Presynaptic BK channels control transmitter release: physiological relevance and potential therapeutic implications

MaxiK channel interactome reveals its interaction with GABA transporter 3 and heat shock protein 60 in the mammalian brain

(2016) H. Singh et al.   NEUROSCIENCE

Presynaptic BK channel localization is dependent on the hierarchical organization of alpha-catulin and dystrobrevin and fine-tuned by CaV2 calcium channels

(2015) Kelly H Oh et al.   BMC NEUROSCIENCE

Genetic upregulation of BK channel activity normalizes multiple synaptic and circuit defects in a mouse model of fragile X syndrome

(2015) Pan-Yue Deng et al.   JOURNAL OF PHYSIOLOGY-LONDON

Independent role for presynaptic FMRP revealed by anFMR1missense mutation associated with intellectual disability and seizures

(2015) Leila K. Myrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two classes of regulatory subunits coassemble in the same BK channel and independently regulate gating

(2015) Vivian Gonzalez-Perez et al.   Nature Communications

Increased Expression of the Large Conductance, Calcium-Activated K+ (BK) Channel in Adult-Onset Neuronal Ceroid Lipofuscinosis

(2015) Julien Donnelier et al.   PLoS One

Large Conductance Voltage- and Ca2+-gated Potassium (BK) Channel β4 Subunit Influences Sensitivity and Tolerance to Alcohol by Altering Its Response to Kinases

(2014) Cristina Velázquez-Marrero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Archaerhodopsin Voltage Imaging: Synaptic Calcium and BK Channels Stabilize Action Potential Repolarization at the Drosophila Neuromuscular Junction

(2014) K. J. Ford et al.   JOURNAL OF NEUROSCIENCE

Large Conductance Calcium-Activated Potassium Channels: Their Expression and Modulation of Glutamate Release from Nerve Terminals Isolated from Rat Trigeminal Caudal Nucleus and Cerebral Cortex

(2014) Irene Samengo et al.   NEUROCHEMICAL RESEARCH

Rescue of fragile X syndrome phenotypes in Fmr1KO mice by a BKCa channel opener molecule

(2014) Betty Hébert et al.   Orphanet Journal of Rare Diseases

Critical role of large-conductance calcium- and voltage-activated potassium channels in leptin-induced neuroprotection of N-methyl-d-aspartate-exposed cortical neurons

(2014) Maria Mancini et al.   PHARMACOLOGICAL RESEARCH

Cysteine String Protein Limits Expression of the Large Conductance, Calcium-Activated K+ (BK) Channel

(2014) Eva Ahrendt et al.   PLoS One

BK channel activators and their therapeutic perspectives

(2014) Bo H. Bentzen et al.   Frontiers in Physiology

The regulation of BK channel activity by pre- and post-translational modifications

(2014) Barry D. Kyle et al.   Frontiers in Physiology

Distinct roles ofDrosophila cacophonyandDmca1DCa2+channels in synaptic homeostasis: Genetic interactions withslowpokeCa2+-activated BK channels in presynaptic excitability and postsynaptic response

(2013) Jihye Lee et al.   Developmental Neurobiology

Quantitative Localization of Cav2.1 (P/Q-Type) Voltage-Dependent Calcium Channels in Purkinje Cells: Somatodendritic Gradient and Distinct Somatic Coclustering with Calcium-Activated Potassium Channels

(2013) D. W. Indriati et al.   JOURNAL OF NEUROSCIENCE

FMRP Regulates Neurotransmitter Release and Synaptic Information Transmission by Modulating Action Potential Duration via BK Channels

(2013) Pan-Yue Deng et al.   NEURON

Mice with Deficient BK Channel Function Show Impaired Prepulse Inhibition and Spatial Learning, but Normal Working and Spatial Reference Memory

(2013) Marei Typlt et al.   PLoS One

Mechanism of the modulation of BK potassium channel complexes with different auxiliary subunit compositions by the omega-3 fatty acid DHA

(2013) T. Hoshi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Large Conductance, Calcium-activated K+ (BK) Channel is regulated by Cysteine String Protein

(2013) Barry D. Kyle et al.   Scientific Reports

The first transmembrane domain (TM1) of β2-subunit binds to the transmembrane domain S1 of α-subunit in BK potassium channels

