Inflammation-Related Functional and Structural Dysconnectivity as a Pathway to Psychopathology

Association between resting-state functional connectivity of amygdala subregions and peripheral pro-inflammation cytokines levels in bipolar disorder

(2022) Jiaying Gong et al.   Brain Imaging and Behavior

Immune targets for therapeutic development in depression: towards precision medicine

(2022) Wayne C. Drevets et al.   NATURE REVIEWS DRUG DISCOVERY

Neuroinflammatory Biomarkers in Cerebrospinal Fluid From 106 Patients With Recent-Onset Depression Compared With 106 Individually Matched Healthy Control Subjects

(2022) Nina Vindegaard Sørensen et al.   BIOLOGICAL PSYCHIATRY

Exaggerated Amygdala Response to Threat and Association with Immune Hyperactivity in Depression

(2022) Sarah Boukezzi et al.   BRAIN BEHAVIOR AND IMMUNITY

Neutrophil to lymphocyte ratio is a transdiagnostic biomarker of depression and structural and functional brain alterations in older adults

(2022) Roger C. McIntosh et al.   JOURNAL OF NEUROIMMUNOLOGY

C-reactive protein is related to a distinct set of alterations in resting-state functional connectivity contributing to a differential pathophysiology of major depressive disorder

(2022) Fienne-Elisa Beckmann et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Functional connectivity in reward circuitry and symptoms of anhedonia as therapeutic targets in depression with high inflammation: evidence from a dopamine challenge study

(2022) Mandakh Bekhbat et al.   MOLECULAR PSYCHIATRY

Cerebrospinal Fluid and Blood Biomarkers of Neuroinflammation and Blood-Brain Barrier in Psychotic Disorders and Individually Matched Healthy Controls

(2022) Rose Jeppesen et al.   SCHIZOPHRENIA BULLETIN

Distinct Phenotypes of Inflammation Associated Macrophages and Microglia in the Prefrontal Cortex Schizophrenia Compared to Controls

(2022) Yunting Zhu et al.   Frontiers in Neuroscience

Inflammation, amygdala-ventromedial prefrontal functional connectivity and symptoms of anxiety and PTSD in African American women recruited from an inner-city hospital: Preliminary results

(2022) Neeti D. Mehta et al.   BRAIN BEHAVIOR AND IMMUNITY

Elevated peripheral inflammation is associated with attenuated striatal reward anticipation in major depressive disorder

(2021) Kaiping Burrows et al.   BRAIN BEHAVIOR AND IMMUNITY

Associations between peripheral inflammation and resting state functional connectivity in adolescents

(2021) Johnna R. Swartz et al.   BRAIN BEHAVIOR AND IMMUNITY

The Role of Peripheral Inflammation in Clinical Outcome and Brain Imaging Abnormalities in Psychosis: A Systematic Review

(2021) Melisa Kose et al.   Frontiers in Psychiatry

Elevated C-Reactive Protein in Patients With Depression, Independent of Genetic, Health, and Psychosocial Factors: Results From the UK Biobank

(2021) Maria C. Pitharouli et al.   AMERICAN JOURNAL OF PSYCHIATRY

Early life Adversity, functional connectivity and cognitive performance in Schizophrenia: The mediating role of IL-6

(2021) Sinead King et al.   BRAIN BEHAVIOR AND IMMUNITY

Peripheral inflammation is associated with micro-structural and functional connectivity changes in depression-related brain networks

(2021) Manfred G. Kitzbichler et al.   MOLECULAR PSYCHIATRY

Association of inflammation with depression and anxiety: evidence for symptom-specificity and potential causality from UK Biobank and NESDA cohorts

(2021) Yuri Milaneschi et al.   MOLECULAR PSYCHIATRY

Transcriptomic signatures of psychomotor slowing in peripheral blood of depressed patients: evidence for immunometabolic reprogramming

(2021) Mandakh Bekhbat et al.   MOLECULAR PSYCHIATRY

White Matter Alterations Associated with Pro-inflammatory Cytokines in Patients with Major Depressive Disorder

(2021) Jaehwa Lim et al.   Clinical Psychopharmacology and Neuroscience

Basal and LPS-stimulated inflammatory markers and the course of anxiety symptoms

(2021) Wessel A. van Eeden et al.   BRAIN BEHAVIOR AND IMMUNITY

Dysconnectivity of a brain functional network was associated with blood inflammatory markers in depression

