Female sex-specific considerations to improve rigor and reproducibility in cardiovascular research

Female Sex-Specific Cardiovascular Risk Factors and Heart Failure Practice Guidelines

(2022) Rana Hassan et al.   AMERICAN HEART JOURNAL

Pregnancy and Reproductive Risk Factors for Cardiovascular Disease in Women

(2022) Anna C. O’Kelly et al.   CIRCULATION RESEARCH

A primer on incorporating sex as a biological variable into the conduct and reporting of basic and clinical research studies

(2022) Quin E. Denfeld et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Association of infertility with atherosclerotic cardiovascular disease among postmenopausal participants in the Women’s Health Initiative

(2022) Gayathree Murugappan et al.   FERTILITY AND STERILITY

Sex Differences in Reported Adverse Drug Reactions to Angiotensin-Converting Enzyme Inhibitors

(2022) Sophie H. Bots et al.   JAMA Network Open

The effect of non‐oral hormonal contraceptives on hypertension and blood pressure: A systematic review and meta‐analysis

(2022) Cindy Z. Kalenga et al.   Physiological Reports

The stronger sex, until menopause: understanding the impact of estrogen loss on heart function

(2022) Cassandra K. Conway-O’Donnell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Female mice exhibit less overall variance, with a higher proportion of structured variance, than males at multiple timescales of continuous body temperature and locomotive activity records

(2022) Benjamin Smarr et al.   Biology of Sex Differences

The Association Between Route of Post-menopausal Estrogen Administration and Blood Pressure and Arterial Stiffness in Community-Dwelling Women

(2022) Cindy Z. Kalenga et al.   Frontiers in Cardiovascular Medicine

Gender-affirming estrogen therapy route of administration and cardiovascular risk: a systematic review and narrative synthesis

(2022) Keila Turino Miranda et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Small Interfering RNA to Reduce Lipoprotein(a) in Cardiovascular Disease

(2022) Michelle L. O’Donoghue et al.   NEW ENGLAND JOURNAL OF MEDICINE

Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk

(2022) Aruna Das Pradhan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inclusion of pregnant and breastfeeding women in nonobstetrical randomized controlled trials

(2022) Sarah C.J. Jorgensen et al.   American Journal of Obstetrics & Gynecology MFM

Menopausal Hormone Therapy and Cardiovascular Disease: The Role of Formulation, Dose, and Route of Delivery

(2021) Chrisandra L Shufelt et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adverse Pregnancy Outcomes and Cardiovascular Disease Risk: Unique Opportunities for Cardiovascular Disease Prevention in Women: A Scientific Statement From the American Heart Association

(2021) Nisha I. Parikh et al.   CIRCULATION

The Lancet women and cardiovascular disease Commission: reducing the global burden by 2030

(2021) Birgit Vogel et al.   LANCET

Do Sex and Gender Matter in Kidney and Cardiovascular Disease?

(2021) Sofia B. Ahmed et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Reinforcing rigor and reproducibility expectations for use of sex and gender in cardiovascular research

(2021) Merry L. Lindsey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Methodological Rigor in Preclinical Cardiovascular Research: Contemporary Performance of AHA Scientific Publications

(2021) Richard Jung et al.   CIRCULATION RESEARCH

Heart failure medication dosage and survival in women and men seen at outpatient clinics

(2021) Sophie Heleen Bots et al.   HEART

Age- and sex-specific risk of urogenital infections in patients with type 2 diabetes treated with sodium-glucose co-transporter 2 inhibitors: A population-based self-controlled case-series study

(2021) Minkyong Kang et al.   MATURITAS

Sex Differences in Drug-Induced Arrhythmogenesis

(2021) Mathias Peirlinck et al.   Frontiers in Physiology

Sex-based outcomes in contemporary antiplatelet therapy trials

(2021) Mirvat Alasnag et al.   Open Heart

When it’s time for the sex talk, words matter

(2021) Austin T. Robinson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Contraception Requirements in Clinical Trials

(2021) Jennifer E. Balkus et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Matters of the heart: Cellular sex differences

