The Integrator complex controls the termination of transcription at diverse classes of gene targets

The oligonucleotide/oligosaccharide-binding fold motif is a poly(ADP-ribose)-binding domain that mediates DNA damage response

(2014) F. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of SOSS1 Complex Assembly and Recognition of ssDNA

(2014) Wendan Ren et al.   Cell Reports

Genome-wide dynamics of Pol II elongation and its interplay with promoter proximal pausing, chromatin, and exons

(2014) Iris Jonkers et al.   eLife

RNA Polymerase II transcription elongation and Pol II CTD Ser2 phosphorylation

(2014) Elizabeth A Bowman et al.   Nucleus

H3K4me3 Interactions with TAF3 Regulate Preinitiation Complex Assembly and Selective Gene Activation

(2013) Shannon M. Lauberth et al.   CELL

Single strand DNA binding proteins 1 and 2 protect newly replicated telomeres

(2013) Peili Gu et al.   CELL RESEARCH

Stable Pausing by RNA Polymerase II Provides an Opportunity to Target and Integrate Regulatory Signals

(2013) Telmo Henriques et al.   MOLECULAR CELL

Human snRNA genes use polyadenylation factors to promote efficient transcription termination

(2013) Dawn O’Reilly et al.   NUCLEIC ACIDS RESEARCH

Telomerase-Null Survivor Screening Identifies Novel Telomere Recombination Regulators

(2013) Yan Hu et al.   PLoS Genetics

RNA Polymerase II Elongation Control

(2012) Qiang Zhou et al.   Annual Review of Biochemistry

Microprocessor, Setx, Xrn2, and Rrp6 Co-operate to Induce Premature Termination of Transcription by RNAPII

(2012) Alexandre Wagschal et al.   CELL

ThehSSB1orthologueObfc2bis essential for skeletogenesis but dispensable for the DNA damage responsein vivo

(2012) Niklas Feldhahn et al.   EMBO JOURNAL

The RNA polymerase II CTD coordinates transcription and RNA processing

(2012) J.-P. Hsin et al.   GENES & DEVELOPMENT

snRNA 3' End Formation Requires Heterodimeric Association of Integrator Subunits

(2012) T. R. Albrecht et al.   MOLECULAR AND CELLULAR BIOLOGY

mRNA Decapping Factors and the Exonuclease Xrn2 Function in Widespread Premature Termination of RNA Polymerase II Transcription

(2012) Kris Brannan et al.   MOLECULAR CELL

Kinetic Competition between RNA Polymerase II and Sen1-Dependent Transcription Termination

(2012) Dane Z. Hazelbaker et al.   MOLECULAR CELL

Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans

(2012) Karen Adelman et al.   NATURE REVIEWS GENETICS

An RNAi screen identifies additional members of the Drosophila Integrator complex and a requirement for cyclin C/Cdk8 in snRNA 3'-end formation

(2012) J. Chen et al.   RNA

The host genomic environment of the provirus determines the abundance of HTLV-1-infected T-cell clones

(2011) N. A. Gillet et al.   BLOOD

Regulating RNA polymerase pausing and transcription elongation in embryonic stem cells

(2011) I. M. Min et al.   GENES & DEVELOPMENT

Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination

(2011) Konstantina Skourti-Stathaki et al.   MOLECULAR CELL

Ser7 Phosphorylation of the CTD Recruits the RPAP2 Ser5 Phosphatase to snRNA Genes

(2011) Sylvain Egloff et al.   MOLECULAR CELL

Unravelling the means to an end: RNA polymerase II transcription termination

(2011) Jason N. Kuehner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Antisense RNA polymerase II divergent transcripts are P-TEFb dependent and substrates for the RNA exosome

(2011) R. A. Flynn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Refinements to Label Free Proteome Quantitation: How to Deal with Peptides Shared by Multiple Proteins

(2010) Ying Zhang et al.   ANALYTICAL CHEMISTRY

snRNA 3′ end formation: the dawn of the Integrator complex

(2010) Jiandong Chen et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

c-Myc Regulates Transcriptional Pause Release

(2010) Peter B. Rahl et al.   CELL

A Subset of Drosophila Integrator Proteins Is Essential for Efficient U7 snRNA and Spliceosomal snRNA 3'-End Formation

(2010) N. Ezzeddine et al.   MOLECULAR AND CELLULAR BIOLOGY

GREAT improves functional interpretation of cis-regulatory regions

(2010) Cory Y McLean et al.   NATURE BIOTECHNOLOGY

Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration

(2010) A. L. Ferris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Streamlined analysis schema for high-throughput identification of endogenous protein complexes

(2010) A. Malovannaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrator3, a Partner of Single-stranded DNA-binding Protein 1, Participates in the DNA Damage Response

(2009) Feng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

hSSB1 and hSSB2 Form Similar Multiprotein Complexes That Participate in DNA Damage Response

(2009) Yongjiang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

INTS3 controls the hSSB1-mediated DNA damage response

(2009) Jeffrey R. Skaar et al.   JOURNAL OF CELL BIOLOGY

Chromatin Structure Is Implicated in "Late" Elongation Checkpoints on the U2 snRNA and  -Actin Genes

(2009) S. Egloff et al.   MOLECULAR AND CELLULAR BIOLOGY

SOSS Complexes Participate in the Maintenance of Genomic Stability

(2009) Jun Huang et al.   MOLECULAR CELL

Progression through the RNA Polymerase II CTD Cycle

(2009) Stephen Buratowski   MOLECULAR CELL

A Core Complex of CPSF73, CPSF100, and Symplekin May Form Two Different Cleavage Factors for Processing of Poly(A) and Histone mRNAs

(2009) Kelly D. Sullivan et al.   MOLECULAR CELL

Single-stranded DNA-binding protein hSSB1 is critical for genomic stability

(2008) Derek J. Richard et al.   NATURE

Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail

(2008) William F. Marzluff et al.   NATURE REVIEWS GENETICS

RNA Exosome Depletion Reveals Transcription Upstream of Active Human Promoters

(2008) Pascal Preker et al.   SCIENCE