Review
Food Science & Technology
Eliana Alves, Abigail Simoes, M. Rosario Domingues
Summary: Thousands of tons of fruit seeds are discarded annually worldwide as agro-industrial byproducts, which have high oil content and rich in fatty acids, yet remain poorly studied in terms of their lipid profile. Current analytical methods allow accurate identification and structural characterization of compounds in small quantities, while lipidomic analysis will provide a new perspective on these value-added byproducts.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Plant Sciences
Laura Gutierrez-Garcia, Montserrat Arro, Teresa Altabella, Albert Ferrer, Albert Boronat
Summary: This study reports the subcellular localization of tomato C22DES in the endoplasmic reticulum (ER) based on confocal fluorescence microscopy and cell fractionation analyses. Modeling studies have revealed that C22DES consists of two well-differentiated domains: a single N-terminal transmembrane-helix domain anchored in the ER-membrane and a globular (or catalytic) domain oriented towards the cytosol. Overall, this study contributes to expand the current knowledge on the structure and function of plant C22DES and to unveil novel aspects related to plant sterol metabolism.
Review
Food Science & Technology
Tiago Jardim Costa, M. Rosario M. Domingues, Eliana Alves
Summary: Tree nuts and oily fruits are highly consumed worldwide due to their nutritional value and health benefits. However, the lipidomic analysis of these foods is still in its early stages.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Sarah R. Barger, Lauren Penfield, Shirin Bahmanyar
Summary: The nuclear envelope serves as a protective barrier for the cell's genome, undergoing dynamic remodeling processes essential for cell growth and maintenance. Recent studies have shown that lipids produced in the endoplasmic reticulum are utilized to remodel nuclear membranes, with lipid species and lipid-protein interactions playing crucial roles in controlling nuclear envelope dynamics. Coordination of lipid biosynthesis is important for ensuring genome protection through nuclear envelope remodeling.
TRENDS IN BIOCHEMICAL SCIENCES
(2022)
Review
Plant Sciences
Shengnan Zhu, Cuiyue Liang, Jiang Tian, Yingbin Xue
Summary: This review summarizes recent discoveries and molecular basis of plant adaptive mechanisms to low phosphate availability, providing insights into the molecular mechanisms underlying plant adaptation to phosphorus starvation and facilitating the development of crop cultivars with high phosphorus utilization efficiency.
Article
Biochemistry & Molecular Biology
Hyun Ku Yeo, Tae Hyun Park, Hee Yeon Kim, Hyonchol Jang, Jueun Lee, Geum-Sook Hwang, Seong Eon Ryu, Si Hoon Park, Hyun Kyu Song, Hyun Seung Ban, Hye-Jin Yoon, Byung Il Lee
Summary: The study revealed the functions of PTPIP51 in phospholipid binding/transfer, particularly of phosphatidic acid, in cells. Depletion of PTPIP51 reduces the mitochondrial cardiolipin level, and the interaction between PTPIP51 and VAPB is mediated by specific structural motifs.
Article
Multidisciplinary Sciences
Dylan Hong Zheng Koh, Tomoki Naito, Minyoung Na, Yee Jie Yeap, Pritisha Rozario, Franklin L. Zhong, Kah-Leong Lim, Yasunori Saheki
Summary: Cholesterol is vital for the integrity and signaling of cell membranes, and its dysregulation is associated with various diseases including neurodegenerative disorders. This study presents the development of a highly sensitive cholesterol biosensor that allows real-time visualization of accessible cholesterol distribution in different cell types. The findings reveal differential dependencies on cholesterol biosynthesis and uptake for maintaining levels of accessible cholesterol.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Tobias C. Walther, Siyoung Kim, Henning Arlt, Gregory A. Voth, Robert V. Farese Jr
Summary: Cells store lipids in organelles called lipid droplets, which are formed in the endoplasmic reticulum by LD assembly complexes (LDAC) consisting of seipin and accessory proteins. LDACs determine the sites of LD formation and are essential for this process. Seipin forms a cage-like structure in the membrane, facilitating the phase transition of neutral lipids and the formation of oil droplets within LDACs. Modeling suggests that seipin anchors the growing LD to the ER bilayer and conformational shifts of seipin open the LDAC dome towards the cytoplasm for the emerging LD to exit the ER.
CURRENT OPINION IN STRUCTURAL BIOLOGY
(2023)
Article
Plant Sciences
Song Zou, Yuanchen Lu, Haiyan Ma, Yanhua Li, Guanqun Chen, Danxiang Han, Qiang Hu
Summary: This study demonstrated the biochemical and biological functions of CrGPATer in green algae, as well as its potential as a genetic engineering target in functional lipid manufacturing.
Article
Veterinary Sciences
Kirsten B. Theinert, Teja Snedec, Fabian Pietsch, Sabrina Theile, Anne-Sophie Leonhardt, Joachim Spilke, Stefan Pichelmann, Erik Bannert, Kristin Reichelt, Gabriele Dobeleit, Herbert Fuhrmann, Walter Baumgartner, Melanie Schaeren-Bannert, Alexander Starke
Summary: Fatty liver syndrome (FLS) is a common disease in high-producing dairy cows. This study aimed to generate primary data on healthy cows to serve as reference values for future research. The results showed that hepatic fat storage is a reversible process and does not necessarily cause clinical disease. However, older cows had a more sustained and greater increase in hepatic TAG concentration, which may explain their increased risk of FLS.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Anna Boccaccio, Cristiana Picco, Eleonora Di Zanni, Joachim Scholz-Starke
Summary: Membrane asymmetry, established by energy-dependent unidirectional lipid translocases, is crucial for cellular physiology. The role of phospholipid scrambling (PLS) in breaking down membrane asymmetry is still unexplored, while the Arabidopsis thaliana genome contains a homolog of the TMEM16 family that may function as an ER-resident lipid scramblase.
Article
Cell Biology
Valentin Guyard, Vera Filipa Monteiro-Cardoso, Mohyeddine Omrane, Cecile Sauvanet, Audrey Houcine, Claire Boulogne, Kalthoum Ben Mbarek, Nicolas Vitale, Orestis Faklaris, Naima El Khallouki, Abdou Rachid Thiam, Francesca Giordano
Summary: This study reveals the role of lipid transfer proteins ORP5 and ORP8 in controlling lipid droplet (LD) biogenesis at mitochondria-associated ER membrane (MAM) subdomains. It uncovers their involvement in LD nucleation and growth and emphasizes the importance of the integrity of ER-mitochondria contact sites for this process.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Ben Zucker, Michael M. Kozlov
Summary: Recent advances in super-resolution microscopy revealed previously unknown nanoscopic organization of endoplasmic reticulum (ER), including various nanostructures, and proposed a common concept based on membrane intrinsic curvature and ultra-low membrane tensions as key factors shaping these structures.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Cell Biology
Karin M. Reinisch, William A. Prinz
Summary: Lipids can be transported between cellular membranes via nonvesicular mechanisms, supporting biogenesis of rapidly expanding membranes or allowing targeted modulation of specific lipid levels. Nonvesicular transport likely occurs at membrane contact sites and involves lipid transport proteins, but many questions remain unanswered regarding the mechanisms involved.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Environmental Sciences
Junjun Peng, Xueyan Dai, Huiqin Fan, Chenghong Xing, Yu Zhuang, Xiaona Gao, Huabin Cao, Guoliang Hu, Fan Yang
Summary: Copper (Cu) at high levels can cause harm to the host physiology, specifically resulting in nephrotoxicity, although the exact mechanism remains unclear. This study explored the relationship between mitochondria-associated ER membranes (MAM) and Cu-induced kidney mitochondrial dysfunction and ER stress. The findings revealed that excessive Cu disrupted MAM integrity, leading to MAM dysfunction, mitochondrial dysfunction, and ER stress, contributing to Cu-induced nephrotoxicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ke-Chun Peng, Chao-Wen Wang, Chih-Hang Wu, Chun-Tzu Huang, Ruey-Fen Liou
MOLECULAR PLANT-MICROBE INTERACTIONS
(2015)
Article
Biochemistry & Molecular Biology
Chao-Wen Wang
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2016)
Article
Cell Biology
Po-Lin Yang, Tzu-Han Hsu, Chao-Wen Wang, Rey-Huei Chen
MOLECULAR BIOLOGY OF THE CELL
(2016)
Article
Multidisciplinary Sciences
Shingo Iwasa, Naoko Sato, Chao-Wen Wang, Yun-Hsin Cheng, Hayato Irokawa, Gi-Wook Hwang, Akira Naganuma, Shusuke Kuge
Article
Cell Biology
Tzu-Han Hsu, Rey-Huei Chen, Yun-Hsin Cheng, Chao-Wen Wang
MOLECULAR BIOLOGY OF THE CELL
(2017)
Editorial Material
Cell Biology
Chao-Wen Wang
Article
Cell Biology
Chih-Hang Wu, Shu-Chuan Lee, Chao-Wen Wang
JOURNAL OF CELL BIOLOGY
(2011)
Article
Cell Biology
Chao-Wen Wang, Yu-Hsuan Miao, Yi-Shun Chang
JOURNAL OF CELL BIOLOGY
(2014)
Article
Cell Biology
Chao-Wen Wang, Shu-Chuan Lee
JOURNAL OF CELL SCIENCE
(2012)
Article
Cell Biology
Chao-Wen Wang, Yu-Hsuan Miao, Yi-Shun Chang
JOURNAL OF CELL SCIENCE
(2014)
Article
Multidisciplinary Sciences
Trevor L. Starr, Silvere Pagant, Chao-Wen Wang, Randy Schekman
Article
Cell Biology
Shu-Chuan Lee, Chih-Hang Wu, Chao-Wen Wang
Article
Cell Biology
Wei-Cheng Su, Yi-Hsiu Lin, Martin Pagac, Chao-Wen Wang
JOURNAL OF CELL BIOLOGY
(2019)
Article
Developmental Biology
Xiaofei Bai, Leng-Jie Huang, Sheng-Wen Chen, Benjamin Nebenfuehr, Brian Wysolmerski, Jui-Ching Wu, Sara K. Olson, Andy Golden, Chao-Wen Wang