(2021) Cierra J. Walker et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Women’s Participation in Cardiovascular Clinical Trials From 2010 to 2017

(2020) Xurui Jin et al.   CIRCULATION

State of the Science in Women's Cardiovascular Disease: A Canadian Perspective on the Influence of Sex and Gender

(2020) Colleen M. Norris et al.   Journal of the American Heart Association

Reasons for Nonadherence to Statins – A Systematic Review of Reviews

(2020) Marianne Vie Ingersgaard et al.   Patient Preference and Adherence

Multi-Fetal Pregnancy, Preeclampsia, and Long-Term Cardiovascular Disease

(2020) Lina Bergman et al.   HYPERTENSION

Recalled Age at Menarche: A Follow-up to the Michigan State University Motor Performance Study

(2020) S. R. Siegel et al.   Measurement in Physical Education and Exercise Science

Assessing and Addressing Cardiovascular Health in LGBTQ Adults: A Scientific Statement From the American Heart Association

(2020) Billy A. Caceres et al.   CIRCULATION

Female infertility and cardiovascular risk – a hype or an underestimated reality?

(2020) Julia K. Bosdou et al.   CURRENT PHARMACEUTICAL DESIGN

Pregnancy Protects Hyperandrogenemic Female Rats From Postmenopausal Hypertension

(2020) Noha M. Shawky et al.   HYPERTENSION

Menstrual cycle regularity and length across the reproductive lifespan and risk of premature mortality: prospective cohort study

(2020) Yi-Xin Wang et al.   BMJ-British Medical Journal

Association between the reproductive health of young women and cardiovascular disease in later life: umbrella review

(2020) Kelvin Okoth et al.   BMJ-British Medical Journal

Association Between Reproductive Life Span and Incident Nonfatal Cardiovascular Disease

(2020) Shiva R. Mishra et al.   JAMA Cardiology

Menopause Transition and Cardiovascular Disease Risk: Implications for Timing of Early Prevention: A Scientific Statement From the American Heart Association

(2020) Samar R. El Khoudary et al.   CIRCULATION

Sexual dimorphism in trait variability and its eco-evolutionary and statistical implications

(2020) Susanne RK Zajitschek et al.   eLife

Twenty Year Trends and Sex Differences in Young Adults Hospitalized with Acute Myocardial Infarction: The ARIC Community Surveillance Study

(2019) Sameer Arora et al.   CIRCULATION

Factors affecting sex-related reporting in medical research: a cross-disciplinary bibliometric analysis

(2019) Cassidy R Sugimoto et al.   LANCET

Recommended Heart Failure Medications and Adverse Drug Reactions in Women

(2019) Sophie H. Bots et al.   CIRCULATION

Systematic Incorporation of Sex‐Specific Information Into Clinical Practice Guidelines for the Management of ST‐Segment–Elevation Myocardial Infarction: Feasibility and Outcomes

(2019) Colleen M. Norris et al.   Journal of the American Heart Association

Are hormones a “female problem” for animal research?

(2019) Rebecca M. Shansky   SCIENCE

Age at Menarche and Risk of Cardiovascular Disease Outcomes: Findings From the National Heart Lung and Blood Institute‐Sponsored Women's Ischemia Syndrome Evaluation

(2019) Julie J. Lee et al.   Journal of the American Heart Association

Is the long-term decline in cardiovascular-disease mortality in high-income countries over? Evidence from national vital statistics

(2019) Alan D Lopez et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Identifying optimal doses of heart failure medications in men compared with women: a prospective, observational, cohort study

(2019) Bernadet T Santema et al.   LANCET

Sex differences in heart failure

(2019) Carolyn S P Lam et al.   EUROPEAN HEART JOURNAL

Association of Premature Natural and Surgical Menopause With Incident Cardiovascular Disease

(2019) Michael C. Honigberg et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Gender/Sex as a Social Determinant of Cardiovascular Risk

(2018) Adrienne O’Neil et al.   CIRCULATION

Promoting Risk Identification and Reduction of Cardiovascular Disease in Women Through Collaboration With Obstetricians and Gynecologists: A Presidential Advisory From the American Heart Association and the American College of Obstetricians and Gynecologists

