Asymmetric dimethylarginine (ADMA) elevation and arginase up-regulation contribute to endothelial dysfunction related to insulin resistance in rats and morbidly obese humans

FM19G11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/eNOS pathway, independently of mTOR/HIF-1α activation

(2015) M El Assar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Diabetes and ageing-induced vascular inflammation

(2015) Mariam El Assar et al.   JOURNAL OF PHYSIOLOGY-LONDON

Serum fetuin-A and arginase-1 in human obesity model: Is there any interaction between inflammatory status and arginine metabolism?

(2015) Sevda Tanrikulu-Küçük et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Differential Effect of Amylin on Endothelial-Dependent Vasodilation in Mesenteric Arteries from Control and Insulin Resistant Rats

(2015) Mariam El Assar et al.   PLoS One

Arginase inhibition restores endothelial function in diet-induced obesity

(2014) Ji Hyung Chung et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

p38 mitogen-activated protein kinase is involved in arginase-II-mediated eNOS-Uncoupling in Obesity

(2014) Yi Yu et al.   Cardiovascular Diabetology

Endothelial Dysfunction, Obesity and Insulin Resistance

(2014) Dolores Prieto et al.   Current Vascular Pharmacology

Arginase inhibition alleviates hypertension in the metabolic syndrome

(2013) Hany M El-Bassossy et al.   BRITISH JOURNAL OF PHARMACOLOGY

Insulin Resistance and not BMI is the Major Determinant of Early Vascular Impairment in Patients with Morbid Obesity

(2013) Graziana Lupattelli et al.   Journal of Atherosclerosis and Thrombosis

Preserved endothelial function in human obesity in the absence of insulin resistance

(2013) Mariam El Assar et al.   Journal of Translational Medicine

Arginase: The Emerging Therapeutic Target for Vascular Oxidative Stress and Inflammation

(2013) Zhihong Yang et al.   Frontiers in Immunology

Positive crosstalk between arginase-II and S6K1 in vascular endothelial inflammation and aging

(2012) Gautham Yepuri et al.   AGING CELL

Endogenous Nitric Oxide Synthase Inhibitors in the Biology of Disease

(2012) Ben Caplin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Insulin Resistance and Coronary Heart Disease in Nondiabetic Individuals

(2012) Gerald Reaven   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Asymmetric Dimethylarginine Plasma Levels and Endothelial Function in Newly Diagnosed Type 2 Diabetic Patients

(2012) Angela Sciacqua et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Atorvastatin modulates the DDAH1/ADMA system in high-fat diet-induced insulin-resistant rats with endothelial dysfunction

(2012) Po Chen et al.   VASCULAR MEDICINE

Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis

(2012) Xiu‐Fen Ming et al.   Journal of the American Heart Association

Effects of pioglitazone and metformin on vascular endothelial function in patients with type 2 diabetes treated with sulfonylureas

(2011) Katerina K Naka et al.   Diabetes & Vascular Disease Research

Weight Loss Improves Endothelial Function Independently of ADMA Reduction in Severe Obesity

(2011) G. Rudofsky et al.   HORMONE AND METABOLIC RESEARCH

Serum asymmetric dimethylarginine and nitric oxide levels in obese postmenopausal women

(2011) Hikmet Kocak et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Insulin Resistance: the Link Between Obesity and Cardiovascular Disease

(2011) Gerald M. Reaven   MEDICAL CLINICS OF NORTH AMERICA

In vivo nitric oxide synthesis, insulin sensitivity, and asymmetric dimethylarginine in obese subjects without and with metabolic syndrome

(2011) Mario Siervo et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Review article: Asymmetric dimethylarginine as a mediator of vascular dysfunction and a marker of cardiovascular disease and mortality: an intriguing interaction with diabetes mellitus

(2010) Maike Anderssohn et al.   Diabetes & Vascular Disease Research

L-arginine, NO and asymmetrical dimethylarginine in hypertension and type 2 diabetes

(2010) Undurti et al.   Frontiers in Bioscience-Landmark

Endothelial dysfunction in aged humans is related with oxidative stress and vascular inflammation

(2009) Leocadio Rodríguez-Mañas et al.   AGING CELL

Vascular Endothelial-Specific Dimethylarginine Dimethylaminohydrolase-1–Deficient Mice Reveal That Vascular Endothelium Plays an Important Role in Removing Asymmetric Dimethylarginine

(2009) Xinli Hu et al.   CIRCULATION

Endothelial dysfunction, ADMA and insulin resistance in essential hypertension

(2009) Francesco Perticone et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Diminished Global Arginine Bioavailability and Increased Arginine Catabolism as Metabolic Profile of Increased Cardiovascular Risk

(2009) W.H. Wilson Tang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Role of the PRMT–DDAH–ADMA axis in the regulation of endothelial nitric oxide production

(2009) Arthur J. Pope et al.   PHARMACOLOGICAL RESEARCH

The Impact of Obesity on Cardiovascular Disease Risk Factors and Subclinical Vascular Disease

(2008) Gregory L. Burke et al.   ARCHIVES OF INTERNAL MEDICINE

Dimethylarginine Dimethylaminohydrolase Overexpression Enhances Insulin Sensitivity

(2008) Karsten Sydow et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Reduced EDHF responses and connexin activity in mesenteric arteries from the insulin-resistant obese Zucker rat

(2008) E. J. Young et al.   DIABETOLOGIA

Asymmetric dimethylarginine levels and carotid intima-media thickness in obese patients with polycystic ovary syndrome and their relationship to metabolic parameters

(2008) Baris Onder Pamuk et al.   FERTILITY AND STERILITY

Insulin resistance functionally limits endothelium-dependent coronary vasodilation in nondiabetic patients

(2008) Noriyuki Fujii et al.   HEART AND VESSELS