Modulation of the host innate immune and inflammatory response by translocated bacterial proteins

Inflammasome Activation in Response to the Yersinia Type III Secretion System Requires Hyperinjection of Translocon Proteins YopB and YopD

(2015) Erin E. Zwack et al.   mBio

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Bacterial CagA protein induces degradation of p53 protein in a p14ARF-dependent manner

(2014) Jinxiong Wei et al.   GUT

The Type III Secretion Effector NleF of Enteropathogenic Escherichia coli Activates NF-κB Early during Infection

(2014) Mitchell A. Pallett et al.   INFECTION AND IMMUNITY

Exploitation of the host ubiquitin system by human bacterial pathogens

(2014) Hiroshi Ashida et al.   NATURE REVIEWS MICROBIOLOGY

The Legionella effector SidC defines a unique family of ubiquitin ligases important for bacterial phagosomal remodeling

(2014) F. Hsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ShigellaIpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages

(2014) Shiho Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Native structure of a type IV secretion system core complex essential for Legionella pathogenesis

(2014) T. Kubori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome

(2014) S. Kailasan Vanaja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IQGAP1 Is Important for Activation of Caspase-1 in Macrophages and Is Targeted by Yersinia pestis Type III Effector YopM

(2014) L. K. Chung et al.   mBio

The Frustrated Host Response to Legionella pneumophila Is Bypassed by MyD88-Dependent Translation of Pro-inflammatory Cytokines

(2014) Seblewongel Asrat et al.   PLoS Pathogens

Legionella pneumophila Effector RomA Uniquely Modifies Host Chromatin to Repress Gene Expression and Promote Intracellular Bacterial Replication

(2013) Monica Rolando et al.   Cell Host & Microbe

SET-domain bacterial effectors target heterochromatin protein 1 to activate host rDNA transcription

(2013) Ting Li et al.   EMBO REPORTS

Impact of Host Membrane Pore Formation by the Yersinia pseudotuberculosis Type III Secretion System on the Macrophage Innate Immune Response

(2013) Laura Kwuan et al.   INFECTION AND IMMUNITY

Bacterial control of host gene expression through RNA polymerase II

(2013) Nataliya Lutay et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-1  Signaling Initiates the Inflammatory Response to Virulent Legionella pneumophila In Vivo

(2013) K. C. Barry et al.   JOURNAL OF IMMUNOLOGY

Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains

(2013) Shan Li et al.   NATURE

A type III effector antagonizes death receptor signalling during bacterial gut infection

(2013) Jaclyn S. Pearson et al.   NATURE

Pathogen signatures activate a ubiquitination pathway that modulates the function of the metabolic checkpoint kinase mTOR

(2013) Stanimir S Ivanov et al.   NATURE IMMUNOLOGY

The E. coli Effector Protein NleF Is a Caspase Inhibitor

(2013) Sonja Blasche et al.   PLoS One

The Shigella Type Three Secretion System Effector OspG Directly and Specifically Binds to Host Ubiquitin for Activation

(2013) Yan Zhou et al.   PLoS One

Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila

(2013) C. L. Case et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation

(2013) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Caspase-11 Activation in Response to Bacterial Secretion Systems that Access the Host Cytosol

(2013) Cierra N. Casson et al.   PLoS Pathogens

The Salmonella Type III Effector SspH2 Specifically Exploits the NLR Co-chaperone Activity of SGT1 to Subvert Immunity

(2013) Amit P. Bhavsar et al.   PLoS Pathogens

Recognition of Bacteria by Inflammasomes

(2012) Jakob von Moltke et al.   Annual Review of Immunology

Yersinia pseudotuberculosis Effector YopJ Subverts the Nod2/RICK/TAK1 Pathway and Activates Caspase-1 to Induce Intestinal Barrier Dysfunction

(2012) Ulrich Meinzer et al.   Cell Host & Microbe

The Yersinia Virulence Effector YopM Binds Caspase-1 to Arrest Inflammasome Assembly and Processing

(2012) Christopher N. LaRock et al.   Cell Host & Microbe

TheCoxiella burnetiitype IV secretion system substrate CaeB inhibits intrinsic apoptosis at the mitochondrial level

(2012) Leonie Klingenbeck et al.   CELLULAR MICROBIOLOGY

Shigella flexneriT3SS effector IpaH4.5 modulates the host inflammatory response via interaction with NF-κB p65 protein

(2012) Fang Wang et al.   CELLULAR MICROBIOLOGY

When bacteria target the nucleus: the emerging family of nucleomodulins

(2012) Hélène Bierne et al.   CELLULAR MICROBIOLOGY

NF- B, the first quarter-century: remarkable progress and outstanding questions

(2012) M. S. Hayden et al.   GENES & DEVELOPMENT

YopK controls both rate and fidelity of Yop translocation

(2012) Rebecca Dewoody et al.   MOLECULAR MICROBIOLOGY

Serine/threonine acetylation of TGF -activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling

(2012) N. Paquette et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two signal models in innate immunity

(2011) Mary F. Fontana et al.   IMMUNOLOGICAL REVIEWS

Attaching and Effacing Bacterial Effector NleC Suppresses Epithelial Inflammatory Responses by Inhibiting NF-κB and p38 Mitogen-Activated Protein Kinase Activation

(2011) Ho Pan Sham et al.   INFECTION AND IMMUNITY

A type III effector protease NleC from enteropathogenic Escherichia coli targets NF-κB for degradation

(2011) Jaclyn S. Pearson et al.   MOLECULAR MICROBIOLOGY

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

(2011) Eric M. Kofoed et al.   NATURE

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

IKKβ phosphorylation regulates RPS3 nuclear translocation and NF-κB function during infection with Escherichia coli strain O157:H7

(2011) Fengyi Wan et al.   NATURE IMMUNOLOGY

The RACK1 Signaling Scaffold Protein Selectively Interacts with Yersinia pseudotuberculosis Virulence Function

(2011) Sara E. Thorslund et al.   PLoS One

Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host

(2011) L. Buti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intestinal inflammation allows Salmonella to use ethanolamine to compete with the microbiota

(2011) P. Thiennimitr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secreted Bacterial Effectors That Inhibit Host Protein Synthesis Are Critical for Induction of the Innate Immune Response to Virulent Legionella pneumophila

(2011) Mary F. Fontana et al.   PLoS Pathogens

A Yersinia Effector Protein Promotes Virulence by Preventing Inflammasome Recognition of the Type III Secretion System

(2010) Igor E. Brodsky et al.   Cell Host & Microbe

The Legionella pneumophila F-box protein Lpp2082 (AnkB) modulates ubiquitination of the host protein parvin B and promotes intracellular replication

(2010) M. Lomma et al.   CELLULAR MICROBIOLOGY

LnaB: a Legionella pneumophila activator of NF-κB

(2010) Vicki P. Losick et al.   CELLULAR MICROBIOLOGY

Metalloprotease type III effectors that specifically cleave JNK and NF-κB

(2010) Kobi Baruch et al.   EMBO JOURNAL

A disulfide driven domain swap switches off the activity ofShigellaIpaH9.8 E3 ligase

(2010) Arefeh Seyedarabi et al.   FEBS LETTERS

Nod1 and Nod2 Regulation of Inflammation in the Salmonella Colitis Model

(2010) K. Geddes et al.   INFECTION AND IMMUNITY

E3 Ubiquitin Ligase Activity and Targeting of BAT3 by Multiple Legionella pneumophila Translocated Substrates

(2010) A. W. Ensminger et al.   INFECTION AND IMMUNITY

Proteasome-independent Degradation of Canonical NFκB Complex Components by the NleC Protein of PathogenicEscherichia coli

(2010) Sabrina Mühlen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gut inflammation provides a respiratory electron acceptor for Salmonella

(2010) Sebastian E. Winter et al.   NATURE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Inhibition of pathogen-induced apoptosis by a Coxiella burnetii type IV effector protein

