Article
Biochemistry & Molecular Biology
Sheng Qiu, Zerong Liang, Qinan Wu, Miao Wang, Mengliu Yang, Chen Chen, Hongting Zheng, Zhiming Zhu, Ling Li, Gangyi Yang
Summary: The study reveals that Nrf2 deficiency promotes hepatic lipid accumulation by enhancing SREBP-1c activity and attenuating autophagy. Additionally, the Nrf2-LAMP1 interaction plays a crucial role in regulating Nrf2-mediated hepatosteatosis.
Article
Food Science & Technology
Eunjeong Hong, Hyuno Kang, Garam Yang, Sejong Oh, Eungseok Kim
Summary: The study aimed to evaluate the protective effect of Lactobacillus johnsonii JNU3402 (LJ3402) against diet-induced non-alcoholic fatty liver disease (NAFLD) and investigate the underlying mechanism. The results show that LJ3402 supplementation alleviates liver steatosis, diet-induced obesity, and insulin resistance by reducing the expression of lipogenic genes and increasing SREBP-1c phosphorylation. Mechanistic study reveals that LJ3402 inhibits SREBP-1c transcriptional activity through the lactate-PKA pathway.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Huiling Hu, Nannan Sun, Haiyan Du, Yuqing He, Kunyi Pan, Xiuli Liu, Xiaoxia Lu, Jie Wei, Mianmian Liao, Chaohui Duan
Summary: Previous studies have shown that PLZF plays a role in promoting gluconeogenic gene expression, hepatic glucose output, and consequent hyperglycemia. However, its role in regulating lipid metabolism was unknown. This study revealed that PLZF is an essential regulator of hepatic lipid and glucose metabolism. Overexpression of PLZF in the liver led to fatty liver, inflammation, impaired glucose tolerance, and insulin sensitivity. Knockdown of PLZF in obese mice alleviated hepatic steatosis. The underlying mechanism involved PLZF activating SREBP-1c gene transcription by binding to its promoter fragment, which depended on its interaction with SIRT1 to induce a repressor-to-activator conversion. These findings suggest that modulating PLZF expression in the liver could be a potential therapeutic approach for treating NAFLD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Huazhen Liu, Yonger Chen, Yifan Wen, Shumin Zhu, Song Huang, Lian He, Shaozhen Hou, Xiaoping Lai, Shuxian Chen, Zhenhua Dai, Jian Liang
Summary: The study demonstrated that phloridzin can effectively alleviate nonalcoholic fatty liver disease by regulating lipid metabolism and insulin resistance through inhibiting the mTORC1/SREBP-1c pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Fei Luo, Chao Xing, Sumeet K. Asrani, Shili Li, Guosheng Liang, Helen H. Hobbs, Jonathan C. Cohen
Summary: This study identified a missense variant in the insulin receptor associated with fatty liver disease in a four generation family, but experiments in mice failed to show a causal relationship between this variant and the disease or any impact on hepatic triglyceride metabolism.
MOLECULAR METABOLISM
(2021)
Article
Pharmacology & Pharmacy
Meng Liang, Mohan Huo, Yi Guo, Yuyi Zhang, Xiao Xiao, Jianwen Xv, Lixue Fang, Tianqi Li, Huan Wang, Siyu Dong, Xiaowen Jiang, Wenhui Yu
Summary: Artemisia capillaris extract can improve NAFLD and obesity by activating the PI3K/AKT pathway, reducing SREBP-1c protein expression, decreasing fatty acid synthesis, and reducing lipid accumulation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Thi Hoa Pham, Gi Ho Lee, Sun Woo Jin, Seung Yeon Lee, Eun Hee Han, Nam Doo Kim, Chul Yung Choi, Gil-Saeng Jeong, Sang Ki Lee, Hyung Sik Kim, Hye Gwang Jeong
Summary: This study found that sesamin can effectively reduce lipid accumulation, alleviate lipotoxicity, and improve lipid metabolism imbalance. Additionally, sesamin can regulate key factors involved in lipogenesis and lipolysis by activating specific signaling pathways. These findings suggest that sesamin may be a promising candidate for treating hepatic steatosis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Atefeh Raesi Vanani, Heibatullah Kalantari, Masoud Mahdavinia, Mohammad Rashno, Layasadat Khorsandi, Mohammad Javad Khodayar
Summary: The study found that DMF supplementation can reduce the development of NAFLD induced by HFD in mice by modulating transcription factors such as Nrf2, SREBP-1c, and NF-kappa B.
