Article
Cardiac & Cardiovascular Systems
Neeltje A. E. Allard, Lando Janssen, Thorben Aussieker, Anouk A. F. Stoffels, Richard J. Rodenburg, Willem J. J. Assendelft, Paul D. Thompson, Tim Snijders, Maria T. E. Hopman, Silvie Timmers
Summary: This study found that a moderate intensity exercise training program improved muscle performance, capillarization, and mitochondrial content in both symptomatic and asymptomatic statin users without worsening muscle symptoms.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Nutrition & Dietetics
Pauline S. Effting, Anand Thirupathi, Alexandre P. Muller, Barbara C. Pereira, Diane M. Sepa-Kishi, Luis F. B. Marqueze, Franciane T. F. Vasconcellos, Renata T. Nesi, Talita C. B. Pereira, Luiza W. Kist, Mauricio R. Bogo, Rolando B. Ceddia, Ricardo A. Pinho
Summary: This study found that ladder climbing, as a model of resistance exercise, can reverse the metabolic and inflammatory effects of high-fat diet-induced obesity in mice. The training reduced body weight, adipocyte size, improved glycemic control, and reduced inflammation in skeletal muscles.
Article
Endocrinology & Metabolism
Ahmet Yardimci, Nazife Ulker, Ozgur Bulmus, Elif Sahin, Ahmet Alver, Ibrahim Halil Gungor, Gaffari Turk, Gokhan Artas, Nalan Kaya Tektemur, Mete Ozcan, Haluk Kelestimur, Sinan Canpolat
Summary: The study suggests that irisin can improve reproductive dysfunction in obese male rats induced by a high-fat diet, including improving erectile function, sperm quality, and reducing testicular damage caused by fat.
NEUROENDOCRINOLOGY
(2022)
Article
Neurosciences
Caroline Bitencourt Soares, Leticia Rossi Dare, Karine Ramires Lima, Luiza Freitas Lopes, Alexandre Garcia Dos Santos, Helen Lidiane Schimidt, Felipe Pivetta Carpes, Ana Lloret, Jose Vina, Pamela Billig Mello-Carpes
Summary: The study found that long-term multicomponent exercise training can prevent amyloid-beta neurotoxicity in the hippocampus, reducing oxidative stress, restoring antioxidant capacity, increasing glutathione levels, and ultimately preventing recognition memory deficits.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Medicine, Research & Experimental
Beatriz Alexandre-Santos, D'Angelo Carlo Magliano, Isabele Gomes Giori, Gabriela Rodrigues de Oliveira Medeiros, Carla P. Vieira, Carlos Adam Conte-Junior, Antonio Claudio Lucas da Nobrega, Eliete Dalla Corte Frantz
Summary: Under high-fat diet conditions, enalapril treatment and/or exercise training can improve visceral fat accumulation and related deleterious outcomes, potentially by favoring the Ang 1-7/MasR arm and B2R expression.
Article
Health Care Sciences & Services
Shengyan Sun, Zhaowei Kong, Qingde Shi, Haifeng Zhang, On-Kei Lei, Jinlei Nie
Summary: The study showed that a short-term low-carbohydrate diet led to significant weight loss and improvements in blood pressure and insulin sensitivity in overweight/obese women. However, the combination with exercise training did not provide additional benefits on the evaluated cardiometabolic profiles.
Article
Nutrition & Dietetics
David Law, Mitchel A. Magrini, Jacob A. Siedlik, Joan Eckerson, Kristen M. Drescher, Eric C. Bredahl
Summary: Exercise and creatine have protective effects against doxorubicin-induced cardiotoxicity. Aerobic exercise and resistance training can reduce cardiac burden caused by DOX, and creatine supplementation can increase cardiac mass. These results indicate that exercise and creatine can serve as a cost-effective complement to cancer treatment, improving patient outcomes.
