Structure of potassium channels

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

(2015) Y. Y. Dong et al.   SCIENCE

Free RCK Arrangement in Kch, a Putative Escherichia coli Potassium Channel, as Suggested by Electron Crystallography

(2015) Qie Kuang et al.   STRUCTURE

Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel

(2014) Stephen G. Brohawn et al.   NATURE

Transmembrane Helix Straightening and Buckling Underlies Activation of Mechanosensitive and Thermosensitive K2P Channels

(2014) Marco Lolicato et al.   NEURON

The projection structure of Kch, a putative potassium channel in Escherichia coli, by electron crystallography

(2013) Qie Kuang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Control of KirBac3.1 Potassium Channel Gating at the Interface between Cytoplasmic Domains

(2013) Lejla Zubcevic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPV1 structures in distinct conformations reveal activation mechanisms

(2013) Erhu Cao et al.   NATURE

Gating of the TrkH ion channel by its associated RCK protein TrkA

(2013) Yu Cao et al.   NATURE

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

X-ray structure of the mammalian GIRK2–βγ G-protein complex

(2013) Matthew R. Whorton et al.   NATURE

Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel

(2013) S. G. Brohawn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Dynamics Simulations of the TrkH Membrane Protein

(2012) Carmen Domene et al.   BIOCHEMISTRY

Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating

(2012) Vassiliy N Bavro et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tracking a complete voltage-sensor cycle with metal-ion bridges

(2012) U. Henrion et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Human K2P TRAAK, a Lipid- and Mechano-Sensitive K+ Ion Channel

(2012) S. G. Brohawn et al.   SCIENCE

Crystal Structure of the Human Two-Pore Domain Potassium Channel K2P1

(2012) A. N. Miller et al.   SCIENCE

Diverse gating in K+ channels: Differential role of the pore-helix glutamate in stabilizing the channel pore

(2011) Mobeen Raja   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Electrostatic interaction between inactivation ball and T1–S1 linker region of Kv1.4 channel

(2011) Zhuo Fan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structural correlates of selectivity and inactivation in potassium channels

(2011) Jason G. McCoy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Crystal Structure of the Mammalian GIRK2 K+ Channel and Gating Regulation by G Proteins, PIP2, and Sodium

(2011) Matthew R. Whorton et al.   CELL

The pore structure and gating mechanism of K2P channels

(2011) Paula L Piechotta et al.   EMBO JOURNAL

Structural studies of ion selectivity in tetrameric cation channels

(2011) Amer Alam et al.   JOURNAL OF GENERAL PHYSIOLOGY

Selectivity and Permeation of Alkali Metal Ions in K+-channels

(2011) Simone Furini et al.   JOURNAL OF MOLECULAR BIOLOGY

Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel

(2011) Peng Yuan et al.   NATURE

Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2

(2011) Scott B. Hansen et al.   NATURE

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

Structure and function of multiple Ca2+-binding sites in a K+ channel regulator of K+ conductance (RCK) domain

(2011) V. P. T. Pau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism for selectivity-inactivation coupling in KcsA potassium channels

(2011) W. W. L. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for gating charge movement in the voltage sensor of a sodium channel

(2011) V. Yarov-Yarovoy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid-dependent gating of a voltage-gated potassium channel

(2011) Hui Zheng et al.   Nature Communications

Ion Binding to KcsA: Implications in Ion Selectivity and Channel Gating

(2010) M. L. Renart et al.   BIOCHEMISTRY

Domain Reorientation and Rotation of an Intracellular Assembly Regulate Conduction in Kir Potassium Channels

(2010) Oliver B. Clarke et al.   CELL

A Shaker K+ Channel with a Miniature Engineered Voltage Sensor

(2010) Yanping Xu et al.   CELL

Lipids driving protein structure? Evolutionary adaptations in Kir channels

(2010) Nazzareno D'Avanzo et al.   Channels

A Structural Determinant for the Control of PIP2Sensitivity in G Protein-gated Inward Rectifier K+Channels

(2010) Atsushi Inanobe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

310helices in channels and other membrane proteins

(2010) Ricardo Simão Vieira-Pires et al.   JOURNAL OF GENERAL PHYSIOLOGY

Solution Structure and Phospholipid Interactions of the Isolated Voltage-Sensor Domain from KvAP

