TGF-β Regulation of T Cells

Neuropilin-1 mediates lung tissue-specific control of ILC2 function in type 2 immunity

(2022) Jingjing Zhang et al.   NATURE IMMUNOLOGY

KIR + CD8 + T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19

(2022) Jing Li et al.   SCIENCE

Corneal tissue-resident memory T cells form a unique immune compartment at the ocular surface

(2022) Joon Keit Loi et al.   Cell Reports

In vivo generating SSA/Ro‐antigen specific regulatory T cells improves experimental Sjögren’s syndrome in mice

(2022) Junji Xu et al.   Arthritis & Rheumatology

Cytotoxic granzyme C–expressing ILC1s contribute to antitumor immunity and neonatal autoimmunity

(2022) Briana G. Nixon et al.   Science Immunology

Transforming growth factor–β1 in regulatory T cell biology

(2022) Joshua M. Moreau et al.   Science Immunology

Defining the role of transforming growth factor β1 in Foxp3+ T regulatory cells

(2021) Garam Choi et al.   IMMUNITY

Autocrine transforming growth factor β1 in regulatory T cell biology—gone but not missed

(2021) Maria Velegraki et al.   IMMUNITY

Modular immune-homeostatic microparticles promote immune tolerance in mouse autoimmune models

(2021) Xin Chen et al.   Science Translational Medicine

Distinct Foxp3 enhancer elements coordinate development, maintenance, and function of regulatory T cells

(2021) Ryoji Kawakami et al.   IMMUNITY

A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance

(2021) Stanislav Dikiy et al.   IMMUNITY

TGF-β: Many Paths to CD103+ CD8 T Cell Residency

(2021) Zhijuan Qiu et al.   Cells

TGFβ promotes low IL10-producing ILC2 with profibrotic ability involved in skin fibrosis in systemic sclerosis

(2021) Paôline Laurent et al.   ANNALS OF THE RHEUMATIC DISEASES

Whole‐genome analysis of TET dioxygenase function in regulatory T cells

(2021) Xiaojing Yue et al.   EMBO REPORTS

Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection

(2021) Sarah S. Gabriel et al.   IMMUNITY

Tissue-specific differentiation of CD8+ resident memory T cells

(2021) Kun Yang et al.   TRENDS IN IMMUNOLOGY

Integrin-αV-mediated activation of TGF-β regulates anti-tumour CD8 T cell immunity and response to PD-1 blockade

(2021) Ines Malenica et al.   Nature Communications

Inhibitory Molecules PD-1, CD73 and CD39 Are Expressed by CD8+ T Cells in a Tissue-Dependent Manner and Can Inhibit T Cell Responses to Stimulation

(2021) Corinne J. Smith et al.   Frontiers in Immunology

Induction of antigen-specific Treg cells in treating autoimmune uveitis via bystander suppressive pathways without compromising anti-tumor immunity

(2021) Zilin Chen et al.   EBioMedicine

γδ T cells and adipocyte IL-17RC control fat innervation and thermogenesis

(2020) Bo Hu et al.   NATURE

Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β

(2020) Alessandra Metelli et al.   Science Translational Medicine

TGF-β induces ST2 and programs ILC2 development

(2020) Li Wang et al.   Nature Communications

TGF-β and IL-15 Synergize through MAPK Pathways to Drive the Conversion of Human NK Cells to an Innate Lymphoid Cell 1–like Phenotype

(2020) Lindsey G. Hawke et al.   JOURNAL OF IMMUNOLOGY

Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells

(2020) Cristina Ferreira et al.   NATURE IMMUNOLOGY

T Cell Factor 1 Suppresses CD103+ Lung Tissue-Resident Memory T Cell Development

(2020) Jingxia Wu et al.   Cell Reports

Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8+ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β

(2020) Henrique Borges da Silva et al.   IMMUNITY

Transforming growth factor beta orchestrates PD-L1 enrichment in tumor-derived exosomes and mediates CD8 T-cell dysfunction regulating early phosphorylation of TCR signalome in breast cancer

(2020) Soumya Chatterjee et al.   CARCINOGENESIS

Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity

(2020) Jacob A. Turner et al.   IMMUNITY

TGF-β and Eomes control the homeostasis of CD8+ regulatory T cells

(2020) Shruti Mishra et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ILC1 drive intestinal epithelial and matrix remodelling

