Treatment with MDL 72527 Ameliorated Clinical Symptoms, Retinal Ganglion Cell Loss, Optic Nerve Inflammation, and Improved Visual Acuity in an Experimental Model of Multiple Sclerosis

B cell-dependent EAE induces visual deficits in the mouse with similarities to human autoimmune demyelinating diseases

(2022) Sandrine Joly et al.   Journal of Neuroinflammation

Antineonatal Fc Receptor Antibody Treatment Ameliorates MOG-IgG–Associated Experimental Autoimmune Encephalomyelitis

(2022) Jana Remlinger et al.   Neurology-Neuroimmunology & Neuroinflammation

Spermine alleviates experimental autoimmune encephalomyelitis via regulating T cell activation and differentiation

(2022) Ruting Zheng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Pharmacological Inhibition of Spermine Oxidase Suppresses Excitotoxicity Induced Neuroinflammation in Mouse Retina

(2022) Moaddey Alfarhan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pterostilbene Protects the Optic Nerves and Retina in a Murine Model of Experimental Autoimmune Encephalomyelitis via Activation of SIRT1 Signaling

(2022) Jiangyuan Guo et al.   NEUROSCIENCE

IFN-γ-Primed hUCMSCs Significantly Reduced Inflammation via the Foxp3/ROR-γt/STAT3 Signaling Pathway in an Animal Model of Multiple Sclerosis

(2022) Xiao Ling et al.   Frontiers in Immunology

Multifocal Electroretinogram Photopic Negative Response: A Reliable Paradigm to Detect Localized Retinal Ganglion Cells’ Impairment in Retrobulbar Optic Neuritis Due to Multiple Sclerosis as a Model of Retinal Neurodegeneration

(2022) Lucilla Barbano et al.   Diagnostics

Selective Upregulation of SIRT1 Expression in Retinal Ganglion Cells by AAV-Mediated Gene Delivery Increases Neuronal Cell Survival and Alleviates Axon Demyelination Associated with Optic Neuritis

(2022) Ahmara G. Ross et al.   Biomolecules

Anemoside B4 ameliorates experimental autoimmune encephalomyelitis in mice by modulating inflammatory responses and the gut microbiota

(2022) Min Zou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Optic neuritis and autoimmune optic neuropathies: advances in diagnosis and treatment

(2022) Jeffrey L Bennett et al.   LANCET NEUROLOGY

Curcumin regulates anti-inflammatory responses by AXL/JAK2/STAT3 signaling pathway in experimental autoimmune encephalomyelitis

(2022) Mengjiao Sun et al.   NEUROSCIENCE LETTERS

Updates on efficacy and safety outcomes of new and emerging disease modifying therapies and stem cell therapy for Multiple Sclerosis: A review

(2022) Sarah Peterson et al.   Multiple Sclerosis and Related Disorders

Deletion of arginase 2 attenuates neuroinflammation in an experimental model of optic neuritis

(2021) Amritha A. Candadai et al.   PLoS One

Baricitinib Ameliorates Experimental Autoimmune Encephalomyelitis by Modulating the Janus Kinase/Signal Transducer and Activator of Transcription Signaling Pathway

(2021) Chun Dang et al.   Frontiers in Immunology

Interferon-β Is Less Effective Than Other Drugs in Controlling the Rate of Retinal Ganglion Cell Loss in MS

(2021) Yuyi You et al.   Neurology-Neuroimmunology & Neuroinflammation

Disorders of vision in multiple sclerosis

(2021) Roshan Dhanapalaratnam et al.   Clinical and Experimental Optometry

Pharmacological Inhibition of STAT3 by Stattic Ameliorates Clinical Symptoms and Reduces Autoinflammation in Myeloid, Lymphoid, and Neuronal Tissue Compartments in Relapsing–Remitting Model of Experimental Autoimmune Encephalomyelitis in SJL/J Mice

(2021) Khalid Alhazzani et al.   Pharmaceutics

Pharmacological Inhibition of Spermine Oxidase Reduces Neurodegeneration and Improves Retinal Function in Diabetic Mice

(2020) Fang Liu et al.   Journal of Clinical Medicine

Chronic demyelination exacerbates neuroaxonal loss in patients with MS with unilateral optic neuritis

