The human batokine EPDR1 regulates β-cell metabolism and function

Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis

(2022) Shogo Sato et al.   Cell Metabolism

Islet Gene View—a tool to facilitate islet research

(2022) Olof Asplund et al.   Life Science Alliance

EPDR1 is a noncanonical effector of insulin-mediated angiogenesis regulated by an endothelial-specific TGF-β receptor complex

(2022) Tasmia Ahmed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EPDR1 is related to stages and metastasize in bladder cancer and can be used as a prognostic biomarker

(2021) Yue Yang et al.   BMC Urology

A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development

(2021) Pia A. Johansson et al.   Cell Stem Cell

EPDR1 up-regulation in human colorectal cancer is related to staging and favours cell proliferation and invasiveness

(2020) F. Gimeno-Valiente et al.   Scientific Reports

The Interplay Between Bone and Glucose Metabolism

(2020) Cristiana Cipriani et al.   Frontiers in Endocrinology

EPDR1 correlates with immune cell infiltration in hepatocellular carcinoma and can be used as a prognostic biomarker

(2020) Ruochan Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D

(2020) Ana Viñuela et al.   Nature Communications

Multiomic Profiling Identifies cis-Regulatory Networks Underlying Human Pancreatic β Cell Identity and Function

(2019) Nathan Lawlor et al.   Cell Reports

Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells

(2019) Elizabeth Haythorne et al.   Nature Communications

Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine

(2019) Atul S. Deshmukh et al.   Cell Metabolism

The effects of high glucose exposure on global gene expression and DNA methylation in human pancreatic islets

(2018) Elin Hall et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Prognostic Values of EPDR1 Hypermethylation and Its Inhibitory Function on Tumor Invasion in Colorectal Cancer

(2018) Chun-Ho Chu et al.   Cancers

Genetics of glaucoma

(2017) Janey L. Wiggs et al.   HUMAN MOLECULAR GENETICS

Mapping of human brown adipose tissue in lean and obese young men

(2017) Brooks P. Leitner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prolonged Activation of the Htr2b Serotonin Receptor Impairs Glucose Stimulated Insulin Secretion and Mitochondrial Function in MIN6 Cells

(2017) Luis Rodrigo Cataldo et al.   PLoS One

Single-cell transcriptomes identify human islet cell signatures and reveal cell-type–specific expression changes in type 2 diabetes

(2016) Nathan Lawlor et al.   GENOME RESEARCH

Dupuytren’s disease susceptibility gene, EPDR1, is involved in myofibroblast contractility

(2016) Kim A. Staats et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma

(2016) Chiea Chuen Khor et al.   NATURE GENETICS

In silico RNA-seq and experimental analyses reveal the differential expression and splicing of EPDR1 and ZNF518B genes in relation to KRAS mutations in colorectal cancer cells

(2016) Ángela L. Riffo-Campos et al.   ONCOLOGY REPORTS

Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses

(2015) Huifang Wei et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets

(2015) David M. Blodgett et al.   DIABETES

Identification of novel genes for glucose metabolism based upon expression pattern in human islets and effect on insulin secretion and glycemia

(2014) Jalal Taneera et al.   HUMAN MOLECULAR GENETICS

Glutamate Acts as a Key Signal Linking Glucose Metabolism to Incretin/cAMP Action to Amplify Insulin Secretion

(2014) Ghupurjan Gheni et al.   Cell Reports

Imaging energy status in live cells with a fluorescent biosensor of the intracellular ATP-to-ADP ratio

(2013) Mathew Tantama et al.   Nature Communications

Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal β-cell lines

(2011) Peter Spégel et al.   BIOCHEMICAL JOURNAL

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion

(2011) Philippe Ravassard et al.   JOURNAL OF CLINICAL INVESTIGATION

Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal β-cells

(2010) Ulrika Krus et al.   BIOCHEMICAL JOURNAL

Regulation of insulin secretion: role of mitochondrial signalling

(2010) S. Jitrapakdee et al.   DIABETOLOGIA

Identification of genes selectively disallowed in the pancreatic islet

(2010) Timothy J. Pullen et al.   Islets

Tight Coupling between Glucose and Mitochondrial Metabolism in Clonal β-Cells Is Required for Robust Insulin Secretion

(2009) Siri Malmgren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Why expression of some genes is disallowed in β-cells

(2008) Roel Quintens et al.   BIOCHEMICAL SOCIETY TRANSACTIONS