(2020) Geraldine M. Jowett et al.   NATURE MATERIALS

CD49a Regulates Cutaneous Resident Memory CD8+ T Cell Persistence and Response

(2020) Shannon K. Bromley et al.   Cell Reports

c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies

(2019) Jochem H. Bernink et al.   NATURE IMMUNOLOGY

High Glucose Intake Exacerbates Autoimmunity through Reactive-Oxygen-Species-Mediated TGF-β Cytokine Activation

(2019) Dunfang Zhang et al.   IMMUNITY

Migratory DCs activate TGF-β to precondition naïve CD8+ T cells for tissue-resident memory fate

(2019) Vinidhra Mani et al.   SCIENCE

T Cell Receptor-Regulated TGF-β Type I Receptor Expression Determines T Cell Quiescence and Activation

(2018) Eric Tu et al.   IMMUNITY

Understanding Subset Diversity in T Cell Memory

(2018) Stephen C. Jameson et al.   IMMUNITY

Trim33 mediates the proinflammatory function of Th17 cells

(2018) Shinya Tanaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

(2018) Daniele V. F. Tauriello et al.   NATURE

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

(2018) Sanjeev Mariathasan et al.   NATURE

Transforming Growth Factor-β Signaling in Regulatory T Cells Controls T Helper-17 Cells and Tissue-Specific Immune Responses

(2017) Joanne E. Konkel et al.   IMMUNITY

Reversing SKI–SMAD4-mediated suppression is essential for TH17 cell differentiation

(2017) Song Zhang et al.   NATURE

D-mannose induces regulatory T cells and suppresses immunopathology

(2017) Dunfang Zhang et al.   NATURE MEDICINE

Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment

(2017) Sadna Budhu et al.   Science Signaling

Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment

(2017) Sadna Budhu et al.   Science Signaling

Garp as a therapeutic target for modulation of T regulatory cell function

(2016) Ethan M. Shevach   EXPERT OPINION ON THERAPEUTIC TARGETS

Transforming Growth Factor-β Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands

(2016) Victor S. Cortez et al.   IMMUNITY

Control of Foxp3 stability through modulation of TET activity

(2016) Xiaojing Yue et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment

(2016) Yohko Kitagawa et al.   NATURE IMMUNOLOGY

Human Vδ2 T cells are a major source of interleukin-9

(2016) Christian Peters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue adaptation of regulatory and intraepithelial CD4+ T cells controls gut inflammation

(2016) T. Sujino et al.   SCIENCE

Transforming growth factor–β and Notch ligands act as opposing environmental cues in regulating the plasticity of type 3 innate lymphoid cells

(2016) Charlotte Viant et al.   Science Signaling

Notch signaling in group 3 innate lymphoid cells modulates their plasticity

(2016) Sylvestre Chea et al.   Science Signaling

The transcription factor network in Th9 cells

(2016) Mark H. Kaplan   Seminars in Immunopathology

TGF 1-Mediated SMAD3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer

(2016) B. V. Park et al.   Cancer Discovery

Transforming growth factor–β and Notch ligands act as opposing environmental cues in regulating the plasticity of type 3 innate lymphoid cells

(2016) Charlotte Viant et al.   Science Signaling

Notch signaling in group 3 innate lymphoid cells modulates their plasticity

(2016) Sylvestre Chea et al.   Science Signaling

Molecular profiling of CD8 T cells in autochthonous melanoma identifies Maf as driver of exhaustion

(2015) M. Giordano et al.   EMBO JOURNAL

Development of thymic Foxp3+ regulatory T cells: TGF-β matters

(2015) WanJun Chen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Integrin αvβ8-Mediated TGF-β Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation

(2015) John J. Worthington et al.   IMMUNITY

IL-9 Expression by Invariant NKT Cells Is Not Imprinted during Thymic Development

(2015) Marta Monteiro et al.   JOURNAL OF IMMUNOLOGY

The DNA-binding inhibitor Id3 regulates IL-9 production in CD4+ T cells

(2015) Hiroko Nakatsukasa et al.   NATURE IMMUNOLOGY

Oral Infection Drives a Distinct Population of Intestinal Resident Memory CD8+ T Cells with Enhanced Protective Function

(2014) Brian S. Sheridan et al.   IMMUNITY

Transforming Growth Factor β-Mediated Suppression of Antitumor T Cells Requires FoxP1 Transcription Factor Expression

