Iripin-1, a new anti-inflammatory tick serpin, inhibits leukocyte recruitment in vivo while altering the levels of chemokines and adhesion molecules

Serpins in Tick Physiology and Tick-Host Interaction

(2022) Muhammad Nadeem Abbas et al.   Frontiers in Cellular and Infection Microbiology

The tick and I: Parasite‐host interactions between ticks and humans

(2022) Michael P. Schön   JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT

Iripin-3, a New Salivary Protein Isolated From Ixodes ricinus Ticks, Displays Immunomodulatory and Anti-Hemostatic Properties In Vitro

(2021) Adéla Chlastáková et al.   Frontiers in Immunology

A Comprehensive Phylogenetic Analysis of the Serpin Superfamily

(2021) Matthew A Spence et al.   MOLECULAR BIOLOGY AND EVOLUTION

The Serpin Superfamily and Their Role in the Regulation and Dysfunction of Serine Protease Activity in COPD and Other Chronic Lung Diseases

(2021) Gillian A. Kelly-Robinson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ixodes ricinus Salivary Serpin Iripin-8 Inhibits the Intrinsic Pathway of Coagulation and Complement

(2021) Jan Kotál et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural and biochemical characterization of the novel serpin Iripin-5 from Ixodes ricinus

(2021) Barbora Kascakova et al.   Acta Crystallographica Section D-Structural Biology

A critical role for plasminogen in inflammation

(2020) Sarah K. Baker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Amblyomma americanum serpin 41 (AAS41) inhibits inflammation by targeting chymase and chymotrypsin

(2020) Tae Kwon Kim et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Rhipicephalus microplus serpins interfere with host immune responses by specifically modulating mast cells and lymphocytes

(2020) Mariana L. Coutinho et al.   Ticks and Tick-Borne Diseases

TickSialoFam (TSFam): A Database That Helps to Classify Tick Salivary Proteins, a Review on Tick Salivary Protein Function and Evolution, With Considerations on the Tick Sialome Switching Phenomenon

(2020) José M. C. Ribeiro et al.   Frontiers in Cellular and Infection Microbiology

Tick Salivary Compounds for Targeted Immunomodulatory Therapy

(2020) Hajer Aounallah et al.   Frontiers in Immunology

Plasmin-mediated fibrinolysis enables macrophage migration in a murine model of inflammation

(2019) Lakmali Munasinghage Silva et al.   BLOOD

Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission

(2019) Ryan O. M. Rego et al.   Parasites & Vectors

A knottin scaffold directs the CXC-chemokine–binding specificity of tick evasins

(2019) Angela W. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Surface loops of trypsin-like serine proteases as determinants of function

(2019) Peter Goettig et al.   BIOCHIMIE

Amblyomma americanum serpin 27 (AAS27) is a tick salivary anti-inflammatory protein secreted into the host during feeding

(2019) Lucas Tirloni et al.   PLoS Neglected Tropical Diseases

The Use of Tick Salivary Proteins as Novel Therapeutics

(2019) Jindřich Chmelař et al.   Frontiers in Physiology

Serine protease inhibitors and human wellbeing interplay: new insights for old friends

(2019) Héla Mkaouar et al.   PeerJ

The immunosuppressive functions of two novel tick serpins, HlSerpin‐a and HlSerpin‐b, from Haemaphysalis longicornis

(2019) Fanqi Wang et al.   IMMUNOLOGY

Biology and therapeutic potential of interleukin-10

(2019) Margarida Saraiva et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Immunomodulatory Effect of IrSPI, a Tick Salivary Gland Serine Protease Inhibitor Involved in Ixodes ricinus Tick Feeding

(2019) Adrien A. Blisnick et al.   Vaccines

The Peritoneal Macrophages in Inflammatory Diseases and Abdominal Cancers

(2018) Ting Liu et al.   ONCOLOGY RESEARCH

Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets

(2018) Yara Alenazi et al.   Scientific Reports

The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hunt for New Therapeutic Targets

