Article
Immunology
Patricia Schroeder, Marion Rivalan, Sami Zaqout, Christina Krueger, Jutta Schueler, Melissa Long, Andreas Meisel, York Winter, Angela M. Kaindl, Seija Lehnardt
Summary: The absence of MyD88 leads to morphological and cellular changes in the mouse brain, as well as alterations in specific behaviors. The data suggest a pathophysiological significance of MyD88 for mammalian CNS development, structure, and function.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Cell Biology
Liming Xu, Xuegang Niu, Yifan Liu, Lining Liu
Summary: This study investigates the role of ST3GAL3 in rheumatoid arthritis (RA) and its potential mechanism of action. The findings suggest that ST3GAL3 may be involved in RA pathogenesis by activating the TLR9/MyD88 pathway.
MEDIATORS OF INFLAMMATION
(2022)
Article
Engineering, Biomedical
Chenkai Mao, Veronique Beiss, Jennifer Fields, Nicole F. Steinmetz, Steven Fiering
Summary: Research found that CPMV elicited stronger cytokine and chemokine induction in mouse splenocytes and exhibited more potent anti-tumor efficacy compared to eCPMV. Both CPMV and eCPMV required MyD88 for immune responses, and their capsids were recognized by MyD88-dependent TLR2 and TLR4. In addition, CPMV was also recognized by TLR7, which was critical for its better efficacy through the secretion of type I interferons.
Article
Immunology
Jeremy Kiripolsky, Eileen M. Kasperek, Chengsong Zhu, Quan-Zhen Li, Jia Wang, Guan Yu, Jill M. Kramer
Summary: Primary Sjogren's syndrome, predominantly seen in women, is characterized by exocrine gland dysfunction and serious systemic manifestations. Research suggests that ECM degradation may represent a novel source of chronic B cell activation in the context of pSS.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yingying Chen, Dongyue Li, Liying Sun, Kai Qi, Lijun Shi
Summary: This study aimed to evaluate the effect and mechanism of toll-like receptor 4 (TLR4) inhibitor TLR4-IN-C34 on gut microbiota in mice with ulcerative colitis (UC). The results showed that TLR4-IN-C34 partially improved dysbiosis of intestinal flora, inflammatory infiltration, oxidative stress, and intestinal barrier function in UC mice.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Cell Biology
Shiju Ye, Lan Su, Peiren Shan, Bozhi Ye, Shengjie Wu, Guang Liang, Weijian Huang
Summary: LCZ696 prevents DOX-induced cardiac damage by reducing the formation of TLR2-MyD88 complexes, suggesting it as a potential effective drug for treating DOX-induced heart failure.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lei Zhang, Guangshuai Liu, Tian Xia, Xiufeng Yang, Guolei Sun, Chao Zhao, Chunzhu Xu, Honghai Zhang
Summary: The study analyzed TLR genes from the genomes and transcriptomes of 102 amphibian species to understand their evolutionary patterns. Results showed that TLR genes can be divided into seven subfamilies, with TLR4 subfamily found only in Anura. Purification selection played a leading role in amphibian TLR evolution, and different domains had different evolution rates. Positive selection patterns and single-nucleotide polymorphisms were observed in TLR genes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Medicine, Research & Experimental
Iulia Rusu, Elvira Mennillo, Jared L. Bain, Zhongmei Li, Xiaofei Sun, Kimberly M. Ly, Yenny Y. Rosli, Mohammad Naser, Zunqiu Wang, Rommel Advincula, Philip Achacoso, Ling Shao, Bahram Razani, Ophir D. Klein, Alexander Marson, Jessie A. Turnbaugh, Peter J. Turnbaugh, Barbara A. Malynn, Averil Ma, Michael G. Kattah
Summary: Anti-TNF therapy is effective for treating inflammatory bowel disease (IBD), but some patients don't respond well to this treatment. In this study, researchers found that the deletion of certain genes in intestinal epithelial cells (IECs) can sensitize mice to both TNF-dependent and TNF-independent cell death. The study also showed that microbial signals, MyD88, and LT alpha all contribute to the TNF-independent intestinal injury. These findings highlight the importance of TNF-independent pathways in the development of IBD and suggest potential targets for therapy.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Chemistry, Multidisciplinary
Xin Zhi, Peipei Yang, Yunxue Xu, Zhifei Dai, Xiuli Yue, Linxue Qian
Summary: This review discusses the functions of Toll-like receptors (TLRs) in the tumor microenvironment and the pathways that activate immune responses. It also summarizes recent developments in nanotechnology for immunomodulation with TLR agonists. Nanotechnology can improve the efficacy of TLR agonist-based immunotherapy and address its limitations.
Review
Biochemistry & Molecular Biology
Yuan-Tung Chu, Min-Tser Liao, Kuo-Wang Tsai, Kuo-Cheng Lu, Wan-Chung Hu
Summary: A comprehensive framework has been established to understand immunological pathways, and specific associations between immune responses and immune receptors have been identified. These findings contribute to the identification of biomarkers for immune cells and provide insights into host immunological pathways.
Article
Immunology
Allison M. Owen, Liming Luan, Katherine R. R. Burelbach, Margaret A. A. McBride, Cody L. L. Stothers, Olivia A. A. Boykin, Kalkena Sivanesam, Jessica F. F. Schaedel, Tazeen K. K. Patil, Jingbin Wang, Antonio Hernandez, Naeem K. K. Patil, Edward R. R. Sherwood, Julia K. K. Bohannon
Summary: Immunocompromised populations are at high risk of life-threatening infections, and strategies to protect these patients are urgently needed. This study explores the use of trained immunity, which enhances the immune response to subsequent infections, as a promising approach. The researchers demonstrate that the MyD88-dependent signaling pathway plays a critical role in TLR-mediated trained immunity, providing valuable insights into the mechanisms underlying this process.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Elsy Janeth Ramos-Gonzalez, Yadira Bastian, Julio Enrique Castaneda-Delgado, Martin Zapata-Zuniga, Mariela Gomez-Moreno, Jose Dionisio Castillo-Ortiz, Cesar Ramos-Remus, Jose Antonio Enciso-Moreno
Summary: The study found that the expression levels of TLR7 and TLR9 are elevated in the early stage of rheumatoid arthritis (RA), and may be associated with the production of autoantibodies, suggesting a role of TLR7 in the development of autoantibodies.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Article
Immunology
Laura A. Mckiel, Laurel L. Ballantyne, Gian Luca Negri, Kimberly A. Woodhouse, Lindsay E. Fitzpatrick
Summary: The adsorption of damage-associated molecular patterns (DAMPs) derived from damaged cells and matrix surrounding the implant on the surface of implanted biomaterial plays a significant role in downstream cell-material interactions. This study shows that DAMPs and other intracellular proteins can readily adsorb to biomaterial surfaces and induce an inflammatory response in adherent macrophages through the MyD88-dependent Toll-like receptor 2 (TLR2) signaling pathway.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Haibo Lan, Wu Li, Jucai Xu, Yuzhe Yang, Zhaolun Tan, Ruili Yang
Summary: LP4, a novel immunomodulatory polysaccharide with a molecular weight of 6.31 x 10(4) g/mol, was extracted from fresh longan pulp. It can activate macrophages mainly through the TLR2 and TLR4-induced PI3K/AKT and MyD88/TRAF6 pathways, leading to increased cytokine production.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Xiaoqin Tang, Qian Xu, Shuo Yang, Xinwu Huang, Long Wang, Feihong Huang, Jiesi Luo, Xiaogang Zhou, Anguo Wu, Qibing Mei, Chunling Zhao, Jianming Wu
Summary: Platelets, as the second most abundant blood component, play a crucial role in various physiological and pathological functions. In addition to its traditional role in hemostasis and thrombosis, platelets also have an indispensable role in inflammatory diseases. Thrombocytopenia, a common hematologic problem, is closely related to the fatality of many diseases, highlighting the significance of its prevention and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Masashi Kanayama, Makoto Inoue, Keiko Danzaki, Gianna Hammer, You-Wen He, Mari L. Shinohara
Nature Communications
(2015)
Article
Cell Biology
Jie Liang, Hsin-I Huang, Fernanda P. Benzatti, Amelia B. Karlsson, Junyi J. Zhang, Nourhan Youssef, Averil Ma, Laura P. Hale, Gianna E. Hammer
Article
Cell Biology
Sarah L. Jaslow, Kyle D. Gibbs, W. Florian Fricke, Liuyang Wang, Kelly J. Pittman, Mark K. Mammel, Joshua T. Thaden, Vance G. Fowler, Gianna E. Hammer, Johanna R. Elfenbein, Dennis C. Ko
Article
Immunology
Timothy T. Lu, Michio Onizawa, Gianna E. Hammer, Emre E. Turer, Qian Yin, Ermelinda Damko, Alexander Agelidis, Nataliya Shifrin, Rommel Advincula, Julio Barrera, Barbara A. Malynn, Hao Wu, Averil Ma
Article
Immunology
Joseph A. Callahan, Gianna E. Hammer, Alexander Agelides, Bao H. Duong, Shigeru Oshima, Jeffrey North, Rommel Advincula, Nataliya Shifrin, Hong-An Truong, Jonathan Paw, Julio Barrera, Anthony DeFranco, Michael D. Rosenblum, Barbara A. Malynn, Averil Ma
JOURNAL OF IMMUNOLOGY
(2013)
Article
Immunology
Gianna Elena Hammer, Emre E. Turer, Kimberly E. Taylor, Celia J. Fang, Rommel Advincula, Shigeru Oshima, Julio Barrera, Eric J. Huang, Baidong Hou, Barbara A. Malynn, Boris Reizis, Anthony DeFranco, Lindsey A. Criswell, Mary C. Nakamura, Averil Ma
Review
Chemistry, Analytical
Bradley B. Barth, Hsin-I Huang, Gianna E. Hammer, Xiling Shen
Article
Multidisciplinary Sciences
Shigao Yang, Alfred T. Harding, Catherine Sweeney, David Miao, Gregory Swan, Connie Zhou, Zhaozhao Jiang, Katherine A. Fitzgerald, Gianna Hammer, Martin O. Bergo, Heather K. Kroh, D. Borden Lacy, Chunxiang Sun, Michael Glogauer, Loretta G. Que, Nicholas S. Heaton, Donghai Wang
Article
Cardiac & Cardiovascular Systems
Xiaohan Lu, Nathan P. Rudemiller, Yi Wen, Jiafa Ren, Gianna E. Hammer, Robert Griffiths, Jamie R. Privratsky, Bo Yang, Matthew A. Sparks, Steven D. Crowley
CIRCULATION RESEARCH
(2019)
Article
Immunology
Takayuki Kanaseki, Nicolas Blanchard, Gianna Elena Hammer, Federico Gonzalez, Nilabh Shastri
Article
Immunology
CW McMahon, AJ Zajac, AM Jamieson, L Corral, GE Hammer, R Ahmed, DH Raulet
JOURNAL OF IMMUNOLOGY
(2002)
Review
Immunology
Gianna Elena Hammer, Takayuki Kanaseki, Nilabh Shastri
Article
Immunology
Gianna Elena Hammer, Federico Gonzalez, Edward James, Hector Nolla, Nilabh Shastri
Article
Immunology
GE Hammer, F Gonzalez, M Champsaur, D Cado, N Shastri