(2018) Haywood L. Brown et al.   CIRCULATION

Fair inclusion of pregnant women in clinical trials: an integrated scientific and ethical approach

(2018) Rieke van der Graaf et al.   Trials

Addressing Barriers to Inclusion of Pregnant Women in Clinical Trials

(2018) Rita Rubin   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Association of Assisted Reproductive Technologies With Arterial Hypertension During Adolescence

(2018) Théo A. Meister et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Implementation of the NIH Sex-Inclusion Policy: Attitudes and Opinions of Study Section Members

(2018) Nicole C. Woitowich et al.   JOURNAL OF WOMENS HEALTH

Sex differences in risk factors for myocardial infarction: cohort study of UK Biobank participants

(2018) Elizabeth R C Millett et al.   BMJ-British Medical Journal

Acute coronary syndrome in women: rising hospitalizations in middle-aged French women, 2004–14

(2017) Amélie Gabet et al.   EUROPEAN HEART JOURNAL

Sex differences in variability across timescales in BALB/c mice

(2017) Benjamin L. Smarr et al.   Biology of Sex Differences

Studying both sexes: a guiding principle for biomedicine

(2016) Janine Austin Clayton   FASEB JOURNAL

Reporting Sex, Gender, or Both in Clinical Research?

(2016) Janine Austin Clayton et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Female rats are not more variable than male rats: a meta-analysis of neuroscience studies

(2016) Jill B. Becker et al.   Biology of Sex Differences

Association of Age at Onset of Menopause and Time Since Onset of Menopause With Cardiovascular Outcomes, Intermediate Vascular Traits, and All-Cause Mortality

(2016) Taulant Muka et al.   JAMA Cardiology

Committee Opinion No. 646

(2015)   OBSTETRICS AND GYNECOLOGY

Opinion: Sex inclusion in basic research drives discovery: Fig. 1.

(2015) Sabra L. Klein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Are females more variable than males in gene expression? Meta-analysis of microarray datasets

(2015) Yuichiro Itoh et al.   Biology of Sex Differences

Sex-based differences in bleeding and long term adverse events after percutaneous coronary intervention for acute myocardial infarction: Three year results from the HORIZONS-AMI trial

(2014) Jennifer Yu et al.   CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS

Trends in Acute Myocardial Infarction in Young Patients and Differences by Sex and Race, 2001 to 2010

(2014) Aakriti Gupta et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Policy: NIH to balance sex in cell and animal studies

(2014) Janine A. Clayton et al.   NATURE

Female mice liberated for inclusion in neuroscience and biomedical research

(2014) Brian J. Prendergast et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Gender and racial disparities in adherence to statin therapy: A meta-analysis

(2013) Jennifer Lewey et al.   AMERICAN HEART JOURNAL

Participation of Women and Sex Analyses in Late-Phase Clinical Trials of New Molecular Entity Drugs and Biologics Approved by the FDA in 2007–2009

(2013) Rita Poon et al.   JOURNAL OF WOMENS HEALTH

Do Younger Women Fare Worse? Sex Differences in Acute Myocardial Infarction Hospitalization and Early Mortality Rates Over Ten Years

(2013) Mona Izadnegahdar et al.   JOURNAL OF WOMENS HEALTH

Impact of Bleeding on Mortality After Percutaneous Coronary Intervention

(2011) Roxana Mehran et al.   JACC-Cardiovascular Interventions

Believe it or not: how much can we rely on published data on potential drug targets?

(2011) Florian Prinz et al.   NATURE REVIEWS DRUG DISCOVERY

Males still dominate animal studies

(2010) Irving Zucker et al.   NATURE

Sex bias in neuroscience and biomedical research

(2010) Annaliese K. Beery et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Of Mice and Women: The Bias in Animal Models

(2010) C. Wald et al.   SCIENCE

Status of Women in Cardiovascular Clinical Trials

(2009) Esther S.H. Kim et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Major Femoral Bleeding Complications After Percutaneous Coronary Intervention

(2008) Brendan J. Doyle et al.   JACC-Cardiovascular Interventions