Review
Agriculture, Dairy & Animal Science
Adriana Dominguez-Oliva, Ismael Hernandez-avalos, Julio Martinez-Burnes, Adriana Olmos-Hernandez, Antonio Verduzco-Mendoza, Daniel Mota-Rojas
Summary: This review emphasizes the importance of animal models in current human and animal health research. Different animal species, including mice, primates, pigs, and zebrafish, have been utilized to study pandemics, such as the 2019 Coronavirus, as well as various diseases like diabetes and obesity. Animal models have played a crucial role in understanding neurological, behavioral, cardiovascular, and oncological disorders, and in the development of new therapeutic approaches. Despite ethical concerns, animal research is considered essential for advancing biomedical science and exploring treatment alternatives for both animals and humans.
Editorial Material
Biochemical Research Methods
Julian Matschinske, Nicolas Alcaraz, Arriel Benis, Martin Golebiewski, Dominik G. Grimm, Lukas Heumos, Tim Kacprowski, Olga Lazareva, Markus List, Zakaria Louadi, Josch K. Pauling, Nico Pfeifer, Richard Roettger, Veit Schwaemmle, Gregor Sturm, Alberto Traverso, Kristel Van Steen, Martiela Vaz de Freitas, Gerda Cristal Villalba Silva, Leonard Wee, Nina K. Wenke, Massimiliano Zanin, Olga Zolotareva, Jan Baumbach, David B. Blumenthal
Summary: The AIMe registry is a community-driven reporting platform for AI in biomedicine, aiming to improve the accessibility, reproducibility, and usability of biomedical AI models, and allowing future revisions by the community.
Article
Biochemistry & Molecular Biology
Alexander G. Little, Matthew E. Pamenter, Divya Sitaraman, Nicole M. Templeman, William G. Willmore, Michael S. Hedrick, Christopher D. Moyes
Summary: This review introduces a Special Issue focused on using non-human models to study biomedical physiology. The concept of a model varies across disciplines, with some used to understand specific human pathologies and others to gain insight into developmental or evolutionary mechanisms. The choice of a model for biomedical research is an ongoing process that must keep pace with existing and emerging technologies.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alexander G. Little, Matthew E. Pamenter, Divya Sitaraman, Nicole M. Templeman, William G. Willmore, Michael S. Hedrick, Christopher D. Moyes
Summary: This review introduces a Special Issue of Comparative Biochemistry and Physiology on using non-human models to study biomedical physiology. Models vary across disciplines, some focused on specific human pathologies, while others on developmental or evolutionary mechanisms. The importance of selecting and validating models for biomedical research, as well as emerging alternative models, is highlighted.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tae-Young Choi, Tae-Ik Choi, Yu-Ri Lee, Seong-Kyu Choe, Cheol-Hee Kim
Summary: Zebrafish are emerging as a powerful animal model for studying mental disorders and metabolic diseases due to their transparency, low maintenance costs, and genetic similarity to humans. Researchers highlight the importance of zebrafish in understanding communication pathways between the brain and other organs, as well as the potential for tracking metabolism and disease progression. The ease of tissue imaging, high offspring numbers, and availability of genetic techniques further contribute to the benefits of using zebrafish in biomedical research.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Computer Science, Information Systems
Masashi Takeshita, Rafal Rzepka, Kenji Araki
Summary: This paper warns readers that it contains examples of offensive language and explores social biases inherited by NLP models. It specifically focuses on biases towards nonhuman animals and identifies a tendency of pre-trained masked language models to associate harmful words with them and use speciesist language for certain nonhuman animal names.
INFORMATION PROCESSING & MANAGEMENT
(2022)
Review
Biochemistry & Molecular Biology
Miray Tonk-Ruegen, Andreas Vilcinskas, Anika E. Wagner
Summary: Insects are highly diverse organisms and have many advantages, such as low cost, short lifespan, and adherence to the 3R principle, making them valuable model organisms in nutritional science research.
