标题
Spatially organized multicellular immune hubs in human colorectal cancer
作者
关键词
-
出版物
CELL
Volume 184, Issue 18, Pages 4734-4752.e20
出版商
Elsevier BV
发表日期
2021-08-26
DOI
10.1016/j.cell.2021.08.003
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition
- (2021) Kevin Litchfield et al. CELL
- IL-1R1–dependent signaling coordinates epithelial regeneration in response to intestinal damage
- (2021) Christian B. Cox et al. Science Immunology
- Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma
- (2021) Giacomo Oliveira et al. NATURE
- CXCL10+ peripheral activation niches couple preferred sites of Th1 entry with optimal APC encounter
- (2021) Hen Prizant et al. Cell Reports
- Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient
- (2020) Neil McCarthy et al. Cell Stem Cell
- B cells are associated with survival and immunotherapy response in sarcoma
- (2020) Florent Petitprez et al. NATURE
- Tertiary lymphoid structures improve immunotherapy and survival in melanoma
- (2020) Rita Cabrita et al. NATURE
- B cells and tertiary lymphoid structures promote immunotherapy response
- (2020) Beth A. Helmink et al. NATURE
- Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer
- (2020) Lei Zhang et al. CELL
- Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer
- (2020) Hae-Ock Lee et al. NATURE GENETICS
- Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front
- (2020) Christian M. Schürch et al. CELL
- Cumulus provides cloud-based data analysis for large-scale single-cell and single-nucleus RNA-seq
- (2020) Bo Li et al. NATURE METHODS
- Single-Cell Sequencing of Developing Human Gut Reveals Transcriptional Links to Childhood Crohn’s Disease
- (2020) Rasa Elmentaite et al. DEVELOPMENTAL CELL
- Pembrolizumab in Microsatellite-Instability–High Advanced Colorectal Cancer
- (2020) Thierry André et al. NEW ENGLAND JOURNAL OF MEDICINE
- Colonic CD90+ Crypt Fibroblasts Secrete Semaphorins to Support Epithelial Growth
- (2019) Olga N. Karpus et al. Cell Reports
- INTRATUMORAL ADAPTIVE IMMUNOSUPPRESSION AND TYPE 17 IMMUNITY IN MISMATCH REPAIR PROFICIENT COLORECTAL TUMORS
- (2019) Nicolas J Llosa et al. CLINICAL CANCER RESEARCH
- Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy
- (2019) Melvyn T. Chow et al. IMMUNITY
- Comprehensive Integration of Single-Cell Data
- (2019) Tim Stuart et al. CELL
- Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis
- (2019) Christopher S. Smillie et al. CELL
- Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts
- (2019) Ela Elyada et al. Cancer Discovery
- Identifying gene expression programs of cell-type identity and cellular activity with single-cell RNA-Seq
- (2019) Dylan Kotliar et al. eLife
- Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways
- (2019) Bing Huang et al. CELL
- Macrophage-Derived CXCL9 and CXCL10 Are Required for Antitumor Immune Responses Following Immune Checkpoint Blockade
- (2019) Imran G. House et al. CLINICAL CANCER RESEARCH
- R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon
- (2019) Christine Harnack et al. Nature Communications
- Single-cell RNA sequencing reveals stromal evolution into LRRC15+ myofibroblasts as a determinant of patient response to cancer immunotherapy
- (2019) Claudia X Dominguez et al. Cancer Discovery
- An intra-tumoral niche maintains and differentiates stem-like CD8 T cells
- (2019) Caroline S. Jansen et al. NATURE
- The Immune Landscape of Cancer
- (2018) Vésteinn Thorsson et al. IMMUNITY
- Durable Clinical Benefit With Nivolumab Plus Ipilimumab in DNA Mismatch Repair–Deficient/Microsatellite Instability–High Metastatic Colorectal Cancer
- (2018) Michael J. Overman et al. JOURNAL OF CLINICAL ONCOLOGY
- Using single‐cell genomics to understand developmental processes and cell fate decisions
- (2018) Jonathan A Griffiths et al. Molecular Systems Biology
- Integrating single-cell transcriptomic data across different conditions, technologies, and species
- (2018) Andrew Butler et al. NATURE BIOTECHNOLOGY
- A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade
- (2018) Daniela S. Thommen et al. NATURE MEDICINE
- Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images
- (2018) Joel Saltz et al. Cell Reports
- Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates
- (2018) Yannick Simoni et al. NATURE
- Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma
- (2018) Hanjie Li et al. CELL
- Lineage tracking reveals dynamic relationships of T cells in colorectal cancer
- (2018) Lei Zhang et al. NATURE
- Pan-tumor genomic biomarkers for PD-1 checkpoint blockade–based immunotherapy
- (2018) Razvan Cristescu et al. SCIENCE
- IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade
- (2017) Mark Ayers et al. JOURNAL OF CLINICAL INVESTIGATION
- Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
- (2017) Daniel Öhlund et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors
- (2017) Huipeng Li et al. NATURE GENETICS
- Massively parallel single-nucleus RNA-seq with DroNc-seq
- (2017) Naomi Habib et al. NATURE METHODS
