The memory B cell response to influenza vaccination is impaired in older persons

Development of Tbet- and CD11c-expressing B cells in a viral infection requires T follicular helper cells outside of germinal centers

(2022) Wenzhi Song et al.   IMMUNITY

Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ

(2021) Louise M. C. Webb et al.   AGING CELL

Human antiviral B cell responses: Emerging lessons from hepatitis B and COVID‐19

(2021) Alice R. Burton et al.   IMMUNOLOGICAL REVIEWS

Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans

(2021) Henry J. Sutton et al.   Cell Reports

Differential abundance testing on single-cell data using k-nearest neighbor graphs

(2021) Emma Dann et al.   NATURE BIOTECHNOLOGY

Impaired HA-specific T follicular helper cell and antibody responses to influenza vaccination are linked to inflammation in humans

(2021) Danika L Hill et al.   eLife

Seasonal Variability and Shared Molecular Signatures of Inactivated Influenza Vaccination in Young and Older Adults

(2020) Stefan Avey et al.   JOURNAL OF IMMUNOLOGY

Memory B Cell Activation, Broad Anti-influenza Antibodies, and Bystander Activation Revealed by Single-Cell Transcriptomics

(2020) Felix Horns et al.   Cell Reports

The Transcription Factor T-bet Resolves Memory B Cell Subsets with Distinct Tissue Distributions and Antibody Specificities in Mice and Humans

(2020) John L. Johnson et al.   IMMUNITY

Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination

(2020) Marisa Stebegg et al.   eLife

Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition

(2020) Emanuela Pasciuto et al.   CELL

Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses

(2020) Jenna J. Guthmiller et al.   IMMUNITY

Human germinal centres engage memory and naive B cells after influenza vaccination

(2020) Jackson S. Turner et al.   NATURE

Understanding immunosenescence and its impact on vaccination of older adults

(2020) Jessica C. Allen et al.   VACCINE

Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage

(2019) Dvir Aran et al.   NATURE IMMUNOLOGY

VH1-69 antiviral broadly neutralizing antibodies: genetics, structures, and relevance to rational vaccine design

(2019) Fang Chen et al.   Current Opinion in Virology

RNA-Seq Signatures Normalized by mRNA Abundance Allow Absolute Deconvolution of Human Immune Cell Types

(2019) Gianni Monaco et al.   Cell Reports

The R package Rsubread is easier, faster, cheaper and better for alignment and quantification of RNA sequencing reads

(2019) Yang Liao et al.   NUCLEIC ACIDS RESEARCH

Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals

(2019) Carole Henry et al.   Cell Host & Microbe

FCRL5+ Memory B Cells Exhibit Robust Recall Responses

(2019) Charles C. Kim et al.   Cell Reports

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Overexpression of T-bet in HIV infection is associated with accumulation of B cells outside germinal centers and poor affinity maturation

(2019) James W. Austin et al.   Science Translational Medicine

Global mortality associated with seasonal influenza epidemics: New burden estimates and predictors from the GLaMOR Project

(2019) John Paget et al.   Journal of Global Health

Orchestrating single-cell analysis with Bioconductor

(2019) Robert A. Amezquita et al.   NATURE METHODS

ggCyto: Next Generation Open-Source Visualization Software for Cytometry

(2018) Phu Van et al.   BIOINFORMATICS

B-cell receptor reconstruction from single-cell RNA-seq with VDJPuzzle

(2018) Simone Rizzetto et al.   BIOINFORMATICS

Circulating T FH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity

(2018) Marios Koutsakos et al.   Science Translational Medicine

Economic burden of seasonal influenza in the United States

(2018) Wayan C.W.S. Putri et al.   VACCINE

Circulating and intrahepatic antiviral B cells are defective in hepatitis B

(2018) Alice R. Burton et al.   JOURNAL OF CLINICAL INVESTIGATION

T-Bet + IgM Memory Cells Generate Multi-lineage Effector B Cells

(2018) Kevin J. Kenderes et al.   Cell Reports

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus

(2018) Scott A. Jenks et al.   IMMUNITY

Structural and functional changes to lymph nodes in ageing mice

(2017) Vivian M. Turner et al.   IMMUNOLOGY

Age-Associated B Cells Express a Diverse Repertoire of VHand Vκ Genes with Somatic Hypermutation

(2017) Lisa M. Russell Knode et al.   JOURNAL OF IMMUNOLOGY

Fc Receptor–like 5 Expression Distinguishes Two Distinct Subsets of Human Circulating Tissue–like Memory B Cells