(2020) Yuyi You et al.   Neurology-Neuroimmunology & Neuroinflammation

Clinical presentation and diagnosis of multiple sclerosis

(2020) Helen Ford   CLINICAL MEDICINE

Alleviation of extensive visual pathway dysfunction by a remyelinating drug in a chronic mouse model of multiple sclerosis

(2020) Maria T. Sekyi et al.   BRAIN PATHOLOGY

Targeting Polyamine Oxidase to Prevent Excitotoxicity-Induced Retinal Neurodegeneration

(2019) Prahalathan Pichavaram et al.   Frontiers in Neuroscience

A metabolic profile of polyamines in parkinson disease: A promising biomarker

(2019) Shinji Saiki et al.   ANNALS OF NEUROLOGY

Deletion of Arginase 2 Ameliorates Retinal Neurodegeneration in a Mouse Model of Multiple Sclerosis

(2019) Chithra D. Palani et al.   MOLECULAR NEUROBIOLOGY

Emotional outcomes in clinically isolated syndrome and early phase multiple sclerosis: a systematic review and meta-analysis

(2019) A. Rintala et al.   JOURNAL OF PSYCHOSOMATIC RESEARCH

Nav1.6 promotes inflammation and neuronal degeneration in a mouse model of multiple sclerosis

(2019) Barakat Alrashdi et al.   Journal of Neuroinflammation

Laquinimod protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model

(2018) Anna T. Wilmes et al.   Journal of Neuroinflammation

Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study

(2018) Ludwig Kappos et al.   LANCET

Neuroprotective potential of spermidine against rotenone induced Parkinson's disease in rats

(2018) Sunaina Sharma et al.   NEUROCHEMISTRY INTERNATIONAL

Multiple Sclerosis: Mechanisms and Immunotherapy

(2018) Clare Baecher-Allan et al.   NEURON

Fatty Acids Dietary Supplements Exert Anti-Inflammatory Action and Limit Ganglion Cell Degeneration in the Retina of the EAE Mouse Model of Multiple Sclerosis

(2018) Massimo Dal Monte et al.   Nutrients

Multiple Sclerosis Pathology

(2018) Hans Lassmann   Cold Spring Harbor Perspectives in Medicine

Systemic Acrolein Elevations in Mice With Experimental Autoimmune Encephalomyelitis and Patients With Multiple Sclerosis

(2018) Melissa Tully et al.   Frontiers in Neurology

Early auto‐immune targeting of photoreceptor ribbon synapses in mouse models of multiple sclerosis

(2018) Mayur Dembla et al.   EMBO Molecular Medicine

Rapamycin and fingolimod modulate Treg/Th17 cells in experimental autoimmune encephalomyelitis by regulating the Akt-mTOR and MAPK/ERK pathways

(2018) Huiqing Hou et al.   JOURNAL OF NEUROIMMUNOLOGY

Sequential phases of RGC axonal and somatic injury in EAE mice examined using DTI and OCT

(2018) Christopher Nishioka et al.   Multiple Sclerosis and Related Disorders

The Role of ERK Signaling in Experimental Autoimmune Encephalomyelitis

(2017) Katharina Birkner et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rapamycin Ameliorates Experimental Autoimmune Encephalomyelitis by Suppressing the mTOR-STAT3 Pathway

(2017) Huiqing Hou et al.   NEUROCHEMICAL RESEARCH

Valproic acid and ASK1 deficiency ameliorate optic neuritis and neurodegeneration in an animal model of multiple sclerosis

(2017) Yuriko Azuchi et al.   NEUROSCIENCE LETTERS

Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis

(2017) Xavier Montalban et al.   NEW ENGLAND JOURNAL OF MEDICINE

The pathology associated with diabetic retinopathy

(2017) Judith Lechner et al.   VISION RESEARCH

Spermine oxidase promotes bile canalicular lumen formation through acrolein production

(2017) Takeshi Uemura et al.   Scientific Reports

Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy

(2016) C. Patel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Spermidine alleviates experimental autoimmune encephalomyelitis through inducing inhibitory macrophages

(2016) Q Yang et al.   CELL DEATH AND DIFFERENTIATION

AAV-mediated transduction and targeting of retinal bipolar cells with improved mGluR6 promoters in rodents and primates

(2016) Q Lu et al.   GENE THERAPY

Calpain inhibition reduces structural and functional impairment of retinal ganglion cells in experimental optic neuritis

