Who is at Risk of Parkinson Disease? Refining the Preclinical Phase of GBA1 and LRRK2 Variant Carriers: a Clinical, Biochemical, and Imaging Approach
出版年份 2023 全文链接
标题
Who is at Risk of Parkinson Disease? Refining the Preclinical Phase of GBA1 and LRRK2 Variant Carriers: a Clinical, Biochemical, and Imaging Approach
作者
关键词
-
出版物
Current Neurology and Neuroscience Reports
Volume 23, Issue 4, Pages 121-130
出版商
Springer Science and Business Media LLC
发表日期
2023-03-07
DOI
10.1007/s11910-023-01259-1
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Differential Phospho‐Signatures in Blood Cells Identify LRRK2 G2019S Carriers in Parkinson's Disease
- (2022) Alicia Garrido et al. MOVEMENT DISORDERS
- Lipid pathway dysfunction is prevalent in patients with Parkinson’s disease
- (2022) Jasmin Galper et al. BRAIN
- Role of Lysosomal Gene Variants in Modulating GBA ‐Associated Parkinson's Disease Risk
- (2022) Letizia Straniero et al. MOVEMENT DISORDERS
- Neuroimaging in Glucocerebrosidase‐Associated Parkinsonism: A Systematic Review
- (2022) Massimo Filippi et al. MOVEMENT DISORDERS
- Sensor-based gait analysis in the premotor stage of LRRK2 G2019S-associated Parkinson's disease
- (2022) Antonio Sánchez-Rodríguez et al. PARKINSONISM & RELATED DISORDERS
- Genetic heterogeneity on sleep disorders in Parkinson’s disease: a systematic review and meta-analysis
- (2022) Jingxuan Huang et al. Translational Neurodegeneration
- Aberrant dopamine transporter and functional connectivity patterns in LRRK2 and GBA mutation carriers
- (2022) Amgad Droby et al. npj Parkinsons Disease
- Transcriptome deregulation of peripheral monocytes and whole blood in GBA-related Parkinson’s disease
- (2022) Giulietta Maria Riboldi et al. Molecular Neurodegeneration
- A 10‐Year Community‐Based Study of Leucine‐Rich Repeat Kinase 2 G2385R Carriers' Conversion to Parkinson's Disease
- (2022) Pei Wang et al. MOVEMENT DISORDERS
- Who to Enroll in Parkinson Disease Prevention Trials?
- (2022) Kellyann Niotis et al. NEUROLOGY
- Genetic variations in GBA1 and LRRK2 genes: Biochemical and clinical consequences in Parkinson disease
- (2022) Laura J. Smith et al. Frontiers in Neurology
- The GBA variant E326K is associated with alpha-synuclein aggregation and lipid droplet accumulation in human cell lines
- (2022) Laura J Smith et al. HUMAN MOLECULAR GENETICS
- Biochemical markers for severity and risk in GBA and LRRK2 Parkinson’s disease
- (2021) Avner Thaler et al. JOURNAL OF NEUROLOGY
- Functional Connectivity Analysis in Heterozygous Glucocerebrosidase Mutation Carriers
- (2021) Mine Sezgin et al. Journal of Parkinsons Disease
- Putative second hit rare genetic variants in families with seemingly GBA-associated Parkinson’s disease
- (2021) Muhammad Aslam et al. npj Genomic Medicine
- Cytokines and Gaucher Biomarkers in Glucocerebrosidase Carriers With and Without Parkinson Disease
- (2021) Jasmin Galper et al. MOVEMENT DISORDERS
- Profiling the Biochemical Signature of GBA‐Related Parkinson's Disease in Peripheral Blood Mononuclear Cells
- (2021) Micol Avenali et al. MOVEMENT DISORDERS
- Cognitive Functioning of Glucocerebrosidase (GBA) Non-manifesting Carriers
- (2021) Eileen E. Moran et al. Frontiers in Neurology
- Genomewide Association Studies of LRRK2 Modifiers of Parkinson's Disease
- (2021) Dongbing Lai et al. ANNALS OF NEUROLOGY
- Mutations in GBA and LRRK2 Are Not Associated with Increased Inflammatory Markers
- (2021) Avner Thaler et al. Journal of Parkinsons Disease
- Effect of Urate-Elevating Inosine on Early Parkinson Disease Progression
- (2021) et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Glucocerebrosidase Activity is not Associated with Parkinson's Disease Risk or Severity
- (2021) Nurit Omer et al. MOVEMENT DISORDERS
- Increased α‐Synuclein Level in CD45 + Blood Cells in Asymptomatic Carriers of GBA Mutations
- (2021) Anton Emelyanov et al. MOVEMENT DISORDERS
- Plasma Glucosylsphingosine in GBA1 Mutation Carriers with and without Parkinson's Disease
- (2021) Matthew Surface et al. MOVEMENT DISORDERS
- Apathy: An underestimated feature in GBA and LRRK2 non-manifesting mutation carriers
