Identification of pyrrolo[3′,4’:3,4]cyclohepta[1,2-d][1,2]oxazoles as promising new candidates for the treatment of lymphomas

GPCR Inhibition in Treating Lymphoma

(2022) Marilia Barreca et al.   ACS Medicinal Chemistry Letters

Synthesis of 2H-Imidazo[2′,1':2,3] [1,3]thiazolo[4,5-e]isoindol-8-yl-phenylureas with promising therapeutic features for the treatment of acute myeloid leukemia (AML) with FLT3/ITD mutations

(2022) Vincenzo Cilibrasi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Insight on pyrimido[5,4-g]indolizine and pyrimido[4,5-c]pyrrolo[1,2-a]azepine systems as promising photosensitizers on malignant cells

(2022) Marilia Barreca et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The New Microtubule-Targeting Agent SIX2G Induces Immunogenic Cell Death in Multiple Myeloma

(2022) Katia Grillone et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

New tricyclic systems as photosensitizers towards triple negative breast cancer cells

(2022) Marilia Barreca et al.   ARCHIVES OF PHARMACAL RESEARCH

Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas

(2022) Marilia Barreca et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Evaluation of Fused Pyrrolothiazole Systems as Correctors of Mutant CFTR Protein

(2021) Virginia Spanò et al.   MOLECULES

Current development of CFTR potentiators in the last decade

(2020) Virginia Spanò et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An overview on anti-tubulin agents for the treatment of lymphoma patients

(2020) Marilia Barreca et al.   PHARMACOLOGY & THERAPEUTICS

Pyrrolo[2′,3′:3,4]cyclohepta[1,2-d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types

(2020) Virginia Spanò et al.   JOURNAL OF MEDICINAL CHEMISTRY

Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes

(2020) Marilia Barreca et al.   Marine Drugs

Insight on [1,3]thiazolo[4,5-e]isoindoles as tubulin polymerization inhibitors

(2020) Virginia Spanò et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and in vitro apoptotic mechanism of novel pyrrolopyrimidine derivatives

(2018) Zühal Kilic-Kurt et al.   BIOORGANIC CHEMISTRY

Hit Identification of a Novel Dual Binder forh-telo/c-mycG-Quadruplex by a Combination of Pharmacophore Structure-Based Virtual Screening and Docking Refinement

(2016) Roberta Rocca et al.   ChemMedChem

Synthesis and biological evaluation of pyrrolo[2,3- b ]pyridine analogues as antiproliferative agents and their interaction with calf thymus DNA

(2016) Suresh Narva et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

[1,2]Oxazolo[5,4- e ]isoindoles as promising tubulin polymerization inhibitors

(2016) Virginia Spanò et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Preclinical Activity of New [1,2]Oxazolo[5,4-e]isoindole Derivatives in Diffuse Malignant Peritoneal Mesothelioma

(2016) Virginia Spanò et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, in Vitro, and in Vivo Anticancer and Antiangiogenic Activity of Novel 3-Arylaminobenzofuran Derivatives Targeting the Colchicine Site on Tubulin

(2015) Romeo Romagnoli et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization

(2014) Andrea E. Prota et al.   JOURNAL OF MOLECULAR BIOLOGY

Synthesis of a new class of pyrrolo[3,4-h]quinazolines with antimitotic activity

(2013) Virginia Spanò et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of the new oligopeptide pyrrole derivative isonetropsin and its one pyrrole unit analogue

(2013) Alessandra Montalbano et al.   TETRAHEDRON

Stathmin and Interfacial Microtubule Inhibitors Recognize a Naturally Curved Conformation of Tubulin Dimers

(2010) Pascale Barbier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiochemical property space distribution among human metabolites, drugs and toxins

(2009) Varun Khanna et al.   BMC BIOINFORMATICS

Synthesis of the new ring system 6,8-dihydro-5H-pyrrolo[3,4-h]quinazoline

(2009) Paola Barraja et al.   TETRAHEDRON LETTERS

Cytotoxic effects of a novel pyrazolopyrimidine derivative entrapped in liposomes in anaplastic thyroid cancer cells in vitro and in xenograft tumors in vivo

(2008) M Celano et al.   ENDOCRINE-RELATED CANCER

Induction of γ-globin mRNA, erythroid differentiation and apoptosis in UVA-irradiated human erythroid cells in the presence of furocumarin derivatives

(2007) Giampietro Viola et al.   BIOCHEMICAL PHARMACOLOGY