(2014) Tom L. Stephen et al.   IMMUNITY

CD4+ T Cell Help Guides Formation of CD103+ Lung-Resident Memory CD8+ T Cells during Influenza Viral Infection

(2014) Brian J. Laidlaw et al.   IMMUNITY

TGF-β prevents T follicular helper cell accumulation and B cell autoreactivity

(2014) Mark J. McCarron et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased Antitumor Effects Using IL-2 with Anti–TGF-β Reveals Competition between Mouse NK and CD8 T Cells

(2014) Maite Alvarez et al.   JOURNAL OF IMMUNOLOGY

Thymocyte apoptosis drives the intrathymic generation of regulatory T cells

(2014) J. E. Konkel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-cell TGF-  signaling abrogation restricts medulloblastoma progression

(2014) D. Gate et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo-Generated Antigen-Specific Regulatory T Cells Treat Autoimmunity Without Compromising Antibacterial Immune Response

(2014) S. Kasagi et al.   Science Translational Medicine

TGF-β Activation and Function in Immunity

(2013) Mark A. Travis et al.   Annual Review of Immunology

TGF-β Cytokine Signaling Promotes CD8+ T Cell Development and Low-Affinity CD4+ T Cell Homeostasis by Regulation of Interleukin-7 Receptor α Expression

(2013) Weiming Ouyang et al.   IMMUNITY

Cutting Edge: Smad2 and Smad4 Regulate TGF- -Mediated Il9 Gene Expression via EZH2 Displacement

(2013) A. Wang et al.   JOURNAL OF IMMUNOLOGY

Smad2/3 and IRF4 Play a Cooperative Role in IL-9-Producing T Cell Induction

(2013) T. Tamiya et al.   JOURNAL OF IMMUNOLOGY

Transcription of RORγt in developing Th17 cells is regulated by E-proteins

(2013) F Zhang et al.   Mucosal Immunology

Transcriptional reprogramming of mature CD4+ helper T cells generates distinct MHC class II–restricted cytotoxic T lymphocytes

(2013) Daniel Mucida et al.   NATURE IMMUNOLOGY

Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4+ T cell immunity

(2013) Bernardo Sgarbi Reis et al.   NATURE IMMUNOLOGY

Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells

(2013) Cara N Skon et al.   NATURE IMMUNOLOGY

The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

(2013) Laura K Mackay et al.   NATURE IMMUNOLOGY

Notch Receptors and Smad3 Signaling Cooperate in the Induction of Interleukin-9-Producing T Cells

(2012) Wassim Elyaman et al.   IMMUNITY

Th9 cells promote antitumor immune responses in vivo

(2012) Yong Lu et al.   JOURNAL OF CLINICAL INVESTIGATION

GARP regulates the bioavailability and activation of TGFβ

(2012) Rui Wang et al.   MOLECULAR BIOLOGY OF THE CELL

Extrathymically generated regulatory T cells control mucosal TH2 inflammation

(2012) Steven Z. Josefowicz et al.   NATURE

OX40 signaling favors the induction of TH9 cells and airway inflammation

(2012) Xiang Xiao et al.   NATURE IMMUNOLOGY

The many lives of IL-9: a question of survival?

(2012) Christoph Wilhelm et al.   NATURE IMMUNOLOGY

TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation

(2012) Nu Zhang et al.   NATURE IMMUNOLOGY

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

Autocrine Transforming Growth Factor-β1 Promotes In Vivo Th17 Cell Differentiation

(2011) Ilona Gutcher et al.   IMMUNITY

An Islet-Specific Pulse of TGF-  Abrogates CTL Function and Promotes   Cell Survival Independent of Foxp3+ T Cells

(2011) M. Wallberg et al.   JOURNAL OF IMMUNOLOGY

Development of Tumor-Infiltrating CD8+ T Cell Memory Precursor Effector Cells and Antimelanoma Memory Responses Are the Result of Vaccination and TGF-  Blockade during the Perioperative Period of Tumor Resection

(2011) E. C. Bellavance et al.   JOURNAL OF IMMUNOLOGY

Control of TH17 cells occurs in the small intestine

(2011) Enric Esplugues et al.   NATURE

Control of the development of CD8αα+ intestinal intraepithelial lymphocytes by TGF-β

(2011) Joanne E Konkel et al.   NATURE IMMUNOLOGY

T helper 17 cell heterogeneity and pathogenicity in autoimmune disease

(2011) Kamran Ghoreschi et al.   TRENDS IN IMMUNOLOGY

Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

(2010) Dan R. Littman et al.   CELL

TGF-β interactions with IL-1 family members trigger IL-4-independent IL-9 production by mouse CD4+ T cells

(2010) Catherine Uyttenhove et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells

(2010) Philip P. Ahern et al.   IMMUNITY

Transforming Growth Factor-β Signaling Curbs Thymic Negative Selection Promoting Regulatory T Cell Development

(2010) Weiming Ouyang et al.   IMMUNITY

Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors

(2010) Jinfang Zhu et al.   IMMUNOLOGICAL REVIEWS

Regulation of human Th9 differentiation by type I interferons and IL-21

(2010) Michael T Wong et al.   IMMUNOLOGY AND CELL BIOLOGY

TGF-  Induces IL-9 Production from Human Th17 Cells

(2010) G. Beriou et al.   JOURNAL OF IMMUNOLOGY

Smad2 and Smad3 Are Redundantly Essential for the TGF- -Mediated Regulation of Regulatory T Plasticity and Th1 Development

(2010) T. Takimoto et al.   JOURNAL OF IMMUNOLOGY

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

(2010) Ye Zheng et al.   NATURE

Inhibition of follicular T-helper cells by CD8+ regulatory T cells is essential for self tolerance

(2010) Hye-Jung Kim et al.   NATURE

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

Regulation of IL-9 expression by IL-25 signaling

(2010) Pornpimon Angkasekwinai et al.   NATURE IMMUNOLOGY

Control of the differentiation of regulatory T cells and TH17 cells by the DNA-binding inhibitor Id3

(2010) Takashi Maruyama et al.   NATURE IMMUNOLOGY

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Transcriptional regulatory networks in Th17 cell differentiation

(2009) Liang Zhou et al.   CURRENT OPINION IN IMMUNOLOGY

Membrane protein GARP is a receptor for latent TGF-β on the surface of activated human Treg

(2009) Julie Stockis et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Generation of mice with a conditional allele for transforming growth factor beta 1 gene

(2009) Mohamad Azhar et al.   GENESIS

Cell-Intrinsic Transforming Growth Factor-β Signaling Mediates Virus-Specific CD8+ T Cell Deletion and Viral Persistence In Vivo

(2009) Roberto Tinoco et al.   IMMUNITY

Opposing Effects of TGF-β and IL-15 Cytokines Control the Number of Short-Lived Effector CD8+ T Cells

(2009) Shomyseh Sanjabi et al.   IMMUNITY

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

(2009) Ethan M. Shevach   IMMUNITY

Development of Foxp3+ Regulatory T Cells Is Driven by the c-Rel Enhanceosome

(2009) Qingguo Ruan et al.   IMMUNITY

Structural Basis for the Blockage of IL-2 Signaling by Therapeutic Antibody Basiliximab

(2009) J. Du et al.   JOURNAL OF IMMUNOLOGY

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

(2009) Meghan A Koch et al.   NATURE IMMUNOLOGY

CD4+ Regulatory T Cells Control TH17 Responses in a Stat3-Dependent Manner

(2009) A. Chaudhry et al.   SCIENCE

Cytokines that regulate autoimmunity

(2008) Caroline Diveu et al.   CURRENT OPINION IN IMMUNOLOGY

Murine CD8+ regulatory T lymphocytes: The new era

(2008) Céline Pomié et al.   HUMAN IMMUNOLOGY

TRAF6 Mediates Smad-Independent Activation of JNK and p38 by TGF-β

(2008) Motozo Yamashita et al.   MOLECULAR CELL

T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance

(2008) Marko Pesu et al.   NATURE

The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

(2008) Alessandro Sorrentino et al.   NATURE CELL BIOLOGY

Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset

(2008) Marc Veldhoen et al.   NATURE IMMUNOLOGY

IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells

(2008) Valérie Dardalhon et al.   NATURE IMMUNOLOGY

A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

(2008) Yongzhong Liu et al.   NATURE IMMUNOLOGY

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

(2008) Nicolas Manel et al.   NATURE IMMUNOLOGY

CD3-specific antibody–induced immune tolerance involves transforming growth factor-β from phagocytes digesting apoptotic T cells

(2008) Sylvain Perruche et al.   NATURE MEDICINE