- (2021) Ioanna Pachi et al. PARKINSONISM & RELATED DISORDERS
- Genetic factors affecting dopaminergic deterioration during the premotor stage of Parkinson disease
- (2021) Myung Jun Lee et al. npj Parkinsons Disease
- Longitudinal Positron Emission Tomography of Dopamine Synthesis in Subjects with GBA1 Mutations
- (2020) Grisel Lopez et al. ANNALS OF NEUROLOGY
- Penetrance of Parkinson's Disease in LRRK2 p.G2019S Carriers Is Modified by a Polygenic Risk Score
- (2020) Hirotaka Iwaki et al. MOVEMENT DISORDERS
- In vivo signatures of neurodegeneration in isolated rapid eye movement behaviour disorder
- (2020) Giulia Carli et al. EUROPEAN JOURNAL OF NEUROLOGY
- Age at Onset of Parkinson’s Disease Among Ashkenazi Jewish Patients: Contribution of Environmental Factors, LRRK2 p.G2019S and GBA p.N370S Mutations
- (2020) Gilad Yahalom et al. Journal of Parkinsons Disease
- Leucine Rich Repeat Kinase 2 and Innate Immunity
- (2020) Diba Ahmadi Rastegar et al. Frontiers in Neuroscience
- CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson’s disease: a study in LRRK2 mutation carriers
- (2020) Nour K. Majbour et al. Translational Neurodegeneration
- Nonsteroidal Anti‐Inflammatory Use and LRRK2 Parkinson's Disease Penetrance
- (2020) Marta San Luciano et al. MOVEMENT DISORDERS
- GBA ‐Related Parkinson's Disease: Dissection of Genotype–Phenotype Correlates in a Large Italian Cohort
- (2020) Simona Petrucci et al. MOVEMENT DISORDERS
- GBA variants in REM sleep behavior disorder: a multicenter study
- (2020) Lynne Krohn et al. NEUROLOGY
- Metabolic syndrome does not influence the phenotype of LRRK2 and GBA related Parkinson’s disease
- (2020) Avner Thaler et al. Scientific Reports
- Current and projected future economic burden of Parkinson’s disease in the U.S.
- (2020) Wenya Yang et al. npj Parkinsons Disease
- Brain-first versus body-first Parkinson’s disease: a multimodal imaging case-control study
- (2020) Jacob Horsager et al. BRAIN
- GBA Variants in Parkinson's Disease: Clinical, Metabolomic, and Multimodal Neuroimaging Phenotypes
- (2020) Andrea Greuel et al. MOVEMENT DISORDERS
- Age at Onset of LRRK2 p. Gly2019Ser Is Related to Environmental and Lifestyle Factors
- (2020) Theresa Lüth et al. MOVEMENT DISORDERS
- If LRRK2 Set the Fire, Can Nonsteroidal Anti‐inflammatory Drugs Wet the Flames?
- (2020) Grace F. Crotty et al. MOVEMENT DISORDERS
- Association of caffeine and related analytes with resistance to Parkinson’s disease among LRRK2 mutation carriers: A metabolomic study
- (2020) Grace F Crotty et al. NEUROLOGY
- Brain Microglial Activation Increased in Glucocerebrosidase ( GBA ) Mutation Carriers without Parkinson's disease
- (2020) Stephen Mullin et al. MOVEMENT DISORDERS
- Higher urate in LRRK2 mutation carriers resistant to Parkinson disease
- (2019) Rachit Bakshi et al. ANNALS OF NEUROLOGY
- α ‐synuclein RT‐QuIC in cerebrospinal fluid of LRRK 2‐linked Parkinson's disease
- (2019) Alicia Garrido et al. Annals of Clinical and Translational Neurology
- GBA, Gaucher Disease, and Parkinson’s Disease: From Genetic to Clinic to New Therapeutic Approaches
- (2019) Giulietta M. Riboldi et al. Cells
- Evolution of prodromal parkinsonian features in a cohort of GBA mutation-positive individuals: a 6-year longitudinal study
- (2019) Micol Avenali et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Evolution and clustering of prodromal parkinsonian features in GBA1 carriers
- (2019) Stephen Mullin et al. MOVEMENT DISORDERS
- Higher Urine bis(Monoacylglycerol)Phosphate Levels in LRRK2 G2019S Mutation Carriers: Implications for Therapeutic Development
- (2019) Roy N. Alcalay et al. MOVEMENT DISORDERS
- Update of the MDS research criteria for prodromal Parkinson's disease
- (2019) Sebastian Heinzel et al. MOVEMENT DISORDERS
- Genetic modifiers of risk and age at onset in GBA associated Parkinson’s disease and Lewy body dementia
- (2019) Cornelis Blauwendraat et al. BRAIN
- LRRK2 and GBA Variants Exert Distinct Influences on Parkinson’s Disease-Specific Metabolic Networks
- (2019) Katharina A Schindlbeck et al. CEREBRAL CORTEX