(2010) A. Luhrmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NleH effectors interact with Bax inhibitor-1 to block apoptosis during enteropathogenic Escherichia coli infection

(2010) C. Hemrajani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome

(2010) E. A. Miao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Type III Secretion Effector NleE Inhibits NF-κB Activation

(2010) Chen Nadler et al.   PLoS Pathogens

The Type III Effectors NleE and NleB from Enteropathogenic E. coli and OspZ from Shigella Block Nuclear Translocation of NF-κB p65

(2010) Hayley J. Newton et al.   PLoS Pathogens

Legionella Metaeffector Exploits Host Proteasome to Temporally Regulate Cognate Effector

(2010) Tomoko Kubori et al.   PLoS Pathogens

NleC, a Type III Secretion Protease, Compromises NF-κB Activation by Targeting p65/RelA

(2010) Hilo Yen et al.   PLoS Pathogens

Histone Methylation by NUE, a Novel Nuclear Effector of the Intracellular Pathogen Chlamydia trachomatis

(2010) Meghan E. Pennini et al.   PLoS Pathogens

Regulation and Function of NF-κB Transcription Factors in the Immune System

(2009) Sivakumar Vallabhapurapu et al.   Annual Review of Immunology

Coxiella burnetii modulates Beclin 1 and Bcl-2, preventing host cell apoptosis to generate a persistent bacterial infection

(2009) C L Vázquez et al.   CELL DEATH AND DIFFERENTIATION

Patterns of Pathogenesis: Discrimination of Pathogenic and Nonpathogenic Microbes by the Innate Immune System

(2009) Russell E. Vance et al.   Cell Host & Microbe

Targeting eEF1A by aLegionella pneumophilaeffector leads to inhibition of protein synthesis and induction of host stress response

(2009) Xihui Shen et al.   CELLULAR MICROBIOLOGY

Hijacking the host ubiquitin pathway: structural strategies of bacterial E3 ubiquitin ligases

(2009) Stuart W Hicks et al.   CURRENT OPINION IN MICROBIOLOGY

Helicobacter pylori CagA activates NF-κB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination

(2009) Acacia Lamb et al.   EMBO REPORTS

Asc and Ipaf Inflammasomes Direct Distinct Pathways for Caspase-1 Activation in Response to Legionella pneumophila

(2009) C. L. Case et al.   INFECTION AND IMMUNITY

A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKγ to dampen the host NF-κB-mediated inflammatory response

(2009) Hiroshi Ashida et al.   NATURE CELL BIOLOGY

A Legionella type IV effector activates the NF- B pathway by phosphorylating the I B family of inhibitors

(2009) J. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A family of Salmonella virulence factors functions as a distinct class of autoregulated E3 ubiquitin ligases

(2009) C. M. Quezada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mimicry by an F-Box Effector of Legionella pneumophila Hijacks a Conserved Polyubiquitination Machinery within Macrophages and Protozoa

(2009) Christopher T. Price et al.   PLoS Pathogens

Innate Immune Recognition of Yersinia pseudotuberculosis Type III Secretion

(2009) Victoria Auerbuch et al.   PLoS Pathogens

Real-Time Analysis of Effector Translocation by the Type III Secretion System of Enteropathogenic Escherichia coli

(2008) Erez Mills et al.   Cell Host & Microbe

Inflammasomes: guardians of cytosolic sanctity

(2008) Mohamed Lamkanfi et al.   IMMUNOLOGICAL REVIEWS

Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functions

(2008) Tomoko Kubori et al.   MOLECULAR MICROBIOLOGY

Diversity of degradation signals in the ubiquitin–proteasome system

(2008) Tommer Ravid et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Yersinia Controls Type III Effector Delivery into Host Cells by Modulating Rho Activity

(2008) Edison Mejía et al.   PLoS Pathogens

Type IV Secretion-Dependent Activation of Host MAP Kinases Induces an Increased Proinflammatory Cytokine Response to Legionella pneumophila

(2008) Sunny Shin et al.   PLoS Pathogens