(2021) Athina R. Aruldass et al.   BRAIN BEHAVIOR AND IMMUNITY

Peripheral immune cell reactivity and neural response to reward in patients with depression and anhedonia

(2021) Sara Costi et al.   Translational Psychiatry

A schizophrenia subgroup with elevated inflammation displays reduced microglia, increased peripheral immune cell and altered neurogenesis marker gene expression in the subependymal zone

(2021) Hayley F. North et al.   Translational Psychiatry

Inflammation and Negative Symptoms of Schizophrenia: Implications for Reward Processing and Motivational Deficits

(2020) David R. Goldsmith et al.   Frontiers in Psychiatry

Efficacy of adjunctive infliximab vs. placebo in the treatment of anhedonia in bipolar I/II depression

(2020) Yena Lee et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuronal activity increases translocator protein (TSPO) levels

(2020) Tina Notter et al.   MOLECULAR PSYCHIATRY

Interferon and anti-TNF therapies differentially modulate amygdala reactivity which predicts associated bidirectional changes in depressive symptoms

(2020) Kevin A. Davies et al.   MOLECULAR PSYCHIATRY

Inflammation, reward circuitry and symptoms of anhedonia and PTSD in trauma-exposed women

(2020) Neeti D Mehta et al.   Social Cognitive and Affective Neuroscience

A double-hit of stress and low-grade inflammation on functional brain network mediates posttraumatic stress symptoms

(2020) Jungyoon Kim et al.   Nature Communications

PET imaging shows no changes in TSPO brain density after IFN-α immune challenge in healthy human volunteers

(2020) M. A. Nettis et al.   Translational Psychiatry

Inflammation is associated with decreased functional connectivity of insula in unmedicated bipolar disorder

(2020) Pan Chen et al.   BRAIN BEHAVIOR AND IMMUNITY

Altered structural connectivity and cytokine levels in Schizophrenia and Genetic high-risk individuals: Associations with disease states and vulnerability

(2020) Yang Wang et al.   SCHIZOPHRENIA RESEARCH

Cerebrospinal fluid, antineuronal autoantibody, EEG, and MRI findings from 992 patients with schizophreniform and affective psychosis

(2020) Dominique Endres et al.   Translational Psychiatry

Peripheral inflammation is associated with dysfunctional corticostriatal circuitry and executive dysfunction in bipolar disorder patients

(2020) Huai-Hsuan Tseng et al.   BRAIN BEHAVIOR AND IMMUNITY

Longitudinal relationships of cytokines, depression and anhedonia in depressed adolescents

(2020) Manivel Rengasamy et al.   BRAIN BEHAVIOR AND IMMUNITY

Large-Scale Evidence for an Association Between Peripheral Inflammation and White Matter Free Water in Schizophrenia and Healthy Individuals

(2020) Maria A Di Biase et al.   SCHIZOPHRENIA BULLETIN

Higher Peripheral Inflammatory Signaling Associated With Lower Resting-State Functional Brain Connectivity in Emotion Regulation and Central Executive Networks

(2019) Robin Nusslock et al.   BIOLOGICAL PSYCHIATRY

Relationships between neural activation during a reward task and peripheral cytokine levels in youth with diverse psychiatric symptoms

(2019) Kailyn A. Bradley et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammation and decreased functional connectivity in a widely-distributed network in depression: Centralized effects in the ventral medial prefrontal cortex

(2019) Lijun Yin et al.   BRAIN BEHAVIOR AND IMMUNITY

A cross-disorder connectome landscape of brain dysconnectivity

(2019) Martijn P. van den Heuvel et al.   NATURE REVIEWS NEUROSCIENCE

Systematic review and meta-analysis of the association between peripheral inflammatory cytokines and generalised anxiety disorder

(2019) Harry Costello et al.   BMJ Open

Retrospectively reported childhood physical abuse, systemic inflammation, and resting corticolimbic connectivity in midlife adults

(2019) Thomas E. Kraynak et al.   BRAIN BEHAVIOR AND IMMUNITY

The Salience Network: A Neural System for Perceiving and Responding to Homeostatic Demands