- Clinical and dopamine transporter imaging characteristics of non-manifest LRRK2 and GBA mutation carriers in the Parkinson's Progression Markers Initiative (PPMI): a cross-sectional study
- (2019) Tanya Simuni et al. LANCET NEUROLOGY
- Cerebral Imaging Markers of GBA and LRRK2 Related Parkinson’s Disease and Their First-Degree Unaffected Relatives
- (2018) Avner Thaler et al. BRAIN TOPOGRAPHY
- Clustering of motor and nonmotor traits in leucine-rich repeat kinase 2 G2019S Parkinson's disease nonparkinsonian relatives: A multicenter family study
- (2018) Tiago A. Mestre et al. MOVEMENT DISORDERS
- Application of the Movement Disorder Society prodromal criteria in healthy G2019S -LRRK2 carriers
- (2018) Anat Mirelman et al. MOVEMENT DISORDERS
- Progression in the LRRK2-Associated Parkinson Disease Population
- (2018) Rachel Saunders-Pullman et al. JAMA Neurology
- The Parkinson Pandemic—A Call to Action
- (2018) E. Ray Dorsey et al. JAMA Neurology
- Integrated Genetic Analysis of Racial Differences of Common GBA Variants in Parkinson's Disease: A Meta-Analysis
- (2018) Yuan Zhang et al. Frontiers in Molecular Neuroscience
- Cognition among individuals along a spectrum of increased risk for Parkinson’s disease
- (2018) Lana M. Chahine et al. PLoS One
- The prodromal phase of leucine-rich repeat kinase 2-associated Parkinson disease: Clinical and imaging Studies
- (2017) Claustre Pont-Sunyer et al. MOVEMENT DISORDERS
- Cognitive and motor functioning in elderly glucocerebrosidase mutation carriers
- (2017) Eileen E. Moran et al. NEUROBIOLOGY OF AGING
- Oligomeric α-synuclein and glucocerebrosidase activity levels in GBA-associated Parkinson’s disease
- (2017) S. Pchelina et al. NEUROSCIENCE LETTERS
- Prodromal Parkinsonism and Neurodegenerative Risk Stratification in REM Sleep Behavior Disorder
- (2017) Thomas R Barber et al. SLEEP
- Prodromal Parkinsonism and Neurodegenerative Risk Stratification in REM Sleep Behavior Disorder
- (2017) Thomas R Barber et al. SLEEP
- Specifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson's
- (2016) Ganqiang Liu et al. ANNALS OF NEUROLOGY
- A cognitive fMRI study in non-manifesting LRRK2 and GBA carriers
- (2016) Noa Bregman et al. Brain Structure & Function
- Prodromal Clinical Markers of Parkinson disease in Gaucher Disease Individuals
- (2016) Emilia M. Gatto et al. EUROPEAN NEUROLOGY
- The epidemiology of Parkinson's disease: risk factors and prevention
- (2016) Alberto Ascherio et al. LANCET NEUROLOGY
- Increased peripheral inflammation in asymptomatic leucine-rich repeat kinase 2 mutation carriers
- (2016) Nicolas Dzamko et al. MOVEMENT DISORDERS
- Cerebrospinal fluid biomarkers and clinical features in leucine-rich repeat kinase 2 (LRRK2) mutation carriers
- (2016) Dolores Vilas et al. MOVEMENT DISORDERS
- Arm swing as a potential new prodromal marker of Parkinson's disease
- (2016) Anat Mirelman et al. MOVEMENT DISORDERS
- Nonmotor symptoms in healthy Ashkenazi Jewish carriers of the G2019S mutation in theLRRK2gene
- (2015) Anat Mirelman et al. MOVEMENT DISORDERS
- Age-specific penetrance ofLRRK2G2019S in the Michael J. Fox Ashkenazi Jewish LRRK2 Consortium
- (2015) Karen Marder et al. NEUROLOGY
- Clinical Correlations With Lewy Body Pathology inLRRK2-Related Parkinson Disease
- (2015) Lorraine V. Kalia et al. JAMA Neurology
- Evolution of Prodromal Clinical Markers of Parkinson Disease in aGBAMutation–Positive Cohort
- (2015) Michelle Beavan et al. JAMA Neurology
- Parkinson disease phenotype in Ashkenazi jews with and withoutLRRK2G2019S mutations
- (2013) Roy N. Alcalay et al. MOVEMENT DISORDERS
- Hyposmia and cognitive impairment in Gaucher disease patients and carriers
- (2012) Alisdair McNeill et al. MOVEMENT DISORDERS
- Gait alterations in healthy carriers of the LRRK2 G2019S mutation
- (2011) Anat Mirelman et al. ANNALS OF NEUROLOGY
- Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease
- (2009) Juliane Neumann et al. BRAIN
- Neuropathology of Parkinson's disease with the R1441G mutation inLRRK2
- (2009) José-Félix Martí-Massó et al. MOVEMENT DISORDERS
- Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
- (2008) Daniel G Healy et al. LANCET NEUROLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started