Article
Chemistry, Applied
Lili Xu, Xinyue Geng, Rui Cao, Jiahao Zhu, Fei Chen, Cuihong Li, Lexuan Wang, Xuekun Wang, Hongbo Suo
Summary: By preparing magnetic MOFs and using an ionic liquid as a linker, enzyme immobilization was successfully achieved. The immobilized enzyme showed excellent activity and stability, with high efficiency in recycling and reusability. This research provides a meaningful reference for the application of other MOF composites in the field of enzyme immobilization.
MICROPOROUS AND MESOPOROUS MATERIALS
(2023)
Article
Biophysics
Hongbo Suo, Moju Li, Renmin Liu, Lili Xu
Summary: In this study, imidazolium-based ionic liquid was successfully grafted to magnetic polydopamine nanoparticles for lipase immobilization. The immobilized lipase showed excellent activity and stability, with increased affinity to substrate. Additionally, the immobilized lipase can be easily separated from the reaction system with a magnet, providing new ideas for further studies in this field.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Physical
Balaji Panchal, Yongjing Hao, Zhibin Han, Tao Chang, Zheng Zhu, Xionglei Wang, Shenjun Qin
Summary: In this study, fatty acid esters were efficiently synthesized using a reusable lipase immobilized with a novel porous ionic polymer. The immobilized lipase showed excellent catalytic activity and stability, making it a cost-effective and environmentally friendly catalyst for biodiesel production.
JOURNAL OF CATALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Moju Li, Xusheng Dai, Aifeng Li, Qi Qi, Wenhui Wang, Jia Cao, Zhenting Jiang, Renmin Liu, Hongbo Suo, Lili Xu
Summary: In this study, an ionic liquid-modified magnetic metal-organic framework composite was prepared and used as a support for enzyme immobilization. The immobilized enzyme showed higher catalytic activity, thermal stability, and anti-denaturant properties compared to soluble enzymes. The results demonstrated that the ionic liquid-modified Fe3O4@UiO-66-NH2 has great potential for immobilized enzymes.
Article
Chemistry, Physical
Ya-Li Wan, Jiao Zhang, Li Wang, Yi-Zhu Lei, Li-Li Wen
Summary: By hybridizing poly(ionic liquid)s with functionalized carbon nanotubes, the catalytic efficiency of poly(ionic liquid)-based catalysts can be boosted, playing an important role in carbon dioxide fixation.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2024)
Article
Engineering, Environmental
Jiahong Li, Lauren Forseth, Vitaliy G. Goncharov, Haixin Zhang, Matthew J. Hurlock, Xiaofeng Guo, Qiang Zhang
Summary: A series of hierarchically porous Zr-based MOFs with precisely adjusted acid-base properties were synthesized and characterized. The catalytic potential of these materials in CO2 cycloaddition with epoxides was investigated. The results showed that increasing the mixed-ligand ratio gradually enhanced the catalytic activity, but further increasing one of the ligands had an inverse effect. The optimized mixed-ligand ratio suggests that HP-UiO-66(1:1) is among the top catalyst choices. The catalytic efficiency and effectiveness of HP-UiO-66(1:1) were further validated through reactions with six other organic epoxides.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Wei Zhang, Zeping Lu, Runtang Liu, Liran Ji, Binbin Nian, Yi Hu
Summary: In this study, ionic liquids were used as novel modifiers of metal-organic frameworks (ILs-NH2-MIL-101) in the immobilization of laccase, resulting in enhanced loading amounts and activity retention. The stability and catalytic activity of the enzyme were also improved, and the efficiency of removing organic pollutants was found to be high. This research presents a simple, practical, and low-cost strategy for enzyme immobilization and provides insights into the development of high-efficiency enzyme immobilization for various industrial productions.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Nanoscience & Nanotechnology
Hao Shen, Zixin Zhou, Wenting He, Hao Chao, Ping Su, Jiayi Song, Yi Yang
Summary: The study describes a multimodal catalytic platform that incorporates glucose oxidase functionalized and immobilized on magnetic layered double hydroxides, achieving efficient cascade reactions. The role of DNA in catalysis and its enhancement of system bioactivity is highlighted, along with the platform's application in glucose sensing.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Physical
Chaonan Jin, Ning Li, En Lin, Xuepeng Chen, Ting Wang, Yan Wang, Mingfang Yang, Wansheng Liu, Jiangyue Yu, Zhenjie Zhang, Yao Chen
Summary: This study developed a photoenzymatic platform for asymmetric catalysis by immobilizing wheat germ lipase (WGL) onto rationally designed photocatalytic porphyrinic covalent organic frameworks (COFs). The WGL@COFs photobiocatalysts demonstrated high enzymatic activity and good operational stability, and exhibited excellent performance for an enantioselective Mannich reaction under visible light irradiation. This work provides a general and efficient strategy for fabricating photobiocatalysts that enable highly efficient photoenzymatic asymmetric catalysis using COFs as photocatalytic platforms for enzyme immobilization.
Article
Chemistry, Multidisciplinary
Kangjing Wang, Xinyi Dong, Ting Li, Qian Wang, Zhongyang Ding, Weifu Dong
Summary: This paper investigates the grafting of epoxy groups onto esterified starch, which improves the grafting efficiency and enhances the adsorption of immobilized lipase on starch. The lipase immobilized on modified starch showed excellent resistance to organic solvents and good reusability. Immobilizing lipases on epoxy-functionalized starch nanoparticles potentially improves the possibilities of industrial enzyme applications.
Article
Biotechnology & Applied Microbiology
Yalda Amini, Mansour Shahedi, Zohreh Habibi, Maryam Yousefi, Maryam Ashjari, Mehdi Mohammadi
Summary: A new method was used to immobilize three lipases on amine-functionalized magnetic nanoparticles. The immobilization process was simple and fast, resulting in high immobilization yields. The immobilized lipases were used for biodiesel production from waste cooking oil, and the production conditions were optimized using response surface methodology.
BIORESOURCES AND BIOPROCESSING
(2022)
Article
Chemistry, Physical
Jose Miguel Junior, Fernanda R. Mattos, Guilherme R. Costa, Ana B. R. Zurlo, Roberto Fernandez-Lafuente, Adriano A. Mendes
Summary: The aim of this study was to produce flavor esters via esterification reactions using immobilized lipase in solvent-free systems. The immobilized lipase showed high conversion percentage, excellent reusability, and environmentally friendly characteristics.
Article
Chemistry, Multidisciplinary
Itoh Toshiyuki
Summary: The use of ILs as solvents and stabilizers for enzymes, specifically lipases, allows for the recyclable use of enzymes, acceleration of transesterification, and enhancement of enzyme stability and reaction activity. This IL engineering approach has a significant impact on lipase-catalyzed reactions and has the potential to improve enzyme capabilities.
Article
Nanoscience & Nanotechnology
Hao Dong, Wenxue Zhang, Qize Xuan, Yao Zhou, Shengmin Zhou, Jiaofang Huang, Ping Wang
Summary: By phage display screening and co-expression of CsgB and LBP2-modified CsgA proteins, E. coli biofilms were developed as a surface for enzyme immobilization, resulting in enhanced catalytic performance of lipase when immobilized on LBP2-functionalized biofilm materials.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Applied
Junxin Zhao, Maomao Ma, Xianghui Yan, Dongman Wan, Zheling Zeng, Ping Yu, Deming Gong
Summary: The study successfully immobilized lipase on functionalized magnetic nanocomposites, showing higher stability and activity. The immobilized lipase exhibited good activity and stability under high temperature and alkaline conditions.
Article
Biochemistry & Molecular Biology
Yue Liu, Peng-Xiao Li, Wen-Wen Mu, Ya-Lei Sun, Ren-Min Liu, Jie Yang, Guo-Yun Liu
Summary: This work focuses on the design and synthesis of barbituric acid derivatives containing 1,3-dimethylbarbituric acid and cinnamic acid scaffolds for the development of potent anticancer agents. The results showed that certain substitutions on the benzyl ring of barbituric acid derivatives led to increased antiproliferative activities. Mechanistic investigation revealed the potential of one derivative to induce cell cycle arrest and increase ROS levels.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Chemistry, Inorganic & Nuclear
Yang Liu, Yuchen Wang, Hui Yan, Hongyan Liu, Wenxiao Guo, Shufang Wang, Zhen Gao, Xia Li, Hongjie Zhu, Hongguo Hao, Daopeng Zhang, Fangna Dai
Summary: In this study, eight new stable porous lanthanide metal-organic frameworks (Ln-OFs) were synthesized and showed excellent ion-exchange and adsorption abilities, making them promising for catalytic reactions and dye adsorption.
INORGANIC CHEMISTRY
(2022)
Article
Biochemical Research Methods
Yue Wang, Guo Li, Tong Meng, Lin Qi, Hui Yan, Zhiguo Wang
Summary: The designed monohydrazone derivative shows specific preference in binding and stabilizing parallel human telomeric G4. The end-stacking binding mode is preferred, with van der Waals interactions playing a leading role in determining binding affinity. These findings support the design of novel selective stabilizers targeting telomeric G4s.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING
(2022)
Article
Chemistry, Multidisciplinary
Zhenfei Gao, Tiannan Wang, Zikun Rao, Hui Yan, Ran Zhang, Guosong Chen
Summary: Supra-amphiphilic compounds containing disaccharides and azobenzene ends were constructed via dynamic covalent bond. The slight structural difference of the disaccharides was found to significantly affect the self-assembled morphologies. Three kinds of azo-disaccharide supra-amphiphiles were found to assemble into different morphologies with only a difference in chemical structure. Molecular simulation revealed that the packing of molecules was influenced by the contribution from hydrogen bonds. This study highlights the importance of saccharide packing, particularly related hydrogen bonding, in determining the final morphology of assembled structures.
CHINESE CHEMICAL LETTERS
(2023)
Article
Medicine, Research & Experimental
Rui Chang, Rongrong Fu, Yujiao Huang, Jibing Zhang, Changshun Feng, Rui Wang, Hui Yan, Guangyong Li, Xiaohong Chu, Fengjiao Yuan, Dianlong Jia, Jun Li
Summary: In this study, a multifunctional liposome (MTLPs) was developed to co-deliver TRAIL and MMC for overcoming TRAIL-resistant tumors. MTLPs exhibited efficient cellular uptake and a strong killing effect against TRAIL-resistant tumor cells. In vivo assays showed that MTLPs achieved 97.8% tumor suppression via the synergistic effect of TRAIL and MMC while ensuring biosafety.
MOLECULAR PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Yutong Li, Zhen Zhao, Xiao Nai, Mingyuan Li, Jing Kong, Yanrong Chen, Min Liu, Qian Zhang, Jie Liu, Hui Yan
Summary: The effects of temperature, metal ions, and biosurfactants on the interaction between CAPE and Hb were studied. It was found that lowering the temperature, adding biosurfactants, and the presence of Cu2+ increased the binding force between CAPE and Hb. These results provide useful data for the targeted delivery and absorption of CAPE and other drugs.
Article
Biochemistry & Molecular Biology
Rui Chang, Xiaohong Chu, Jibing Zhang, Rongrong Fu, Changshun Feng, Dianlong Jia, Rui Wang, Hui Yan, Guangyong Li, Jun Li
Summary: Antitumor immunity is crucial for cancer therapy and is primarily mediated by innate immune response. CD47 and Toll-like receptor 7 (TLR7) are promising therapeutic targets. A fusion protein called Fc-CV1 and liposomes loaded with imiquimod (TLR7 agonist) were used to target colon tumor models. In vitro and in vivo studies showed that this immunotherapy preparation had superior properties and low toxicity, making it an effective strategy for tumor therapy.
Article
Energy & Fuels
Han Jia, Xin Wei, Qiuxia Wang, Haidong Jia, Hui Yan, Qiang Wang, Fangning Fan, Shijie Wen, Kaihe Lv, Dexin Liu
Summary: Ionic liquids (ILs) have been proven to be effective additives for inhibiting shale hydration swelling. Imidazolium-based bola-form ionic liquids (IBFILs) with modified functional groups can greatly enhance their inhibition ability. The study investigated the effect of different modified functional groups on the inhibition properties of three novel IBFILs and analyzed the inhibition mechanisms through various tests and measurements. The results provide insights into the design and development of efficient IL inhibitors with modified functional groups.
Article
Chemistry, Multidisciplinary
Tong Meng, Zhen Zhao, Guangyong Li, Jun Li, Hui Yan
Summary: Adsorbing CO2-sensitive surfactants on the surface of nanoparticles is an important strategy for preparing stimuli-responsive Pickering emulsions. In this study, molecular dynamics simulations were employed to explore the mechanism behind the reversible emulsification/demulsification of a Pickering emulsion stabilized by silica nanoparticles and CO(2)-switchable surfactants. The simulations revealed that the protonated surfactant CPMAH(+) forms an adsorption layer at the oil-water interface, while the ionic surfactants are tightly adsorbed on the NP surface through electrostatic interactions. The different binding configurations and stability between NP and CPMA or CPMAH(+) are the fundamental reasons for the reversible emulsification/demulsification of the Pickering emulsion.
Article
Chemistry, Multidisciplinary
Hongbo Suo, Qi Qi, Xusheng Dai, Xinyue Geng, Qi Li, Jie Yang, Guoyun Liu, Renmin Liu, Lili Xu
Summary: Recently, ionic liquids (ILs) have emerged as promising tools for activating and stabilizing enzymes. In this study, magnetic Ca2+-based metal-organic framework (CaBDC) was functionalized with imidazolium-based ILs and used to immobilize lipase. The resulting PPL-ILs/MCaBDC composites exhibited significantly enhanced activity, thermal and storage stability compared to PPL-MCaBDC. The study also analyzed the interactions between the support and the enzyme, providing insights into the structural changes of the immobilized lipase.
REACTION CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Huiqi Zou, Rongyun Li, Li Ding, Jing Lu, Haiquan Tian, Hui Yan, Houting Liu, Suna Wang, Yunwu Li
Summary: Three isostructural metal-organic frameworks with different metal cations were synthesized. The presence of coordination and lattice water molecules in the crystal structures allowed for hydrogen bonding and proton transfer. The proton conductivities of the MOF 1-3/Nafion composite membranes differed, with the order of conductivity being 1 (Co2+)/Nafion > 2 (Mn2+)/Nafion > 3 (Zn2+)/Nafion. These differences were attributed to the acidity of the coordinated water molecules, influenced by the metal cation size and valence electron configurations. Additionally, compound 1 showed a single crystal to single crystal transformation and exhibited magnetic changes.
Article
Chemistry, Inorganic & Nuclear
Xiaoxue Ma, Lu Zhang, Ronghua Liu, Xin Li, Hui Yan, Xin Zhao, Yikai Yang, Hongjie Zhu, Xiangjin Kong, Jie Yin, Huawei Zhou, Xia Li, Lingqian Kong, Hongguo Hao, Dichang Zhong, Fangna Dai
Summary: The design and development of proton conduction materials for clean energy-related applications is important and challenging. In this study, an ultrastable cobalt-based metal-organic framework (LCUH-103) was successfully synthesized. It exhibited excellent stability and high proton conductivity. The proton conductivity was further enhanced by encapsulating imidazole molecules into the framework. LCUH-103 also demonstrated excellent carrier capability for palladium nanoparticles, showing outstanding conversion efficiency, high rate constant, and exceptional cycling stability.
INORGANIC CHEMISTRY
(2023)
Article
Materials Science, Biomaterials
Izabela Stupka, Artur P. Biela, Bernard Piette, Agnieszka Kowalczyk, Karolina Majsterkiewicz, Kinga Borzecka-Solarz, Antonina Naskalska, Jonathan G. Heddle
Summary: Artificial protein cages, such as TRAP-cages, have potential applications in vaccines and drug delivery. TRAP-cages have the ability to control the disassembly conditions by modifying the interface between their building blocks. By using TRAP rings with different numbers of monomers, it is possible to predict the formation of other cages.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Guo Zhang, Yu Wang, Hua Qiu, Lei Lu
Summary: This study presents a one-pot synthesis method for flower-like AMPs@EAMP particles by combining antimicrobial peptides with ellagic acid, offering enlarged surface area, excellent biocompatibility, and broad-spectrum antibacterial activity. In vivo studies indicate their potential for tissue repair and immune barrier reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Jiamei Zhang, Lingshuang Wang, Cheng Xu, Yingui Cao, Shengsheng Liu, Rui L. Reis, Subhas C. Kundu, Xiao Yang, Bo Xiao, Lian Duan
Summary: Pluronic F127 modified silk fibroin film with different types of antibacterial agents could accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria, and facilitating angiogenesis and re-epithelialization.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Yinsheng Liu, Mingyue Wang, Yinfei Hui, Lei Sun, Yanrui Hao, Henlong Ren, Hao Guo, Wu Yang
Summary: In this study, a rare-earth hybrid luminescent material was developed for the detection of a biomarker for anthrax. The material showed excellent selectivity and high sensitivity, allowing for the determination of the biomarker in saliva and urine. Additionally, a convenient point-of-care testing method using fluorescent test paper and a smartphone was established for the initial diagnosis of anthrax.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Review
Materials Science, Biomaterials
Wenshuai Yang, Jingsi Chen, Ziqian Zhao, Meng Wu, Lu Gong, Yimei Sun, Charley Huang, Bin Yan, Hongbo Zeng
Summary: Injectable hydrogels with shear-thinning and/or in situ formation properties offer distinct advantages in bioengineering applications, as they can be directly delivered to target sites, possess self-healing abilities, and simplify the implantation process.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
