Antipsychotic-induced sensitization and tolerance: Behavioral characteristics, developmental impacts, and neurobiological mechanisms

Adolescent olanzapine sensitization is correlated with hippocampal stem cell proliferation in a maternal immune activation rat model of schizophrenia

(2015) Shinnyi Chou et al.   BRAIN RESEARCH

Repeated administration of aripiprazole produces a sensitization effect in the suppression of avoidance responding and phencyclidine-induced hyperlocomotion and increases D2 receptor-mediated behavioral function

(2015) Jun Gao et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Asenapine sensitization from adolescence to adulthood and its potential molecular basis

(2014) Qing Shu et al.   BEHAVIOURAL BRAIN RESEARCH

Effect of environmental cues on the behavioral efficacy of haloperidol, olanzapine, and clozapine in rats

(2014) Tao Sun et al.   BEHAVIOURAL PHARMACOLOGY

Experiencing antipsychotic discontinuation: results from a survey of Australian consumers

(2014) C. Salomon et al.   Journal of Psychiatric and Mental Health Nursing

Differential effects of intermittent versus continuous haloperidol treatment throughout adolescence on haloperidol sensitization and social behavior in adulthood

(2014) Jun Gao et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Use of Antipsychotic Drugs Among Dutch Youths Between 1997 and 2005

(2014) Luuk J. Kalverdijk et al.   PSYCHIATRIC SERVICES

Effects of central activation of serotonin 5-HT2A/2C or dopamine D2/3 receptors on the acute and repeated effects of clozapine in the conditioned avoidance response test

(2014) Min Feng et al.   PSYCHOPHARMACOLOGY

Prior Antipsychotic Drug Treatment Prevents Response to Novel Antipsychotic Agent in the Methylazoxymethanol Acetate Model of Schizophrenia

(2014) K. M. Gill et al.   SCHIZOPHRENIA BULLETIN

Time-dependence of risperidone and asenapine sensitization and associated D2 receptor mechanism

(2013) Jun Gao et al.   BEHAVIOURAL BRAIN RESEARCH

Preclinical models of antipsychotic drug action

(2013) José L. Moreno et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Olanzapine treatment of adolescent rats alters adult reward behaviour and nucleus accumbens function

(2013) Monika Vinish et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Adult response to olanzapine or clozapine treatment is altered by adolescent antipsychotic exposure: A preclinical test in the phencyclidine hyperlocomotion model

(2013) Qing Shu et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis

(2013) Stefan Leucht et al.   LANCET

Repeated asenapine treatment produces a sensitization effect in two preclinical tests of antipsychotic activity

(2013) Rongyin Qin et al.   NEUROPHARMACOLOGY

Tardive dyskinesia syndromes: current concepts

(2013) Camila Catherine H. Aquino et al.   PARKINSONISM & RELATED DISORDERS

Olanzapine Treatment of Adolescent Rats Causes Enduring Specific Memory Impairments and Alters Cortical Development and Function

(2013) Jean A. Milstein et al.   PLoS One

Long-term impacts of adolescent risperidone treatment on behavioral responsiveness to olanzapine and clozapine in adulthood

(2013) Jing Qiao et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Long-lasting sensitization induced by repeated risperidone treatment in adolescent Sprague-Dawley rats: a possible D2 receptor mediated phenomenon?

(2013) Jing Qiao et al.   PSYCHOPHARMACOLOGY

Environmental and behavioral controls of the expression of clozapine tolerance: Evidence from a novel across-model transfer paradigm

(2012) Min Feng et al.   BEHAVIOURAL BRAIN RESEARCH

Drug–drug conditioning between citalopram and haloperidol or olanzapine in a conditioned avoidance response model

(2012) Nathan L. Sparkman et al.   BEHAVIOURAL PHARMACOLOGY

Parametric studies of antipsychotic-induced sensitization in the conditioned avoidance response model

(2012) Natashia Swalve et al.   BEHAVIOURAL PHARMACOLOGY

New insights into the mechanism of drug-induced dyskinesia

(2012) Anton J. M. Loonen et al.   CNS SPECTRUMS

Hyperactivity induced by the dopamine D2/D3 receptor agonist quinpirole is attenuated by inhibitors of endocannabinoid degradation in mice

(2012) María Jesús Luque-Rojas et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Olanzapine Sensitization and Clozapine Tolerance: From Adolescence to Adulthood in the Conditioned Avoidance Response Model

(2012) Jing Qiao et al.   NEUROPSYCHOPHARMACOLOGY

Neural basis of the potentiated inhibition of repeated haloperidol and clozapine treatment on the phencyclidine-induced hyperlocomotion

(2012) Changjiu Zhao et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Gender differences in cognitive function of patients with chronic schizophrenia

(2012) Mei Han et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Risperidone reverses phencyclidine induced decrease in glutathione levels and alterations of antioxidant defense in rat brain

(2012) Tihomir Stojković et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Neurological Functions of the Masterswitch Protein Kinase – Gsk-3

(2012) Oksana Kaidanovich-Beilin et al.   Frontiers in Molecular Neuroscience

Contextual and behavioral control of antipsychotic sensitization induced by haloperidol and olanzapine

(2011) Chen Zhang et al.   BEHAVIOURAL PHARMACOLOGY

Effects of risperidone treatment in adolescence on hippocampal neurogenesis, parvalbumin expression, and vascularization following prenatal immune activation in rats

(2011) Yael Piontkewitz et al.   BRAIN BEHAVIOR AND IMMUNITY

Tracing the development of psychosis and its prevention: What can be learned from animal models

(2011) Yael Piontkewitz et al.   NEUROPHARMACOLOGY

Time course of the attenuation effect of repeated antipsychotic treatment on prepulse inhibition disruption induced by repeated phencyclidine treatment

