Diverse regulation of 3′ splice site usage

hnRNP L inhibits CD44 V10 exon splicing through interacting with its upstream intron

(2015) Tiing Jen Loh et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Evolutionary Emergence of a Novel Splice Variant with an Opposite Effect on the Cell Cycle

(2015) Muhammad Sohail et al.   MOLECULAR AND CELLULAR BIOLOGY

Identification of U2AF(35)-dependent exons by RNA-Seq reveals a link between 3′ splice-site organization and activity of U2AF-related proteins

(2015) Jana Kralovicova et al.   NUCLEIC ACIDS RESEARCH

Genomic functions of U2AF in constitutive and regulated splicing

(2015) Tongbin Wu et al.   RNA Biology

Evolutionarily emerged G tracts between the polypyrimidine tract and 3′ AG are splicing silencers enriched in genes involved in cancer

(2015) Muhammad Sohail et al.   BMC GENOMICS

Refinement of the spectra of exon usage by combined effects of extracellular stimulus and intracellular factors

(2014) Guodong Liu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The Noncoding RNA Revolution—Trashing Old Rules to Forge New Ones

(2014) Thomas R. Cech et al.   CELL

Differential evolution of signal-responsive RNA elements and upstream factors that control alternative splicing

(2014) Jiuyong Xie   CELLULAR AND MOLECULAR LIFE SCIENCES

Pre-mRNA splicing is facilitated by an optimal RNA polymerase II elongation rate

(2014) Nova Fong et al.   GENES & DEVELOPMENT

A Global Regulatory Mechanism for Activating an Exon Network Required for Neurogenesis

(2014) Bushra Raj et al.   MOLECULAR CELL

Mechanisms for U2AF to define 3′ splice sites and regulate alternative splicing in the human genome

(2014) Changwei Shao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The RNA-Binding Protein QKI Suppresses Cancer-Associated Aberrant Splicing

(2014) Feng-Yang Zong et al.   PLoS Genetics

The genetic basis of myelodysplasia and its clinical relevance

(2013) M. Cazzola et al.   BLOOD

Clinical and biological implications of driver mutations in myelodysplastic syndromes

(2013) E. Papaemmanuil et al.   BLOOD

Direct Competition between hnRNP C and U2AF65 Protects the Transcriptome from the Exonization of Alu Elements

(2013) Kathi Zarnack et al.   CELL

Emerging mechanisms and consequences of calcium regulation of alternative splicing in neurons and endocrine cells

(2013) Aleh Razanau et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery

(2013) M. Bezzi et al.   GENES & DEVELOPMENT

Genome-wide Analysis Reveals SR Protein Cooperation and Competition in Regulated Splicing

(2013) Shatakshi Pandit et al.   MOLECULAR CELL

Phosphorylation of the alternative mRNA splicing factor 45 (SPF45) by Clk1 regulates its splice site utilization, cell migration and invasion

(2013) Yuying Liu et al.   NUCLEIC ACIDS RESEARCH

HnRNP L and hnRNP LL antagonistically modulate PTB-mediated splicing suppression of CHRNA1 pre-mRNA

(2013) Mohammad Alinoor Rahman et al.   Scientific Reports

Spliceosome mutations involvingSRSF2,SF3B1, andU2AF35in chronic myelomonocytic leukemia: Prevalence, clinical correlates, and prognostic relevance

(2012) Mrinal M. Patnaik et al.   AMERICAN JOURNAL OF HEMATOLOGY

Nucleosome organization in sequences of alternative events in human genome

(2012) Huan Huang et al.   BIOSYSTEMS

Alternative splicing produces structural and functional changes in CUGBP2

(2012) Hitoshi Suzuki et al.   BMC BIOCHEMISTRY

A Conserved Serine of Heterogeneous Nuclear Ribonucleoprotein L (hnRNP L) Mediates Depolarization-regulated Alternative Splicing of Potassium Channels