Article
Biochemistry & Molecular Biology
Tomomi Yamazaki, Megumi Ihato
Summary: PPAR-alpha prevents fatty liver caused by excessive sucrose intake through regulating SREBP-1c target gene expression and liver TG accumulation. Gender differences may be related to the expression level of PPAR-gamma.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.
Article
Food Science & Technology
Yue-Qiang Huang, Yi-Xi Tang, Bai-Hao Qiu, Milton Talukder, Xue-Nan Li, Jin-Long Li
Summary: DEHP exposure can cause liver damage in quails, resulting in lipid metabolism disorders and inflammatory response.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Medicine, Research & Experimental
Lu Fan, Hongjuan Niu, Linyi Zhao, Rongfei Yao, Xu He, Binan Lu, Zongran Pang
Summary: The study found that PRD has significant therapeutic effects on aged type 2 diabetes mellitus with non-alcoholic fatty liver disease. After treatment, insulin sensitivity and insulin resistance were improved, and lipid metabolism indexes in the blood and lipid accumulation in the liver tissue were significantly reduced.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Food Science & Technology
Bo Ra Moon, Ji Sook Han
Summary: This study investigated the effects of HM-chromanone on lipid accumulation in adipose tissue and liver of ob/ob mice. HM-chromanone treatment resulted in reduced body weight, liver weight, fat mass, and fat size. Furthermore, HM-chromanone administration decreased serum lipid levels and hepatic lipid accumulation. These effects were mediated by the activation of AMPK and inhibition of SREBP-1c, PPAR gamma, C/EBP alpha, FAS, and ACC in adipose tissue and liver.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Food Science & Technology
Wenjuan Yang, Shirui Cheng, Meng Liu, Nan Li, Jing Wang, Wenbo Yao, Fuxin Chen, Jianwu Xie, Pin Gong
Summary: Tea polysaccharide FTP3 has lipid-lowering effects and can reduce lipid accumulation, activate AMPK, and decrease the expressions of SREBP-1C and FAS proteins.
Article
Agriculture, Dairy & Animal Science
Yiwei Zhu, Lin Lei, Xinghui Wang, Qianming Jiang, Juan J. Loor, Fanrong Kong, Linfang Chen, Jinxia Li, Chenchen Zhao, Menglin Liu, Guowen Liu, Xinwei Li
Summary: This study aims to investigate the potential role of the INSIG1-SCAP-SREBP-1c axis in the progression of fatty liver in dairy cows. It was found that cows with severe fatty liver had higher levels of β-hydroxybutyrate and free fatty acids and lower level of glucose in their blood. The liver of these cows also exhibited lower abundance of INSIG1 protein and higher abundance of SCAP and SREBP-1c proteins. Furthermore, in vitro experiments showed that decreased INSIG1 abundance contributed to enhanced SREBP-1c processing and triglyceride synthesis in hepatocytes. Therefore, the INSIG1-SCAP-SREBP-1c axis may serve as a potential target for the treatment of fatty liver in dairy cows.
JOURNAL OF DAIRY SCIENCE
(2023)
Review
Neurosciences
Puneet Talwar, Renu Gupta, Suman Kushwaha, Rachna Agarwal, Luciano Saso, Shrikant Kukreti, Ritushree Kukreti
CURRENT NEUROPHARMACOLOGY
(2019)
Review
Medicine, Research & Experimental
Vikas Yadav, Puneet Talwar
BIOMEDICINE & PHARMACOTHERAPY
(2019)
Article
Biochemistry & Molecular Biology
Rukshar Khan, Vinitha Kadamkode, Devesh Kesharwani, Sudarshana Purkayastha, Gautam Banerjee, Malabika Datta
Correction
Pharmacology & Pharmacy
Debleena Guin, Jyoti Rani, Priyanka Singh, Sandeep Grover, Shivangi Bora, Puneet Talwar, Muthusamy Karthikeyan, K. Satyamoorthy, C. Adithan, S. Ramachandran, Luciano Saso, Yasha Hasija, Ritushree Kukreti
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Cell Biology
Dror Sever, Anat Hershko-Moshe, Rohit Srivastava, Roy Eldor, Daniel Hibsher, Hadas Keren-Shaul, Ido Amit, Federico Bertuzzi, Lars Krogvold, Knut Dahl-Jorgensen, Iddo Z. Ben-Dov, Limor Landsman, Danielle Melloul
Summary: NF-kappa B plays a crucial role in the early developmental stages of insulin-producing cells, affecting the balance of beta-cell proliferation and apoptosis. Inhibiting NF-kappa B activation in beta-cells during embryogenesis increases beta-cell turnover, leading to reduced beta-cell mass.
CELL DEATH DISCOVERY
(2021)
Article
Oncology
Arun Nandwani, Shalu Rathore, Malabika Datta
Summary: Long noncoding RNAs (lncRNAs) play critical roles in regulating cellular processes and maintaining cell function, associated with a range of diseases and potential therapeutic targets. Interaction with chromatin, proteins, or RNA affects cellular proliferation, migration, differentiation, apoptosis, and cell death, making them key players in various cancers.
Article
Biochemistry & Molecular Biology
V. M. Balaramnavar, R. Srivastava, S. Varshney, S. Kumar, A. K. Rawat, H. Chandasana, Y. S. Chhonker, R. S. Bhatta, A. K. Srivastava, A. N. Gaikwad, V Lakshmi, A. K. Saxena
Summary: Rohitukine was extracted from the stem bark of Dysoxylum binectariferum and derivatized to arylsulphanimides, which showed significant inhibition on protein tyrosine phosphatase 1B in vitro. Among them, compound K5 exhibited the most potent anti-diabetic and anti-dyslipidemic activity both in vitro and in vivo, demonstrating promising potential as a therapeutic agent.
BIOORGANIC CHEMISTRY
(2021)
Review
Clinical Neurology
Masoud Tahmasian, Andre Aleman, Ole A. Andreassen, Zahra Arab, Marion Baillet, Francesco Benedetti, Tom Bresser, Joanna Bright, Michael W. L. Chee, Daphne Chylinski, Wei Cheng, Michele Deantoni, Martin Dresler, Simon B. Eickhoff, Claudia R. Eickhoff, Torbjorn Elvsashagen, Jianfeng Feng, Jessica C. Foster-Dingley, Habib Ganjgahi, Hans J. Grabe, Nynke A. Groenewold, Tiffany C. Ho, Seung Bong Hong, Josselin Houenou, Benson Irungu, Neda Jahanshad, Habibolah Khazaie, Hosung Kim, Ekaterina Koshmanova, Desi Kocevska, Peter Kochunov, Oti Lakbila-Kamal, Jeanne Leerssen, Meng Li, Annemarie Luik, Vincenzo Muto, Justinas Narbutas, Gustav Nilsonne, Victoria S. O'Callaghan, Alexander Olsen, Ricardo S. Osorio, Sara Poletti, Govinda Poudel, Joyce E. Reesen, Liesbeth Reneman, Mathilde Reyt, Dieter Riemann, Ivana Rosenzweig, Masoumeh Rostampour, Amin Saberi, Julian Schiel, Christina Schmidt, Anouk Schrantee, Emma Sciberras, Tim J. Silk, Kang Sim, Hanne Smevik, Jair C. Soares, Kai Spiegelhalder, Dan J. Stein, Puneet Talwar, Sandra Tamm, Giana L. Teresi, Sofie L. Valk, Eus Van Someren, Gilles Vandewalle, Maxime Van Egroo, Henry Volzke, Martin Walter, Rick Wassing, Frederik D. Weber, Antoine Weihs, Lars Tjelta Westlye, Margaret J. Wright, Mon-Ju Wu, Nathalia Zak, Mojtaba Zarei
Summary: Advancements in neuroimaging and genetics studies have shed light on the neurobiology of sleep and its disorders. However, individual studies often face limitations in identifying consistent effects, calling for a large-scale multi-centre effort to increase sample sizes and harmonize methodologies. The ENIGMA consortium provides a collaborative framework for combining datasets across different sites, allowing for more comprehensive research on the neurobiology of impaired sleep quality and related disorders.