(2018) Elden Berla Thangam et al.   Frontiers in Immunology

Plasma kallikrein modulates immune cell trafficking during neuroinflammation via PAR2 and bradykinin release

(2018) Kerstin Göbel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extended Cleavage Specificity of Human Neutrophil Elastase, Human Proteinase 3, and Their Distant Ortholog Clawed Frog PR3—Three Elastases With Similar Primary but Different Extended Specificities and Stability

(2018) Zhirong Fu et al.   Frontiers in Immunology

Ticks from diverse genera encode chemokine-inhibitory evasin proteins

(2017) Jenni Hayward et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Essential Role of Tick Salivary Glands and Saliva in Tick Feeding and Pathogen Transmission

(2017) Ladislav Šimo et al.   Frontiers in Cellular and Infection Microbiology

Transendothelial migration: unifying principles from the endothelial perspective

(2016) William A. Muller   IMMUNOLOGICAL REVIEWS

The putative role of Rhipicephalus microplus salivary serpins in the tick-host relationship

(2016) Lucas Tirloni et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Ixodes ricinus Salivary Serpin IRS-2 Affects Th17 Differentiation via Inhibition of the Interleukin-6/STAT-3 Signaling Pathway

(2015) Jana Páleníková et al.   INFECTION AND IMMUNITY

Tick saliva increases production of three chemokines including monocyte chemoattractant protein-1, a histamine-releasing cytokine

(2015) H. Langhansová et al.   PARASITE IMMUNOLOGY

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

(2014) Jason W. Griffith et al.   Annual Review of Immunology

Leukocyte Migration into Inflamed Tissues

(2014) Sussan Nourshargh et al.   IMMUNITY

Plasma kallikrein: the bradykinin-producing enzyme

(2013) Jenny Björkqvist et al.   THROMBOSIS AND HAEMOSTASIS

So Many Plasminogen Receptors: Why?

(2012) Edward F. Plow et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Early Immunologic Events at the Tick-Host Interface

(2012) Dar M. Heinze et al.   PLoS One

Serpin structure, function and dysfunction

(2011) J. A. HUNTINGTON   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Extracellular matrix determinants of proteolytic and non-proteolytic cell migration

(2011) Katarina Wolf et al.   TRENDS IN CELL BIOLOGY

Decreased CXCR1 and CXCR2 expression on neutrophils in anti-neutrophil cytoplasmic autoantibody-associated vasculitides potentially increases neutrophil adhesion and impairs migration

(2011) Nan Hu et al.   ARTHRITIS RESEARCH & THERAPY

A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation

(2010) J. Chmelar et al.   BLOOD

Proinflammatory activation pattern of human umbilical vein endothelial cells induced by IL-1β, TNF-α, and LPS

(2010) Veronika Makó et al.   CYTOMETRY PART A

Tick Histamine Release Factor Is Critical for Ixodes scapularis Engorgement and Transmission of the Lyme Disease Agent

(2010) Jianfeng Dai et al.   PLoS Pathogens

Exosites mediate the anti-inflammatory effects of a multifunctional serpin from the saliva of the tickIxodes ricinus

(2009) Pierre-Paul Prevot et al.   FEBS Journal

CD99 Is Essential for Leukocyte Diapedesis In Vivo

(2008) Eric M. Dufour et al.   CELL COMMUNICATION AND ADHESION

Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice

(2008) Yanqing Gong et al.   JOURNAL OF CLINICAL INVESTIGATION

Salivating for Knowledge: Potential Pharmacological Agents in Tick Saliva

(2008) Joppe W. R Hovius et al.   PLOS MEDICINE

Good statistical practice in pharmacology Problem 2

(2007) M Lew   BRITISH JOURNAL OF PHARMACOLOGY

Mechanisms underlying the nociceptive and inflammatory responses induced by trypsin in the mouse paw

(2007) Ana Flávia Paszcuk et al.   EUROPEAN JOURNAL OF PHARMACOLOGY