- TRRUST v2: an expanded reference database of human and mouse transcriptional regulatory interactions
- (2017) Heonjong Han et al. NUCLEIC ACIDS RESEARCH
- Identification of a characteristic vascular belt zone in human colorectal cancer
- (2017) Jakob Nikolas Kather et al. PLoS One
- CD34+mesenchymal cells are a major component of the intestinal stem cells niche at homeostasis and after injury
- (2017) Igor Stzepourginski et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade
- (2017) Dung T. Le et al. SCIENCE
- Maturation of tertiary lymphoid structures and recurrence of stage II and III colorectal cancer
- (2017) Florian Posch et al. OncoImmunology
- Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade
- (2016) Joseph L. Benci et al. CELL
- Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics
- (2016) Karthik Shekhar et al. CELL
- RSPO3 expands intestinal stem cell and niche compartments and drives tumorigenesis
- (2016) John Hilkens et al. GUT
- Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability
- (2016) Bernhard Mlecnik et al. IMMUNITY
- Mismatch Repair and Colon Cancer: Mechanisms and Therapies Explored
- (2016) Stephen K.H. Li et al. TRENDS IN MOLECULAR MEDICINE
- Alternative preprocessing of RNA-Sequencing data in The Cancer Genome Atlas leads to improved analysis results
- (2015) Mumtahena Rahman et al. BIOINFORMATICS
- Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential
- (2015) Daniel L. Worthley et al. CELL
- Tumor angiogenesis: MMP-mediated induction of intravasation- and metastasis-sustaining neovasculature
- (2015) Elena I. Deryugina et al. MATRIX BIOLOGY
- Spatial reconstruction of single-cell gene expression data
- (2015) Rahul Satija et al. NATURE BIOTECHNOLOGY
- The consensus molecular subtypes of colorectal cancer
- (2015) Justin Guinney et al. NATURE MEDICINE
- PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
- (2015) Dung T. Le et al. NEW ENGLAND JOURNAL OF MEDICINE
- RegNetwork: an integrated database of transcriptional and post-transcriptional regulatory networks in human and mouse
- (2015) Zhi-Ping Liu et al. Database-The Journal of Biological Databases and Curation
- Community Detection in Signed Networks: the Role of Negative ties in Different Scales
- (2015) Pouya Esmailian et al. Scientific Reports
- The Molecular Signatures Database Hallmark Gene Set Collection
- (2015) Arthur Liberzon et al. Cell Systems
- PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors
- (2014) Alena Gros et al. JOURNAL OF CLINICAL INVESTIGATION
- Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature
- (2014) Yael Haberman et al. JOURNAL OF CLINICAL INVESTIGATION
- Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche
- (2014) Hayley Davis et al. NATURE MEDICINE
- Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
- (2014) A. P. Patel et al. SCIENCE
- An interleukin-17–mediated paracrine network promotes tumor resistance to anti-angiogenic therapy
- (2013) Alicia S Chung et al. NATURE MEDICINE
- Smart-seq2 for sensitive full-length transcriptome profiling in single cells
- (2013) Simone Picelli et al. NATURE METHODS
- Gene Expression Classification of Colon Cancer into Molecular Subtypes: Characterization, Validation, and Prognostic Value
- (2013) Laetitia Marisa et al. PLOS MEDICINE
- A vaccine strategy that protects against genital herpes by establishing local memory T cells
- (2012) Haina Shin et al. NATURE
- Recurrent R-spondin fusions in colon cancer
- (2012) Somasekar Seshagiri et al. NATURE
- Colocalization of Inflammatory Response with B7-H1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune Escape
- (2012) J. M. Taube et al. Science Translational Medicine
- Unique Ectopic Lymph Node-Like Structures Present in Human Primary Colorectal Carcinoma Are Identified by Immune Gene Array Profiling
- (2011) Domenico Coppola et al. AMERICAN JOURNAL OF PATHOLOGY
- Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium
- (2011) Toshiro Sato et al. GASTROENTEROLOGY
- Microsatellite Instability in Colorectal Cancer
- (2010) C. Richard Boland et al. GASTROENTEROLOGY
- Stability of graph communities across time scales
- (2010) J.- C. Delvenne et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Chemokine Expression in Melanoma Metastases Associated with CD8+ T-Cell Recruitment
- (2009) H. Harlin et al. CANCER RESEARCH
- Diagnosis of ulcerative colitis before onset of inflammation by multivariate modeling of genome-wide gene expression data
- (2009) Jrgen Olsen et al. INFLAMMATORY BOWEL DISEASES
- The tumor-promoting actions of TNF-α involve TNFR1 and IL-17 in ovarian cancer in mice and humans
- (2009) Kellie A. Charles et al. JOURNAL OF CLINICAL INVESTIGATION
- CD8+ T lymphocyte mobilization to virus-infected tissue requires CD4+ T-cell help
- (2009) Yusuke Nakanishi et al. NATURE
- DNA Copy-Number Alterations Underlie Gene Expression Differences between Microsatellite Stable and Unstable Colorectal Cancers
- (2008) R. N. Jorissen et al. CLINICAL CANCER RESEARCH
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now