Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain

Non-invasive MR imaging of human brain lymphatic networks with connections to cervical lymph nodes

(2022) Mehmet Sait Albayram et al.   Nature Communications

Meningeal lymphatic vessels mediate neurotropic viral drainage from the central nervous system

(2022) Xiaojing Li et al.   NATURE NEUROSCIENCE

Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis

(2022) Fadi E. Pulous et al.   NATURE NEUROSCIENCE

Functional characterization of the dural sinuses as a neuroimmune interface

(2021) Justin Rustenhoven et al.   CELL

Toxoplasma gondii infection and its implications within the central nervous system

(2021) Sumit K. Matta et al.   NATURE REVIEWS MICROBIOLOGY

Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma

(2021) Andrea Cugurra et al.   SCIENCE

Meningeal lymphatic vessels regulate brain tumor drainage and immunity

(2020) Xueting Hu et al.   CELL RESEARCH

VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours

(2020) Eric Song et al.   NATURE

Meningeal Immunity and Its Function in Maintenance of the Central Nervous System in Health and Disease

(2020) Kalil Alves de Lima et al.   Annual Review of Immunology

T. gondii infection induces IL-1R dependent chronic cachexia and perivascular fibrosis in the liver and skeletal muscle

(2020) Stephanie J. Melchor et al.   Scientific Reports

Mechanisms of Pathogen Invasion into the Central Nervous System

(2019) Matthew D. Cain et al.   NEURON

Toxoplasma and Dendritic Cells: An Intimate Relationship That Deserves Further Scrutiny

(2019) Anaïs F. Poncet et al.   TRENDS IN PARASITOLOGY

The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future

(2018) Benjamin A. Plog et al.   Annual Review of Pathology-Mechanisms of Disease

Advances in Meningeal Immunity

(2018) Rejane Rua et al.   TRENDS IN MOLECULAR MEDICINE

CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature

(2018) Antoine Louveau et al.   NATURE NEUROSCIENCE

Dendritic cell and antigen dispersal landscapes regulate T cell immunity

(2017) Michael Y. Gerner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice

(2017) Qiaoli Ma et al.   Nature Communications

Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI

(2017) Martina Absinta et al.   eLife

CD103+ CD8 T Cells in the Toxoplasma-Infected Brain Exhibit a Tissue-Resident Memory Transcriptional Profile

(2017) Tyler A. Landrith et al.   Frontiers in Immunology

CCR7 deficient inflammatory Dendritic Cells are retained in the Central Nervous System

(2017) Benjamin D. Clarkson et al.   Scientific Reports

Implications of Lymphatic Transport to Lymph Nodes in Immunity and Immunotherapy

(2016) Susan N. Thomas et al.   Annual Review of Biomedical Engineering

The lymphatic vascular system of the mouse head

(2016) Melanie Lohrberg et al.   CELL AND TISSUE RESEARCH

Functions of Murine Dendritic Cells

(2016) Vivek Durai et al.   IMMUNITY

Continuous Effector CD8 + T Cell Production in a Controlled Persistent Infection Is Sustained by a Proliferative Intermediate Population

(2016) H. Hamlet Chu et al.   IMMUNITY

Costimulatory and Coinhibitory Receptor Pathways in Infectious Disease

(2016) John Attanasio et al.   IMMUNITY

Lymph node - an organ for T-cell activation and pathogen defense

(2016) Georg Gasteiger et al.   IMMUNOLOGICAL REVIEWS

Regulatory T Cells Promote Myositis and Muscle Damage inToxoplasma gondiiInfection

(2016) Richard M. Jin et al.   JOURNAL OF IMMUNOLOGY

Endogenous Nur77 Is a Specific Indicator of Antigen Receptor Signaling in Human T and B Cells

(2016) Judith F. Ashouri et al.   JOURNAL OF IMMUNOLOGY

Understanding the Role of T Cells in CNS Homeostasis

(2016) Erik Ellwardt et al.   TRENDS IN IMMUNOLOGY

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fitting Linear Mixed-Effects Models Usinglme4

(2015) Douglas Bates et al.   Journal of Statistical Software

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Lymphatic system: An active pathway for immune protection

(2015) Shan Liao et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Revisiting the Mechanisms of CNS Immune Privilege

(2015) Antoine Louveau et al.   TRENDS IN IMMUNOLOGY

Development and Function of Dendritic Cell Subsets

(2014) Alexander Mildner et al.   IMMUNITY

Immune cell trafficking from the brain maintains CNS immune tolerance

(2014) Mohammad G. Mohammad et al.   JOURNAL OF CLINICAL INVESTIGATION

Swift Entry of Myelin-Specific T Lymphocytes into the Central Nervous System in Spontaneous Autoimmune Encephalomyelitis

(2014) G. C. Furtado et al.   JOURNAL OF IMMUNOLOGY

Immune privilege of the CNS is not the consequence of limited antigen sampling

(2014) Melissa G. Harris et al.   Scientific Reports

The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting

(2013) Miriam Merad et al.   Annual Review of Immunology

Molecular Control of Steady-State Dendritic Cell Maturation and Immune Homeostasis

(2013) Gianna Elena Hammer et al.   Annual Review of Immunology

Dendritic Cell Interactions with Lymphatic Endothelium

(2013) Erica Russo et al.   Lymphatic Research and Biology

Brain dendritic cells: biology and pathology

(2012) Paul M. D’Agostino et al.   ACTA NEUROPATHOLOGICA

Migration of monocytes after intracerebral injection at entorhinal cortex lesion site

(2012) Miriam Kaminski et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Generalized Lévy walks and the role of chemokines in migration of effector CD8+ T cells

(2012) Tajie H. Harris et al.   NATURE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

T cell receptor signal strength in Tregand iNKT cell development demonstrated by a novel fluorescent reporter mouse

(2011) Amy E. Moran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Analysis of Behavior and Trafficking of Dendritic Cells within the Brain during Toxoplasmic Encephalitis

(2011) Beena John et al.   PLoS Pathogens

Behavior of Parasite-Specific Effector CD8+ T Cells in the Brain and Visualization of a Kinesis-Associated System of Reticular Fibers

(2009) Emma H. Wilson et al.   IMMUNITY

Toxoplasmosis snapshots: Global status of Toxoplasma gondii seroprevalence and implications for pregnancy and congenital toxoplasmosis

(2009) Georgios Pappas et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Dynamic Imaging of T Cell-Parasite Interactions in the Brains of Mice Chronically Infected with Toxoplasma gondii

(2009) Marie Schaeffer et al.   JOURNAL OF IMMUNOLOGY

Surgical excision of CNS-draining lymph nodes reduces relapse severity in chronic-relapsing experimental autoimmune encephalomyelitis

(2008) Marloes van Zwam et al.   JOURNAL OF PATHOLOGY

Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology

(2008) R. O. Carare et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY