Kv1.3 Channel as a Key Therapeutic Target for Neuroinflammatory Diseases: State of the Art and Beyond

Antibodies and venom peptides: new modalities for ion channels

(2019) Heike Wulff et al.   NATURE REVIEWS DRUG DISCOVERY

Sea Anemone Toxins: A Structural Overview

(2019) Bruno Madio et al.   Marine Drugs

Complete loss of KCNA1 activity causes neonatal epileptic encephalopathy and dyskinesia

(2019) Edgard Verdura et al.   JOURNAL OF MEDICAL GENETICS

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease

(2018) Srikant Rangaraju et al.   Molecular Neurodegeneration

Voltage Gated Potassium Channel Kv1.3 Is Upregulated on Activated Astrocytes in Experimental Autoimmune Encephalomyelitis

(2018) Iva Bozic et al.   NEUROCHEMICAL RESEARCH

The Kv1.3 channel-inhibitory toxin BF9 also displays anticoagulant activity via inhibition of factor XIa

(2018) Li Ding et al.   TOXICON

Sea Anemones: Quiet Achievers in the Field of Peptide Toxins

(2018) Peter J. Prentis et al.   Toxins

Microglia after Seizures and in Epilepsy

(2018) Toshimitsu Hiragi et al.   Cells

Kv1.3 channel blockade with the Vm24 scorpion toxin attenuates the CD4+ effector memory T cell response to TCR stimulation

(2018) José Ignacio Veytia-Bucheli et al.   Cell Communication and Signaling

Cnidarian peptide neurotoxins: a new source of various ion channel modulators or blockers against central nervous systems disease

(2018) Qiwen Liao et al.   DRUG DISCOVERY TODAY

The voltage-gated potassium channel Kv1.3 is required for microglial pro-inflammatory activation in vivo

(2018) Jacopo Di Lucente et al.   GLIA

Alleviating airway inflammation by inhibiting ERK-NF-κB signaling pathway by blocking Kv1.3 channels

(2018) Qian-Lan Zhou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

(2017) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Recent advances in epilepsy

(2017) Mark Manford   JOURNAL OF NEUROLOGY

Venom-derived peptide inhibitors of voltage-gated potassium channels

(2017) Raymond S. Norton et al.   NEUROPHARMACOLOGY

Multiple sclerosis - etiology and diagnostic potential

(2017) Joanna Kamińska et al.   Postepy Higieny I Medycyny Doswiadczalnej

Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions

(2017) Eugene Y. Chiang et al.   Nature Communications

Kv1.3 channel blocker (ImKTx88) maintains blood–brain barrier in experimental autoimmune encephalomyelitis

(2017) Jie Huang et al.   Cell and Bioscience

Inhibition of the potassium channel Kv1.3 reduces infarction and inflammation in ischemic stroke

(2017) Yi-Je Chen et al.   Annals of Clinical and Translational Neurology

Safety and pharmacodynamics of dalazatide, a Kv1.3 channel inhibitor, in the treatment of plaque psoriasis: A randomized phase 1b trial

(2017) Eric J. Tarcha et al.   PLoS One

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Evolution of endovascular stroke therapies and devices

(2016) Adam N Wallace et al.   Expert Review of Medical Devices

Microglia-Neuron Communication in Epilepsy

(2016) Ukpong B. Eyo et al.   GLIA

Immunosuppressive evidence ofTityus serrulatustoxins Ts6 and Ts15: insights of a novel K+channel pattern in T cells

(2016) Manuela B. Pucca et al.   IMMUNOLOGY

Applications and Challenges for Use of Cell-Penetrating Peptides as Delivery Vectors for Peptide and Protein Cargos

(2016) Mie Kristensen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Scorpion Potassium Channel-blocking Defensin Highlights a Functional Link with Neurotoxin

(2016) Lanxia Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Margatoxin-bound quantum dots as a novel inhibitor of the voltage-gated ion channel Kv1.3

(2016) Austin B. Schwartz et al.   JOURNAL OF NEUROCHEMISTRY

Role of atherosclerosis, clot extent, and penumbra volume in headache during ischemic stroke

(2016) Hendrikus J.A. van Os et al.   NEUROLOGY

Mapping the Interaction Anatomy of BmP02 on Kv1.3 Channel

(2016) B. Wu et al.   Scientific Reports

Decrease of a Current Mediated by K v 1.3 Channels Causes Striatal Cholinergic Interneuron Hyperexcitability in Experimental Parkinsonism

(2016) Cecilia Tubert et al.   Cell Reports

Ion Channels in Innate and Adaptive Immunity

(2015) Stefan Feske et al.   Annual Review of Immunology

Molecular dynamics of Kv1.3 ion channel and structural basis of its inhibition by scorpion toxin-OSK1 derivatives

(2015) Rajabrata Bhuyan et al.   BIOPHYSICAL CHEMISTRY

Ataxia and myoclonic epilepsy due to a heterozygous new mutation inKCNA2: proposal for a new channelopathy

(2015) S.D.J. Pena et al.   CLINICAL GENETICS

The voltage-gated potassium channel Kv1.3 is a promising multitherapeutic target against human pathologies

(2015) Mireia Pérez-Verdaguer et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Focused ultrasound-mediated drug delivery through the blood–brain barrier

(2015) Alison Burgess et al.   Expert Review of Neurotherapeutics

Nuclear Localization and Functional Characteristics of Voltage-gated Potassium Channel Kv1.3

(2015) Soo Hwa Jang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

The relation between α-synuclein and microglia in Parkinson’s disease: Recent developments

(2015) V. Sanchez-Guajardo et al.   NEUROSCIENCE

Solid phase synthesis, NMR structure determination of α-KTx3.8, its in silico docking to Kv1.x potassium channels, and electrophysiological analysis provide insights into toxin-channel selectivity

(2015) Bastian Kohl et al.   TOXICON

Swedish mutant APP-based BACE1 binding site peptide reduces APP β-cleavage and cerebral Aβ levels in Alzheimer’s mice

(2015) Song Li et al.   Scientific Reports

Toxins Targeting the KV1.3 Channel: Potential Immunomodulators for Autoimmune Diseases

(2015) Yipeng Zhao et al.   Toxins

Focused ultrasound-mediated drug delivery through the blood–brain barrier

(2015) Alison Burgess et al.   Expert Review of Neurotherapeutics

Role of the Blood–Brain Barrier in Multiple Sclerosis

(2014) Genaro Gabriel Ortiz et al.   ARCHIVES OF MEDICAL RESEARCH

Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases

(2014) Sandeep Chhabra et al.   FASEB JOURNAL

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Physiological significance of delayed rectifier K+ channels (Kv1.3) expressed in T lymphocytes and their pathological significance in chronic kidney disease

(2014) Itsuro Kazama   Journal of Physiological Sciences

Margatoxin is a non-selective inhibitor of human Kv1.3 K+ channels

(2014) Adam Bartok et al.   TOXICON

A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases

(2014) M. Harunur Rashid et al.   Scientific Reports

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

The astrocyte in multiple sclerosis revisited

(2013) Celia F. Brosnan et al.   GLIA

BF9, the First Functionally Characterized Snake Toxin Peptide with Kunitz-Type Protease and Potassium Channel Inhibiting Properties

(2013) Weishan Yang et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Blockade of Kv1.3 channels ameliorates radiation-induced brain injury

(2013) Ying Peng et al.   NEURO-ONCOLOGY

Structure, Function, and Chemical Synthesis of Vaejovis mexicanus Peptide 24: A Novel Potent Blocker of Kv1.3 Potassium Channels of Human T Lymphocytes

(2012) Georgina B. Gurrola et al.   BIOCHEMISTRY

Two dyad-free Shaker-type K+ channel blockers from scorpion venom

(2012) Limei Zhu et al.   TOXICON

C5b-9-activated, Kv1.3 channels mediate oligodendrocyte cell cycle activation and dedifferentiation

(2011) Cosmin A. Tegla et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Venoms as a platform for human drugs: translating toxins into therapeutics

(2011) Glenn F King   EXPERT OPINION ON BIOLOGICAL THERAPY

Th17 expansion in MS patients is counterbalanced by an expanded CD39+ regulatory T cell population during remission but not during relapse

(2011) Evelyn Peelen et al.   JOURNAL OF NEUROIMMUNOLOGY

Stroke and the immune system: from pathophysiology to new therapeutic strategies

(2011) Richard Macrez et al.   LANCET NEUROLOGY

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases

(2011) Victor Chi et al.   TOXICON

Lymphocyte activation in type 1 diabetes mellitus: The increased significance of Kv1.3 potassium channels

(2010) Gergely Toldi et al.   IMMUNOLOGY LETTERS

Kv1.3 potassium channels as a therapeutic target in multiple sclerosis

(2009) Srikant Rangaraju et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Engineering a Stable and Selective Peptide Blocker of the Kv1.3 Channel in T Lymphocytes

(2009) M. W. Pennington et al.   MOLECULAR PHARMACOLOGY

Voltage-gated potassium channels as therapeutic targets

(2009) Heike Wulff et al.   NATURE REVIEWS DRUG DISCOVERY

Aberrant modulation of a delayed rectifier potassium channel by glutamate in Alzheimer's disease

(2009) Cornelia Poulopoulou et al.   NEUROBIOLOGY OF DISEASE

Astrocytes in multiple sclerosis: A product of their environment

(2008) A. Nair et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

K+Channel Modulators for the Treatment of Neurological Disorders and Autoimmune Diseases

(2008) Heike Wulff et al.   CHEMICAL REVIEWS

Imaging of Effector Memory T Cells during a Delayed-Type Hypersensitivity Reaction and Suppression by Kv1.3 Channel Block

(2008) Melanie P. Matheu et al.   IMMUNITY

Structural Basis of a Potent Peptide Inhibitor Designed for Kv1.3 Channel, a Therapeutic Target of Autoimmune Disease

(2008) Song Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The antipsychotic spiperone attenuates inflammatory response in cultured microglia via the reduction of proinflammatory cytokine expression and nitric oxide production

(2008) Long Tai Zheng et al.   JOURNAL OF NEUROCHEMISTRY

Co-occurrence of Alzheimer's disease β-amyloid and tau pathologies at synapses

(2008) Reisuke H. Takahashi et al.   NEUROBIOLOGY OF AGING