(2011) Ming Li et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Discovery of  -Arrestin-Biased Dopamine D2 Ligands for Probing Signal Transduction Pathways Essential for Antipsychotic Efficacy

(2011) J. A. Allen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functions of GSK-3 Signaling in Development of the Nervous System

(2011) Woo-Yang Kim et al.   Frontiers in Molecular Neuroscience

All Roads to Schizophrenia Lead to Dopamine Supersensitivity and Elevated Dopamine D2High Receptors

(2010) Philip Seeman   CNS Neuroscience & Therapeutics

“Extended” Antipsychotic Dosing in the Maintenance Treatment of Schizophrenia

(2010) Gary Remington et al.   JOURNAL OF CLINICAL PSYCHIATRY

A naturalistic controlled study of relapsing schizophrenic patients with tardive dyskinesia and supersensitivity psychosis

(2010) Paul Fallon et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Anxiolytic-like property of risperidone and olanzapine as examined in multiple measures of fear in rats

(2010) Tao Sun et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Olanzapine and risperidone disrupt conditioned avoidance responding by selectively weakening motivational salience of conditioned stimulus: Further evidence

(2010) Chen Zhang et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Distinct neural mechanisms underlying acute and repeated administration of antipsychotic drugs in rat avoidance conditioning

(2010) Ming Li et al.   PSYCHOPHARMACOLOGY

Antipsychotic Dosing: How Much but also How Often?

(2010) G. Remington et al.   SCHIZOPHRENIA BULLETIN

Risperidone Administered During Asymptomatic Period of Adolescence Prevents the Emergence of Brain Structural Pathology and Behavioral Abnormalities in an Animal Model of Schizophrenia

(2010) Y. Piontkewitz et al.   SCHIZOPHRENIA BULLETIN

Signaling pathways in schizophrenia: emerging targets and therapeutic strategies

(2010) Caline S. Karam et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Roles of the Akt/GSK-3 and Wnt Signaling Pathways in Schizophrenia and Antipsychotic Drug Action

(2009) Zachary Freyberg et al.   AMERICAN JOURNAL OF PSYCHIATRY

Olanzapine and risperidone disrupt conditioned avoidance responding in phencyclidine-pretreated or amphetamine-pretreated rats by selectively weakening motivational salience of conditioned stimulus

(2009) Ming Li et al.   BEHAVIOURAL PHARMACOLOGY

An investigation of the behavioral mechanisms of antipsychotic action using a drug–drug conditioning paradigm

(2009) Ming Li et al.   BEHAVIOURAL PHARMACOLOGY

Clozapine Administration in Adolescence Prevents Postpubertal Emergence of Brain Structural Pathology in an Animal Model of Schizophrenia

(2009) Yael Piontkewitz et al.   BIOLOGICAL PSYCHIATRY

Effects of repeated risperidone exposure on serotonin receptor subtypes in developing rats

(2009) Yong Kee Choi et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Avoidance-suppressing effect of antipsychotic drugs is progressively potentiated after repeated administration: an interoceptive drug state mechanism

(2009) A. Mead et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Atypical antipsychotics as noncompetitive inhibitors of α4β2 and α7 neuronal nicotinic receptors

(2009) Vladimir P. Grinevich et al.   NEUROPHARMACOLOGY

The receptor mechanisms underlying the disruptive effects of haloperidol and clozapine on rat maternal behavior: A double dissociation between dopamine D2 and 5-HT2A/2C receptors

(2009) Changjiu Zhao et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Less Is More: Antipsychotic Drug Effects Are Greater with Transient Rather Than Continuous Delivery

(2008) Anne-Noël Samaha et al.   BIOLOGICAL PSYCHIATRY

Repeated antipsychotic treatment progressively potentiates inhibition on phencyclidine-induced hyperlocomotion, but attenuates inhibition on amphetamine-induced hyperlocomotion: Relevance to animal models of antipsychotic drugs

(2008) Tao Sun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effects of risperidone on glutamate receptor subtypes in developing rat brain

(2008) Yong Kee Choi et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Switching antipsychotics. Antipsychotic tolerance, withdrawal and relapse: unresolved issues and research implications

(2008) AJ Goudie et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Developmental treatment with the dopamine D2/3 agonist quinpirole selectively impairs spatial learning in the Morris water maze

(2008) Charles V. Vorhees et al.   NEUROTOXICOLOGY AND TERATOLOGY

Epidemiologic Features of Antipsychotic Prescribing to Children and Adolescents in Primary Care in the United Kingdom

(2008) F. Rani et al.   PEDIATRICS

Antipsychotic Drugs: Comparison in Animal Models of Efficacy, Neurotransmitter Regulation, and Neuroprotection

(2008) J. A. Lieberman et al.   PHARMACOLOGICAL REVIEWS

Clozapine and olanzapine exhibit an intrinsic anxiolytic property in two conditioned fear paradigms: Contrast with haloperidol and chlordiazepoxide

(2008) A MEAD et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Sedation and disruption of maternal motivation underlie the disruptive effects of antipsychotic treatment on rat maternal behavior

(2008) Changjiu Zhao et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Antagonism of dopamine D2 receptor/ -arrestin 2 interaction is a common property of clinically effective antipsychotics

(2008) B. Masri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluating Early Preventive Antipsychotic and Antidepressant Drug Treatment in an Infection-Based Neurodevelopmental Mouse Model of Schizophrenia

(2008) U. Meyer et al.   SCHIZOPHRENIA BULLETIN

Does switching to a new antipsychotic improve outcomes?

(2008) Robert A Rosenheck et al.   SCHIZOPHRENIA RESEARCH

Dopamine D2High receptors moderately elevated by sertindole

(2008) Philip Seeman   SYNAPSE