(2012) Francisco J. Morera et al.   FEBS LETTERS

BK potassium channel modulation by leucine-rich repeat-containing proteins

(2012) J. Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sparse But Highly Efficient Kv3 Outpace BKCa Channels in Action Potential Repolarization at Hippocampal Mossy Fiber Boutons

(2011) H. Alle et al.   JOURNAL OF NEUROSCIENCE

Dystrobrevin Controls Neurotransmitter Release and Muscle Ca2+ Transients by Localizing BK Channels in Caenorhabditis elegans

(2011) B. Chen et al.   JOURNAL OF NEUROSCIENCE

Nanodomain coupling between Ca2+ channels and sensors of exocytosis at fast mammalian synapses

(2011) Emmanuel Eggermann et al.   NATURE REVIEWS NEUROSCIENCE

Movements of Individual BKCa Channels in Live Cell Membrane Monitored by Site-Specific Labeling Using Quantum Dots

(2010) Sehoon Won et al.   BIOPHYSICAL JOURNAL

Pre-synaptic BK channels selectively control glutamate versus GABA release from cortical and hippocampal nerve terminals

(2010) Maria Martire et al.   JOURNAL OF NEUROCHEMISTRY

Ca2+ and Ca2+-Activated K+ Channels That Support and Modulate Transmitter Release at the Olivocochlear Efferent-Inner Hair Cell Synapse

(2010) J. Zorrilla de San Martin et al.   JOURNAL OF NEUROSCIENCE

A Novel Auxiliary Subunit Critical to BK Channel Function in Caenorhabditis elegans

(2010) B. Chen et al.   JOURNAL OF NEUROSCIENCE

LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium

(2010) Jiusheng Yan et al.   NATURE

An Epilepsy/Dyskinesia-Associated Mutation Enhances BK Channel Activation by Potentiating Ca2+ Sensing

(2010) Junqiu Yang et al.   NEURON

Ca2+-Activated K+ Channels: From Protein Complexes to Function

(2010) Henrike Berkefeld et al.   PHYSIOLOGICAL REVIEWS

Ion sensing in the RCK1 domain of BK channels

(2010) G. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Human BK Channel Ca2+-Activation Apparatus at 3.0 A Resolution

(2010) P. Yuan et al.   SCIENCE

Compartmentalized   Subunit Distribution Determines Characteristics and Ethanol Sensitivity of Somatic, Dendritic, and Terminal Large-Conductance Calcium-Activated Potassium Channels in the Rat Central Nervous System

(2009) P. M. Wynne et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

β subunit-specific modulations of BK channel function by a mutation associated with epilepsy and dyskinesia

(2009) Urvi S. Lee et al.   JOURNAL OF PHYSIOLOGY-LONDON

Structure of the BK potassium channel in a lipid membrane from electron cryomicroscopy

(2009) Liguo Wang et al.   NATURE

BK channels modulate pre- and postsynaptic signaling at reciprocal synapses in retina

(2009) William N Grimes et al.   NATURE NEUROSCIENCE

Down-regulation of BK channel expression in the pilocarpine model of temporal lobe epilepsy

(2008) Luis F. Pacheco Otalora et al.   BRAIN RESEARCH

Anticonvulsant effects of the BK-channel antagonist paxilline

(2008) Jesse J. Sheehan et al.   EPILEPSIA

Measurements of the BKCaChannel's High-Affinity Ca2+Binding Constants: Effects of Membrane Voltage

(2008) Tara-Beth Sweet et al.   JOURNAL OF GENERAL PHYSIOLOGY

Regulation of Synaptic Transmission by Presynaptic CaMKII and BK Channels

(2008) Zhao-Wen Wang   MOLECULAR NEUROBIOLOGY

Activation of large-conductance Ca2+-activated K+ channels depresses basal synaptic transmission in the hippocampal CA1 area in APP (swe/ind) TgCRND8 mice

(2008) Hui Ye et al.   NEUROBIOLOGY OF AGING

A seizure-induced gain-of-function in BK channels is associated with elevated firing activity in neocortical pyramidal neurons

(2008) Sonal Shruti et al.   NEUROBIOLOGY OF DISEASE

Control of KCa Channels by Calcium Nano/Microdomains

(2008) Bernd Fakler et al.   NEURON

Pre- and post-synaptic mechanisms of synaptic strength homeostasis revealed by slowpoke and shaker K+ channel mutations in Drosophila

(2008) J. Lee et al.   NEUROSCIENCE

Locations of the  1 transmembrane helices in the BK potassium channel

(2008) G. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA