Piceatannol protects against sepsis-induced myocardial dysfunction via direct inhibition of JAK2

Protective effect of piceatannol and bioactive stilbene derivatives against hypoxia-induced toxicity in H9c2 cardiomyocytes and structural elucidation as 5-LOX inhibitors

(2019) Mariarosaria Boccellino et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inhibiting the formation of advanced glycation end-products by three stilbenes and the identification of their adducts

(2019) Weixin Wang et al.   FOOD CHEMISTRY

Sepsis-induced myocardial dysfunction

(2018) Keith R. Walley   Current Opinion in Critical Care

Divergent antiarrhythmic effects of resveratrol and piceatannol in a whole-heart model of long QT syndrome

(2017) Christian Ellermann et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014

(2017) Chanu Rhee et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

JAK inhibition as a therapeutic strategy for immune and inflammatory diseases

(2017) Daniella M. Schwartz et al.   NATURE REVIEWS DRUG DISCOVERY

Kinetic and high-throughput profiling of epigenetic interactions by 3D-carbene chip-based surface plasmon resonance imaging technology

(2017) Shuai Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into the Structural Features Essential for JAK2 Inhibition and Selectivity

(2016) Chao Zhao et al.   CURRENT MEDICINAL CHEMISTRY

Cardiac dysfunction, mitochondrial architecture, energy production, and inflammatory pathways: Interrelated aspects in endotoxemia and sepsis

(2016) Silvia Alvarez et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Anti-inflammatory effect of resveratrol through the suppression of NF- B and JAK/STAT signaling pathways

(2015) C. Ma et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

SPRi determination of inter-peptide interaction by using 3D supramolecular co-assembly polyrotaxane film

(2015) Yanmei Wang et al.   BIOSENSORS & BIOELECTRONICS

Trimetazidine prevents macrophage-mediated septic myocardial dysfunction via activation of the histone deacetylase sirtuin 1

(2015) Jing Chen et al.   BRITISH JOURNAL OF PHARMACOLOGY

SOCS3 promotes inflammation and apoptosis via inhibiting JAK2/STAT3 signaling pathway in 3T3-L1 adipocyte

(2015) Zhenjiang Liu et al.   IMMUNOBIOLOGY

Protective Effect of Astragaloside IV Against Paraquat-Induced Lung Injury in Mice by Suppressing Rho Signaling

(2015) Tong Chen et al.   INFLAMMATION

Inhibition of Janus kinases by tyrosine phosphorylation inhibitor, Tyrphostin AG-490

(2015) Sajid Rashid et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Cyclovirobuxinum D suppresses lipopolysaccharide-induced inflammatory responses in murine macrophages in vitro by blocking JAK-STAT signaling pathway

(2014) Dan Guo et al.   ACTA PHARMACOLOGICA SINICA

The cardioprotective effect of sodium tanshinone IIA sulfonate and the optimizing of therapeutic time window in myocardial ischemia/reperfusion injury in rats

(2014) Bo Wei et al.   ATHEROSCLEROSIS

Discovery and Development of Janus Kinase (JAK) Inhibitors for Inflammatory Diseases

(2014) James D. Clark et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sepsis: recognition and treatment

(2013) J. Soong et al.   CLINICAL MEDICINE

Benchmarking the Incidence and Mortality of Severe Sepsis in the United States*

(2013) David F. Gaieski et al.   CRITICAL CARE MEDICINE

Piceatannol facilitates conduction block and ventricular fibrillation induction in ischemia-reperfused rabbit hearts with pacing-induced heart failure

(2013) Chung-Chuan Chou et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

JAK2/STAT3 activation by melatonin attenuates the mitochondrial oxidative damage induced by myocardial ischemia/reperfusion injury

(2013) Yang Yang et al.   JOURNAL OF PINEAL RESEARCH

Oxymatrine protects against myocardial injury via inhibition of JAK2/STAT3 signaling in rat septic shock

(2013) MINGHAO ZHANG et al.   Molecular Medicine Reports

Vitamin E and telmisartan attenuates doxorubicin induced cardiac injury in rat through down regulation of inflammatory response

(2012) Najah Hadi et al.   BMC Cardiovascular Disorders

Clinical Spectrum, Frequency, and Significance of Myocardial Dysfunction in Severe Sepsis and Septic Shock

(2012) Juan N. Pulido et al.   MAYO CLINIC PROCEEDINGS

Role of the JAK/STAT signaling pathway in the pathogenesis of acute myocardial infarction in rats and its effect on NF-κB expression

(2012) SONG ZHANG et al.   Molecular Medicine Reports

Mitochondrial STAT3 Activation and Cardioprotection by Ischemic Postconditioning in Pigs With Regional Myocardial Ischemia/Reperfusion

(2011) Gerd Heusch et al.   CIRCULATION RESEARCH

Biological activity of piceatannol: Leaving the shadow of resveratrol

(2011) Hanna Piotrowska et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Cecal ligation and puncture: the gold standard model for polymicrobial sepsis?

(2011) Lien Dejager et al.   TRENDS IN MICROBIOLOGY

Virtual screening and synthesis of quinazolines as novel JAK2 inhibitors

(2010) Su Hui Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The current status and the future of JAK2 inhibitors for the treatment of myeloproliferative diseases

(2010) Yasumichi Hitoshi et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

JAK2 inhibition prevents innate immune responses and rescues animals from sepsis

(2010) Geber Peña et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptide

(2010) Anne-Kathrin Anders et al.   NATURE IMMUNOLOGY

STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria

(2009) Lobelia Samavati et al.   MOLECULAR IMMUNOLOGY