Voltage-gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology

Effect of knockout of α2δ-1 on action potentials in mouse sensory neurons

(2016) Wojciech Margas et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Thrombospondin-4 reduces binding affinity of [3H]-gabapentin to calcium-channel α2δ-1-subunit but does not interact with α2δ-1 on the cell-surface when co-expressed

(2016) Beatrice Lana et al.   Scientific Reports

Genomic analysis identifies candidate pathogenic variants in 9 of 18 patients with unexplained West syndrome

(2015) Naomi Hino-Fukuyo et al.   HUMAN GENETICS

Expression and cellular localization of the voltage-gated calcium channel α2δ3in the rodent retina

(2015) Luis Pérez de Sevilla Müller et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Alternative Splicing in CaV2.2 Regulates Neuronal Trafficking via Adaptor Protein Complex-1 Adaptor Protein Motifs

(2015) N. Macabuag et al.   JOURNAL OF NEUROSCIENCE

The Upregulation of α2δ-1 Subunit Modulates Activity-Dependent Ca2+Signals in Sensory Neurons

(2015) Marianna D'Arco et al.   JOURNAL OF NEUROSCIENCE

Small Organic Molecule Disruptors of Cav3.2 - USP5 Interactions Reverse Inflammatory and Neuropathic Pain

(2015) Vinicius M Gadotti et al.   Molecular Pain

Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder

(2015) Jerome Mertens et al.   NATURE

Targeting voltage-gated calcium channels in neurological and psychiatric diseases

(2015) Gerald W. Zamponi   NATURE REVIEWS DRUG DISCOVERY

Nanoscale Distribution of Presynaptic Ca 2+ Channels and Its Impact on Vesicular Release during Development

(2015) Yukihiro Nakamura et al.   NEURON

Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders

(2015) Samuel Heyes et al.   PROGRESS IN NEUROBIOLOGY

Structure of the voltage-gated calcium channel Cav1.1 complex

(2015) J. Wu et al.   SCIENCE

The molecular architecture of dihydropyrindine receptor/L-type Ca2+ channel complex

(2015) Hongli Hu et al.   Scientific Reports

The Low-Threshold Calcium Channel Cav3.2 Determines Low-Threshold Mechanoreceptor Function

(2015) Amaury François et al.   Cell Reports

Pharmacology of L-type Calcium Channels: Novel Drugs for Old Targets?

(2015) Jorg Striessnig et al.   Current Molecular Pharmacology

Calcium Channel α2δ-1 Subunit Knockout Causes Diabetes Due to Impaired Insulin Release

(2015) Petronel Tuluc et al.   BIOPHYSICAL JOURNAL

Anticonvulsant activity of pregabalin in the maximal electroshock-induced seizure assay in α2δ1 (R217A) and α2δ2 (R279A) mouse mutants

(2014) Susan Lotarski et al.   EPILEPSY RESEARCH

Genomic aberrations of the CACNA2D1 gene in three patients with epilepsy and intellectual disability

(2014) Sarah Vergult et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Functional Characterization of CaVα2δ Mutations Associated with Sudden Cardiac Death

(2014) Benoîte Bourdin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 2 3 Is Essential for Normal Structure and Function of Auditory Nerve Synapses and Is a Novel Candidate for Auditory Processing Disorders

(2014) A. Pirone et al.   JOURNAL OF NEUROSCIENCE

Inhibition of A-Type Potassium Current by the Peptide Toxin SNX-482

(2014) T. Kimm et al.   JOURNAL OF NEUROSCIENCE

Painful nerve injury upregulates thrombospondin-4 expression in dorsal root ganglia

(2014) Bin Pan et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A Comparison of RNA-Seq and Exon Arrays for Whole Genome Transcription Profiling of the L5 Spinal Nerve Transection Model of Neuropathic Pain in the Rat

(2014) James R Perkins et al.   Molecular Pain

Synaptic, transcriptional and chromatin genes disrupted in autism

(2014) Silvia De Rubeis et al.   NATURE

A polygenic burden of rare disruptive mutations in schizophrenia

(2014) Shaun M. Purcell et al.   NATURE

Control and Plasticity of the Presynaptic Action Potential Waveform at Small CNS Nerve Terminals

(2014) Michael B. Hoppa et al.   NEURON

T-type channel-mediated neurotransmitter release

(2014) Emilio Carbone et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Genome-Wide Transcriptional Profiling of Skin and Dorsal Root Ganglia after Ultraviolet-B-Induced Inflammation

(2014) John M. Dawes et al.   PLoS One

Functional exofacially tagged N-type calcium channels elucidate the interaction with auxiliary  2 -1 subunits

(2014) J. S. Cassidy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Refinement and Discovery of New Hotspots of Copy-Number Variation Associated with Autism Spectrum Disorder

(2013) Santhosh Girirajan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The inhibition of functional expression of calcium channels by prion protein demonstrates competition with α2δ for GPI-anchoring pathways

(2013) Anita Alvarez-Laviada et al.   BIOCHEMICAL JOURNAL

Expression of voltage-gated calcium channel α2δ4subunits in the mouse and rat retina

(2013) Luis Pérez De Sevilla Müller et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Early infantile epileptic encephalopathy associated with a high voltage gated calcium channelopathy

(2013) Simon Edvardson et al.   JOURNAL OF MEDICAL GENETICS

 2 -1 Gene Deletion Affects Somatosensory Neuron Function and Delays Mechanical Hypersensitivity in Response to Peripheral Nerve Damage

(2013) R. Patel et al.   JOURNAL OF NEUROSCIENCE

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

(2013)   LANCET

Structural basis for Ca2+ selectivity of a voltage-gated calcium channel

(2013) Lin Tang et al.   NATURE

Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension

(2013) Elena A B Azizan et al.   NATURE GENETICS

Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism

(2013) Ute I Scholl et al.   NATURE GENETICS

Differential triggering of spontaneous glutamate release by P/Q-, N- and R-type Ca2+ channels

(2013) Yaroslav S Ermolyuk et al.   NATURE NEUROSCIENCE

Differential upregulation in DRG neurons of an α2δ-1 splice variant with a lower affinity for gabapentin after peripheral sensory nerve injury

(2013) Beatrice Lana et al.   PAIN

A Novel Null Homozygous Mutation Confirms CACNA2D2 as a Gene Mutated in Epileptic Encephalopathy

(2013) Tommaso Pippucci et al.   PLoS One

Phosphorylation sites required for regulation of cardiac calcium channels in the fight-or-flight response

(2013) Y. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic switching of calmodulin interactions underlies Ca2+ regulation of CaV1.3 channels

(2013) Manu Ben Johny et al.   Nature Communications

Functional Consequences of Mutations in Postsynaptic Scaffolding Proteins and Relevance to Psychiatric Disorders

(2012) Jonathan T. Ting et al.   Annual Review of Neuroscience

CaV1.1: The atypical prototypical voltage-gated Ca2+ channel

(2012) Roger A. Bannister et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Regulation of CaV2 calcium channels by G protein coupled receptors

(2012) Gerald W. Zamponi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Voltage-Gated Calcium Channel α2δ Subunits in Lipid Rafts: The Importance of Proteolytic Cleavage Into α2 and δ

(2012) Ivan Kadurin et al.   BIOPHYSICAL JOURNAL

CNVs: Harbingers of a Rare Variant Revolution in Psychiatric Genetics

(2012) Dheeraj Malhotra et al.   CELL

Pregabalin for the treatment of fibromyalgia

(2012) Maree T Smith et al.   EXPERT OPINION ON PHARMACOTHERAPY

Calcium Currents Are Enhanced by α2δ-1 Lacking Its Membrane Anchor

(2012) Ivan Kadurin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zona glomerulosa cells of the mouse adrenal cortex are intrinsic electrical oscillators

(2012) Changlong Hu et al.   JOURNAL OF CLINICAL INVESTIGATION

Quantitative Regional and Ultrastructural Localization of the Cav2.3 Subunit of R-type Calcium Channel in Mouse Brain

(2012) L. K. Parajuli et al.   JOURNAL OF NEUROSCIENCE

Erratum: Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond

(2012) Annette C. Dolphin   NATURE REVIEWS NEUROSCIENCE

De Novo Gene Disruptions in Children on the Autistic Spectrum

(2012) Ivan Iossifov et al.   NEURON

Identification of a disulfide bridge essential for structure and function of the voltage-gated Ca2+ channel α2δ-1 auxiliary subunit

(2011) Aida Calderón-Rivera et al.   CELL CALCIUM

Identification of a novel loss-of-function calcium channel gene mutation in short QT syndrome (SQTS6)

(2011) C. Templin et al.   EUROPEAN HEART JOURNAL

Pregabalin is a potent and selective ligand for α2δ-1 and α2δ-2 calcium channel subunits

(2011) Zheng Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Newer-Generation Antiepileptic Drugs and the Risk of Major Birth Defects

(2011) Ditte Mølgaard-Nielsen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

β-Subunits Promote the Expression of CaV2.2 Channels by Reducing Their Proteasomal Degradation

(2011) Dominic Waithe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anxiolytic-Like Activity of Pregabalin in the Vogel Conflict Test in  2 -1 (R217A) and  2 -2 (R279A) Mouse Mutants

(2011) S. M. Lotarski et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

Presynaptic HCN1 channels regulate CaV3.2 activity and neurotransmission at select cortical synapses

(2011) Zhuo Huang et al.   NATURE NEUROSCIENCE

A Genome-wide Drosophila Screen for Heat Nociception Identifies α2δ3 as an Evolutionarily Conserved Pain Gene

(2010) G. Gregory Neely et al.   CELL

Time course and specificity of the pharmacological disruption of the trafficking of voltage-gated calcium channels by gabapentin

(2010) Fay Heblich et al.   Channels

Progress in the structural understanding of voltage-gated calcium channel (CaV) function and modulation

(2010) Felix Findeisen et al.   Channels

Multiple C-terminal tail Ca2+/CaMs regulate CaV1.2 function but do not mediate channel dimerization

(2010) Eun Young Kim et al.   EMBO JOURNAL

Mutations in the cardiac L-type calcium channel associated with inherited J-wave syndromes and sudden cardiac death

(2010) Elena Burashnikov et al.   HEART RHYTHM

Different Relationship of N- and P/Q-Type Ca2+ Channels to Channel-Interacting Slots in Controlling Neurotransmission at Cultured Hippocampal Synapses

(2010) Y. Q. Cao et al.   JOURNAL OF NEUROSCIENCE

The  2  Ligand Gabapentin Inhibits the Rab11-Dependent Recycling of the Calcium Channel Subunit  2 -2

(2010) A. Tran-Van-Minh et al.   JOURNAL OF NEUROSCIENCE

Mechanism of Cancer Pain

(2010) B. L. Schmidt et al.   MOLECULAR INTERVENTIONS

The Cavβ subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels

(2010) Christophe Altier et al.   NATURE NEUROSCIENCE

Loss of Cav1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness

(2010) Shahid M Baig et al.   NATURE NEUROSCIENCE

The β Subunit of Voltage-Gated Ca2+ Channels

(2010) Zafir Buraei et al.   PHYSIOLOGICAL REVIEWS

Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain

(2010) C. S. Muller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The  2  subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function

(2010) A. Davies et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanism of Calcium Channel Regulation in the Fight-or-Flight Response

(2010) M. D. Fuller et al.   Science Signaling

Targeted disruption of the voltage-dependent calcium channel α2/δ-1-subunit

(2009) Geraldine A. Fuller-Bicer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Gabapentin Receptor α2δ-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis

(2009) Çagla Eroglu et al.   CELL

Three-dimensional Structure of CaV3.1

(2009) Conor P. Walsh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Robust Pacemaking in Substantia Nigra Dopaminergic Neurons

(2009) J. N. Guzman et al.   JOURNAL OF NEUROSCIENCE

Cav1.3 Channel Voltage Dependence, Not Ca2+ Selectivity, Drives Pacemaker Activity and Amplifies Bursts in Nigral Dopamine Neurons

(2009) I. Putzier et al.   JOURNAL OF NEUROSCIENCE

The Increased Trafficking of the Calcium Channel Subunit  2 -1 to Presynaptic Terminals in Neuropathic Pain Is Inhibited by the  2  Ligand Pregabalin

(2009) C. S. Bauer et al.   JOURNAL OF NEUROSCIENCE

Presynaptic α2δ-3 is required for synaptic morphogenesis independent of its Ca2+-channel functions

(2009) Peri T Kurshan et al.   NATURE NEUROSCIENCE

From Basic Science to Blockbuster Drug: The Discovery of Lyrica

(2008) Richard B. Silverman   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PredGPI: a GPI-anchor predictor

(2008) Andrea Pierleoni et al.   BMC BIOINFORMATICS

Thrombospondins: from structure to therapeutics

(2008) S. Kazerounian et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Origin of the Voltage Dependence of G-Protein Regulation of P/Q-type Ca2+ Channels

(2008) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Molecular Pharmacology of Human Cav3.2 T-Type Ca2+ Channels: Block by Antihypertensives, Antiarrhythmics, and Their Analogs

(2008) E. Perez-Reyes et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A modular switch for spatial Ca2+ selectivity in the calmodulin regulation of CaV channels

(2008) Ivy E. Dick et al.   NATURE

Immunostaining of rat brain, spinal cord, sensory neurons and skeletal muscle for calcium channel alpha2-delta (α2-δ) type 1 protein

(2008) C.P. Taylor et al.   NEUROSCIENCE

Pharmacological disruption of calcium channel trafficking by the  2  ligand gabapentin

(2008) J. Hendrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of CaV2 Ca2+/CaM-IQ Domain Complexes Reveal Binding Modes that Underlie Calcium-Dependent Inactivation and Facilitation

(2008) Eun Young Kim et al.   STRUCTURE

Crystal Structure of the CaV2 IQ Domain in Complex with Ca2+/Calmodulin: High-Resolution Mechanistic Implications for Channel Regulation by Ca2+

(2008) Masayuki X. Mori et al.   STRUCTURE