Article
Physiology
Anamei Silva-Reis, Maysa Alves Rodrigues Brandao-Rangel, Renilson Moraes-Ferreira, Thiago Gibson Goncalves-Alves, Victor Hugo Souza-Palmeira, Helida Cristina Aquino-Santos, Andre Luis Lacerda Bachi, Luis Vicente Franco de Oliveira, Rodrigo Alvaro Brandao Lopes-Martins, Iranse Oliveira-Silva, Regiane Albertini, Claudio Ricardo Frison, Rodolfo P. Vieira
Summary: This study investigated the effects of combined physical exercise on lung function and immune response in non-obese, overweight, and obese grade I women. The results showed that combined physical exercise improved lung function and mechanics in obese grade I women and reduced pro-fibrotic IGF-1 levels while increasing anti-fibrotic Klotho levels.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Neurosciences
Angelo Sabag, Johnathan P. Little, Nathan A. Johnson
Summary: Low-volume HIIT, involving short bouts of high-intensity exercise, has shown to provide similar, or even greater, health benefits compared to traditional aerobic exercises. The improvements seen in cardiorespiratory health, glucose control, and cardiac function may be attributed to enhanced mitochondrial function and insulin sensitivity. Additionally, low-volume HIIT is well-tolerated and safe for adults, with high exercise adherence rates and minimal adverse effects reported.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Sport Sciences
Ming-Lu Lin, Chih-Chin Hsu, Tieh-Cheng Fu, Yu-Ting Lin, Yu-Chieh Huang, Jong-Shyan Wang
Summary: This study investigates the effects of interval and continuous exercise on NK cell phenotypes and mitochondrial bioenergetics. The results show that both high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) can increase the expressions of cytotoxic granule proteins and decrease mitochondrial matrix oxidant burden (MOB) in NK cells. Additionally, HIIT is superior to MICT in improving aerobic capacity.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Cell Biology
Luyao Wang, Yurong Chen, Jiarui Wei, Fucheng Guo, Leyi Li, Zhen Han, Zhengzhu Wang, Haibo Zhu, Xiaoling Zhang, Ziyi Li, Xiangpeng Dai
Summary: In this study, it was found that nicotinamide mononucleotide (NMN) could improve the oocyte quality of obese mice, possibly by restoring mitochondrial function and actin dynamics, reducing meiotic defects, DNA damage, and ROS levels, as well as altering lipid droplet distribution. Furthermore, NMN treatment also restored the offspring body weight of obese mice.
CELL PROLIFERATION
(2022)
Review
Nutrition & Dietetics
Agata Stanek, Klaudia Brozyna-Tkaczyk, Wojciech Myslinski
Summary: PVAT plays a significant role in regulating vascular tone, thermoregulation, and VSMC proliferation. Obesity-induced dysfunction can be improved by physical activity and diet interventions.
Article
Sport Sciences
Nakisa Soltani, Sayyed Mohammad Marandi, Volga Hovsepian, Mohammad Kazemi, Nafiseh Esmaeil
Summary: This study compared the effects of different types of high-intensity interval training (HIIT) on meta-inflammation during obesity. The results showed that resistance exercise training can significantly decrease the levels of TLR4, TRIF, IRF3, TNF alpha, and IFN gamma, enhancing the immunomodulatory adaptations to HIIT.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Public, Environmental & Occupational Health
Yukun Hu, Yong Zhang, XiaoYa Qi, XiaoYang Xu, Jamal Rahmani, Ruixue Bai, Ying Mei
Summary: Wearable physical activity trackers are gaining popularity for weight management, but there is limited evidence of their effectiveness. Studies have shown that supervised exercise is better than unsupervised exercise, but there is no evidence comparing remote supervision exercise with self-directed exercise based on mHealth. This study compared the effects of mHealth-based supervised exercise to mHealth-based self-directed exercise on weight control in overweight and obese individuals. The results showed that supervised exercise was more effective in improving health factors compared to self-directed exercise.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Psychology, Biological
Penghua Fang, Wancheng Guo, Mengxian Ju, Yujie Huang, Hanjin Zeng, Yajing Wang, Mei Yu, Zhenwen Zhang
Summary: Exercise training improves obesity-induced metabolic diseases by regulating adipokines. The expression of adipocyte-spexin is increased in the adipose tissue of obese mice after exercise, contributing to the improvement of insulin resistance. In addition, exercise increases the levels of GLUT4, SIRT1 and PGC-1 alpha in the skeletal muscles of mice.
