Phloridzin Ameliorates Lipid Deposition in High-Fat-Diet-Fed Mice with Nonalcoholic Fatty Liver Disease via Inhibiting the mTORC1/SREBP-1c Pathway

Causal relationships between NAFLD, T2D and obesity have implications for disease subphenotyping

(2020) Zhipeng Liu et al.   JOURNAL OF HEPATOLOGY

Dual SGLT1/SGLT2 Inhibitor Phlorizin Ameliorates Non-Alcoholic Fatty Liver Disease and Hepatic Glucose Production in Type 2 Diabetic Mice

(2020) Aline David-Silva et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition

(2020) Issei Tomita et al.   Cell Metabolism

Physiological Disturbance in Fatty Liver Energy Metabolism Converges on IGFBP2 Abundance and Regulation in Mice and Men

(2020) Pia Fahlbusch et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of Apple Phytochemicals, Phloretin and Phloridzin, in Modulating Processes Related to Intestinal Inflammation

(2019) Danuta Zielinska et al.   Nutrients

Natural products with SGLT2 inhibitory activity: Possibilities of application for the treatment of diabetes

(2019) Reyhaneh Moradi‐Marjaneh et al.   PHYTOTHERAPY RESEARCH

Palbociclib in combination with simvastatin induce severe rhabdomyolysis: a case report

(2019) Vardan Nersesjan et al.   BMC Neurology

Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics

(2018) Stergios A. Polyzos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Phloridzin, an Apple Polyphenol, Exerted Unfavorable Effects on Bone and Muscle in an Experimental Model of Type 2 Diabetes in Rats

(2018) Piotr Londzin et al.   Nutrients

Polyphenol-rich apple extract inhibits dexamethasone-induced sebaceous lipids production by regulating SREBP1 expression

(2017) Kyung-Eun Lee et al.   EXPERIMENTAL DERMATOLOGY

Effects of ezetimibe/simvastatin combination on metabolic parameters

(2016) Theodosios D. Filippatos et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Insulin Sensitivity-Enhancing Activity of Phlorizin Is Associated with Lipopolysaccharide Decrease and Gut Microbiota Changes in Obese and Type 2 Diabetes (db/db) Mice

(2016) Xueran Mei et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning

(2016) Dianxin Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

NAFLD and diabetes mellitus

(2016) Herbert Tilg et al.   Nature Reviews Gastroenterology & Hepatology

Phlorizin Supplementation Attenuates Obesity, Inflammation, and Hyperglycemia in Diet-Induced Obese Mice Fed a High-Fat Diet

(2016) Su-Kyung Shin et al.   Nutrients

Hepatic insulin resistance in NAFLD: relationship with markers of atherosclerosis and metabolic syndrome components

(2015) Graziella Privitera et al.   ACTA DIABETOLOGICA

The Effect of Diabetes, Hyperlipidemia, and Statins on the Development of Rotator Cuff Disease

(2015) Tony Tung-Liang Lin et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Autophagy and Lipid Droplets in the Liver

(2015) Nuria Martinez-Lopez et al.   Annual Review of Nutrition

Statins decrease the risk of stroke in individuals with heterozygous familial hypercholesterolemia: A systematic review and meta-analysis

(2015) Fotios Barkas et al.   ATHEROSCLEROSIS

Influence of metabolic syndrome factors and insulin resistance on the efficacy of ezetimibe/simvastatin and atorvastatin in patients with metabolic syndrome and atherosclerotic coronary heart disease risk

(2015) Jeffrey B. Rosen et al.   Lipids in Health and Disease

CD4+RORγt++ and Tregs in a Mouse Model of Diet-Induced Nonalcoholic Steatohepatitis

(2015) Luisa Vonghia et al.   MEDIATORS OF INFLAMMATION

Diacylglycerol kinase-ζ regulates mTORC1 and lipogenic metabolism in cancer cells through SREBP-1

(2015) P Torres-Ayuso et al.   Oncogenesis

A Central Role for mTOR in Lipid Homeostasis

(2013) Dudley W. Lamming et al.   Cell Metabolism

Phloretin and phlorizin promote lipolysis and inhibit inflammation in mouse 3T3-L1 cells and in macrophage-adipocyte co-cultures

(2013) Wen-Chung Huang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Ablation of gp78 in Liver Improves Hyperlipidemia and Insulin Resistance by Inhibiting SREBP to Decrease Lipid Biosynthesis

(2012) Tong-Fei Liu et al.   Cell Metabolism

Phloridzin reduces blood glucose levels and alters hepatic gene expression in normal BALB/c mice

(2012) Masuko Kobori et al.   FOOD AND CHEMICAL TOXICOLOGY

Simultaneous separation and purification of total polyphenols, chlorogenic acid and phlorizin from thinned young apples

(2012) Lijun Sun et al.   FOOD CHEMISTRY

SREBP-1 und Fettleber

(2012) D. Müller-Wieland et al.   HERZ

Two discreet subsets of CD8 T cells modulate PLP91–110 induced experimental autoimmune encephalomyelitis in HLA-DR3 transgenic mice

(2012) Ashutosh K. Mangalam et al.   JOURNAL OF AUTOIMMUNITY

Quantitative proteomics study on the protective mechanism of phlorizin on hepatic damage in diabetic db/db mice

(2012) Hai-Qing Gao   Molecular Medicine Reports

Distinct mTORC1 pathways for transcription and cleavage of SREBP-1c

(2012) W. J. Quinn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase

(2012) J. L. Owen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-17 exacerbates hepatic steatosis and inflammation in non-alcoholic fatty liver disease

(2011) Y. Tang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Clinical and laboratory phenotype of patients experiencing statin intolerance attributable to myalgia

(2011) Leonard J. Harris et al.   Journal of Clinical Lipidology

Suppressive CD8+ T Cells Arise in the Absence of CD4 Help and Compromise Control of Persistent Virus

(2011) M. J. Molloy et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

Phloridzin reduces blood glucose levels and improves lipids metabolism in streptozotocin-induced diabetic rats

(2011) Mahmood Najafian et al.   MOLECULAR BIOLOGY REPORTS

Human Fatty Liver Disease: Old Questions and New Insights

(2011) J. C. Cohen et al.   SCIENCE

Nonalcoholic fatty liver disease in type 2 diabetes mellitus

(2011) Kenneth Cusi   Current Opinion in Endocrinology Diabetes and Obesity

Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c

(2010) P. Ferré et al.   DIABETES OBESITY & METABOLISM

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Phloridzin: Biosynthesis, distribution and physiological relevance in plants

(2010) Christian Gosch et al.   PHYTOCHEMISTRY

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

(2010) Shijie Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

Polymer–phloridzin conjugates as an anti-diabetic drug that Inhibits glucose absorption through the Na+/glucose cotransporter (SGLT1) in the small intestine

(2007) Yusuke Ikumi et al.   JOURNAL OF CONTROLLED RELEASE