Review
Cardiac & Cardiovascular Systems
Junqi Wang, Xiaoping Chen
Summary: This review summarizes the roles of JAMs in the development of atherosclerosis and predicts future research directions.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Carina Mauersberger, Julia Hinterdobler, Heribert Schunkert, Thorsten Kessler, Hendrik B. Sager
Summary: This article comprehensively reviews the process of leukocyte recruitment relevant to atherosclerosis, with a focus on endothelial cells, monocytes and macrophages, neutrophils, T lymphocytes and platelets. Therapeutic options targeting leukocyte recruitment into atherosclerotic lesions, as well as potential insights into its precise mechanisms, are also highlighted.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Microbiology
Zhaolei Zou, Juan Fang, Wanting Ma, Junyi Guo, Zhongyan Shan, Da Ma, Qiannan Hu, Liling Wen, Zhi Wang
Summary: In this study, it was found that gingipains from P. gingivalis can degrade PECAM-1 to facilitate bacterial penetration and at the same time reduce leukocyte TEM capacity. The role of gingipains in modulating vascular barrier permeability and TEM processes provides a new understanding of the distal colonization of P. gingivalis and its associated systemic diseases.
MICROBIOLOGY SPECTRUM
(2023)
Review
Oncology
Katerina Jerabkova-Roda, Amandine Dupas, Nael Osmani, Vincent Hyenne, Jacky G. Goetz
Summary: The intravascular behavior of tumor-derived extracellular vesicles (EVs) and circulating tumor cells (CTCs) plays a crucial role in the metastatic cascade. Understanding the role of cellular adhesion molecules (CAMs) and their endothelial ligands in dictating the arrest site and exit capacity of EVs/CTCs could provide insight into novel targets for therapies. Exploring the differences and similarities between CAMs on CTCs and EVs may help in understanding their role in organotropism of different cancer types.
Article
Oncology
Jiayin Yuan, Takako Kihara, Neinei Kimura, Takashi Yamasaki, Makoto Yoshida, Koji Isozaki, Akihiko Ito, Seiichi Hirota
Summary: High expression of CADM1 in small intestinal GISTs may contribute to tumor cell metastasis by enhancing adhesion to endothelial cells and transendothelial migration. CADM1 could be a potential therapeutic target for inhibiting metastasis in small intestinal GISTs.
Article
Cell Biology
Aarren J. Mannion, Adam F. Odell, Alison Taylor, Pamela F. Jones, Graham P. Cook
Summary: CD99 plays a complex role in tumor progression, by promoting adhesion between tumor cells and endothelial cells while inhibiting invasion and migratory activity. It negatively regulates CDC42 and cell migration, demonstrating its dual pro- and anti-tumor activities, with implications in inhibiting metastatic progression in breast cancer.
JOURNAL OF CELL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Max Laurens Bastiaan Gronloh, Janine Johanna Geertruida Arts, Eike Karin Mahlandt, Martijn A. Nolte, Joachim Goedhart, Jaap Diederik van Buul
Summary: During inflammation, primary neutrophil adhesion to the endothelium triggers the formation of transmigration hotspots, allowing secondary neutrophils to cross the endothelium more efficiently. This process is mediated by the activation of JNK1 and MARCKSL1, which induces the formation of filopodia and increases neutrophil adhesion.
Article
Biochemistry & Molecular Biology
Taiki Tojo, Minako Yamaoka-Tojo
Summary: This study investigated the molecular and cellular mechanisms underlying stenotic calcification of the aortic valve. Gene expression analysis of human aortic stenosis and normal aortic valve tissue identified differentially expressed genes (DEGs) associated with valve calcification and disease progression. Protein-protein interaction analysis revealed hub genes that could serve as potential biomarkers and therapeutic targets for aortic stenosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Biomaterials
Zhe Hou, Maolong Xiang, Nuoya Chen, Xiao Cai, Bo Zhang, Rifang Luo, Li Yang, Xiaoyi Ma, Lifeng Zhou, Fugui He, Hongchi Yu, Yunbing Wang
Summary: Magnesium alloy shows promise in cardiovascular stent applications, but it may affect migration and adhesion of endothelial cells, leading to inhibited re-endothelialization within the stent.
REGENERATIVE BIOMATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Marie Cade, Javier Munoz-Garcia, Antoine Babuty, Louis Pare, Denis Cochonneau, Karim Fekir, Mathias Chatelais, Marie-Francoise Heymann, Anna Lokajczyk, Catherine Boisson-Vidal, Dominique Heymann
Summary: This study discovered that recombinant human FVIII has direct biological activities on endothelial cells, including decreased cell adhesion, regulation of transcriptomic and protein profiles, increased vascular permeability, and enhanced monocyte adhesion. The findings highlight new functions of FVIII in regulating vascular permeability and leukocyte adhesion and migration.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Max L. B. Gronloh, Janine J. G. Arts, Sebastian Palacios Martinez, Amerens A. van Der Veen, Lanette Kempers, Abraham C. van Steen, Joris J. T. H. Roelofs, Martijn A. Nolte, Joachim Goedhart, Jaap D. van Buul
Summary: Using a photoconvertible probe, researchers traced and identified the original endothelial transmigration hotspots, and found that these hotspots function to limit vascular leakage during transmigration events. The distribution of ICAM-1 determines the location of the transmigration hotspot.
Article
Oncology
Noureddine Ben Khalaf, Dalal Al-Mehatab, Dahmani M. Fathallah
Summary: In this study, it was shown that ERp72 is overexpressed on vascular endothelial cells in the early phase of the inflammatory response following skeletal muscle injury. This upregulation of ERp72 may potentially play a role in skeletal muscle inflammation and modulate leukocyte-endothelial cell interactions.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Immunology
Kim C. M. Jeucken, Charlotte C. N. van Rooijen, Yik Y. Kan, Lotte A. Kocken, Aldo Jongejan, Abraham C. van Steen, Jaap D. van Buul, Henric K. Olsson, Jan Piet van Hamburg, Sander W. Tas
Summary: The study shows that CD4(+) memory T cells can induce inflammatory responses in endothelial cells, and inhibition of NF-kappa B signaling can modulate these responses. Moreover, pharmacological inhibitors of NF-kappa B signaling can potentiate the effects of current therapies for IMIDs on endothelial cell inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Thomas D. Manes, Vivian Wang, Jordan S. Pober
Summary: Endothelial cells can present antigens to T cells, triggering antigen-specific extravasation. Our study found that certain costimulator proteins expressed by endothelial cells can modulate T cell migration and cytokine production, with effects varying between different T cell types.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Xinyue Yao, Wanwan Dai, Siyu Yang, Zhaoli Wang, Qian Zhang, Qinghui Meng, Tao Zhang
Summary: Highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) can infect porcine pulmonary microvascular endothelial cells (MVECs) and damage the endothelial glycocalyx. This study further explored the synergistic effect of HP-PRRSV and lipopolysaccharide (LPS) on the inflammatory response of MVECs. The results provide insights into the mechanism of severe lung injury caused by secondary bacterial infection following HP-PRRSV infection.