Three-Dimensional Tracking of Intracellular Calcium and Redox State during Real-Time Control in a Hypoxic Gradient in Microglia Culture: Comparison of the Channel Blocker and Reoxygenation under Ischemic Shock

Three-dimensional-cultured MSC-derived exosome with hydrogel for cerebral ischemia repair

(2023) Min Han et al.   Biomaterials Advances

Ca2+ Signalling and Hypoxia/Acidic Tumour Microenvironment Interplay in Tumour Progression

(2022) Madelaine Magalì Audero et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroprotective Effect of Polyphenol Extracts from Terminalia chebula Retz. against Cerebral Ischemia-Reperfusion Injury

(2022) Kuan Lin et al.   MOLECULES

MiR-145 enriched exosomes derived from bone marrow-derived mesenchymal stem cells protects against cerebral ischemia-reperfusion injury through downregulation of FOXO1

(2022) Hai Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Non-prophylactic resveratrol mediated protection of neurite integrity under chronic hypoxia is associated with reduction of Cav1.2 channel expression and calcium overloading

(2022) Debasmita Saha et al.   NEUROCHEMISTRY INTERNATIONAL

Cobalt induces neurodegenerative damages through impairing autophagic flux by activating hypoxia-inducible factor-1α triggered ROS overproduction

(2022) Jianping Tang et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Early intervention attenuates synaptic plasticity impairment and neuroinflammation in 5xFAD mice

(2021) Kai Li et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Effects of Microglial Activation and Polarization on Brain Injury After Stroke

(2021) Rui Dong et al.   Frontiers in Neurology

FDA approved L-type channel blocker Nifedipine reduces cell death in hypoxic A549 cells through modulation of mitochondrial calcium and superoxide generation

(2021) Kuruba Manohar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neuronal Loss after Stroke Due to Microglial Phagocytosis of Stressed Neurons

(2021) Guy C. Brown   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In vivo real‐time ATP imaging in zebrafish hearts reveals G0s2 induces ischemic tolerance

(2020) Hidetaka Kioka et al.   FASEB JOURNAL

A Robust Model System for Retinal Hypoxia: Live Imaging of Calcium Dynamics and Gene Expression Studies in Primary Human Mixed Retinal Culture

(2020) Shahna Shahulhameed et al.   Frontiers in Neuroscience

Technical Feasibility and Physiological Relevance of Hypoxic Cell Culture Models

(2020) Jiri Pavlacky et al.   Frontiers in Endocrinology

SIRT1 Mediates Melatonin’s Effects on Microglial Activation in Hypoxia: In Vitro and In Vivo Evidence

(2020) Sara Merlo et al.   Biomolecules

Real-time monitoring of intracellular pH in live cells with fluorescent ionic liquid

(2020) Lifang Gao et al.   ANALYTICA CHIMICA ACTA

Three‐dimensional imaging and quantification of real‐time cytosolic calcium oscillations in microglial cells cultured on electrospun matrices using laser scanning confocal microscopy

(2020) Kojja Venkateswarlu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Microglial calcium signaling is attuned to neuronal activity in awake mice

(2020) Anthony D Umpierre et al.   eLife

Alteration of miRNA Biogenesis Regulating Proteins in the Human Microglial Cell Line HMC-3 After Ischemic Stress

(2020) Clara Voelz et al.   MOLECULAR NEUROBIOLOGY

Microglial Calcium Waves During the Hyperacute Phase of Ischemic Stroke

(2020) Lei Liu et al.   STROKE

Crosstalk between Calcium and ROS in Pathophysiological Conditions

(2019) Simona Feno et al.   Oxidative Medicine and Cellular Longevity

Microglial activation after ischaemic stroke

(2019) Shengxiang Zhang   JOURNAL OF INVESTIGATIVE MEDICINE

STAT1 drives M1 microglia activation and neuroinflammation under hypoxia

(2019) Elena Butturini et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Blockade of microglial Cav1.2 Ca2+ channel exacerbates the symptoms in a Parkinson’s disease model