(2019) William W. Seeley   JOURNAL OF NEUROSCIENCE

Chronic inflammation in the etiology of disease across the life span

(2019) David Furman et al.   NATURE MEDICINE

Positron Emission Tomography Studies of the Glial Cell Marker Translocator Protein in Patients With Psychosis: A Meta-analysis Using Individual Participant Data

(2018) Pontus Plavén-Sigray et al.   BIOLOGICAL PSYCHIATRY

Treatment-resistant depression and peripheral C-reactive protein

(2018) Samuel R. Chamberlain et al.   BRITISH JOURNAL OF PSYCHIATRY

Imaging the Role of Inflammation in Mood and Anxiety-related Disorders

(2018) Jennifer C. Felger   Current Neuropharmacology

What does plasma CRP tell us about peripheral and central inflammation in depression?

(2018) Jennifer C. Felger et al.   MOLECULAR PSYCHIATRY

Association of T and non-T cell cytokines with anhedonia: Role of gender differences

(2018) Manish K. Jha et al.   PSYCHONEUROENDOCRINOLOGY

Antidepressant treatment resistance is associated with increased inflammatory markers in patients with major depressive disorder

(2018) Ebrahim Haroon et al.   PSYCHONEUROENDOCRINOLOGY

Resilience and immunity

(2018) Robert Dantzer et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammation negatively correlates with amygdala-ventromedial prefrontal functional connectivity in association with anxiety in patients with depression: Preliminary results

(2018) Neeti D. Mehta et al.   BRAIN BEHAVIOR AND IMMUNITY

Increased macrophages and changed brain endothelial cell gene expression in the frontal cortex of people with schizophrenia displaying inflammation

(2018) Helen Q. Cai et al.   MOLECULAR PSYCHIATRY

Altered temporal variance and functional connectivity of BOLD signal is associated with state anxiety during acute systemic inflammation

(2018) Franziska Labrenz et al.   NEUROIMAGE

Effects of Peripheral Immune Challenge on In Vivo Firing of Basolateral Amygdala Neurons in Adult Male Rats

(2018) Soumyabrata Munshi et al.   NEUROSCIENCE

Functional neuroanatomy of peripheral inflammatory physiology: A meta-analysis of human neuroimaging studies

(2018) Thomas E. Kraynak et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Relationship between white matter integrity and serum inflammatory cytokine levels in drug-naive patients with major depressive disorder: diffusion tensor imaging study using tract-based spatial statistics

(2018) Koichiro Sugimoto et al.   Translational Psychiatry

Increased inflammation and brain glutamate define a subtype of depression with decreased regional homogeneity, impaired network integrity, and anhedonia

(2018) Ebrahim Haroon et al.   Translational Psychiatry

Metabolic-inflammatory status as predictor of clinical outcome at 1-year follow-up in patients with first episode psychosis

(2018) Maria Antonietta Nettis et al.   PSYCHONEUROENDOCRINOLOGY

Association between baseline pro-inflammatory cytokines and brain activation during social exclusion in patients with vulnerability to suicide and depressive disorder

(2018) I Conejero et al.   PSYCHONEUROENDOCRINOLOGY

Social stress induces neurovascular pathology promoting depression

(2017) Caroline Menard et al.   NATURE NEUROSCIENCE

Biological profiling of prospective antidepressant response in major depressive disorder: Associations with (neuro)inflammation, fatty acid metabolism, and amygdala-reactivity

(2017) R.J.T. Mocking et al.   PSYCHONEUROENDOCRINOLOGY

Can C-reactive protein inform antidepressant medication selection in depressed outpatients? Findings from the CO-MED trial

(2017) Manish K. Jha et al.   PSYCHONEUROENDOCRINOLOGY

The role of anxious distress in immune dysregulation in patients with major depressive disorder

(2017) Roxanne Gaspersz et al.   Translational Psychiatry

Acute Changes in Striatal Microstructure Predict the Development of Interferon-Alpha Induced Fatigue

(2016) Nicholas G. Dowell et al.   BIOLOGICAL PSYCHIATRY

A Neurocomputational Account of How Inflammation Enhances Sensitivity to Punishments Versus Rewards