PHYSIOLOGY & BEHAVIOR
(2022)
Review
Medicine, Research & Experimental
Joseph H. Dayan, Catherine L. Ly, Raghu P. Kataru, Babak J. Mehrara
ANNUAL REVIEW OF MEDICINE, VOL 69
(2018)
Article
Surgery
Geoffrey E. Hespe, Catherine L. Ly, Raghu P. Kataru, Babak J. Mehrara
PLASTIC AND RECONSTRUCTIVE SURGERY
(2019)
Article
Surgery
Catherine L. Ly, Daniel A. Cuzzone, Raghu P. Kataru, Babak J. Mehrara
PLASTIC AND RECONSTRUCTIVE SURGERY
(2019)
Article
Medical Laboratory Technology
Catherine L. Ly, Gabriela D. Garcia Nores, Raghu P. Kataru, Babak J. Mehrara
TRANSLATIONAL RESEARCH
(2019)
Review
Medical Laboratory Technology
Raghu P. Kataru, Itay Wiser, Jung Eun Baik, Hyeung Ju Park, Sonia Renal, Jin Peon Shin, Babak J. Mehrara
TRANSLATIONAL RESEARCH
(2019)
Article
Oncology
Raghu P. Kataru, Catherine L. Ly, Jinyeon Shin, Hyeung Ju Park, Jung Eun Baik, Sonia Rehal, Sagrario Ortega, David Lyden, Babak J. Mehrara
CANCER IMMUNOLOGY RESEARCH
(2019)
Article
Multidisciplinary Sciences
Shiri Gur-Cohen, Hanseul Yang, Sanjeethan C. Baksh, Yuxuan Miao, John Levorse, Raghu P. Kataru, Xiaolei Liu, June de la Cruz-Racelis, Babak J. Mehrara, Elaine Fuchs
Article
Cell Biology
Elizabeth J. Haining, Kate L. Lowe, Surasak Wichaiyo, Raghu P. Kataru, Zoltan Nagy, Dean Pj Kavanagh, Sian Lax, Ying Di, Bernhard Nieswandt, Benoit Ho-Tin-Noe, Babak J. Mehrara, Yotis A. Senis, Julie Rayes, Steve P. Watson
Summary: The study found that CLEC-2 expression on platelets is not necessary to maintain a barrier between the blood and lymphatic systems in unchallenged mice, but deficiency in CLEC-2 can lead to lymphatic vessel blood filling under conditions of chronic vascular remodeling. CLEC-2-driven platelet activation plays an essential role in vascular developmental programs.
Review
Biochemistry & Molecular Biology
Claire Y. Li, Raghu P. Kataru, Babak J. Mehrara
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Physiology
Raghu P. Kataru, Hyeong Ju Park, Jung Eun Baik, Claire Li, Jinyeon Shin, Babak J. Mehrara
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Endocrinology & Metabolism
Sonia Rehal, Raghu P. Kataru, Geoffrey E. Hespe, Jung Eun Baik, Hyeung Ju Park, Catherine Ly, JinYeon Shin, Babak J. Mehrara
MOLECULAR METABOLISM
(2020)
Article
Biochemistry & Molecular Biology
Raghu P. Kataru, Jung Eun Baik, Hyeung Ju Park, Catherine L. Ly, Jinyeon Shin, Noa Schwartz, Theresa T. Lu, Sagrario Ortega, Babak J. Mehrara
Summary: The study shows that intracellular modulation of the VEGF-C signaling pathway can induce the formation of functional lymphatic networks without off-target effects and inflammation.
Article
Multidisciplinary Sciences
Daniel Szoke, Gabor Kovacs, Eva Kemecsei, Laszlo Balint, Kitti Szotak-Ajtay, Petra Aradi, Andrea Styevkone Dinnyes, Barbara L. Mui, Ying K. Tam, Thomas D. Madden, Katalin Kariko, Raghu P. Kataru, Michael J. Hope, Drew Weissman, Babak J. Mehrara, Norbert Pardi, Zoltan Jakus
Summary: Dysfunction of the lymphatic system leads to secondary lymphedema and decreases quality of life. Researchers demonstrate that delivery of nucleoside-modified Vascular Endothelial Growth Factor C (VEGFC) mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Babak J. Mehrara, Hyeung Ju Park, Raghu P. Kataru, Jacqueline Bromberg, Michelle Coriddi, Jung Eun Baik, Jinyeon Shin, Claire Li, Michele R. Cavalli, Elizabeth M. Encarnacion, Meghan Lee, Kimberly J. Van Zee, Elyn Riedel, Joseph H. Dayan
Summary: The study aimed to examine the effect of inhibiting Th2 inflammation in lymphedema by using QBX258, a combination of IL4/13 neutralizing antibodies, and found that it improved quality of life and reduced pathological skin changes in women with breast cancer-related lymphedema. Treatment with QBX258 showed improvements in skin stiffness and quality of life measurements, particularly in physical and social aspects, with histological evidence of decreased epidermal changes and cytokine expression in lymphedematous skin.
Review
Immunology
Raghu P. Kataru, Jung Eun Baik, Hyeung Ju Park, Itay Wiser, Sonia Rehal, Jin Yeon Shin, Babak J. Mehrara
FRONTIERS IN IMMUNOLOGY
(2019)