(2019) Xinshuang Wang et al.   Scientific Reports

Progressive hypoxia‐on‐a‐chip: An in vitro oxygen gradient model for capturing the effects of hypoxia on primary hepatocytes in health and disease

(2019) Young Bok (Abraham) Kang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Long-term imaging of calcium dynamics using genetically encoded calcium indicators and automatic tracking of cultured cells

(2018) Igor Razlivanov et al.   BIOTECHNIQUES

Reduced mitochondrial response sensitivity is involved in the anti‑apoptotic effect of dexmedetomidine pretreatment in cardiomyocytes

(2018) Xiaojian Weng et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Glutamate as a potential “survival factor” in an in vitro model of neuronal hypoxia/reoxygenation injury: leading role of the Na+/Ca2+ exchanger

(2018) Silvia Piccirillo et al.   Cell Death & Disease

Role of hypoxia-inducible factor-1α in autophagic cell death in microglial cells induced by hypoxia

(2017) Xintao Wang et al.   Molecular Medicine Reports

O2-controllable hydrogels for studying cellular responses to hypoxic gradients in three dimensions in vitro and in vivo

(2017) Daniel M Lewis et al.   Nature Protocols

CoCl2 increases the expression of hypoxic markers HIF‑1α, VEGF and CXCR4 in breast cancer MCF‑7 cells

(2017) Qing Li et al.   Oncology Letters

IL-17A Enhances Microglial Response to OGD by Regulating p53 and PI3K/Akt Pathways with Involvement of ROS/HMGB1

(2017) Bin Zhang et al.   Frontiers in Molecular Neuroscience

Modeling Ischemic Stroke In Vitro: Status Quo and Future Perspectives

(2016) Paul M. Holloway et al.   STROKE

Optimized Real-Time Monitoring of Glutathione Redox Status in Single Pyramidal Neurons in Organotypic Hippocampal Slices during Oxygen–Glucose Deprivation and Reperfusion

(2015) Bocheng Yin et al.   ACS Chemical Neuroscience

Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response

(2014) S R McKeown   BRITISH JOURNAL OF RADIOLOGY

Calcium ion influx in microglial cells: Physiological and therapeutic significance

(2014) Purnima Sharma et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Anti-Neuroinflammatory Effects of the Calcium Channel Blocker Nicardipine on Microglial Cells: Implications for Neuroprotection

(2014) Bor-Ren Huang et al.   PLoS One

Hypoxia Induces Autophagic Cell Death through Hypoxia-Inducible Factor 1α in Microglia

(2014) Zhao Yang et al.   PLoS One

A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion

(2013) Helena W Morrison et al.   Journal of Neuroinflammation

Brain tissue oxygen monitoring identifies cortical hypoxia and thalamic hyperoxia after experimental cardiac arrest in rats

(2013) Mioara D. Manole et al.   PEDIATRIC RESEARCH

Evaluation of intramitochondrial ATP levels identifies G0/G1 switch gene 2 as a positive regulator of oxidative phosphorylation

(2013) H. Kioka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

trans-Resveratrol Protects Ischemic PC12 Cells by Inhibiting the Hypoxia Associated Transcription Factors and Increasing the Levels of Antioxidant Defense Enzymes

(2012) Megha Agrawal et al.   ACS Chemical Neuroscience

Brain-Immune Interactions and Ischemic Stroke

(2012) Costantino Iadecola   ARCHIVES OF NEUROLOGY

Activation of Microglia Depends on Na+/H+ Exchange-Mediated H+ Homeostasis

(2010) Y. Liu et al.   JOURNAL OF NEUROSCIENCE

Hepatic Ischemia Induced Immediate Oxidative Stress after Reperfusion and Determined the Severity of the Reperfusion-Induced Damage

(2009) Sanae Haga et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondria and reactive oxygen species

(2009) Alicia J. Kowaltowski et al.   FREE RADICAL BIOLOGY AND MEDICINE