Langerin-mediated internalization of a modified peptide routes antigens to early endosomes and enhances cross-presentation by human Langerhans cells

Cross-presentation through langerin and DC-SIGN targeting requires different formulations of glycan-modified antigens

(2015) Cynthia M. Fehres et al.   JOURNAL OF CONTROLLED RELEASE

Topical rather than intradermal application of the TLR7 ligand imiquimod leads to human dermal dendritic cell maturation and CD8+T-cell cross-priming

(2014) Cynthia M. Fehres et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Langerin-expressing dendritic cells in human tissues are related to CD1c+ dendritic cells and distinct from Langerhans cells and CD141high XCR1+ dendritic cells

(2014) Venetia Bigley et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Targeting Uptake Receptors on Human Plasmacytoid Dendritic Cells Triggers Antigen Cross-Presentation and Robust Type I IFN Secretion

(2013) J. Tel et al.   JOURNAL OF IMMUNOLOGY

TLR7 Triggering with Polyuridylic Acid Promotes Cross-Presentation in CD8 + Conventional Dendritic Cells by Enhancing Antigen Preservation and MHC Class I Antigen Permanence on the Dendritic Cell Surface

(2013) M. I. Crespo et al.   JOURNAL OF IMMUNOLOGY

The C-type lectin receptor CLEC9A mediates antigen uptake and (cross-)presentation by human blood BDCA3+ myeloid dendritic cells

(2012) G. Schreibelt et al.   BLOOD

Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells

(2012) B. Chatterjee et al.   BLOOD

Antigen presentation by Langerhans cells

(2012) Botond Z Igyártó et al.   CURRENT OPINION IN IMMUNOLOGY

Human Epidermal Langerhans Cells Maintain Immune Homeostasis in Skin by Activating Skin Resident Regulatory T Cells

(2012) Julien Seneschal et al.   IMMUNITY

Glycan-modified liposomes boost CD4+ and CD8+ T-cell responses by targeting DC-SIGN on dendritic cells

(2012) Wendy W.J. Unger et al.   JOURNAL OF CONTROLLED RELEASE

Characterization of resident and migratory dendritic cells in human lymph nodes

(2012) Elodie Segura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Resident CD141 (BDCA3)+dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation

(2012) Chung-Ching Chu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Changing Views of the Role of Langerhans Cells

(2012) Nikolaus Romani et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

CD70–CD27 Interaction Augments CD8+ T-Cell Activation by Human Epidermal Langerhans Cells

(2012) Marta E. Polak et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Characterization of four conventional dendritic cell subsets in human skin-draining lymph nodes in relation to T-cell activation

(2011) R. van de Ven et al.   BLOOD

Human Langerhans cells capture measles virus through Langerin and present viral antigens to CD4+ T cells but are incapable of cross-presentation

(2011) Michiel van der Vlist et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Skin-Resident Murine Dendritic Cell Subsets Promote Distinct and Opposing Antigen-Specific T Helper Cell Responses

(2011) Botond Z. Igyártó et al.   IMMUNITY

Identification of TROP2 (TACSTD2), an EpCAM-Like Molecule, as a Specific Marker for TGF-β1-Dependent Human Epidermal Langerhans Cells

(2011) Gregor Eisenwort et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR

(2010) E. Klechevsky et al.   BLOOD

Human CD141+(BDCA-3)+dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens

(2010) Sarah L. Jongbloed et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+cells as homologues of mouse CD8+dendritic cells

(2010) Annabell Bachem et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of human DNGR-1+BDCA3+leukocytes as putative equivalents of mouse CD8α+dendritic cells

(2010) Lionel Franz Poulin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human Langerhans Cells Are More Efficient Than CD14−CD1c+ Dermal Dendritic Cells at Priming Naive CD4+ T Cells

(2010) Laetitia Furio et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Structural Basis for Langerin Recognition of Diverse Pathogen and Mammalian Glycans through a Single Binding Site

(2010) Hadar Feinberg et al.   JOURNAL OF MOLECULAR BIOLOGY

CD207+CD103+dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells

(2009) Sandrine Henri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Poly(I:C)-Treated Human Langerhans Cells Promote the Differentiation of CD4+ T Cells Producing IFN-γ and IL-10

(2009) Laetitia Furio et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Epidermal Langerhans Cells Rapidly Capture and Present Antigens from C-Type Lectin-Targeting Antibodies Deposited in the Dermis

(2009) Vincent Flacher et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells

(2009) Sammy Bedoui et al.   NATURE IMMUNOLOGY

Functional Specializations of Human Epidermal Langerhans Cells and CD14+ Dermal Dendritic Cells

(2008) Eynav Klechevsky et al.   IMMUNITY

Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I

(2008) Tiziana Di Pucchio et al.   NATURE IMMUNOLOGY

hDectin-1 is involved in uptake and cross-presentation of cellular antigens

(2007) M. M. Weck et al.   BLOOD