(2016) Amena W. Smith et al.   JOURNAL OF NEUROCHEMISTRY

The incidence and prevalence of psychiatric disorders in multiple sclerosis: A systematic review

(2015) Ruth Ann Marrie et al.   Multiple Sclerosis Journal

Prenatal maternal immune activation increases anxiety- and depressive-like behaviors in offspring with experimental autoimmune encephalomyelitis

(2015) J. Majidi-Zolbanin et al.   NEUROSCIENCE

Molecular Mechanisms of Acrolein Toxicity: Relevance to Human Disease

(2015) Akshata Moghe et al.   TOXICOLOGICAL SCIENCES

Spermidine promotes retinal ganglion cell survival and optic nerve regeneration in adult mice following optic nerve injury

(2015) T Noro et al.   Cell Death & Disease

The incidence and prevalence of psychiatric disorders in multiple sclerosis: A systematic review

(2015) Ruth Ann Marrie et al.   Multiple Sclerosis Journal

Re-evaluating the treatment of acute optic neuritis

(2014) Jeffrey L Bennett et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase

(2014) R Chaturvedi et al.   ONCOGENE

Relationship between Optical Coherence Tomography and Electrophysiology of the Visual Pathway in Non-Optic Neuritis Eyes of Multiple Sclerosis Patients

(2014) Prema Sriram et al.   PLoS One

Arginase 2 deficiency reduces hyperoxia-mediated retinal neurodegeneration through the regulation of polyamine metabolism

(2014) S P Narayanan et al.   Cell Death & Disease

MitoQ, a mitochondria-targeted antioxidant, delays disease progression and alleviates pathogenesis in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis

(2013) Peizhong Mao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A role for spermine oxidase as a mediator of reactive oxygen species production in HIV-Tat-induced neuronal toxicity

(2013) Caterina Capone et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inflammatory demyelination induces glia alterations and ganglion cell loss in the retina of an experimental autoimmune encephalomyelitis model

(2013) Lioba Horstmann et al.   Journal of Neuroinflammation

A New Transgenic Mouse Model for Studying the Neurotoxicity of Spermine Oxidase Dosage in the Response to Excitotoxic Injury

(2013) Manuela Cervelli et al.   PLoS One

Metabolic profiling of Alzheimer's disease brains

(2013) Koichi Inoue et al.   Scientific Reports

Preclinical Retinal Neurodegeneration in a Model of Multiple Sclerosis

(2012) R. Fairless et al.   JOURNAL OF NEUROSCIENCE

Ganglion Cell Loss in Relation to Visual Disability in Multiple Sclerosis

(2012) Scott D. Walter et al.   OPHTHALMOLOGY

Spermine oxidase: ten years after

(2011) Manuela Cervelli et al.   AMINO ACIDS

Primary retinal pathology in multiple sclerosis as detected by optical coherence tomography

(2011) Shiv Saidha et al.   BRAIN

Vision in Multiple Sclerosis

(2011) Reiko E. Sakai et al.   JOURNAL OF NEURO-OPHTHALMOLOGY

Oxidative stress and reduced glutamine synthetase activity in the absence of inflammation in the cortex of mice with experimental allergic encephalomyelitis

(2011) A. Castegna et al.   NEUROSCIENCE

Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis

(2011) A. C. Goodwin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyamine patterns in the cerebrospinal fluid of patients with Parkinson's disease and multiple system atrophy

(2010) Man-Jeong Paik et al.   CLINICA CHIMICA ACTA

Anti-acrolein treatment improves behavioral outcome and alleviates myelin damage in experimental autoimmune enchephalomyelitis mouse

(2010) G. Leung et al.   NEUROSCIENCE

Polyamine Catabolism Is Enhanced after Traumatic Brain Injury

(2009) Kamyar Zahedi et al.   JOURNAL OF NEUROTRAUMA

Inflammatory demyelination induces axonal injury and retinal ganglion cell apoptosis in experimental optic neuritis

(2008) Kenneth S. Shindler et al.   EXPERIMENTAL EYE RESEARCH

Nuclear localization of human spermine oxidase isoforms - possible implications in drug response and disease etiology

(2008) Tracy Murray-Stewart et al.   FEBS Journal

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

Role of polyamine metabolism in kainic acid excitotoxicity in organotypic hippocampal slice cultures

(2003) Wei Liu et al.   JOURNAL OF NEUROCHEMISTRY