Reversible Myc hypomorphism identifies a key Myc-dependency in early cancer evolution

The MYC oncogene — the grand orchestrator of cancer growth and immune evasion

(2021) Renumathy Dhanasekaran et al.   Nature Reviews Clinical Oncology

Myc instructs and maintains pancreatic adenocarcinoma phenotype

(2020) Nicole M Sodir et al.   Cancer Discovery

Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity

(2020) Megan J. Bywater et al.   Nature Communications

Role of c-Myc haploinsufficiency in the maintenance of HSCs

(2020) Yue Sheng et al.   BLOOD

Super-enhancers: critical roles and therapeutic targets in hematologic malignancies

(2019) Yunlu Jia et al.   Journal of Hematology & Oncology

Transcriptional Dysregulation of MYC Reveals Common Enhancer-Docking Mechanism

(2018) Jurian Schuijers et al.   Cell Reports

Deletion of the murine ortholog of the 8q24 gene desert has anti-cancer effects in transgenic mammary cancer models

(2018) Collin Homer-Bouthiette et al.   BMC CANCER

Therapeutic Inhibition of Myc in Cancer. Structural Bases and Computer-Aided Drug Discovery Approaches

(2018) Lavinia Carabet et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genetic compensation: A phenomenon in search of mechanisms

(2017) Mohamed A. El-Brolosy et al.   PLoS Genetics

Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth

(2017) Kashyap Dave et al.   eLife

Determination of the physiological and pathological roles of E2F3 in adult tissues

(2017) Ivonne Gamper et al.   Scientific Reports

Reduced Expression of MYC Increases Longevity and Enhances Healthspan

(2015) Jeffrey W. Hofmann et al.   CELL

Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers

(2015) Xiaoyang Zhang et al.   NATURE GENETICS

Finding cancer’s weakest link

(2015) Nicole Michel Sodir et al.   Oncotarget

The mutational landscapes of genetic and chemical models of Kras-driven lung cancer

(2014) Peter M. K. Westcott et al.   NATURE

Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles

(2014) Susanne Walz et al.   NATURE

A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia

(2014) Daniel Herranz et al.   NATURE MEDICINE

Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice

(2013) L. Soucek et al.   GENES & DEVELOPMENT

The Role of MIZ-1 in MYC-Dependent Tumorigenesis

(2013) K. E. Wiese et al.   Cold Spring Harbor Perspectives in Medicine

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

Mice Lacking a Myc Enhancer That Includes Human SNP rs6983267 Are Resistant to Intestinal Tumors

(2012) I. K. Sur et al.   SCIENCE

Endogenous Myc maintains the tumor microenvironment

(2011) N. M. Sodir et al.   GENES & DEVELOPMENT

Focal Adhesion Kinase Is Required for Intestinal Regeneration and Tumorigenesis Downstream of Wnt/c-Myc Signaling

(2010) Gabrielle H. Ashton et al.   DEVELOPMENTAL CELL

Myc heterozygosity attenuates the phenotypes of APC deficiency in the small intestine

(2010) D Athineos et al.   ONCOGENE

8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC

(2010) N. Ahmadiyeh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endometrial Decidualization: Of Mice and Men

(2010) Cyril Ramathal et al.   SEMINARS IN REPRODUCTIVE MEDICINE

c-Myc-mediated control of cell fate in megakaryocyte-erythrocyte progenitors

(2009) Y. Guo et al.   BLOOD

Distinct Thresholds Govern Myc's Biological Output In Vivo

(2008) Daniel J. Murphy et al.   CANCER CELL

Placental rescue reveals a sole requirement for c-Myc in embryonic erythroblast survival and hematopoietic stem cell function

(2008) N. C. Dubois et al.   DEVELOPMENT

Modelling Myc inhibition as a cancer therapy

(2008) Laura Soucek et al.   NATURE