(2012) Guodong Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

hnRNP A1 Proofreads 3′ Splice Site Recognition by U2AF

(2012) Joao Paulo Tavanez et al.   MOLECULAR CELL

Structure, phosphorylation and U2AF65 binding of the N-terminal domain of splicing factor 1 during 3′-splice site recognition

(2012) Yun Zhang et al.   NUCLEIC ACIDS RESEARCH

Control of alternative splicing by forskolin through hnRNP K during neuronal differentiation

(2012) Wenguang Cao et al.   NUCLEIC ACIDS RESEARCH

YB-1 binds to CAUC motifs and stimulates exon inclusion by enhancing the recruitment of U2AF to weak polypyrimidine tracts

(2012) Wen-Juan Wei et al.   NUCLEIC ACIDS RESEARCH

Position-dependent splicing activation and repression by SR and hnRNP proteins rely on common mechanisms

(2012) S. Erkelenz et al.   RNA

Evolutionary Dynamics of Gene and Isoform Regulation in Mammalian Tissues

(2012) J. Merkin et al.   SCIENCE

The Evolutionary Landscape of Alternative Splicing in Vertebrate Species

(2012) N. L. Barbosa-Morais et al.   SCIENCE

Pre-mRNA splicing in disease and therapeutics

(2012) Ravi K. Singh et al.   TRENDS IN MOLECULAR MEDICINE

The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes

(2012) Minna-Liisa Änkö et al.   GENOME BIOLOGY

GC content around splice sites affects splicing through pre-mRNA secondary structures

(2011) Jing Zhang et al.   BMC GENOMICS

CAPER-α alternative splicing regulates the expression of vascular endothelial growth factor165 in Ewing sarcoma cells

(2011) Gangxiong Huang et al.   CANCER

RNA-Seq analysis in mutant zebrafish reveals role of U1C protein in alternative splicing regulation

(2011) Tanja Dorothe Rösel et al.   EMBO JOURNAL

Evolution of a tissue-specific splicing network

(2011) J. Matthew Taliaferro et al.   GENES & DEVELOPMENT

Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A

(2011) A. Corrionero et al.   GENES & DEVELOPMENT

Regulation of alternative splicing by the core spliceosomal machinery

(2011) A. L. Saltzman et al.   GENES & DEVELOPMENT

Extensive relationship between antisense transcription and alternative splicing in the human genome

(2011) A. Sorana Morrissy et al.   GENOME RESEARCH

Deciphering 3′ss Selection in the Yeast Genome Reveals an RNA Thermosensor that Mediates Alternative Splicing

(2011) Markus Meyer et al.   MOLECULAR CELL

Frequent pathway mutations of splicing machinery in myelodysplasia

(2011) Kenichi Yoshida et al.   NATURE

Secondary structure is required for 3′ splice site recognition in yeast

(2011) Ondřej Gahura et al.   NUCLEIC ACIDS RESEARCH

Pseudogenes: Pseudo-functional or key regulators in health and disease?

(2011) R. C. Pink et al.   RNA

Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP

(2010) Markus Hafner et al.   CELL

Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin

(2010) Valerie Edmond et al.   EMBO JOURNAL

A disulfide driven domain swap switches off the activity ofShigellaIpaH9.8 E3 ligase

(2010) Arefeh Seyedarabi et al.   FEBS LETTERS

The U2AF35-related protein Urp contacts the 3' splice site to promote U12-type intron splicing and the second step of U2-type intron splicing

(2010) H. Shen et al.   GENES & DEVELOPMENT

The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome

(2010) E. J. Song et al.   GENES & DEVELOPMENT

Global impact of RNA polymerase II elongation inhibition on alternative splicing regulation

(2010) J. Y. Ip et al.   GENOME RESEARCH

Mechanism of Dephosphorylation of the SR Protein ASF/SF2 by Protein Phosphatase 1

(2010) Chen-Ting Ma et al.   JOURNAL OF MOLECULAR BIOLOGY

A methyl transferase links the circadian clock to the regulation of alternative splicing

(2010) Sabrina E. Sanchez et al.   NATURE

Expansion of the eukaryotic proteome by alternative splicing

(2010) Timothy W. Nilsen et al.   NATURE

Alternative splicing and evolution: diversification, exon definition and function

(2010) Hadas Keren et al.   NATURE REVIEWS GENETICS

iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution

(2010) Julian König et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation

(2010) Gabriel A. Roybal et al.   NUCLEIC ACIDS RESEARCH

Analysis of in situ pre-mRNA targets of human splicing factor SF1 reveals a function in alternative splicing

(2010) Margherita Corioni et al.   NUCLEIC ACIDS RESEARCH

The organization of nucleosomes around splice sites

(2010) Wei Chen et al.   NUCLEIC ACIDS RESEARCH

HnRNP L-mediated regulation of mammalian alternative splicing by interference with splice site recognition

(2010) Monika Heiner et al.   RNA Biology

Competing RNA secondary structures are required for mutually exclusive splicing of the Dscam exon 6 cluster

(2010) G. E. May et al.   RNA

Regulation of Alternative Splicing by Histone Modifications

(2010) R. F. Luco et al.   SCIENCE

The Spliceosome: Design Principles of a Dynamic RNP Machine

(2009) Markus C. Wahl et al.   CELL

In VivoSelection of Kinase-responsive RNA Elements Controlling Alternative Splicing

(2009) Hongzhao Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide Analysis of PTB-RNA Interactions Reveals a Strategy Used by the General Splicing Repressor to Modulate Exon Inclusion or Skipping

(2009) Yuanchao Xue et al.   MOLECULAR CELL

Structural basis for the sequence-specific RNA-recognition mechanism of human CUG-BP1 RRM3

(2009) Kengo Tsuda et al.   NUCLEIC ACIDS RESEARCH

Neuronal cell depolarization induces intragenic chromatin modifications affecting NCAM alternative splicing

(2009) I. E. Schor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The protein factors MBNL1 and U2AF65 bind alternative RNA structures to regulate splicing

(2009) M. B. Warf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Jmjd6 Catalyses Lysyl-Hydroxylation of U2AF65, a Protein Associated with RNA Splicing

(2009) Celia J. Webby et al.   SCIENCE

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

The CUGBP2 Splicing Factor Regulates an Ensemble of Branchpoints from Perimeter Binding Sites with Implications for Autoregulation

(2009) Jill A. Dembowski et al.   PLoS Genetics

A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition

(2008) M. Beltran et al.   GENES & DEVELOPMENT

The Heterogeneous Nuclear Ribonucleoprotein L Is an Essential Component in the Ca2+/Calmodulin-dependent Protein Kinase IV-regulated Alternative Splicing through Cytidine-Adenosine Repeats

(2008) Jiankun Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Multiple Core Spliceosomal Proteins by Alternative Splicing-Coupled Nonsense-Mediated mRNA Decay

(2008) A. L. Saltzman et al.   MOLECULAR AND CELLULAR BIOLOGY

Alternative isoform regulation in human tissue transcriptomes

(2008) Eric T. Wang et al.   NATURE

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

(2008) Qun Pan et al.   NATURE GENETICS

Polypyrimidine tract binding protein controls the transition from exon definition to an intron defined spliceosome

(2008) Shalini Sharma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A role for ubiquitin in the spliceosome assembly pathway

(2008) Priya Bellare et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Signal-Regulated Pre-mRNA Occupancy by the General Splicing Factor U2AF

(2008) Anne Tisserant et al.   PLoS One

Conserved RNA secondary structures promote alternative splicing

(2008) P. J. Shepard et al.   RNA

Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation

(2008) A. N. Kuhn et al.   RNA