(2016) Huifang Li et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: IL-4, IL-21, and IFN-γ Interact To Govern T-bet and CD11c Expression in TLR-Activated B Cells

(2016) Martin S. Naradikian et al.   JOURNAL OF IMMUNOLOGY

Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination

(2016) Ali H Ellebedy et al.   NATURE IMMUNOLOGY

The cellular composition of the human immune system is shaped by age and cohabitation

(2016) Edward J Carr et al.   NATURE IMMUNOLOGY

Shaping Variation in the Human Immune System

(2016) Adrian Liston et al.   TRENDS IN IMMUNOLOGY

HIV-dependent depletion of influenza-specific memory B cells impacts B cell responsiveness to seasonal influenza immunisation

(2016) Adam K. Wheatley et al.   Scientific Reports

destiny: diffusion maps for large-scale single-cell data in R

(2015) Philipp Angerer et al.   BIOINFORMATICS

Change-O: a toolkit for analyzing large-scale B cell immunoglobulin repertoire sequencing data: Table 1.

(2015) Namita T. Gupta et al.   BIOINFORMATICS

The ageing human B cell repertoire: a failure of selection?

(2015) D. K. Dunn-Walters   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Systems Analysis of Immunity to Influenza Vaccination across Multiple Years and in Diverse Populations Reveals Shared Molecular Signatures

(2015) Helder I. Nakaya et al.   IMMUNITY

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

Orchestrating high-throughput genomic analysis with Bioconductor

(2015) Wolfgang Huber et al.   NATURE METHODS

Immune history profoundly affects broadly protective B cell responses to influenza

(2015) Sarah F. Andrews et al.   Science Translational Medicine

Malaria-associated atypical memory B cells exhibit markedly reduced B cell receptor signaling and effector function

(2015) Silvia Portugal et al.   eLife

Global Analyses of Human Immune Variation Reveal Baseline Predictors of Postvaccination Responses

(2014) John S. Tsang et al.   CELL

Flow Cytometry Reveals that H5N1 Vaccination Elicits Cross-Reactive Stem-Directed Antibodies from Multiple Ig Heavy-Chain Lineages

(2014) J. R. R. Whittle et al.   JOURNAL OF VIROLOGY

Full-length RNA-seq from single cells using Smart-seq2

(2014) Simone Picelli et al.   Nature Protocols

Molecular Signatures of Hemagglutinin Stem-Directed Heterosubtypic Human Neutralizing Antibodies against Influenza A Viruses

(2014) Yuval Avnir et al.   PLoS Pathogens

An In Vivo Human-Plasmablast Enrichment Technique Allows Rapid Identification of Therapeutic Influenza A Antibodies

(2013) Gerald Nakamura et al.   Cell Host & Microbe

Atypical and classical memory B cells producePlasmodium falciparumneutralizing antibodies

(2013) Matthias F. Muellenbeck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The aged microenvironment contributes to the age-related functional defects of CD4 T cells in mice

(2012) Julie S. Lefebvre et al.   AGING CELL

Structural and genetic basis for development of broadly neutralizing influenza antibodies

(2012) Daniel Lingwood et al.   NATURE

Pandemic H1N1 Influenza Infection and Vaccination in Humans Induces Cross-Protective Antibodies that Target the Hemagglutinin Stem

(2012) C. A. Thomson et al.   Frontiers in Immunology

A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice

(2011) Y. Hao et al.   BLOOD

Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c+ B-cell population is important for the development of autoimmunity

(2011) A. V. Rubtsov et al.   BLOOD

Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection

(2011) Jens Wrammert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Distinct response in maintenance of human naive and memory B cells via IL-21 receptor and TCL1/Akt pathways

(2009) Haruo Nagumo et al.   CELLULAR IMMUNOLOGY

Atypical Memory B Cells Are Greatly Expanded in Individuals Living in a Malaria-Endemic Area

(2009) G. E. Weiss et al.   JOURNAL OF IMMUNOLOGY

Safety, immunogencity, and efficacy of a cold-adapted A/Ann Arbor/6/60 (H2N2) vaccine in mice and ferrets

(2009) Grace L. Chen et al.   VIROLOGY

Analysis of somatic hypermutation in X-linked hyper-IgM syndrome shows specific deficiencies in mutational targeting

(2008) N. S. Longo et al.   BLOOD

Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals

(2008) Susan Moir et al.   JOURNAL OF EXPERIMENTAL MEDICINE