(2010) Joel A. Butterwick et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of the gating ring from the human large-conductance Ca2+-gated K+ channel

(2010) Yunkun Wu et al.   NATURE

Structural mechanism of C-type inactivation in K+ channels

(2010) Luis G. Cuello et al.   NATURE

Structural basis for the coupling between activation and inactivation gates in K+ channels

(2010) Luis G. Cuello et al.   NATURE

Mapping the sequence of conformational changes underlying selectivity filter gating in the Kv11.1 potassium channel

(2010) David T Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Novel insights into K+ selectivity from high-resolution structures of an open K+ channel pore

(2010) Sheng Ye et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ion Channel Voltage Sensors: Structure, Function, and Pathophysiology

(2010) William A. Catterall   NEURON

Signaling complexes of voltage-gated sodium and calcium channels

(2010) William A. Catterall   NEUROSCIENCE LETTERS

Ancillary Subunits Associated With Voltage-Dependent K+ Channels

(2010) Olaf Pongs et al.   PHYSIOLOGICAL REVIEWS

Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles

(2010) Hiroshi Hibino et al.   PHYSIOLOGICAL REVIEWS

Molecular Background of Leak K+ Currents: Two-Pore Domain Potassium Channels

(2010) Péter Enyedi et al.   PHYSIOLOGICAL REVIEWS

Tuning the ion selectivity of tetrameric cation channels by changing the number of ion binding sites

(2010) M. G. Derebe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of ligand-gated potassium efflux in bacterial pathogens

(2010) T. P. Roosild et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Principles of conduction and hydrophobic gating in K+ channels

(2010) M. O. Jensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis underlying the dual gate properties of KcsA

(2010) S. Imai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement

(2010) X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Human BK Channel Ca2+-Activation Apparatus at 3.0 A Resolution

(2010) P. Yuan et al.   SCIENCE

A Gating Charge Transfer Center in Voltage Sensors

(2010) X. Tao et al.   SCIENCE

Coupling of activation and inactivation gate in a K+-channel: potassium and ligand sensitivity

(2009) Christian Ader et al.   EMBO JOURNAL

Assembly of Kch, a putative potassium channel from Escherichia coli

(2009) Anna-Karin Lundbäck et al.   JOURNAL OF STRUCTURAL BIOLOGY

Structure of the BK potassium channel in a lipid membrane from electron cryomicroscopy

(2009) Liguo Wang et al.   NATURE

Physical determinants of strong voltage sensitivity of K+ channel block

(2009) Yanping Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of potassium-channel selectivity revealed by Na+ and Li+ binding sites within the KcsA pore

(2009) Ameer N Thompson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Atypical mechanism of conduction in potassium channels

(2009) S. Furini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Eukaryotic Strong Inward-Rectifier K+ Channel Kir2.2 at 3.1 A Resolution

(2009) X. Tao et al.   SCIENCE

KTN (RCK) Domains Regulate K+ Channels and Transporters by Controlling the Dimer-Hinge Conformation

(2009) Tarmo P. Roosild et al.   STRUCTURE

Two Separate Interfaces between the Voltage Sensor and Pore Are Required for the Function of Voltage-Dependent K+ Channels

(2009) Seok-Yong Lee et al.   PLOS BIOLOGY

PIP2 Is a Necessary Cofactor for Ion Channel Function: How and Why?

(2008) Byung-Chang Suh et al.   Annual Review of Biophysics

The Role of Conformation in Ion Permeation in a K+Channel

(2008) Carmen Domene et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sensing voltage across lipid membranes

(2008) Kenton J. Swartz   NATURE

Inverse coupling in leak and voltage-activated K+ channel gates underlies distinct roles in electrical signaling

(2008) Yuval Ben-Abu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Extent of Voltage Sensor Movement during Gating of Shaker K+ Channels

(2008) David J. Posson et al.   NEURON

Structure of the transmembrane regions of a bacterial cyclic nucleotide-regulated channel

(2008) G. M. Clayton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Binding of Anionic Lipids to at Least Three Nonannular Sites on the Potassium Channel KcsA is Required for Channel Opening

(2007) Phedra Marius et al.   BIOPHYSICAL JOURNAL