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Tertiary lymphoid structures in cancer

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Hallmarks of Cancer: New Dimensions

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B cells and tertiary lymphoid structures as determinants of tumour immune contexture and clinical outcome

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Deciphering the immunopeptidome in vivo reveals new tumour antigens

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Tracking Cancer Evolution through the Disease Course

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The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer

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Spatially organized multicellular immune hubs in human colorectal cancer

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Conventional type I dendritic cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lymph nodes

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Applications of Single-Cell Omics in Tumor Immunology

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Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification

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Antigen presentation by lung epithelial cells directs CD4+ TRM cell function and regulates barrier immunity

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Narrative online guides for the interpretation of digital-pathology images and tissue-atlas data

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Tertiary lymphoid structures improve immunotherapy and survival in melanoma

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B cells and tertiary lymphoid structures promote immunotherapy response

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Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1−CD8+ Tumor-Infiltrating T Cells

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Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy

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Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

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Characterization of cell fate probabilities in single-cell data with Palantir

(2019) Manu Setty et al.   NATURE BIOTECHNOLOGY

ilastik: interactive machine learning for (bio)image analysis

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Qualifying antibodies for image-based immune profiling and multiplexed tissue imaging

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An intra-tumoral niche maintains and differentiates stem-like CD8 T cells

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CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer

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Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes

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Overview of the Mechanisms that May Contribute to the Non-Redundant Activities of Interferon-Inducible CXC Chemokine Receptor 3 Ligands

(2018) Mieke Metzemaekers et al.   Frontiers in Immunology

A Structured Tumor-Immune Microenvironment in Triple Negative Breast Cancer Revealed by Multiplexed Ion Beam Imaging

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Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates

(2018) Yannick Simoni et al.   NATURE

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

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A BaSiC tool for background and shading correction of optical microscopy images

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Antigen-Presenting Intratumoral B Cells Affect CD4 + TIL Phenotypes in Non–Small Cell Lung Cancer Patients

(2017) Tullia C. Bruno et al.   Cancer Immunology Research

Tertiary Lymphoid Structures in Cancer: Drivers of Antitumor Immunity, Immunosuppression, or Bystander Sentinels in Disease?

(2017) Emily Jayne Colbeck et al.   Frontiers in Immunology

Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy

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Mutational landscape ofEGFR-,MYC-, andKras-driven genetically engineered mouse models of lung adenocarcinoma

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Multiplexed Epitope-Based Tissue Imaging for Discovery and Healthcare Applications

(2016) Bernd Bodenmiller   Cell Systems

Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses

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Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

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Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease

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Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

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Rapid modelling of cooperating genetic events in cancer through somatic genome editing

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T-Regulatory Cells: Key Players in Tumor Immune Escape and Angiogenesis

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Endogenous T Cell Responses to Antigens Expressed in Lung Adenocarcinomas Delay Malignant Tumor Progression

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The Cell-Specific Induction of CXC Chemokine Ligand 9 Mediated by IFN-  in Microglia of the Central Nervous System Is Determined by the Myeloid Transcription Factor PU.1

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elastix: A Toolbox for Intensity-Based Medical Image Registration

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Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase

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