influence on wound closure and exhibited antibacterial properties.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Article
Biochemistry & Molecular Biology
Ziwei Hu, Dandan Liu, Mengmeng Wang, Chenrui Yu, Zhenxing Han, Maodong Xu, Wenjin Yue, Guangjun Nie
Summary: The introduction of amino acid (AA) can enhance the crosslinking and mechanical properties of chitosan (CS)/poly-(gamma-glutamic acid) (gamma-PGA) hydrogel. 0.5% beta-alanine (beta-Ala) can strengthen the load and release capacity of benzalkonium chlorides (BAC) in alkaline environment, making CS/beta-Ala/gamma-PGA hydrogel a potential material for wound dressing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Weiwei Zhang, Hanwen Chen, Junkai Zhao, Panfeng Chai, Guanglei Ma, Yahao Dong, Xing He, Yuqin Jiang, Qing Wu, Zhiguo Hu, Qingcong Wei
Summary: In this study, a body temperature-induced adhesive and removable hydrogel was developed for skin wound treatment. The hybrid gel exhibited enhanced mechanical properties and bactericidal ability, as well as immunoregulatory effects. It promoted skin regeneration in a mouse model by inhibiting inflammation and promoting collagen deposition and angiogenesis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Pathum Chandika, Fazlurrahman Khan, Seong-Yong Heo, Tae -Hee Kim, Young-Mog Kim, Myunggi Yi, Won-Kyo Jung
Summary: In this study, chitooligosaccharide/sinapic acid conjugate and photo cross-linkable hyaluronic acid were successfully synthesized and encapsulated in dual cross-linked polyvinyl alcohol/methacrylated hyaluronic acid composite hydrogel for full-thickness wound healing application. The composite hydrogel exhibited excellent physical and mechanical properties, and the introduction of the conjugate significantly enhanced its biocompatibility, antioxidant, and antimicrobial properties, thereby promoting wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Eray Altan, Yasin Karacelebi, Elif Saatcioglu, Songul Ulag, Ali Sahin, Burak Aksu, Alexa-Maria Croitoru, Cosmin Iulian Codrea, Denisa Ficai, Oguzhan Gunduz, Anton Ficai
Summary: This study found that adding juglone can enhance the antibacterial properties of PLA scaffolds but may reduce mechanical strength. In terms of cytotoxicity, there was toxicity initially, but with an increase in juglone ratio, fibroblast cell metabolic activity increased.
Article
Biochemistry & Molecular Biology
Chunyan Dou, Zheng Li, Ying Luo, Jixian Gong, Qiujin Li, Jianfei Zhang, Qingsong Zhang, Changsheng Qiao
Summary: A hybrid double-network (DN) full biological hydrogel was successfully constructed by introducing a physically cross-linked gelatin (GEL) network in a covalently cross-linked poly (gamma-glutamic acid) (gamma-PGA) network. The gamma-PGA-GEL DN hydrogel exhibited excellent mechanical properties and biocompatibility, with ultra-high compression performance and satisfactory tensile performance. It also showed better recovery and healing properties compared to the gamma-PGA single-network (SN) hydrogel. In addition, the gamma-PGA-GEL DN hydrogel had good transparency, swelling, and degradability. In vitro cell experiments demonstrated its benefits in cell adhesion and proliferation. Evaluation on a rat skin defect model showed that the gamma-PGA-GEL DN hydrogel could significantly accelerate wound healing, making it an ideal candidate material for wound dressing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Rawaiz Khan, Sajjad Haider, Muhammad Umar Aslam Khan, Adnan Haider, Saiful Izwan Abd Razak, Anwarul Hasan, Raees Khan, Mat Uzir Wahit
Summary: The development of advanced multifunctional wound dressings remains a major challenge. In this study, a novel multilayer electrospun nanofibers wound dressing based on diethylenetriamine (DETA) functionalized polyacrylonitrile (PAN), TiO2 nanoparticles (NPs) coating, and bioderived gelatin (Gel) was developed. The ML PAN-DETA-Ct-Gel membrane showed good surface roughness, porosity, and better wettability, and exhibited good cell morphology, proliferation, viability, and antibacterial activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Shaohua Wu, Ye Qi, Wen Shi, Mitchell Kuss, Shaojuan Chen, Bin Duan
Summary: This study developed conductive PPDO/CNT composite nanofiber yarns, demonstrating their potential for nerve regeneration applications. The PPDO/CNT NYs showed excellent mechanical properties and biocompatibility, and were able to promote cell differentiation and maturation through electrical stimulation.
ACTA BIOMATERIALIA
(2022)
Article
Materials Science, Textiles
Ye Qi, Huiyuan Zhai, Yaning Sun, Hongxing Xu, Shaohua Wu, Shaojuan Chen
Summary: Electrospun nanofibrous scaffolds made of biodegradable PCL/PPDO blends were fabricated in this study, with varying ratios of PCL and PPDO components. The study found that the properties of the nanofibrous meshes could be adjusted by changing the composition, and different ratios of PCL/PPDO meshes showed varying effects on promoting the adhesion and proliferation of human adipose derived mesenchymal stem cells.
TEXTILE RESEARCH JOURNAL
(2022)
Article
Chemistry, Applied
Fang Zhou, Congjing Cui, Shibin Sun, Shaohua Wu, Shaojuan Chen, Jianwei Ma, Chang Ming Li
Summary: A multifunctional bilayer membrane with antibacterial, anti-inflammatory, and effective cell contact guide functions was designed and fabricated using electrospinning. The outer layer exhibited great antibacterial activity, while the inner layer provided anti-inflammatory and cell contact guide functions. The membrane showed obvious inhibitory effects against E. coli and S. aureus and was non-cytotoxic to fibroblasts.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Congjing Cui, Shibin Sun, Xueyan Li, Shaojuan Chen, Shaohua Wu, Fang Zhou, Jianwei Ma
Summary: This study successfully optimized the structure and drug release characteristics of a nanofibrous membrane, resulting in controlled release of ciprofloxacin and exhibiting good antibacterial properties and biocompatibility. The findings of this research are of great significance for promoting wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Biomedical
Shaohua Wu, Yiran Li, Caidan Zhang, Litao Tao, Mitchell Kuss, Jung Yul Lim, Jonathan Butcher, Bin Duan
Summary: In this study, tri-layered gel-like nanofibrous PLGA-PASP scaffolds were successfully fabricated, which featured anisotropic mechanical properties similar to native heart valve tissues and promoted the proliferation and secretion of human aortic valvular interstitial cells. Furthermore, these scaffolds effectively inhibited the osteogenic differentiation of cells. RNA sequencing analysis revealed the significant influence of age on cell behavior.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Tao Li, Mingchao Sun, Shaohua Wu
Summary: Electrospun nanofiber materials, particularly those based on gelatin, have shown promise as advanced dressings for wound healing and skin regeneration. They possess high porosity, excellent barrier performance against pathogens, and a mimicry of extracellular matrix fibrils. Various crosslinking approaches and innovative electrospinning strategies have been used to enhance their mechanical properties. Additionally, bioactive components and therapeutic agents can be incorporated to impart multiple functions to these nanofiber dressings. This review provides a comprehensive overview of gelatin-based nanofiber dressings and their applications in wound healing and skin regeneration.
Review
Materials Science, Multidisciplinary
Shaohua Wu, Ting Dong, Yiran Li, Mingchao Sun, Ye Qi, Jiao Liu, Mitchell A. Kuss, Shaojuan Chen, Bin Duan
Summary: The COVID-19 pandemic has increased the use of biotextiles in our daily lives. Nanofibrous materials, with their superior properties compared to microfibers, are being used to create nanofibrous biotextiles through innovative electrospinning techniques. This review covers the strategies for nanofiber fabrication and the applications of nanofibrous biotextiles in various biomedical fields.
APPLIED MATERIALS TODAY
(2022)
Article
Engineering, Biomedical
Jiangyu Cai, Jiao Liu, Junjie Xu, Yufeng Li, Ting Zheng, Tianlun Zhang, Kang Han, Shaojuan Chen, Jia Jiang, Shaohua Wu, Jinzhong Zhao
Summary: In this study, innovative nano-micro fibrous woven scaffolds with tendon-like structure and high-strength mechanical properties were fabricated for the treatment of large-size tendon injury. These scaffolds showed improved cell adhesion, elongation, proliferation, and maintained tenocyte phenotype. In vivo experiments demonstrated that the scaffold facilitated Achilles tendon regeneration with improved structure and biomechanical properties.
Article
Materials Science, Biomaterials
Shibin Sun, Qifan Yuan, Xueyan Li, Xueqin Wang, Shaohua Wu, Shaojuan Chen, Jianwei Ma, Fang Zhou
Summary: This study developed curcumin functionalized composite fibers with pH real-time monitoring, antibacterial, and anti-inflammatory properties, which showed great potential for the treatment of wound infection.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Polymer Science
Ye Qi, Conger Wang, Qiuyu Wang, Fang Zhou, Tao Li, Bo Wang, Weidong Su, Dawei Shang, Shaohua Wu
Summary: The study reports on a simple, quick, and cost-effective method to produce nanofiber-constructed yarns (NYs) using a combination of electrospinning, hand winding, and stretching post-treatment. The NYs demonstrated improved surface hydrophilicity and wettability with increasing silk fibroin (SF) content. Cells were able to sense and respond to the nanofibrous morphology and orientation of the NYs and SF promoted cell growth and proliferation. This research provides a simple and feasible method for fabricating PCL/SF NYs and NY-based biotextiles with great potential for tissue engineering and regenerative medicine applications.
EUROPEAN POLYMER JOURNAL
(2023)
Review
Engineering, Biomedical
Yiran Li, Qi Meng, Shaojuan Chen, Peixue Ling, Mitchell A. Kuss, Bin Duan, Shaohua Wu
Summary: Surgical sutures play a vital role in the closure and healing of damaged tissues and organs. Recent advancements in multiple disciplines have led to the development of innovative surgical sutures with humanization and multi-functionalization. This review summarizes the materials, fabrication strategies, structures, functionalizations, and commercial products of surgical sutures, and discusses the challenges and future prospects in the field.
ACTA BIOMATERIALIA
(2023)
Article
Agricultural Engineering
Yiran Li, Hui Zhao, Tao Li, Dawei Shang, Limin Wu, Ning Guan, Shaohua Wu
Summary: A novel two-step modification strategy was used to functionalize commonly used cotton fibers into highly effective antibacterial fibers. These fibers demonstrated high antibacterial sustainability and durability, while maintaining low cost. By blending only 10% of these functionalized fibers into nonwoven fabrics, strong antibacterial efficiency was achieved without compromising cytocompatibility. This study presents a simple and cost-effective technique for fabricating advanced functional textiles that can be widely applied in daily lives.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Engineering, Biomedical
Shaohua Wu, Yiran Li, Shaojuan Chen, Huiyuan Zhai, Peixue Ling
Summary: This study developed a simple and cost-effective technique roadmap for generating high performance PLLA nanofiber-constructed yarns or threads with controllable structures. By combining a modified electrospinning method with traditional textile processes such as hot stretching, twisting, and plying, PLLA ENYs with adjustable morphology, structure, and tensile properties were successfully fabricated. The study investigated the effects of different treatments on the alignment and crystallinity of the fibers, as well as the enhancements in tensile properties.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)