期刊
TETRAHEDRON LETTERS
卷 50, 期 38, 页码 5389-5391出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.07.045
关键词
Pyrrolo[3,4-h]quinazolines; Antiproliferative activity; Isoindole building blocks; Pyrimidine annelation
资金
- Ministero dell'Istruzione dell'Universita e della Ricerca
A convenient synthesis of the pyrrolo[3,4-h]quinazoline ring system is reported. Our synthetic approach consisted of the annelation of a pyrimidine ring to an isoindole moiety using tetrahydroisoindole-4-ones as building blocks. The antiproliferative activity of the new compounds was investigated and one of them showed antitumor activity against all the 59 tested cell lines at micromolar concentrations (1.46-18.4 mu M). (C) 2009 Elsevier Ltd. All rights reserved.
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