(2016) Neil A. Harrison et al.   BIOLOGICAL PSYCHIATRY

Interferon-α acutely impairs whole-brain functional connectivity network architecture – A preliminary study

(2016) Ottavia Dipasquale et al.   BRAIN BEHAVIOR AND IMMUNITY

Mood disturbance during experimental endotoxemia: Predictors of state anxiety as a psychological component of sickness behavior

(2016) Julie Lasselin et al.   BRAIN BEHAVIOR AND IMMUNITY

Alterations in functional connectivity of resting state networks during experimental endotoxemia – An exploratory study in healthy men

(2016) Franziska Labrenz et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammatory markers are associated with decreased psychomotor speed in patients with major depressive disorder

(2016) David R. Goldsmith et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammatory cytokines influence measures of white matter integrity in Bipolar Disorder

(2016) Francesco Benedetti et al.   JOURNAL OF AFFECTIVE DISORDERS

A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression

(2016) D R Goldsmith et al.   MOLECULAR PSYCHIATRY

Conceptual convergence: increased inflammation is associated with increased basal ganglia glutamate in patients with major depression

(2016) E Haroon et al.   MOLECULAR PSYCHIATRY

Therapeutic Implications of Brain–Immune Interactions: Treatment in Translation

(2016) Andrew H Miller et al.   NEUROPSYCHOPHARMACOLOGY

Inflammation Effects on Motivation and Motor Activity: Role of Dopamine

(2016) Jennifer C Felger et al.   NEUROPSYCHOPHARMACOLOGY

Inflammation, Glutamate and Glia: A Trio of Trouble in Mood Disorders

(2016) Ebrahim Haroon et al.   NEUROPSYCHOPHARMACOLOGY

So depression is an inflammatory disease, but where does the inflammation come from?

(2016) Michael Berk et al.   BMC Medicine

Depressive Rumination, the Default-Mode Network, and the Dark Matter of Clinical Neuroscience

(2015) J. Paul Hamilton et al.   BIOLOGICAL PSYCHIATRY

Reward processing dysfunction in major depression, bipolar disorder and schizophrenia

(2015) Alexis E. Whitton et al.   CURRENT OPINION IN PSYCHIATRY

Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression

(2015) J C Felger et al.   MOLECULAR PSYCHIATRY

Inflammation as a predictive biomarker for response to omega-3 fatty acids in major depressive disorder: a proof-of-concept study

(2015) M H Rapaport et al.   MOLECULAR PSYCHIATRY

Interoceptive predictions in the brain

(2015) Lisa Feldman Barrett et al.   NATURE REVIEWS NEUROSCIENCE

Differential susceptibility of white matter tracts to inflammatory mediators in schizophrenia: An integrated DTI study

(2015) Konasale M. Prasad et al.   SCHIZOPHRENIA RESEARCH

Large-Scale Network Dysfunction in Major Depressive Disorder

(2015) Roselinde H. Kaiser et al.   JAMA Psychiatry

Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes

(2015) Elaine Setiawan et al.   JAMA Psychiatry

An Inflammatory Biomarker as a Differential Predictor of Outcome of Depression Treatment With Escitalopram and Nortriptyline

(2014) Rudolf Uher et al.   AMERICAN JOURNAL OF PSYCHIATRY

Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides

(2014) Susana G. Torres-Platas et al.   BRAIN BEHAVIOR AND IMMUNITY

The longitudinal associations between C-reactive protein and depressive symptoms: evidence from the English Longitudinal Study of Ageing (ELSA)

(2014) Bonnie Au et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Effects of Inflammation on Hippocampus and Substantia Nigra Responses to Novelty in Healthy Human Participants

(2014) Neil A Harrison et al.   NEUROPSYCHOPHARMACOLOGY

IFN-Alpha-Induced Cortical and Subcortical Glutamate Changes Assessed by Magnetic Resonance Spectroscopy

(2014) Ebrahim Haroon et al.   NEUROPSYCHOPHARMACOLOGY

Type I interferon signaling genes in recurrent major depression: increased expression detected by whole-blood RNA sequencing

(2013) S Mostafavi et al.   MOLECULAR PSYCHIATRY

Inflammatory cytokines in depression: Neurobiological mechanisms and therapeutic implications