JOURNAL OF SLEEP RESEARCH
(2021)
Review
Immunology
Saurabh Vig, Joost M. Lambooij, Arnaud Zaldumbide, Bruno Guigas
Summary: In type 1 diabetes, beta-cell destruction is caused by inflammation and autoimmunity, with the interaction between the endoplasmic reticulum (ER) and mitochondria playing a crucial role in beta-cell dysfunction and immune activation. The crosstalk between these organelles regulates calcium homeostasis, oxidative stress, and the generation of mitochondrial-derived factors, impacting the pathogenesis of the disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Devesh Kesharwani, Amit Kumar, Mukta Poojary, Vinod Scaria, Malabika Datta
Summary: This study identified differentially regulated mRNAs and lncRNAs in the skeletal muscle of diabetic mice, showing enrichment in pathways related to insulin, FOXO, and AMPK signaling. The findings highlight the potential cross-talk and interactions between ncRNome and transcriptome in skeletal muscle during diabetes, providing insights for potential therapeutic interventions to improve insulin sensitivity.
BIOSCIENCE REPORTS
(2021)
Article
Neurosciences
Justinas Narbutas, Maxime Van Egroo, Daphne Chylinski, Mohamed Ali Bahri, Ekaterina Koshmanova, Puneet Talwar, Gabriel Besson, Vincenzo Muto, Christina Schmidt, Andre Luxen, Evelyne Balteau, Christophe Phillips, Pierre Maquet, Eric Salmon, Christine Bastin, Gilles Vandewalle, Fabienne Collette
Summary: In healthy late middle-aged individuals without Aβ burden, increased cognitive complaints are associated with lower episodic memory efficiency, higher anxiety and depression, and potentially higher Aβ burden, indicating possible subtle cognitive decline. Future studies should explore the longitudinal relationship between cognitive complaints and objective cognition and AD biomarkers in healthy aging populations.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Clinical Neurology
Puneet Talwar, Suman Kushwaha, Monali Chaturvedi, Vidur Mahajan
Summary: A comprehensive examination of neural correlates of cognitive dysfunction in Alzheimer's disease using various neuroimaging modalities revealed early anatomical changes, functional disruptions, and metabolic alterations associated with AD. The combination of different imaging techniques may lead to the identification of early diagnostic and prognostic biomarkers for AD.
CLINICAL NEURORADIOLOGY
(2021)
Review
Chemistry, Medicinal
Swayam Prakash Srivastava, Rohit Srivastava, Subhash Chand, Julie E. Goodwin
Summary: The review discusses the severity of COVID-19 in patients with diabetes and diabetic kidney disease, highlighting various mechanisms that may lead to organ damage and emphasizing the importance of comprehensive treatment for patients with diabetic COVID-19.
Article
Endocrinology & Metabolism
Saurabh Vig, Joost M. M. Lambooij, Mette C. C. Dekkers, Frank Otto, Francoise Carlotti, Bruno Guigas, Arnaud Zaldumbide
Summary: This study investigates the role of endoplasmic reticulum stress in type 1 diabetes and reveals that cellular stress can lead to mitochondrial dysfunction and accumulation of cytosolic mitochondrial DNA, triggering neutrophil migration.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biology
Ilenia Paparella, Islay Campbell, Roya Sharifpour, Elise Beckers, Alexandre Berger, Jose Fermin Balda Aizpurua, Ekaterina Koshmanova, Nasrin Mortazavi, Puneet Talwar, Christian Degueldre, Laurent Lamalle, Siya Sherif, Christophe Phillips, Pierre Maquet, Gilles Vandewalle
Summary: Exposure to blue wavelength light can enhance the connection between the posterior associative thalamus and the intraparietal sulcus, thus affecting non-visual cognitive activity.
COMMUNICATIONS BIOLOGY
(2023)