Article
Biochemistry & Molecular Biology
Liesbeth Aerts, Beatrice Miccoli, Aaron Delahanty, Hilda Witters, Sandra Verstraelen, Bart De Strooper, Dries Braeken, Patrik Verstreken
Summary: The use of animals in neuroscience and biomedical research is controversial, with policies promoting the development and adoption of animal-free methods. However, the majority of studies in Alzheimer's and Parkinson's disease research still rely on animals or animal-derived models. The limited contribution of innovative animal-free models suggests that the role and scientific value of both animal and animal-free approaches are intertwined. Calls to halt all animal experiments appear premature due to insufficient non-animal-based alternatives and their lag in development. Objective and unbiased monitoring, along with robust performance indicators of animal-free approaches, are highlighted as necessary.
Article
Psychology, Multidisciplinary
Nuria Izquierdo-Useros, Miguel Angel Marin Lopez, Marta Monguio-Tortajada, Jose A. Munoz-Moreno, Cristina Agusti Benito, Sara Moron-Lopez, Harvey Evans, Melisa Gualdron-Lopez, Joerg Mueller, Julia G. Prado
Summary: The survey revealed gender differences in the impact of COVID-19 lockdowns on scientific activities, with female researchers performing more invisible tasks and experiencing greater mental health impacts.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Shashank Pandey, Tomas Chmelir, Magdalena Chottova Dvorakova
Summary: Diabetes mellitus is a serious disease with increasing incidence worldwide. Animal models have been extensively used in diabetes research, but there are challenges in translating the findings to human clinical trials.
Review
Clinical Neurology
Sarinnapha M. Vasunilashorn, Nadia Lunardi, John C. Newman, Gregory Crosby, Leah Acker, Ted Abel, Seema Bhatnagar, Colm Cunningham, Rafael de Cabo, Laura Dugan, Joseph A. Hippensteel, Yumiko Ishizawa, Shouri Lahiri, Edward R. Marcantonio, Zhongcong Xie, Sharon K. Inouye, Niccolo Terrando, Roderic G. Eckenhoff
Summary: Delirium is a common, morbid, and costly syndrome closely associated with Alzheimer's disease (AD) and AD-related dementias (ADRD). While human studies have improved our understanding of delirium in terms of incidence, risk factors, outcomes, and management, limited knowledge exists about the neurobiology of delirium. This article discusses the use of preclinical and translational animal models to advance our understanding of delirium neurobiology and develop new prevention and treatment strategies. Recommendations for the development and validation of these models are provided to enhance awareness in this important field.
ALZHEIMERS & DEMENTIA
(2023)
Review
Veterinary Sciences
Monika Burns
Summary: The use of common marmosets in biomedical research has increased in recent years, but there is a need for additional guidelines on their care and use. This manuscript reviews relevant publications and provides comprehensive guidance to promote optimal health and welfare of marmosets in biomedical research settings.
VETERINARY SCIENCES
(2023)
Article
Pediatrics
Marie-Elizabeth Ramas, Sarah Webber, Andrea L. Braden, Elizabeth Goelz, Mark Linzer, Heather Farley
Summary: Despite improvements in representation, promotion and career advancement in academic medicine remain unequal for women compared to men. Innovative approaches are needed to promote well-being and address unique barriers faced by women physicians. Three wellness-oriented models aim to promote professional fulfillment and well-being for women physicians by redefining productivity, promoting equity, and improving diversity, equity, and inclusion.
Review
Oncology
Reza Fakhraei, Serena S. Peck, Husam Abdel-Qadir, Paaladinesh Thavendiranathan, Catherine M. Sabiston, Fernando Rivera-Theurel, Paul Oh, Ani Orchanian-Cheff, Leanna Lee, Scott C. Adams
Summary: This study evaluated the quality of reporting and evidence from CR-based intervention studies in oncology and found low-to-moderate reporting quality and moderate-to-high risk of bias, which limits the interpretation, reproducibility, and translation of evidence into practice.
JACC: CARDIOONCOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Hye Sook Shin, Heather Hyeyoon Shin, Yasuhiro Shudo
Summary: Establishing an appropriate disease model, frequent modifications to surgical procedures, and insufficient transparency in reporting are three major inhibitors in current preclinical myocardial infarction research.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)