(2013) J.C. Felger et al.   NEUROSCIENCE

Dopaminergic Mechanisms of Reduced Basal Ganglia Responses to Hedonic Reward During Interferon Alfa Administration

(2012) Lucile Capuron et al.   ARCHIVES OF GENERAL PSYCHIATRY

Inflammation and neurological disease-related genes are differentially expressed in depressed patients with mood disorders and correlate with morphometric and functional imaging abnormalities

(2012) Jonathan Savitz et al.   BRAIN BEHAVIOR AND IMMUNITY

Neural response to emotional stimuli during experimental human endotoxemia

(2012) Jennifer S. Kullmann et al.   HUMAN BRAIN MAPPING

Cytokines in bipolar disorder: A systematic review and meta-analysis

(2012) Klaus Munkholm et al.   JOURNAL OF AFFECTIVE DISORDERS

Glucose Metabolism in the Insula and Cingulate Is Affected by Systemic Inflammation in Humans

(2012) J. Hannestad et al.   JOURNAL OF NUCLEAR MEDICINE

Elevated C-Reactive Protein Levels, Psychological Distress, and Depression in 73 131 Individuals

(2012) Marie Kim Wium-Andersen et al.   JAMA Psychiatry

A Randomized Controlled Trial of the Tumor Necrosis Factor Antagonist Infliximab for Treatment-Resistant Depression

(2012) Charles L. Raison et al.   JAMA Psychiatry

Acute amygdaloid response to systemic inflammation

(2011) Harald Engler et al.   BRAIN BEHAVIOR AND IMMUNITY

The association between anxiety and C-reactive protein (CRP) levels: Results from the Northern Finland 1966 Birth Cohort Study

(2011) T. Liukkonen et al.   EUROPEAN PSYCHIATRY

Inflammation selectively enhances amygdala activity to socially threatening images

(2011) Tristen K. Inagaki et al.   NEUROIMAGE

Chronic Interferon-Alpha Administration Disrupts Sleep Continuity and Depth in Patients with Hepatitis C: Association with Fatigue, Motor Slowing, and Increased Evening Cortisol

(2010) Charles L. Raison et al.   BIOLOGICAL PSYCHIATRY

Inflammation-Induced Anhedonia: Endotoxin Reduces Ventral Striatum Responses to Reward

(2010) Naomi I. Eisenberger et al.   BIOLOGICAL PSYCHIATRY

Inflammation and social experience: An inflammatory challenge induces feelings of social disconnection in addition to depressed mood

(2010) Naomi I. Eisenberger et al.   BRAIN BEHAVIOR AND IMMUNITY

Neural Origins of Human Sickness in Interoceptive Responses to Inflammation

(2009) Neil A. Harrison et al.   BIOLOGICAL PSYCHIATRY

Inflammation Causes Mood Changes Through Alterations in Subgenual Cingulate Activity and Mesolimbic Connectivity

(2009) Neil A. Harrison et al.   BIOLOGICAL PSYCHIATRY

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

The complement system in schizophrenia

(2009) K.R. Mayilyan et al.   DRUG NEWS & PERSPECTIVES

Does cytokine-induced depression differ from idiopathic major depression in medically healthy individuals?

(2009) Lucile Capuron et al.   JOURNAL OF AFFECTIVE DISORDERS

An fMRI study of cytokine-induced depressed mood and social pain: The role of sex differences

(2009) Naomi I. Eisenberger et al.   NEUROIMAGE

The default mode network and self-referential processes in depression

(2009) Yvette I. Sheline et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis

(2009) M Bryant Howren et al.   PSYCHOSOMATIC MEDICINE

Peripheral Inflammation is Associated with Altered Substantia Nigra Activity and Psychomotor Slowing in Humans

(2008) Lena Brydon et al.   BIOLOGICAL PSYCHIATRY

Activation of Central Nervous System Inflammatory Pathways by Interferon-Alpha: Relationship to Monoamines and Depression

(2008) Charles L. Raison et al.   BIOLOGICAL PSYCHIATRY

IFN-alpha-induced motor slowing is associated with increased depression and fatigue in patients with chronic hepatitis C

(2008) Matthias Majer et al.   BRAIN BEHAVIOR AND IMMUNITY

Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study

(2008) D. Gimeno et al.   PSYCHOLOGICAL MEDICINE

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE