Article
Critical Care Medicine
Xiangxu Tang, Yaqian Xu, Xiaomeng Dai, Yun Xing, Duomeng Yang, Qingyang Huang, Hongmei Li, Xiuxiu Lv, Yiyang Wang, Daxiang Lu, Huadong Wang
Summary: The study found that intrinsic myocardial depression occurs earlier than hepatic and renal dysfunction in sepsis, and serum cTnI, NT-proBNP, and H-FABP are not suitable as early biomarkers for sepsis-induced myocardial dysfunction. DOB treatment can improve survival in septic rats, but does not significantly impact myocardial function and hemodynamics.
Article
Cardiac & Cardiovascular Systems
Alexander B. Veitinger, Audrey Komguem, Lena Assling-Simon, Martina Heep, Julia Schipke, Christian Muehlfeld, Bernd Niemann, Philippe Grieshaber, Kerstin Boengler, Andreas Boening
Summary: In non-infarcted rat hearts, esmolol-based cardioplegia, particularly ECCP, offers better myocardial protection than Calafiore. After an acute myocardial infarction, cardioprotection with esmolol-based cardioplegia is similar to that with Calafiore.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Critical Care Medicine
Qian Li, Mingming Zhang, Ying Zhao, Maolong Dong
Summary: The study showed that irisin mitigated septic cardiac dysfunction by inhibiting TLR4 and NLRP3 inflammasome signaling pathways, reducing myocardial cell apoptosis, pyroptosis and inflammatory response.
Article
Plant Sciences
M. F. Nagoor Meeran, Sheikh Azimullah, Ernest Adeghate, Shreesh Ojha
Summary: This study investigated the cardioprotective effects of Nootkatone (NKT) in rats against isoproterenol-induced myocardial infarction, showing that NKT significantly restored or modulated altered biochemical and molecular parameters in the heart tissues. Histopathological observations confirmed the myocardial restoring effect of NKT, suggesting it as a potential alternative to cardioprotective agents in ischemic heart diseases.
Article
Immunology
Lingpeng Xie, Yuting Wu, Chuying Zhou, Zhangbin Tan, Honglin Xu, Guanghong Chen, Hongmei Chen, Guiqiong Huang, Huijie Fan, Lei Gao, Bin Liu, Yingchun Zhou
Summary: The study found that PIC can alleviate sepsis-induced myocardial dysfunction by inhibiting the JAK2/STAT3 signaling pathway, reducing cardiomyocyte apoptosis and inflammatory responses.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Qian Zhang, Yuan-Ye Dang, Xiu Luo, Ji-Jun Fu, Zhi-Cong Zou, Xue-Jing Jia, Guo-Dong Zheng, Chu-Wen Li
Summary: Kazinol B (KB), an isoprenylated flavan derived from Broussonetia kazinoki Sieb. (Moraceae) root, has protective effects on hypoxia and reoxygenation-induced cardiac injury in H9c2 rat cardiac myoblasts, and its mechanism involves modulating the AKT and AMPK-mediated Nrf2 induction.
PHARMACEUTICAL BIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Cun-Cun Hua, Xin-Ming Liu, Li-Rong Liang, Le-Feng Wang, Jiu-Chang Zhong
Summary: This article reviews the roles of miR-34a in cardiovascular diseases, including cardiovascular fibrosis, apoptosis, autophagy, inflammation, senescence, and remodeling. Further understanding of the effects of miR-34a will aid the development of effective interventions.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Shichao Lv, Yunjiao Wang, Wanqin Zhang, Hongcai Shang
Summary: Heart failure is a clinical syndrome in the late stage of cardiovascular disease, and research shows that the gut microbiota metabolite TMAO is associated with adverse outcomes in HF. Lowering TMAO levels may improve the prognosis of HF patients.
Article
Critical Care Medicine
Ying Ma, Zhenshun Cheng, Yong Zheng, Wei Wang, Shaojun He, Xiaolian Zhou, Jiong Yang, Chaojie Wei
Summary: Through experiments, it was found that low-dose esmolol could reduce T-lymphocyte apoptosis and restore the balance of T(H)2/T(H)1 ratio in septic shock. Esmolol may alleviate T-lymphocyte apoptosis by modulating the Akt/Bcl-2/Caspase-3 pathway and inhibiting Erk1/2 activity, leading to a decrease in T(H)0 differentiation to T(H)2. Esmolol may be a potential immunoregulator for septic shock.
Article
Biochemistry & Molecular Biology
Hang Zhu, Jin Wang, Ting Xin, Shanshan Chen, Ruiying Hu, Yukun Li, Mingming Zhang, Hao Zhou
Summary: This study investigated the involvement of dual specificity phosphatase 1 (DUSP1) and valosin-containing protein (VCP) in mitochondrial quality control (MQC) and myocardial function during LPS-induced endotoxemia. The researchers found that DUSP1 expression was downregulated in the heart during endotoxemia, while DUSP1 overexpression in mice and cells resulted in reduced inflammation, apoptosis, and cardiac injury, as well as improved cardiac function. The study also revealed that DUSP1 interacted with VCP on the mitochondria to prevent LPS-mediated VCP phosphorylation, preserving MQC. These findings suggest the involvement of the novel DUSP1/VCP/MQC pathway in the pathogenesis of endotoxemia-caused myocardial dysfunction.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Cell Biology
Landon Haslem, Jennifer M. Hays, Franklin A. Hays
Summary: This article reviews the important role of p66Shc in cardiovascular pathologies by regulating pro-apoptotic ROS signals. It also discusses p66Shc's signaling and mitochondrial functions, and presents a new model of p66Shc's mitochondrial function.
Article
Oncology
Gang Qin, Liuqing Wei, Fufu Jiang, Jiayan Li, Bo Zhang, Dongxu Pan, Xinglin Lu
Summary: The study showed that lncRNA-NR024118 is downregulated in sepsis patients and is associated with increased levels of IL-6. Patients with sepsis and myocardial dysfunction had even lower NR024118 expression and higher IL-6 levels, which were inversely correlated. Functional studies demonstrated that NR024118 negatively regulated p65 phosphorylation and NF-kappa B activation, suppressing sepsis and inhibiting LPS-induced apoptosis of cardiomyocytes.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Jie Zhang, Siqi Liu, Longyuan Jiang, Jingying Hou, Zhengfei Yang
Summary: Curcumin improves post-resuscitation myocardial dysfunction by ameliorating mitochondrial structure, enhancing energy metabolism, and inhibiting mitochondrial apoptosis pathway. UCP2, UCP3, and mtTFA may also be involved in the protective effects of curcumin on mitochondria.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Immunology
Celeste Faia, Karlie Plaisance-Bonstaff, Cecilia Vittori, Dorota Wyczechowska, Adam Lassak, Mary Meyaski-Schluter, Krzysztof Reiss, Francesca Peruzzi
Summary: Research indicates that in HIV-infected individuals, pro-inflammatory signals dominate over negative feedback signals, leading to an abnormally trained phenotype in monocyte-derived macrophages.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jianhui Weng, Yuqi Wang, Yan Zhang, Deju Ye
Summary: This study introduces an activatable small-molecule NIR fluorescent probe capable of targeting multiple biomarkers of apoptosis for early diagnosis of acute kidney injury, showcasing the potential for longitudinal monitoring of renal cell apoptosis and real-time tracking of kidney function recovery.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)