Small molecule-based fluorescent probes for the detection of α-Synuclein aggregation states

Current Progress in the Development of Probes for Targeting α-Synuclein Aggregates

(2022) Qi Zeng et al.   ACS Chemical Neuroscience

Foldamers reveal and validate therapeutic targets associated with toxic α-synuclein self-assembly

(2022) Jemil Ahmed et al.   Nature Communications

Inhibition of Amyloid Protein Aggregation Using Selected Peptidomimetics

(2022) Debabrata Maity   ChemMedChem

Peptidomimetic-Based Vesicles Inhibit Amyloid-β Fibrillation and Attenuate Cytotoxicity

(2021) Debabrata Maity et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorescent Probe for Selective Imaging of α-Synuclein Fibrils in Living Cells

(2021) Pankaj Gaur et al.   ACS Chemical Neuroscience

Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function

(2021) L. Palanikumar et al.   Nature Communications

A Comparative Photophysical Study of Structural Modifications of Thioflavin T-Inspired Fluorophores

(2020) Lisa-Maria Needham et al.   Journal of Physical Chemistry Letters

Selected peptide-based fluorescent probes for biological applications

(2020) Debabrata Maity   Beilstein Journal of Organic Chemistry

High Selectivity and Sensitivity of Oligomeric p-Phenylene Ethynylenes for Detecting Fibrillar and Pre-Fibrillar Amyloid Protein Aggregates

(2019) Adeline Marianne Fanni et al.   ACS Chemical Neuroscience

A “Clickable” Photoconvertible Small Fluorescent Molecule as a Minimalist Probe for Tracking Individual Biomolecule Complexes

(2019) Joomyung Vicky Jun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein

(2019) Leah K. Cuddy et al.   NEURON

Synthesis of a fluorescent probe for sensing multiple protein states

(2018) Oleksandr A Kucherak et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Modulation of Fluorescent Protein Chromophores To Detect Protein Aggregation with Turn-On Fluorescence

(2018) Yu Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective α-Synuclein Knockdown in Monoamine Neurons by Intranasal Oligonucleotide Delivery: Potential Therapy for Parkinson’s Disease

(2018) Diana Alarcón-Arís et al.   MOLECULAR THERAPY

Zeroing in on neurodegenerative α-synuclein

(2017) Katie Kingwell   NATURE REVIEWS DRUG DISCOVERY

Modulating membrane binding of α-synuclein as a therapeutic strategy

(2017) André Pineda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

(2017) Giuliana Fusco et al.   SCIENCE

Cell Biology and Pathophysiology of α-Synuclein

(2017) Jacqueline Burré et al.   Cold Spring Harbor Perspectives in Medicine

The Synucleinopathies: Twenty Years On

(2017) Michel Goedert et al.   Journal of Parkinsons Disease

GABA transmission via ATP-dependent K+channels regulates α-synuclein secretion in mouse striatum

(2016) Evangelia Emmanouilidou et al.   BRAIN

A FRET-enabled molecular peptide beacon with a significant red shift for the ratiometric detection of nucleic acids

(2016) Debabrata Maity et al.   CHEMICAL COMMUNICATIONS

New insights into cellular α-synuclein homeostasis in health and disease

(2016) Ulf Dettmer et al.   CURRENT OPINION IN NEUROBIOLOGY

A High Affinity Red Fluorescence and Colorimetric Probe for Amyloid β Aggregates

(2016) K. Rajasekhar et al.   Scientific Reports

The Parkinson Disease gene SNCA: Evolutionary and structural insights with pathological implication

(2016) Irum Javaid Siddiqui et al.   Scientific Reports

Fast Flow Microfluidics and Single-Molecule Fluorescence for the Rapid Characterization of α-Synuclein Oligomers

(2015) Mathew H. Horrocks et al.   ANALYTICAL CHEMISTRY

Anle138b and related compounds are aggregation specific fluorescence markers and reveal high affinity binding to α-synuclein aggregates

(2015) Andreas A. Deeg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Detection of oligomers and fibrils of α-synuclein by AIEgen with strong fluorescence

(2015) Chris Wai Tung Leung et al.   CHEMICAL COMMUNICATIONS

Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations

(2015) Benjamin Dehay et al.   LANCET NEUROLOGY

Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease

(2013) Jens Wagner et al.   ACTA NEUROPATHOLOGICA

A conformation-switching fluorescent protein probe for detection of alpha synuclein oligomers

(2013) Michael Hernandez et al.   CHEMICAL COMMUNICATIONS

In VivoCross-linking Reveals Principally Oligomeric Forms of α-Synuclein and β-Synuclein in Neurons and Non-neural Cells

(2013) Ulf Dettmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tri- and Pentamethine Cyanine Dyes for Fluorescent Detection of α-Synuclein Oligomeric Aggregates

(2012) V. B. Kovalska et al.   JOURNAL OF FLUORESCENCE

Detection of α-Synuclein Amyloidogenic Aggregates in Vitro and in Cells using Light-Switching Dipyridophenazine Ruthenium(II) Complexes

(2012) Nathan P. Cook et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

100 years of Lewy pathology

(2012) Michel Goedert et al.   Nature Reviews Neurology

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

The role of the C-terminus of human α-synuclein: Intra-disulfide bonds between the C-terminus and other regions stabilize non-fibrillar monomeric isomers

(2011) Dong-Pyo Hong et al.   FEBS LETTERS

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

(2011) Christian Hansen et al.   JOURNAL OF CLINICAL INVESTIGATION

 -Synuclein Negatively Regulates Protein Kinase C  Expression to Suppress Apoptosis in Dopaminergic Neurons by Reducing p300 Histone Acetyltransferase Activity

(2011) H. Jin et al.   JOURNAL OF NEUROSCIENCE

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Molecular mechanism of Thioflavin-T binding to amyloid fibrils

(2010) Matthew Biancalana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Fluorescent Ratiometric MFC Probe Sensitive to Early Stages of α-Synuclein Aggregation

(2010) Dmytro A. Yushchenko et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein Recognition by an Ensemble of Fluorescent DNA G-Quadruplexes

(2009) David Margulies et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Triple-Emission Fluorescent Probe Reveals Distinctive Amyloid Fibrillar Polymorphism of Wild-Type α-Synuclein and Its Familial Parkinson’s Disease Mutants

(2009) M. Soledad Celej et al.   BIOCHEMISTRY

Branching in Amyloid Fibril Growth

(2009) Christian Beyschau Andersen et al.   BIOPHYSICAL JOURNAL

Real-time analysis of amyloid fibril formation of α-synuclein using a fibrillation-state-specific fluorescent probe of JC-1

(2008) Jung-Ho Lee et al.   BIOCHEMICAL JOURNAL

Fluorescent N-Arylaminonaphthalene Sulfonate Probes for Amyloid Aggregation of α-Synuclein

(2008) M. Soledad Celej et al.   BIOPHYSICAL JOURNAL

Structure of membrane-bound  -synuclein from site-directed spin labeling and computational refinement

(2008) C. C. Jao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific fluorescent detection of fibrillar α-synuclein using mono- and trimethine cyanine dyes

(2007) K.D. Volkova et al.   BIOORGANIC & MEDICINAL CHEMISTRY